Resveratrol_NCI-H596 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Resveratrol perturbation in NCI-H596 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Resveratrol_NCI-H596 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
NALF1 NALCN channel auxiliary factor 1 0.173615
NKD1 naked cuticle homolog 1 (Drosophila) 0.150097
SPAG9 sperm associated antigen 9 0.12427
NAMPT nicotinamide phosphoribosyltransferase 0.122216
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.110597
RIGI RNA sensor RIG-I 0.0980446
PTK2 protein tyrosine kinase 2 0.0957351
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) 0.0949066
PCBP2 poly(rC) binding protein 2 0.0947721
ZC3HAV1 zinc finger CCCH-type, antiviral 1 0.0933607
LMO7 LIM domain 7 0.0908899
FN1 fibronectin 1 0.088197
NAV2 neuron navigator 2 0.0871289
OGA O-GlcNAcase 0.0849517
MYCBP2 MYC binding protein 2, E3 ubiquitin protein ligase 0.0817675
HNRNPD heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa) 0.0729737
PRKCA protein kinase C, alpha 0.068925
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0673022
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0667607
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0667308
ZBTB20 zinc finger and BTB domain containing 20 0.0605643
CDH13 cadherin 13 0.0598091
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0594055
PTMA prothymosin, alpha 0.0567382
EFNA5 ephrin-A5 0.0566541
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0565002
FNDC3A fibronectin type III domain containing 3A 0.0563256
RPL26 ribosomal protein L26 0.056215
KDM2A lysine (K)-specific demethylase 2A 0.0528484
GMDS GDP-mannose 4,6-dehydratase 0.0518226
PRKD3 protein kinase D3 0.0512278
LSAMP limbic system-associated membrane protein 0.0507254
SH3KBP1 SH3-domain kinase binding protein 1 0.0503335
ENO1 enolase 1, (alpha) 0.0483461
SLTM SAFB-like, transcription modulator 0.048112
AKAP9 A kinase (PRKA) anchor protein 9 0.0477136
CD109 CD109 molecule 0.0465792
AOPEP aminopeptidase O (putative) 0.0463359
RSF1 remodeling and spacing factor 1 0.045909
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0451131
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0448997
PIBF1 progesterone immunomodulatory binding factor 1 0.0445383
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 0.0444021
ELL2 elongation factor, RNA polymerase II, 2 0.0430688
PSD3 pleckstrin and Sec7 domain containing 3 0.0389471
APP amyloid beta (A4) precursor protein 0.0374188
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma 0.0369282
TXNRD1 thioredoxin reductase 1 0.0367678
PARD3 par-3 family cell polarity regulator 0.0358442
FNIP1 folliculin interacting protein 1 0.0354479
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0353747
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0352269
LAMA4 laminin, alpha 4 0.0341145
LDHA lactate dehydrogenase A 0.0336487
KMT2C lysine (K)-specific methyltransferase 2C 0.031903
ATP9B ATPase, class II, type 9B 0.0315545
EXT1 exostosin glycosyltransferase 1 0.0314814
KTN1 kinectin 1 (kinesin receptor) 0.0313369
CUX1 cut-like homeobox 1 0.0303302
ATXN1 ataxin 1 0.0292787
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa 0.0267606
CANX calnexin 0.0267475
LPP LIM domain containing preferred translocation partner in lipoma 0.026499
ZNF292 zinc finger protein 292 0.026366
AKAP13 A kinase (PRKA) anchor protein 13 0.0256267
SRPK2 SRSF protein kinase 2 0.0250121
PDLIM5 PDZ and LIM domain 5 0.0246598
RPL23 ribosomal protein L23 0.0246442
PDE3A phosphodiesterase 3A, cGMP-inhibited 0.0239855
ARID2 AT rich interactive domain 2 (ARID, RFX-like) 0.023589
TCF12 transcription factor 12 0.023034
SLC2A13 solute carrier family 2 (facilitated glucose transporter), member 13 0.0223246
PRELID2 PRELI domain containing 2 0.0223196
SMC5 structural maintenance of chromosomes 5 0.0215694
CXCL8 chemokine (C-X-C motif) ligand 8 0.0202597
MARCHF7 membrane associated ring-CH-type finger 7 0.019537
SRSF11 serine/arginine-rich splicing factor 11 0.0188392
EXOC4 exocyst complex component 4 0.0186951
TAS2R14 taste receptor, type 2, member 14 0.0182483
KLF6 Kruppel-like factor 6 0.0176345
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0159175
ELOVL5 ELOVL fatty acid elongase 5 0.0148874
THSD4 thrombospondin, type I, domain containing 4 0.0147584
BBX bobby sox homolog (Drosophila) 0.0144738
NUFIP2 nuclear fragile X mental retardation protein interacting protein 2 0.0141138
RUNX1 runt-related transcription factor 1 0.0140083
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0125079
RPLP1 ribosomal protein, large, P1 0.0114477
ESYT2 extended synaptotagmin-like protein 2 0.0113336
CERS6 ceramide synthase 6 0.0106703
LAMB3 laminin, beta 3 0.0105968
ADAM10 ADAM metallopeptidase domain 10 0.0105862
RAD51B RAD51 paralog B 0.0102861
RTN4 reticulon 4 0.0102223
SHANK2 SH3 and multiple ankyrin repeat domains 2 0.0101215
TGFBI transforming growth factor, beta-induced, 68kDa 0.0100194
PDE4D phosphodiesterase 4D, cAMP-specific 0.00857325
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 0.0085724
