Retigabine Gene Set

Dataset DeepCoverMOA Drug Mechanisms of Action
Category proteomics
Type drug perturbation
External Link https://pubchem.ncbi.nlm.nih.gov/compound/121892
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Genes

200 proteins with high or low expression in Retigabine relative to other proteins from the DeepCoverMOA Drug Mechanisms of Action dataset.

high expression

Symbol Name Standardized Value
MYO3A myosin IIIA 1.9
PPP1R26 protein phosphatase 1, regulatory subunit 26 0.92
CXXC5 CXXC finger protein 5 0.66
COA5 cytochrome c oxidase assembly factor 5 0.53
JPT1 Jupiter microtubule associated homolog 1 0.51
ZSCAN32 zinc finger and SCAN domain containing 32 0.5
SGSH N-sulfoglucosamine sulfohydrolase 0.46
DNAL4 dynein, axonemal, light chain 4 0.46
RND3 Rho family GTPase 3 0.45
SYDE2 synapse defective 1, Rho GTPase, homolog 2 (C. elegans) 0.45
MID1IP1 MID1 interacting protein 1 0.44
ANKRD39 ankyrin repeat domain 39 0.43
LRRC58 leucine rich repeat containing 58 0.41
ZRSR2 zinc finger (CCCH type), RNA-binding motif and serine/arginine rich 2 0.4
ZNF594 zinc finger protein 594 0.39
ZNF724 zinc finger protein 724 0.39
WSB1 WD repeat and SOCS box containing 1 0.39
IP6K2 inositol hexakisphosphate kinase 2 0.38
FADS1 fatty acid desaturase 1 0.38
ALPK3 alpha-kinase 3 0.37
CCDC102A coiled-coil domain containing 102A 0.37
COPRS coordinator of PRMT5, differentiation stimulator 0.36
C16ORF70 chromosome 16 open reading frame 70 0.36
ZNF669 zinc finger protein 669 0.35
MCFD2 multiple coagulation factor deficiency 2 0.35
ANAPC16 anaphase promoting complex subunit 16 0.34
MYCBP MYC binding protein 0.34
TIMM13 translocase of inner mitochondrial membrane 13 homolog (yeast) 0.34
UQCRB ubiquinol-cytochrome c reductase binding protein 0.34
MAP3K1 mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase 0.34
MRPL49 mitochondrial ribosomal protein L49 0.34
PPP2R5C protein phosphatase 2, regulatory subunit B', gamma 0.34
NUDT16 nudix (nucleoside diphosphate linked moiety X)-type motif 16 0.34
SRF serum response factor (c-fos serum response element-binding transcription factor) 0.33
RPLP2 ribosomal protein, large, P2 0.33
ZNF444 zinc finger protein 444 0.33
CKS2 CDC28 protein kinase regulatory subunit 2 0.33
P3H2 prolyl 3-hydroxylase 2 0.33
CMC1 C-x(9)-C motif containing 1 0.33
CSRNP1 cysteine-serine-rich nuclear protein 1 0.32
ATXN1L ataxin 1-like 0.32
MED22 mediator complex subunit 22 0.31
GID8 GID complex subunit 8 0.31
NPHP3 nephronophthisis 3 (adolescent) 0.31
