Resveratrol_NCI-H460 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Resveratrol perturbation in NCI-H460 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Resveratrol_NCI-H460 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
GDA guanine deaminase 0.103847
MYOF myoferlin 0.0820986
FMNL2 formin-like 2 0.0679847
PDLIM5 PDZ and LIM domain 5 0.0607877
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0597477
KYNU kynureninase 0.0588277
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0555983
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 0.0480601
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0438628
CXCL8 chemokine (C-X-C motif) ligand 8 0.0419621
SQSTM1 sequestosome 1 0.040896
SAMD4A sterile alpha motif domain containing 4A 0.0406882
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 0.0405754
COL8A1 collagen, type VIII, alpha 1 0.0402883
NPAS2 neuronal PAS domain protein 2 0.0384953
FNDC3B fibronectin type III domain containing 3B 0.0381579
NFE2L2 nuclear factor, erythroid 2-like 2 0.0380375
TRIO trio Rho guanine nucleotide exchange factor 0.0376118
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0368177
TXNRD1 thioredoxin reductase 1 0.036496
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0357976
NHSL1 NHS-like 1 0.035792
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0348985
SH3KBP1 SH3-domain kinase binding protein 1 0.0347041
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0318052
PTEN phosphatase and tensin homolog 0.0315722
IGF1R insulin-like growth factor 1 receptor 0.0314434
FNIP1 folliculin interacting protein 1 0.0310994
RPL23 ribosomal protein L23 0.030804
STC2 stanniocalcin 2 0.0304323
EPB41L3 erythrocyte membrane protein band 4.1-like 3 0.0298384
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0293085
ZSWIM6 zinc finger, SWIM-type containing 6 0.0285508
EEF2 eukaryotic translation elongation factor 2 0.0283299
IGFBP3 insulin-like growth factor binding protein 3 0.0281276
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.0273702
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0273255
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0266144
RPS12 ribosomal protein S12 0.02653
PCBP2 poly(rC) binding protein 2 0.0263257
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0262919
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0257861
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0252799
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0251364
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) 0.0246108
CDH13 cadherin 13 0.0246096
INTS6 integrator complex subunit 6 0.0244551
VMP1 vacuole membrane protein 1 0.0244303
FTL ferritin, light polypeptide 0.0236028
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 0.0234688
GRAMD1B GRAM domain containing 1B 0.0233753
VCL vinculin 0.0232487
SMOC1 SPARC related modular calcium binding 1 0.023105
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0229911
GPAT3 glycerol-3-phosphate acyltransferase 3 0.0225665
MT2A metallothionein 2A 0.0219586
CTSC cathepsin C 0.021682
SOD2 superoxide dismutase 2, mitochondrial 0.0215755
DNER delta/notch-like EGF repeat containing 0.0214033
AUTS2 autism susceptibility candidate 2 0.0213093
CTSL cathepsin L 0.0205255
TPM3 tropomyosin 3 0.0202125
RAD51B RAD51 paralog B 0.0200396
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.0198784
AHNAK AHNAK nucleoprotein 0.0197994
CARD16 caspase recruitment domain family, member 16 0.0196478
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0194756
CEMIP2 cell migration inducing hyaluronidase 2 0.0193854
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0188126
TNPO1 transportin 1 0.0184545
FLNB filamin B, beta 0.0182676
ERC1 ELKS/RAB6-interacting/CAST family member 1 0.018056
AKAP13 A kinase (PRKA) anchor protein 13 0.0176004
MYH9 myosin, heavy chain 9, non-muscle 0.0175874
COL4A6 collagen, type IV, alpha 6 0.0175112
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0174307
MCTP1 multiple C2 domains, transmembrane 1 0.0174231
USP9X ubiquitin specific peptidase 9, X-linked 0.0171187
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0170882
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.0170682
LRPPRC leucine-rich pentatricopeptide repeat containing 0.0169566
EXOC4 exocyst complex component 4 0.0167701
ASPH aspartate beta-hydroxylase 0.0164747
TIPARP TCDD-inducible poly(ADP-ribose) polymerase 0.0163175
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0160913
CLTC clathrin, heavy chain (Hc) 0.0160812
DST dystonin 0.0159704
MYO10 myosin X 0.0159382
GOLGA4 golgin A4 0.0158114
SFPQ splicing factor proline/glutamine-rich 0.0157557
MED13 mediator complex subunit 13 0.0155886
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0154734
NTN4 netrin 4 0.0154361
GLS2 glutaminase 2 (liver, mitochondrial) 0.0153037
TMEM178B transmembrane protein 178B 0.0152556
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0152039
APLP2 amyloid beta (A4) precursor-like protein 2 0.0151927
CAB39 calcium binding protein 39 0.0151141
VPS13C vacuolar protein sorting 13 homolog C (S. cerevisiae) 0.0150311
RPS4X ribosomal protein S4, X-linked 0.0149731

decreased expression

Symbol Name Standardized Value
