Retinoic acid_A-172 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Retinoic acid perturbation in A-172 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Retinoic acid_A-172 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
CDH13 cadherin 13 0.142792
TRIO trio Rho guanine nucleotide exchange factor 0.134184
COL5A1 collagen, type V, alpha 1 0.105229
MAP1B microtubule-associated protein 1B 0.0974225
SLC39A11 solute carrier family 39, member 11 0.0935217
NAV1 neuron navigator 1 0.0930219
PODXL podocalyxin-like 0.0850031
IGFBP3 insulin-like growth factor binding protein 3 0.0833701
FN1 fibronectin 1 0.0816331
EGFR epidermal growth factor receptor 0.0798656
HDAC9 histone deacetylase 9 0.0758462
CACNA2D3 calcium channel, voltage-dependent, alpha 2/delta subunit 3 0.0714475
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0690746
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 0.0684672
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 0.064212
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0608306
FBXL7 F-box and leucine-rich repeat protein 7 0.0571957
MACF1 microtubule-actin crosslinking factor 1 0.0564823
DST dystonin 0.056369
EFNA5 ephrin-A5 0.0559266
PBX3 pre-B-cell leukemia homeobox 3 0.0542692
PRELID2 PRELI domain containing 2 0.0541512
LHFPL2 lipoma HMGIC fusion partner-like 2 0.0497328
ASPH aspartate beta-hydroxylase 0.0495536
SAMD9 sterile alpha motif domain containing 9 0.0450831
NAV2 neuron navigator 2 0.0441235
DOCK5 dedicator of cytokinesis 5 0.0434456
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0424337
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0413607
PLXNA2 plexin A2 0.0412075
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2 0.0408147
CYTH3 cytohesin 3 0.0404375
ARHGEF10 Rho guanine nucleotide exchange factor (GEF) 10 0.0401739
FLNA filamin A, alpha 0.0401626
RIGI RNA sensor RIG-I 0.0400803
RUNX1 runt-related transcription factor 1 0.0395684
SEPTIN9 septin 9 0.0395443
PRKAG2 protein kinase, AMP-activated, gamma 2 non-catalytic subunit 0.0386172
ZC3HAV1 zinc finger CCCH-type, antiviral 1 0.0383038
NCOR2 nuclear receptor corepressor 2 0.0382169
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) 0.0379153
SIPA1L3 signal-induced proliferation-associated 1 like 3 0.0379026
IGFN1 immunoglobulin-like and fibronectin type III domain containing 1 0.0364243
PTPN14 protein tyrosine phosphatase, non-receptor type 14 0.0361988
SMAD3 SMAD family member 3 0.0357536
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0355971
TPM3 tropomyosin 3 0.0355309
GLIS3 GLIS family zinc finger 3 0.0353897
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.035054
SMYD3 SET and MYND domain containing 3 0.0349246
MSN moesin 0.0342387
EXT1 exostosin glycosyltransferase 1 0.0342252
ANKRD11 ankyrin repeat domain 11 0.0341473
RSAD2 radical S-adenosyl methionine domain containing 2 0.033601
HS3ST3A1 heparan sulfate (glucosamine) 3-O-sulfotransferase 3A1 0.0323655
PLEC plectin 0.03196
INTS6 integrator complex subunit 6 0.031688
DGKG diacylglycerol kinase, gamma 90kDa 0.0316113
MPRIP myosin phosphatase Rho interacting protein 0.0312306
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.0301657
RASAL2 RAS protein activator like 2 0.029614
MYH9 myosin, heavy chain 9, non-muscle 0.0295414
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0294336
PALM2AKAP2 PALM2 and AKAP2 fusion 0.0294148
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.0292302
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 0.0291528
TENM3 teneurin transmembrane protein 3 0.0290486
DIP2C DIP2 disco-interacting protein 2 homolog C (Drosophila) 0.0290355
VCL vinculin 0.0289661
MYOF myoferlin 0.0282094
MBNL1 muscleblind-like splicing regulator 1 0.0281789
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0276638
XKR6 XK, Kell blood group complex subunit-related family, member 6 0.0275306
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0274678
PRKCE protein kinase C, epsilon 0.0272667
FMN2 formin 2 0.0266596
ASCC3 activating signal cointegrator 1 complex subunit 3 0.0266176
CUX1 cut-like homeobox 1 0.0263635
APP amyloid beta (A4) precursor protein 0.0263345
TAOK1 TAO kinase 1 0.0262603
PDLIM5 PDZ and LIM domain 5 0.026243
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3 0.0261208
ZSWIM6 zinc finger, SWIM-type containing 6 0.0258936
VEGFC vascular endothelial growth factor C 0.0258566
RHOBTB3 Rho-related BTB domain containing 3 0.0257092
DCLK2 doublecortin-like kinase 2 0.025017
RNF144A ring finger protein 144A 0.0247842
SP100 SP100 nuclear antigen 0.0244947
GOLGB1 golgin B1 0.0242909
ALCAM activated leukocyte cell adhesion molecule 0.0242204
TLE4 transducin-like enhancer of split 4 0.0238464
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0238119
DIAPH3 diaphanous-related formin 3 0.0238026
AHNAK2 AHNAK nucleoprotein 2 0.0237808
MCL1 myeloid cell leukemia 1 0.0236866
SPIRE1 spire-type actin nucleation factor 1 0.0236382
ADARB1 adenosine deaminase, RNA-specific, B1 0.0234697
PKM pyruvate kinase, muscle 0.0232519
