Resveratrol_SNU-423 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Resveratrol perturbation in SNU-423 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Resveratrol_SNU-423 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
SOD2 superoxide dismutase 2, mitochondrial 0.152258
VEGFA vascular endothelial growth factor A 0.138015
AKAP12 A kinase (PRKA) anchor protein 12 0.133164
IGFBP3 insulin-like growth factor binding protein 3 0.101012
FTH1 ferritin, heavy polypeptide 1 0.0890541
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.084936
VCAN versican 0.0775131
RND3 Rho family GTPase 3 0.0640822
HDAC9 histone deacetylase 9 0.0617384
NDRG1 N-myc downstream regulated 1 0.0584683
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0582848
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 0.0578389
COL6A3 collagen, type VI, alpha 3 0.0536389
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0531088
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0504928
MMP12 matrix metallopeptidase 12 0.0485932
PLIN2 perilipin 2 0.0453672
FNDC3B fibronectin type III domain containing 3B 0.0404942
GRIN2A glutamate receptor, ionotropic, N-methyl D-aspartate 2A 0.0400379
NAV2 neuron navigator 2 0.0396759
TRIO trio Rho guanine nucleotide exchange factor 0.0388613
TNS3 tensin 3 0.0387028
FNIP1 folliculin interacting protein 1 0.0371869
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0361193
GPC6 glypican 6 0.0349235
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.034807
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.033828
JMJD1C jumonji domain containing 1C 0.0338007
NAMPT nicotinamide phosphoribosyltransferase 0.0335999
FMNL2 formin-like 2 0.0335366
FBXO32 F-box protein 32 0.032015
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 0.031826
BACE2 beta-site APP-cleaving enzyme 2 0.0316533
STC2 stanniocalcin 2 0.0312059
RPS12 ribosomal protein S12 0.0310223
EGFR epidermal growth factor receptor 0.0305411
VAC14 Vac14 homolog (S. cerevisiae) 0.0298918
CEP250 centrosomal protein 250kDa 0.0296315
ZHX2 zinc fingers and homeoboxes 2 0.0290467
ZMIZ1 zinc finger, MIZ-type containing 1 0.0288586
PPARD peroxisome proliferator-activated receptor delta 0.0285766
MACF1 microtubule-actin crosslinking factor 1 0.0284438
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0282668
TMEM132D transmembrane protein 132D 0.0282348
INHBA inhibin, beta A 0.0273308
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0272759
AFF3 AF4/FMR2 family, member 3 0.0263641
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.0257886
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 0.0251607
DOCK5 dedicator of cytokinesis 5 0.0251436
SMYD3 SET and MYND domain containing 3 0.0241553
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.023165
SQSTM1 sequestosome 1 0.0230294
EFNA5 ephrin-A5 0.0227502
MT2A metallothionein 2A 0.0226747
PPP1R18 protein phosphatase 1, regulatory subunit 18 0.0217538
PHF3 PHD finger protein 3 0.0215441
YEATS2 YEATS domain containing 2 0.0213879
OPTN optineurin 0.021212
IGFN1 immunoglobulin-like and fibronectin type III domain containing 1 0.0212025
RAB7A RAB7A, member RAS oncogene family 0.0206023
XIAP X-linked inhibitor of apoptosis, E3 ubiquitin protein ligase 0.0205429
IGF1R insulin-like growth factor 1 receptor 0.0202546
AFF4 AF4/FMR2 family, member 4 0.0201859
ERRFI1 ERBB receptor feedback inhibitor 1 0.020066
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1 0.0200045
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0198835
HLA-A major histocompatibility complex, class I, A 0.0198059
MYOF myoferlin 0.0197354
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 0.0195081
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.0193067
ZNF292 zinc finger protein 292 0.0192825
CSGALNACT2 chondroitin sulfate N-acetylgalactosaminyltransferase 2 0.0191066
KIRREL1 kirre like nephrin family adhesion molecule 1 0.0188557
FRMPD4 FERM and PDZ domain containing 4 0.0184526
GDF15 growth differentiation factor 15 0.0184061
AKT3 v-akt murine thymoma viral oncogene homolog 3 0.0183636
FLOT1 flotillin 1 0.0177648
KDM4C lysine (K)-specific demethylase 4C 0.0177033
CDH13 cadherin 13 0.0174458
SH3PXD2B SH3 and PX domains 2B 0.0173162
PAG1 phosphoprotein membrane anchor with glycosphingolipid microdomains 1 0.0172836
EVC Ellis van Creveld protein 0.017173
RUNX1 runt-related transcription factor 1 0.0170935
ZCCHC7 zinc finger, CCHC domain containing 7 0.016949
RAI14 retinoic acid induced 14 0.0169482
TMSB4X thymosin beta 4, X-linked 0.0169137
ARHGEF3 Rho guanine nucleotide exchange factor (GEF) 3 0.016794
SMAD3 SMAD family member 3 0.0167142
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2 0.0167058
LOXL2 lysyl oxidase-like 2 0.0164897
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.016323
OSBPL8 oxysterol binding protein-like 8 0.0163125
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 0.0162396
EXOC4 exocyst complex component 4 0.015999
CD109 CD109 molecule 0.0159163
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0158471
