Resveratrol_NCI-H661 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Resveratrol perturbation in NCI-H661 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Resveratrol_NCI-H661 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HDAC9 histone deacetylase 9 0.0589955
TSC22D2 TSC22 domain family, member 2 0.0572686
KMT2E lysine (K)-specific methyltransferase 2E 0.0501408
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2 0.0486633
ADGRV1 adhesion G protein-coupled receptor V1 0.0465246
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0416388
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A 0.0399335
UBN2 ubinuclein 2 0.0383842
CDH19 cadherin 19, type 2 0.0378193
ZEB2 zinc finger E-box binding homeobox 2 0.0363249
TRPS1 trichorhinophalangeal syndrome I 0.0361866
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit 0.0349605
ANK2 ankyrin 2, neuronal 0.0346654
MYO10 myosin X 0.0330099
SPAG9 sperm associated antigen 9 0.0324011
ANKRD33B ankyrin repeat domain 33B 0.0318272
FOXP2 forkhead box P2 0.0312324
PDLIM5 PDZ and LIM domain 5 0.0306448
LHFPL6 LHFPL tetraspan subfamily member 6 0.0296196
RPS12 ribosomal protein S12 0.0292533
PGAP1 post-GPI attachment to proteins 1 0.0262768
AFF1 AF4/FMR2 family, member 1 0.0262407
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.0256407
GLS2 glutaminase 2 (liver, mitochondrial) 0.0252168
QKI QKI, KH domain containing, RNA binding 0.0251725
KDM6A lysine (K)-specific demethylase 6A 0.0247583
NHSL1 NHS-like 1 0.0246217
CSRNP3 cysteine-serine-rich nuclear protein 3 0.0243972
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) 0.0241592
HNRNPR heterogeneous nuclear ribonucleoprotein R 0.02358
POLR2B polymerase (RNA) II (DNA directed) polypeptide B, 140kDa 0.0232713
CHD1 chromodomain helicase DNA binding protein 1 0.0229423
MED13L mediator complex subunit 13-like 0.022388
HYCC1 hyccin PI4KA lipid kinase complex subunit 1 0.0220738
ZSWIM6 zinc finger, SWIM-type containing 6 0.0219614
AKT3 v-akt murine thymoma viral oncogene homolog 3 0.021815
SENP6 SUMO1/sentrin specific peptidase 6 0.0217566
CDH6 cadherin 6, type 2, K-cadherin (fetal kidney) 0.021306
BMPR1A bone morphogenetic protein receptor, type IA 0.0212585
EPB41L5 erythrocyte membrane protein band 4.1 like 5 0.0212328
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.0212145
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.0210634
PRRC2C proline-rich coiled-coil 2C 0.0207334
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 0.0206115
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box) 0.0206038
PTBP2 polypyrimidine tract binding protein 2 0.0205423
FNDC3B fibronectin type III domain containing 3B 0.0203741
COL5A2 collagen, type V, alpha 2 0.0202954
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 0.0199443
RREB1 ras responsive element binding protein 1 0.0197205
CTBP2 C-terminal binding protein 2 0.019669
ATXN2 ataxin 2 0.0196225
FOXO1 forkhead box O1 0.0194524
GOLPH3 golgi phosphoprotein 3 (coat-protein) 0.0194011
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 0.0193288
CECR2 cat eye syndrome chromosome region, candidate 2 0.0193023
RFX7 regulatory factor X, 7 0.0192493
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.0190293
SRPK2 SRSF protein kinase 2 0.0187781
RCOR1 REST corepressor 1 0.0187387
DDAH1 dimethylarginine dimethylaminohydrolase 1 0.0186823
TBC1D12 TBC1 domain family, member 12 0.0186423