CTIF CBP80/20-dependent translation initiation factor 0.00835278
JARID2 jumonji, AT rich interactive domain 2 0.00719751

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.320455
TMSB10 thymosin beta 10 -0.130377
VIM vimentin -0.117609
FTH1 ferritin, heavy polypeptide 1 -0.111994
NAP1L1 nucleosome assembly protein 1-like 1 -0.1067
VCL vinculin -0.0931506
FTL ferritin, light polypeptide -0.0926359
RPS12 ribosomal protein S12 -0.0899245
PDE10A phosphodiesterase 10A -0.086257
RPS6 ribosomal protein S6 -0.0858834
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0821431
RPL11 ribosomal protein L11 -0.0815595
BRIP1 BRCA1 interacting protein C-terminal helicase 1 -0.079884
STC1 stanniocalcin 1 -0.0772302
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0759825
RPS8 ribosomal protein S8 -0.0749951
POTEF POTE ankyrin domain family, member F -0.073928
OSMR oncostatin M receptor -0.072767
EIF1 eukaryotic translation initiation factor 1 -0.0689107
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0662273
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.06063
SPTBN1 spectrin, beta, non-erythrocytic 1 -0.0597576
MCL1 myeloid cell leukemia 1 -0.0546051
S100A9 S100 calcium binding protein A9 -0.0538227
LOXL2 lysyl oxidase-like 2 -0.0536937
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.0523643
MYO1E myosin IE -0.0520252
RPL37A ribosomal protein L37a -0.0515926
NDRG1 N-myc downstream regulated 1 -0.0503484
RPL35A ribosomal protein L35a -0.0482001
AKAP12 A kinase (PRKA) anchor protein 12 -0.0464354
ASPH aspartate beta-hydroxylase -0.0463921
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.0450375
FLNB filamin B, beta -0.0435732
GPC6 glypican 6 -0.0414107
AKT3 v-akt murine thymoma viral oncogene homolog 3 -0.040374
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0401931
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.0396493
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.0395506
LIMCH1 LIM and calponin homology domains 1 -0.0387094
MAP1B microtubule-associated protein 1B -0.0385326
KMT2E lysine (K)-specific methyltransferase 2E -0.03646
GSK3B glycogen synthase kinase 3 beta -0.0357608
COL6A3 collagen, type VI, alpha 3 -0.035478
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.0351169
HLA-A major histocompatibility complex, class I, A -0.0335401
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.0330453
UBC ubiquitin C -0.0330266
MACF1 microtubule-actin crosslinking factor 1 -0.0328652
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0327618
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0323917
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0319878
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0305644
TPT1 tumor protein, translationally-controlled 1 -0.03056
H3-3B H3.3 histone B -0.029185
EGFR epidermal growth factor receptor -0.0291554
MAP4 microtubule-associated protein 4 -0.0286454
DST dystonin -0.0282507
TRIO trio Rho guanine nucleotide exchange factor -0.0271153
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0268081
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase -0.0264623
PRRC2C proline-rich coiled-coil 2C -0.0258329
JMJD1C jumonji domain containing 1C -0.0251454
MT2A metallothionein 2A -0.0250683
JUN jun proto-oncogene -0.0242669
INTS6 integrator complex subunit 6 -0.0242271
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.024158
SAMD4A sterile alpha motif domain containing 4A -0.0221737
ANXA2 annexin A2 -0.0214927
S100A6 S100 calcium binding protein A6 -0.021103
PKM pyruvate kinase, muscle -0.0210828
HLA-B major histocompatibility complex, class I, B -0.0208142
RBM39 RNA binding motif protein 39 -0.0206308
DSCAM Down syndrome cell adhesion molecule -0.0205341
SND1 staphylococcal nuclease and tudor domain containing 1 -0.0201123
SETD5 SET domain containing 5 -0.0182548
TOR1AIP2 torsin A interacting protein 2 -0.0177585
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0157735
B2M beta-2-microglobulin -0.0157423
AHNAK AHNAK nucleoprotein -0.0154671
SLC38A1 solute carrier family 38, member 1 -0.0148404
IGFBP3 insulin-like growth factor binding protein 3 -0.0146012
CCNI cyclin I -0.0142
SBF2 SET binding factor 2 -0.0140526
PLEKHA5 pleckstrin homology domain containing, family A member 5 -0.0131679
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0121917
HMGA2 high mobility group AT-hook 2 -0.011719
YBX1 Y box binding protein 1 -0.0116062
ATRX alpha thalassemia/mental retardation syndrome X-linked -0.0110587
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 -0.0102965
GRB10 growth factor receptor-bound protein 10 -0.00947514
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 -0.00917545
COL8A1 collagen, type VIII, alpha 1 -0.00852156
EEF2 eukaryotic translation elongation factor 2 -0.0069397
INHBA inhibin, beta A -0.006857
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.00648133
FNDC3B fibronectin type III domain containing 3B -0.00641621
SMAD3 SMAD family member 3 -0.00596329
HYCC1 hyccin PI4KA lipid kinase complex subunit 1 -0.00556562
NF1 neurofibromin 1 -0.00543804