SLC39A11 solute carrier family 39, member 11 0.0158123
SUPT3H suppressor of Ty 3 homolog (S. cerevisiae) 0.0156824
NFATC2 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 0.0156641

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.164458
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.143435
TMSB10 thymosin beta 10 -0.124134
VCL vinculin -0.106128
TPT1 tumor protein, translationally-controlled 1 -0.0993112
FN1 fibronectin 1 -0.093085
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0864584
PTMA prothymosin, alpha -0.0817359
COL1A1 collagen, type I, alpha 1 -0.0795594
HLA-B major histocompatibility complex, class I, B -0.0748119
VIM vimentin -0.0740888
FRMD4A FERM domain containing 4A -0.0666425
UBC ubiquitin C -0.0626639
ANXA2 annexin A2 -0.0592264
FTL ferritin, light polypeptide -0.0591871
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0514882
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0506753
PGK1 phosphoglycerate kinase 1 -0.0505845
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0475627
RPS27A ribosomal protein S27a -0.0473763
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0473591
NAP1L1 nucleosome assembly protein 1-like 1 -0.0462285
RPS24 ribosomal protein S24 -0.0457285
GNAS GNAS complex locus -0.045693
COL1A2 collagen, type I, alpha 2 -0.0455039
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.0431519
IER3 immediate early response 3 -0.0420956
GLIS3 GLIS family zinc finger 3 -0.0403033
THBS1 thrombospondin 1 -0.0400301
ZFAND3 zinc finger, AN1-type domain 3 -0.0397158
IQCJ-SCHIP1 IQCJ-SCHIP1 readthrough -0.0382549
ACTG1 actin gamma 1 -0.0367272
EIF4A1 eukaryotic translation initiation factor 4A1 -0.0348196
EXT1 exostosin glycosyltransferase 1 -0.0345643
RTN4 reticulon 4 -0.0339191
NABP1 nucleic acid binding protein 1 -0.033763
KPNB1 karyopherin (importin) beta 1 -0.0330067
KDM3A lysine (K)-specific demethylase 3A -0.0329014
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0328999
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0326396
PALLD palladin, cytoskeletal associated protein -0.0324037
OGA O-GlcNAcase -0.0321672
RBM39 RNA binding motif protein 39 -0.0320786
SLC38A2 solute carrier family 38, member 2 -0.0311926
TUBB tubulin, beta class I -0.0311055
MKI67 marker of proliferation Ki-67 -0.031083
SRGN serglycin -0.0306308
PNRC1 proline-rich nuclear receptor coactivator 1 -0.0300692
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II -0.029984
ACSL4 acyl-CoA synthetase long-chain family member 4 -0.0294967
RRBP1 ribosome binding protein 1 -0.0294179
ANLN anillin, actin binding protein -0.0283933
DEK DEK proto-oncogene -0.0281389
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0278569
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0276601
CALR calreticulin -0.0276057
SFRP1 secreted frizzled-related protein 1 -0.0272643
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0269165
VDAC1 voltage-dependent anion channel 1 -0.0267899
PNISR PNN-interacting serine/arginine-rich protein -0.0267881
POTEF POTE ankyrin domain family, member F -0.0266814
TGFBI transforming growth factor, beta-induced, 68kDa -0.0265937
TMEM263 transmembrane protein 263 -0.0260561
CD44 CD44 molecule (Indian blood group) -0.0257366
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0254038
GLIPR1 GLI pathogenesis-related 1 -0.0254021
NRN1 neuritin 1 -0.0253127
FLNA filamin A, alpha -0.025269
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.0249074
ENO1 enolase 1, (alpha) -0.0248528
CENPF centromere protein F, 350/400kDa -0.0244786
ADM adrenomedullin -0.0241775
RPS21 ribosomal protein S21 -0.0240573
ATRX alpha thalassemia/mental retardation syndrome X-linked -0.0234594
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0232277
LAMP2 lysosomal-associated membrane protein 2 -0.0230272
RPLP2 ribosomal protein, large, P2 -0.0229355
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.0227146
RPL9 ribosomal protein L9 -0.0224052
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0223486
CD2AP CD2-associated protein -0.0221778
SLC25A5 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 -0.0221772
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase -0.0220136
KLF6 Kruppel-like factor 6 -0.0219671
IFI6 interferon, alpha-inducible protein 6 -0.0219002
STC1 stanniocalcin 1 -0.0217249
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0217141
SLC38A1 solute carrier family 38, member 1 -0.0212873
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0210643
TENT5A terminal nucleotidyltransferase 5A -0.0210363
RPL11 ribosomal protein L11 -0.0210284
TNNC1 troponin C type 1 (slow) -0.0209665
THOC2 THO complex 2 -0.0209058
RPS4X ribosomal protein S4, X-linked -0.0207553
PTP4A2 protein tyrosine phosphatase type IVA, member 2 -0.0206609
CTNND1 catenin (cadherin-associated protein), delta 1 -0.0204756
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0203603
ZNFX1 zinc finger, NFX1-type containing 1 -0.0203369
TMEM123 transmembrane protein 123 -0.0201716
CLIC4 chloride intracellular channel 4 -0.0201556