PPID peptidylprolyl isomerase D 0.0186002
PUM1 pumilio RNA-binding family member 1 0.0185756
LUZP2 leucine zipper protein 2 0.0183878
RYBP RING1 and YY1 binding protein 0.0183076
PUM2 pumilio RNA-binding family member 2 0.0182708
OSBPL10 oxysterol binding protein-like 10 0.0181568
NCOR2 nuclear receptor corepressor 2 0.01815
CSNK1A1 casein kinase 1, alpha 1 0.0179045
JARID2 jumonji, AT rich interactive domain 2 0.017815
SLIT2 slit homolog 2 (Drosophila) 0.0174506
PRTG protogenin 0.017291
RB1CC1 RB1-inducible coiled-coil 1 0.0172117
SLC44A5 solute carrier family 44, member 5 0.0171816
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3 0.0171362
NALF1 NALCN channel auxiliary factor 1 0.0170788
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0170377
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.0169836
VEGFA vascular endothelial growth factor A 0.0169779
WNK1 WNK lysine deficient protein kinase 1 0.0169603
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.016903
HS3ST5 heparan sulfate (glucosamine) 3-O-sulfotransferase 5 0.0166446
ZNF292 zinc finger protein 292 0.0166324
RBM26 RNA binding motif protein 26 0.0164743
ELOF1 elongation factor 1 homolog (S. cerevisiae) 0.0163772
COL8A1 collagen, type VIII, alpha 1 0.0163265
UNC5C unc-5 homolog C (C. elegans) 0.016214
ASPH aspartate beta-hydroxylase 0.0162009
DENND1A DENN/MADD domain containing 1A 0.0159646
ERBB4 erb-b2 receptor tyrosine kinase 4 0.0159631
PICALM phosphatidylinositol binding clathrin assembly protein 0.0158211
KLHL15 kelch-like family member 15 0.0157164
MPP2 membrane protein, palmitoylated 2 (MAGUK p55 subfamily member 2) 0.0155656
RNF19A ring finger protein 19A, RBR E3 ubiquitin protein ligase 0.0154635
TMEM131 transmembrane protein 131 0.0154259
IGFBP3 insulin-like growth factor binding protein 3 0.0153283
FGFR1OP2 FGFR1 oncogene partner 2 0.0152431
NAV3 neuron navigator 3 0.0151805
POGZ pogo transposable element with ZNF domain 0.0150409

decreased expression

Symbol Name Standardized Value
VIM vimentin -0.273616
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.121308
COL3A1 collagen, type III, alpha 1 -0.0971524
PTMA prothymosin, alpha -0.0969625
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0939467
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0916132
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0823793
RPS6 ribosomal protein S6 -0.0764444
CDH10 cadherin 10, type 2 (T2-cadherin) -0.0739156
HCN1 hyperpolarization activated cyclic nucleotide gated potassium channel 1 -0.0724224
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0690976
POTEF POTE ankyrin domain family, member F -0.0662067
ACTG1 actin gamma 1 -0.0640865
TMSB10 thymosin beta 10 -0.0612311
CENPF centromere protein F, 350/400kDa -0.0596041
MDK midkine (neurite growth-promoting factor 2) -0.0593076
COL1A2 collagen, type I, alpha 2 -0.0576536
PCLO piccolo presynaptic cytomatrix protein -0.0573289
PEG10 paternally expressed 10 -0.0568575
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0554744
SNX6 sorting nexin 6 -0.0535261
SRP54 signal recognition particle 54kDa -0.0533528
RALGAPA1 Ral GTPase activating protein, alpha subunit 1 (catalytic) -0.0522286
H1-0 H1.0 linker histone -0.0509014
ITGAV integrin, alpha V -0.0507599
MKI67 marker of proliferation Ki-67 -0.0500704
TMSB4X thymosin beta 4, X-linked -0.0499121
ANKRD12 ankyrin repeat domain 12 -0.0484132