UBQLN1 ubiquilin 1 0.31
TNIP2 TNFAIP3 interacting protein 2 0.31
PFDN1 prefoldin subunit 1 0.31
NDUFB8 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 8, 19kDa 0.31
COX5A cytochrome c oxidase subunit Va 0.31
COX5B cytochrome c oxidase subunit Vb 0.31
YAP1 Yes-associated protein 1 0.31
S100A2 S100 calcium binding protein A2 0.31
SHC4 SHC (Src homology 2 domain containing) family, member 4 0.31
DOHH deoxyhypusine hydroxylase/monooxygenase 0.3
TNNC2 troponin C type 2 (fast) 0.3
GSKIP GSK3B interacting protein 0.3
ATP8B3 ATPase, aminophospholipid transporter, class I, type 8B, member 3 0.3
ST3GAL4 ST3 beta-galactoside alpha-2,3-sialyltransferase 4 0.29
METTL6 methyltransferase like 6 0.29
PIP prolactin-induced protein 0.29
MRFAP1 Morf4 family associated protein 1 0.29
CIAO2B cytosolic iron-sulfur assembly component 2B 0.29
SLC41A2 solute carrier family 41 (magnesium transporter), member 2 0.29
PFDN5 prefoldin subunit 5 0.29
COX7A2 cytochrome c oxidase subunit VIIa polypeptide 2 (liver) 0.28
FXN frataxin 0.28
PDCD5 programmed cell death 5 0.28
SSNA1 Sjogren syndrome nuclear autoantigen 1 0.28
TTLL4 tubulin tyrosine ligase-like family member 4 0.28
EFCAB7 EF-hand calcium binding domain 7 0.28
PRPF40B PRP40 pre-mRNA processing factor 40 homolog B (S. cerevisiae) 0.28
RPLP1 ribosomal protein, large, P1 0.28
ERVK3-1 endogenous retrovirus group K3, member 1 0.28
LSM1 LSM1, U6 small nuclear RNA associated 0.28
STARD4 StAR-related lipid transfer (START) domain containing 4 0.28
MAP3K5 mitogen-activated protein kinase kinase kinase 5 0.28
NDUFA4 NDUFA4, mitochondrial complex associated 0.27
NFYB nuclear transcription factor Y, beta 0.27
HYPK huntingtin interacting protein K 0.27
MTPN myotrophin 0.27
TENT5A terminal nucleotidyltransferase 5A 0.27
TPM1 tropomyosin 1 (alpha) 0.27
CASP10 caspase 10, apoptosis-related cysteine peptidase 0.27
UBE2B ubiquitin-conjugating enzyme E2B 0.27
BCAS2 breast carcinoma amplified sequence 2 0.27
PTMA prothymosin, alpha 0.27
ZNF367 zinc finger protein 367 0.26
ZNRD2 zinc ribbon domain containing 2 0.26
MID2 midline 2 0.26
AKAP6 A kinase (PRKA) anchor protein 6 0.26
DCTPP1 dCTP pyrophosphatase 1 0.26
UBQLN2 ubiquilin 2 0.26
TRIM15 tripartite motif containing 15 0.26
ELOB elongin B 0.25
DBI diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein) 0.25
C1ORF122 chromosome 1 open reading frame 122 0.25
COMMD8 COMM domain containing 8 0.25
HGH1 HGH1 homolog (S. cerevisiae) 0.25
CLTA clathrin, light chain A 0.25
MIEN1 migration and invasion enhancer 1 0.25

