Retinoic acid_A-427 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Retinoic acid perturbation in A-427 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Retinoic acid_A-427 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
RRM2 ribonucleotide reductase M2 0.0330031
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0230273
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.021091
TOP2A topoisomerase (DNA) II alpha 170kDa 0.019005
SRSF1 serine/arginine-rich splicing factor 1 0.0154195
CALR calreticulin 0.0147033
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0134192
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0126617
YAP1 Yes-associated protein 1 0.0102994
CENPF centromere protein F, 350/400kDa 0.0100829
SMC4 structural maintenance of chromosomes 4 0.00877847
TPX2 TPX2, microtubule-associated 0.00810312
TPR translocated promoter region, nuclear basket protein 0.00757194
KIF4A kinesin family member 4A 0.00718889
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1 0.00716142
NDC80 NDC80 kinetochore complex component 0.00703754
NR4A3 nuclear receptor subfamily 4, group A, member 3 0.00673125
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.00642584
SYNE2 spectrin repeat containing, nuclear envelope 2 0.00642442
WWOX WW domain containing oxidoreductase 0.00619284
PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma) 0.00595641
TRA2B transformer 2 beta homolog (Drosophila) 0.00591714
NR4A1 nuclear receptor subfamily 4, group A, member 1 0.00587185
CIP2A cellular inhibitor of PP2A 0.00584844
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.00568851
RPS7 ribosomal protein S7 0.00567926
ZSWIM6 zinc finger, SWIM-type containing 6 0.00565024
SMC1A structural maintenance of chromosomes 1A 0.00564371
RACGAP1 Rac GTPase activating protein 1 0.00563627
CENPE centromere protein E, 312kDa 0.00562739
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.00559021
HSPA8 heat shock 70kDa protein 8 0.00549306
PRELID2 PRELI domain containing 2 0.00540693
CCNL1 cyclin L1 0.00537608
EPHA6 EPH receptor A6 0.00536306
HELB helicase (DNA) B 0.00534934
NR4A2 nuclear receptor subfamily 4, group A, member 2 0.00524333
KIF11 kinesin family member 11 0.0051623
RBBP7 retinoblastoma binding protein 7 0.00516032
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.00514806
ADIPOR2 adiponectin receptor 2 0.00511882
TPM3 tropomyosin 3 0.00504836
SPTSSA serine palmitoyltransferase, small subunit A 0.00500958
STAT1 signal transducer and activator of transcription 1, 91kDa 0.00499452
TFG TRK-fused gene 0.00497945
FOXM1 forkhead box M1 0.00497686
AURKA aurora kinase A 0.00483642
NASP nuclear autoantigenic sperm protein (histone-binding) 0.00481935
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.00468443
HNRNPUL2 heterogeneous nuclear ribonucleoprotein U-like 2 0.00462779
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit 0.0045966
DDX23 DEAD (Asp-Glu-Ala-Asp) box polypeptide 23 0.00449757
ANKRD36 ankyrin repeat domain 36 0.00445788
B4GALNT1 beta-1,4-N-acetyl-galactosaminyl transferase 1 0.00443555
INTS6 integrator complex subunit 6 0.00437128
KIAA1328 KIAA1328 0.00431539
MAPRE1 microtubule-associated protein, RP/EB family, member 1 0.00430187
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.00429184
GDI2 GDP dissociation inhibitor 2 0.00427245
CEP128 centrosomal protein 128kDa 0.00424348
ARRDC3 arrestin domain containing 3 0.00422946
IQGAP3 IQ motif containing GTPase activating protein 3 0.00422885
HMGB2 high mobility group box 2 0.00420941
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.00420701
SUPT6H suppressor of Ty 6 homolog (S. cerevisiae) 0.00420148
SDK1 sidekick cell adhesion molecule 1 0.00414949
SERGEF secretion regulating guanine nucleotide exchange factor 0.00413889
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.00412589
UHMK1 U2AF homology motif (UHM) kinase 1 0.00412152
SMARCA5 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5 0.00411358
ZEB1 zinc finger E-box binding homeobox 1 0.004102
DSCAM Down syndrome cell adhesion molecule 0.00409905
PPID peptidylprolyl isomerase D 0.00400146
KIF18A kinesin family member 18A 0.00399711
MSN moesin 0.00395982
BZW1 basic leucine zipper and W2 domains 1 0.00395086
SFPQ splicing factor proline/glutamine-rich 0.00394013
KIFC1 kinesin family member C1 0.00391854
FAM111A family with sequence similarity 111, member A 0.00389615
FANCI Fanconi anemia, complementation group I 0.00377459
SEC31A SEC31 homolog A (S. cerevisiae) 0.00374507
TBC1D22A TBC1 domain family, member 22A 0.00373601
HSPH1 heat shock 105kDa/110kDa protein 1 0.00372372
FLNA filamin A, alpha 0.00371686
SRSF5 serine/arginine-rich splicing factor 5 0.00369429
PCNA proliferating cell nuclear antigen 0.00367203
FBXL7 F-box and leucine-rich repeat protein 7 0.00366039
NUMA1 nuclear mitotic apparatus protein 1 0.00365232
LAMP2 lysosomal-associated membrane protein 2 0.00364109
CEP192 centrosomal protein 192kDa 0.00363714
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.00363207
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein 0.00362044
CRISPLD1 cysteine-rich secretory protein LCCL domain containing 1 0.00357963
TBC1D15 TBC1 domain family, member 15 0.00355791