EMP1 epithelial membrane protein 1 -0.0477816
GNAS GNAS complex locus -0.0474338
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0460339
KPNB1 karyopherin (importin) beta 1 -0.0457652
PRKDC protein kinase, DNA-activated, catalytic polypeptide -0.0448199
PFN1 profilin 1 -0.0436836
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0416877
RPS16 ribosomal protein S16 -0.0393394
ATP5F1B ATP synthase F1 subunit beta -0.0390201
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0390099
MEIS2 Meis homeobox 2 -0.0379842
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.037657
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0375254
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0375082
TPX2 TPX2, microtubule-associated -0.036731
G2E3 G2/M-phase specific E3 ubiquitin protein ligase -0.036623
PLPP1 phospholipid phosphatase 1 -0.0361136
CADM2 cell adhesion molecule 2 -0.0358622
HMGB1 high mobility group box 1 -0.0351658
TPT1 tumor protein, translationally-controlled 1 -0.0349201
RAD21 RAD21 homolog (S. pombe) -0.0343203
WASF2 WAS protein family, member 2 -0.0341175
S100A10 S100 calcium binding protein A10 -0.0337888
TUBA1B tubulin, alpha 1b -0.0334796
COL11A1 collagen, type XI, alpha 1 -0.033449
UBC ubiquitin C -0.0324411
DEK DEK proto-oncogene -0.0319928
CFL2 cofilin 2 (muscle) -0.0316836
FBL fibrillarin -0.031652
PTGES3 prostaglandin E synthase 3 (cytosolic) -0.0311935
MYL12B myosin, light chain 12B, regulatory -0.0310959
EAPP E2F-associated phosphoprotein -0.0309828
PRKD1 protein kinase D1 -0.0308517
MAP4 microtubule-associated protein 4 -0.0306682
ZFR zinc finger RNA binding protein -0.0304282
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1 -0.0301368
DST dystonin -0.0294866
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.029438
AHNAK AHNAK nucleoprotein -0.0294043
SPTSSA serine palmitoyltransferase, small subunit A -0.029115
SCAF11 SR-related CTD-associated factor 11 -0.0290013
RPS27A ribosomal protein S27a -0.0288371
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0281683
ZBTB20 zinc finger and BTB domain containing 20 -0.0281287
AKAP9 A kinase (PRKA) anchor protein 9 -0.0280527
ADGRL2 adhesion G protein-coupled receptor L2 -0.0279505
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0277581
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) -0.0277104
IRF2BP2 interferon regulatory factor 2 binding protein 2 -0.0275944
RAI1 retinoic acid induced 1 -0.0275194
SEPTIN7 septin 7 -0.0274682
NCOR1 nuclear receptor corepressor 1 -0.0272832
CCT6A chaperonin containing TCP1, subunit 6A (zeta 1) -0.0268442
BPTF bromodomain PHD finger transcription factor -0.0266748
HSPB1 heat shock 27kDa protein 1 -0.0265805
CALU calumenin -0.0264681
SGO2 shugoshin 2 -0.0261663
TCF12 transcription factor 12 -0.025901
METAP2 methionyl aminopeptidase 2 -0.0257612
CAPNS1 calpain, small subunit 1 -0.0257406
CKAP2 cytoskeleton associated protein 2 -0.0256967
JMJD1C jumonji domain containing 1C -0.0255822
POU3F2 POU class 3 homeobox 2 -0.025313
GLO1 glyoxalase I -0.0252836
SF3B2 splicing factor 3b, subunit 2, 145kDa -0.0251425
ERC2 ELKS/RAB6-interacting/CAST family member 2 -0.0250837
NSD3 nuclear receptor binding SET domain protein 3 -0.0249574
RPLP1 ribosomal protein, large, P1 -0.0248602
TMEM123 transmembrane protein 123 -0.0248204
HMGA1 high mobility group AT-hook 1 -0.0247602
RPL23 ribosomal protein L23 -0.0247367
RPLP0 ribosomal protein, large, P0 -0.0246625