low expression

Symbol Name Standardized Value
ATE1 arginyltransferase 1 -0.72
SMARCC2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 2 -0.63
JUN jun proto-oncogene -0.48
ATG4D autophagy related 4D, cysteine peptidase -0.42
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.41
RNF170 ring finger protein 170 -0.38
F13A1 coagulation factor XIII, A1 polypeptide -0.38
PXMP4 peroxisomal membrane protein 4, 24kDa -0.37
ZNF496 zinc finger protein 496 -0.37
GEMIN2 gem (nuclear organelle) associated protein 2 -0.36
ERO1B endoplasmic reticulum oxidoreductase 1 beta -0.35
TM2D3 TM2 domain containing 3 -0.35
ATP7B ATPase, Cu++ transporting, beta polypeptide -0.35
PRIMPOL primase and polymerase (DNA-directed) -0.34
FHIT fragile histidine triad -0.33
CMTM4 CKLF-like MARVEL transmembrane domain containing 4 -0.33
YDJC YdjC homolog (bacterial) -0.33
GTDC1 glycosyltransferase-like domain containing 1 -0.32
ARHGAP23 Rho GTPase activating protein 23 -0.31
PALB2 partner and localizer of BRCA2 -0.31
CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3 -0.3
SH3BP5L SH3-binding domain protein 5-like -0.3
ARHGAP31 Rho GTPase activating protein 31 -0.3
ABCC10 ATP-binding cassette, sub-family C (CFTR/MRP), member 10 -0.3
HIST2H2AA3 histone cluster 2, H2aa3 -0.29
ZFYVE28 zinc finger, FYVE domain containing 28 -0.29
FAM117B family with sequence similarity 117, member B -0.28
CARD19 caspase recruitment domain family member 19 -0.28
ZBED9 zinc finger, BED-type containing 9 -0.28
PBLD phenazine biosynthesis-like protein domain containing -0.28
C18ORF32 chromosome 18 open reading frame 32 -0.28
GPANK1 G patch domain and ankyrin repeats 1 -0.28
TBRG1 transforming growth factor beta regulator 1 -0.27
RNF6 ring finger protein (C3H2C3 type) 6 -0.27
MAN2C1 mannosidase, alpha, class 2C, member 1 -0.27
TYSND1 trypsin domain containing 1 -0.27
ALPP alkaline phosphatase, placental -0.26
EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3 -0.26
HYKK hydroxylysine kinase -0.26
ZNF672 zinc finger protein 672 -0.26
DHRSX dehydrogenase/reductase (SDR family) X-linked -0.25
TTC9C tetratricopeptide repeat domain 9C -0.25
NAPEPLD N-acyl phosphatidylethanolamine phospholipase D -0.25
MPZL2 myelin protein zero-like 2 -0.25
LARP6 La ribonucleoprotein domain family, member 6 -0.25
SGSM1 small G protein signaling modulator 1 -0.24
PLEK pleckstrin -0.24
MISP3 MISP family member 3 -0.24
SIGIRR single immunoglobulin and toll-interleukin 1 receptor (TIR) domain -0.24
GREB1 growth regulation by estrogen in breast cancer 1 -0.24
KLF4 Kruppel-like factor 4 (gut) -0.24
FOXRED2 FAD-dependent oxidoreductase domain containing 2 -0.24
TUB tubby bipartite transcription factor -0.23
APOE apolipoprotein E -0.23
GLI2 GLI family zinc finger 2 -0.23
XRCC5 X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining) -0.23
TMEM242 transmembrane protein 242 -0.23
ZMAT3 zinc finger, matrin-type 3 -0.23
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor) -0.23
GABPB1 GA binding protein transcription factor, beta subunit 1 -0.23
C15ORF61 chromosome 15 open reading frame 61 -0.23
TMTC2 transmembrane and tetratricopeptide repeat containing 2 -0.23
TMEM161B transmembrane protein 161B -0.22
LRRC46 leucine rich repeat containing 46 -0.22
ABHD13 abhydrolase domain containing 13 -0.22
PCBD2 pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha (TCF1) 2 -0.22
ST6GALNAC4 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 4 -0.21
ENPP5 ectonucleotide pyrophosphatase/phosphodiesterase 5 (putative) -0.21
MFSD14B major facilitator superfamily domain containing 14B -0.21
TRAPPC6A trafficking protein particle complex 6A -0.21
CBARP CACN subunit beta associated regulatory protein -0.21
FGF19 fibroblast growth factor 19 -0.21
SRD5A3 steroid 5 alpha-reductase 3 -0.21
B4GALT2 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 2 -0.21
FRRS1 ferric-chelate reductase 1 -0.21
ZNF791 zinc finger protein 791 -0.21
HBA1 hemoglobin, alpha 1 -0.21
KLK7 kallikrein-related peptidase 7 -0.21
TMOD2 tropomodulin 2 (neuronal) -0.2
MISO1 mitochondrial inner membrane subdomain organizer 1 -0.2
GTF2IRD1 GTF2I repeat domain containing 1 -0.2
ZNF250 zinc finger protein 250 -0.2
F8 coagulation factor VIII, procoagulant component -0.2
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1 -0.2
CTHRC1 collagen triple helix repeat containing 1 -0.2
BET1 Bet1 golgi vesicular membrane trafficking protein -0.2
TIMP3 TIMP metallopeptidase inhibitor 3 -0.2
TMEM134 transmembrane protein 134 -0.2
WTIP Wilms tumor 1 interacting protein -0.2
KLF10 Kruppel-like factor 10 -0.2
MCPH1 microcephalin 1 -0.19
ARHGEF4 Rho guanine nucleotide exchange factor (GEF) 4 -0.19
MBP myelin basic protein -0.19
SIPA1L2 signal-induced proliferation-associated 1 like 2 -0.19
CHRD chordin -0.18
COX19 COX19 cytochrome c oxidase assembly factor -0.18
DUSP4 dual specificity phosphatase 4 -0.18
BTG3 BTG family, member 3 -0.18
CDH1 cadherin 1, type 1, E-cadherin (epithelial) -0.18
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3 -0.18