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.193669
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.148415
FN1 fibronectin 1 -0.144223
PDE4D phosphodiesterase 4D, cAMP-specific -0.129142
PDE3A phosphodiesterase 3A, cGMP-inhibited -0.0692477
TPT1 tumor protein, translationally-controlled 1 -0.0676127
TM4SF1 transmembrane 4 L six family member 1 -0.058254
WARS1 tryptophanyl-tRNA synthetase 1 -0.0527881
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0443619
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0404492
TMSB10 thymosin beta 10 -0.039694
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) -0.0385678
SRGN serglycin -0.0338382
PTMA prothymosin, alpha -0.0336755
IL6 interleukin 6 -0.0329706
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0328547
RGS2 regulator of G-protein signaling 2 -0.0297953
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0289468
KIAA0825 KIAA0825 -0.0289129
B2M beta-2-microglobulin -0.0288609
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0281743
RPS24 ribosomal protein S24 -0.0280781
SLC39A8 solute carrier family 39 (zinc transporter), member 8 -0.0273359
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.0272593
S100A6 S100 calcium binding protein A6 -0.0256814
FNDC3A fibronectin type III domain containing 3A -0.0250928
HLA-B major histocompatibility complex, class I, B -0.0245021
FOXC1 forkhead box C1 -0.0243514
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0238121
SCN3A sodium channel, voltage gated, type III alpha subunit -0.0237472
ANK3 ankyrin 3, node of Ranvier (ankyrin G) -0.0237469
PALLD palladin, cytoskeletal associated protein -0.0236705
PRSS23 protease, serine, 23 -0.023573
RPS13 ribosomal protein S13 -0.0234979
PSD3 pleckstrin and Sec7 domain containing 3 -0.0233344
BCAS3 breast carcinoma amplified sequence 3 -0.0230717
CTNND2 catenin (cadherin-associated protein), delta 2 -0.0229739
P3H2 prolyl 3-hydroxylase 2 -0.0229737
RPLP0 ribosomal protein, large, P0 -0.0228245
ADGRD1 adhesion G protein-coupled receptor D1 -0.0223315
HLA-A major histocompatibility complex, class I, A -0.0222707
TGFBI transforming growth factor, beta-induced, 68kDa -0.0219839
RPS21 ribosomal protein S21 -0.0214683
VDAC1 voltage-dependent anion channel 1 -0.0204635
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 -0.0198994
OSMR oncostatin M receptor -0.0197663
PLEKHA5 pleckstrin homology domain containing, family A member 5 -0.0195832
LAMB1 laminin, beta 1 -0.0195655
VIM vimentin -0.0193345
ELL2 elongation factor, RNA polymerase II, 2 -0.0189195
CNOT2 CCR4-NOT transcription complex, subunit 2 -0.0184724
S100A10 S100 calcium binding protein A10 -0.0184085
MAML3 mastermind-like 3 (Drosophila) -0.0183979
LMNA lamin A/C -0.0183273
ERC2 ELKS/RAB6-interacting/CAST family member 2 -0.0183205
NCOA7 nuclear receptor coactivator 7 -0.0180997
NCKAP5 NCK-associated protein 5 -0.0180614
SLC38A2 solute carrier family 38, member 2 -0.0178934
POTEF POTE ankyrin domain family, member F -0.017787
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 -0.0175926
ADGRB3 adhesion G protein-coupled receptor B3 -0.017569
CCL5 chemokine (C-C motif) ligand 5 -0.0172922
PGM2L1 phosphoglucomutase 2-like 1 -0.0170522
TBXT T-box transcription factor T -0.0167879
GPRIN3 GPRIN family member 3 -0.0167738
SEMA3D sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3D -0.01664
SMYD3 SET and MYND domain containing 3 -0.0166225
SLC2A13 solute carrier family 2 (facilitated glucose transporter), member 13 -0.0165834
RPL38 ribosomal protein L38 -0.0163179
ATP5F1B ATP synthase F1 subunit beta -0.0162899
OASL 2'-5'-oligoadenylate synthetase-like -0.015891
KPNB1 karyopherin (importin) beta 1 -0.0157647
TMX4 thioredoxin-related transmembrane protein 4 -0.015554
DPYD dihydropyrimidine dehydrogenase -0.0155442
BMERB1 bMERB domain containing 1 -0.0154724
NRCAM neuronal cell adhesion molecule -0.0153476
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1 -0.0151502
CCDC68 coiled-coil domain containing 68 -0.0151225
BTG1 B-cell translocation gene 1, anti-proliferative -0.0148377
STEAP1B STEAP family member 1B -0.0148302
RPL9 ribosomal protein L9 -0.0146723
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.0141686
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.01406
CEMIP cell migration inducing protein, hyaluronan binding -0.0139403
ABLIM1 actin binding LIM protein 1 -0.0138121
DLGAP1 discs, large (Drosophila) homolog-associated protein 1 -0.0137947
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 -0.0137812
TENT5A terminal nucleotidyltransferase 5A -0.0137263
PCDH15 protocadherin-related 15 -0.0137252
PDE10A phosphodiesterase 10A -0.0136197
ZBTB38 zinc finger and BTB domain containing 38 -0.0135076
GLIS3 GLIS family zinc finger 3 -0.0134759
PLAUR plasminogen activator, urokinase receptor -0.0133811
RSL1D1 ribosomal L1 domain containing 1 -0.0132918
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0132453
BABAM2 BRISC and BRCA1 A complex member 2 -0.0131989
RPS23 ribosomal protein S23 -0.013163
ZMYND8 zinc finger, MYND-type containing 8 -0.0130434
SAR1A secretion associated, Ras related GTPase 1A -0.0128935
PBX1 pre-B-cell leukemia homeobox 1 -0.0128789