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 0.0231818
E2F7 E2F transcription factor 7 0.0231055

decreased expression

Symbol Name Standardized Value
TMSB10 thymosin beta 10 -0.187326
MT2A metallothionein 2A -0.168317
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.125278
FBN1 fibrillin 1 -0.121331
VIM vimentin -0.121006
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.120895
AKAP12 A kinase (PRKA) anchor protein 12 -0.092786
PTMA prothymosin, alpha -0.0776332
SOD2 superoxide dismutase 2, mitochondrial -0.0750607
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.0717227
LOX lysyl oxidase -0.0691051
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0687534
NDRG1 N-myc downstream regulated 1 -0.0673322
UBC ubiquitin C -0.0654634
COL1A2 collagen, type I, alpha 2 -0.0621684
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0604035
PLAT plasminogen activator, tissue -0.0565373
COL3A1 collagen, type III, alpha 1 -0.0546367
TPT1 tumor protein, translationally-controlled 1 -0.0498282
CSTB cystatin B (stefin B) -0.048892
STC1 stanniocalcin 1 -0.0485572
MT1X metallothionein 1X -0.0483339
HLA-B major histocompatibility complex, class I, B -0.0471978
B2M beta-2-microglobulin -0.0439993
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0438142
EIF1 eukaryotic translation initiation factor 1 -0.0425947
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II -0.0409054
LOXL2 lysyl oxidase-like 2 -0.0408668
S100A6 S100 calcium binding protein A6 -0.0393819
GARS1 glycyl-tRNA synthetase 1 -0.0382678
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0378227
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0375853
ELL2 elongation factor, RNA polymerase II, 2 -0.0370382
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.036742
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.036473
WTAP Wilms tumor 1 associated protein -0.0361581
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0360366
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0355837
NAP1L1 nucleosome assembly protein 1-like 1 -0.0352219
NT5C2 5'-nucleotidase, cytosolic II -0.0351139
FTH1 ferritin, heavy polypeptide 1 -0.0346399
NAMPT nicotinamide phosphoribosyltransferase -0.0329016
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b -0.0328557
IER3 immediate early response 3 -0.0327928
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0316108
DLG1 discs, large homolog 1 (Drosophila) -0.0313615
OGA O-GlcNAcase -0.0311641
FTL ferritin, light polypeptide -0.0309114
S100A10 S100 calcium binding protein A10 -0.0298306
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 -0.0295694
DPYSL3 dihydropyrimidinase-like 3 -0.0294192
GNAS GNAS complex locus -0.0293862
KDM3A lysine (K)-specific demethylase 3A -0.0282002
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0278557
THBS2 thrombospondin 2 -0.0278512
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0270456
RPL23 ribosomal protein L23 -0.026737
MXI1 MAX interactor 1, dimerization protein -0.0266601
KLF6 Kruppel-like factor 6 -0.0265084
TMSB4X thymosin beta 4, X-linked -0.026498
CD99 CD99 molecule -0.0257899
RPL35A ribosomal protein L35a -0.0255799
RPL12 ribosomal protein L12 -0.0253197
ARL15 ADP-ribosylation factor-like 15 -0.0250218
SBF2 SET binding factor 2 -0.024726
FAM162A family with sequence similarity 162, member A -0.0245403
RPL34 ribosomal protein L34 -0.0243965
MAP3K2 mitogen-activated protein kinase kinase kinase 2 -0.0241288
UGCG UDP-glucose ceramide glucosyltransferase -0.024014
MYL12B myosin, light chain 12B, regulatory -0.0235028
ADM adrenomedullin -0.0229962
IFITM3 interferon induced transmembrane protein 3 -0.0227078
INSIG1 insulin induced gene 1 -0.0225362
RPS6 ribosomal protein S6 -0.022459
CLU clusterin -0.0223754
RPS24 ribosomal protein S24 -0.0223609
HLA-E major histocompatibility complex, class I, E -0.0218831
ANKRD10 ankyrin repeat domain 10 -0.0215551
RPS19 ribosomal protein S19 -0.0214126
IRF2BP2 interferon regulatory factor 2 binding protein 2 -0.0213983
HILPDA hypoxia inducible lipid droplet-associated -0.0213573
LGALS1 lectin, galactoside-binding, soluble, 1 -0.0210833
WDR45B WD repeat domain 45B -0.0206799
TMOD1 tropomodulin 1 -0.020608
NPEPPS aminopeptidase puromycin sensitive -0.0203889
CAVIN1 caveolae associated protein 1 -0.0202373
RPL36 ribosomal protein L36 -0.0201497
UBE2O ubiquitin-conjugating enzyme E2O -0.0200712
RBM25 RNA binding motif protein 25 -0.0197379
NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta -0.0196477
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 -0.0193695
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0192055
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0191488
PIAS1 protein inhibitor of activated STAT, 1 -0.0190853
S100A9 S100 calcium binding protein A9 -0.0187381
RPLP1 ribosomal protein, large, P1 -0.0186391
PRRC2C proline-rich coiled-coil 2C -0.0185337
RPL28 ribosomal protein L28 -0.0184728
TXNIP thioredoxin interacting protein -0.0184434
IRF1 interferon regulatory factor 1 -0.0184251