UBQLN1 ubiquilin 1 0.0035215
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.00350402
EPS8 epidermal growth factor receptor pathway substrate 8 0.00349413
PSMD11 proteasome (prosome, macropain) 26S subunit, non-ATPase, 11 0.00348449
PPP1CB protein phosphatase 1, catalytic subunit, beta isozyme 0.0034747
PCMTD1 protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 1 0.00345179

decreased expression

Symbol Name Standardized Value
VIM vimentin -0.139342
TMSB10 thymosin beta 10 -0.111317
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0825773
MMP12 matrix metallopeptidase 12 -0.0799415
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0717316
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0662132
ALDH1A1 aldehyde dehydrogenase 1 family, member A1 -0.060646
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0513847
ANKRD12 ankyrin repeat domain 12 -0.0427322
MYL12B myosin, light chain 12B, regulatory -0.0412647
RPL35A ribosomal protein L35a -0.0373045
AREG amphiregulin -0.0370179
RPL23 ribosomal protein L23 -0.0357721
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2 -0.0350001
EHBP1 EH domain binding protein 1 -0.034597
SLC38A2 solute carrier family 38, member 2 -0.0343487
DLC1 DLC1 Rho GTPase activating protein -0.0330412
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 -0.0329237
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 -0.0321769
NLGN1 neuroligin 1 -0.0314864
RPS6 ribosomal protein S6 -0.0309512
PCDH7 protocadherin 7 -0.0304059
RASAL2 RAS protein activator like 2 -0.0303211
BCHE butyrylcholinesterase -0.029877
VMP1 vacuole membrane protein 1 -0.0274868
ANXA1 annexin A1 -0.0272753
RPL19 ribosomal protein L19 -0.0271596
FTL ferritin, light polypeptide -0.0269859
PTMA prothymosin, alpha -0.026941
LRRTM4 leucine rich repeat transmembrane neuronal 4 -0.0265936
RPS19 ribosomal protein S19 -0.0258398
CLDN1 claudin 1 -0.0254677
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C -0.0253059
AHNAK AHNAK nucleoprotein -0.0249878
DPYD dihydropyrimidine dehydrogenase -0.0246655
RPLP1 ribosomal protein, large, P1 -0.024597
HMGA2 high mobility group AT-hook 2 -0.0240535
EIF1 eukaryotic translation initiation factor 1 -0.0236735
HSPB1 heat shock 27kDa protein 1 -0.0228276
ERC1 ELKS/RAB6-interacting/CAST family member 1 -0.0227028
ATP5F1B ATP synthase F1 subunit beta -0.0226429
NR5A2 nuclear receptor subfamily 5, group A, member 2 -0.0224684
JMJD1C jumonji domain containing 1C -0.0224142
HMGA1 high mobility group AT-hook 1 -0.0220532
S100A6 S100 calcium binding protein A6 -0.0218801
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1 -0.0218128
RPL8 ribosomal protein L8 -0.02178
NHSL1 NHS-like 1 -0.0216743
RPS21 ribosomal protein S21 -0.0216388
GARS1 glycyl-tRNA synthetase 1 -0.0213496
ZBTB20 zinc finger and BTB domain containing 20 -0.0212512
AKAP12 A kinase (PRKA) anchor protein 12 -0.0209752
PFN1 profilin 1 -0.0208407
EGR1 early growth response 1 -0.0206624
USP34 ubiquitin specific peptidase 34 -0.0205604
IPO7 importin 7 -0.0202599
KRR1 KRR1, small subunit (SSU) processome component, homolog (yeast) -0.0201654
ACTG1 actin gamma 1 -0.0198861
BIRC6 baculoviral IAP repeat containing 6 -0.0196301
CARD16 caspase recruitment domain family, member 16 -0.0191853
KLF6 Kruppel-like factor 6 -0.0191736
CSNK1A1 casein kinase 1, alpha 1 -0.019044
KPNB1 karyopherin (importin) beta 1 -0.0190078
RPLP2 ribosomal protein, large, P2 -0.0187026
GNAS GNAS complex locus -0.0186896
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0185844
SLC38A1 solute carrier family 38, member 1 -0.0183818
RPS14 ribosomal protein S14 -0.0183024
CUX1 cut-like homeobox 1 -0.0182841
IFIH1 interferon induced with helicase C domain 1 -0.0182839
RPL36 ribosomal protein L36 -0.0182012
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 -0.0180883
CNRIP1 cannabinoid receptor interacting protein 1 -0.0179821
RPS23 ribosomal protein S23 -0.0179711
TXNRD1 thioredoxin reductase 1 -0.0179125
DST dystonin -0.0177998
RAB10 RAB10, member RAS oncogene family -0.0177559
RPS16 ribosomal protein S16 -0.0177273
CMIP c-Maf inducing protein -0.0174179
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0173611
RAB7A RAB7A, member RAS oncogene family -0.0173259
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -0.0172434
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0172356
RPL26 ribosomal protein L26 -0.0171901
MAP4 microtubule-associated protein 4 -0.0171127
GJA1 gap junction protein, alpha 1, 43kDa -0.0170417
RERE arginine-glutamic acid dipeptide (RE) repeats -0.0170146
FBXO11 F-box protein 11 -0.0169404
STARD4 StAR-related lipid transfer (START) domain containing 4 -0.0168663
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase -0.0167546
ITGBL1 integrin, beta-like 1 (with EGF-like repeat domains) -0.0167031
TMEM41B transmembrane protein 41B -0.0167026
CUBN cubilin (intrinsic factor-cobalamin receptor) -0.0164741
EEF2 eukaryotic translation elongation factor 2 -0.0159493
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0159387
PTMS parathymosin -0.0158689
RPL34 ribosomal protein L34 -0.0158484
TPI1 triosephosphate isomerase 1 -0.0158162
NF1 neurofibromin 1 -0.0158141
LRPPRC leucine-rich pentatricopeptide repeat containing -0.015789