Retinoic acid_A549 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Retinoic acid perturbation in A549 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Retinoic acid_A549 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
NRIP1 nuclear receptor interacting protein 1 0.0739148
SMAD3 SMAD family member 3 0.0650879
ARHGAP26 Rho GTPase activating protein 26 0.0557254
CYP24A1 cytochrome P450, family 24, subfamily A, polypeptide 1 0.0541826
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0482325
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0453869
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0403299
CMIP c-Maf inducing protein 0.0311885
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0296027
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0265862
FNDC3B fibronectin type III domain containing 3B 0.023612
MSN moesin 0.0236023
RASA2 RAS p21 protein activator 2 0.0234524
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0207773
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0203408
TGM2 transglutaminase 2 0.0197174
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0191838
PCBP2 poly(rC) binding protein 2 0.0182979
TRIO trio Rho guanine nucleotide exchange factor 0.0181812
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0181762
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0170733
RNF145 ring finger protein 145 0.0165343
NAV2 neuron navigator 2 0.0163952
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0163406
GLS2 glutaminase 2 (liver, mitochondrial) 0.0160916
TNIP1 TNFAIP3 interacting protein 1 0.015849
SHB Src homology 2 domain containing adaptor protein B 0.0156623
PDLIM5 PDZ and LIM domain 5 0.0154009
GRAMD1B GRAM domain containing 1B 0.0153592
CNTN1 contactin 1 0.0149003
MYH9 myosin, heavy chain 9, non-muscle 0.0148224
CCNL1 cyclin L1 0.0145803
TNFAIP2 tumor necrosis factor, alpha-induced protein 2 0.0145518
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0143454
BICC1 BicC family RNA binding protein 1 0.0140651
WWOX WW domain containing oxidoreductase 0.0139332
APLP2 amyloid beta (A4) precursor-like protein 2 0.0138897
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0137091
PSME4 proteasome (prosome, macropain) activator subunit 4 0.0134818
SKAP2 src kinase associated phosphoprotein 2 0.013233
JAK1 Janus kinase 1 0.0131131
LOXL2 lysyl oxidase-like 2 0.0130211
AHR aryl hydrocarbon receptor 0.012956
MYO1B myosin IB 0.0128248
SEPTIN9 septin 9 0.0127164
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0125448
PCSK5 proprotein convertase subtilisin/kexin type 5 0.0124361
ITGB5 integrin, beta 5 0.0123052
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0123048
GPC6 glypican 6 0.0122912
HELZ helicase with zinc finger 0.0119243
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.0118219
PRKCE protein kinase C, epsilon 0.0117359
LHFPL2 lipoma HMGIC fusion partner-like 2 0.0117025
ADGRG6 adhesion G protein-coupled receptor G6 0.0115867
RARB retinoic acid receptor, beta 0.0114428
WDR43 WD repeat domain 43 0.0112937
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0112863
RAI14 retinoic acid induced 14 0.0112414
TPM3 tropomyosin 3 0.0112301
TNS1 tensin 1 0.0112144
CA8 carbonic anhydrase VIII 0.0111509
ADAM17 ADAM metallopeptidase domain 17 0.0111301
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0109835
TFPI2 tissue factor pathway inhibitor 2 0.0109732
ABTB3 ankyrin repeat and BTB domain containing 3 0.0108517
PRELID2 PRELI domain containing 2 0.0108482
EPAS1 endothelial PAS domain protein 1 0.0106957
RPL3 ribosomal protein L3 0.0105801
MBNL1 muscleblind-like splicing regulator 1 0.0104316
ECT2 epithelial cell transforming 2 0.0103609
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0101635
PTPRJ protein tyrosine phosphatase, receptor type, J 0.0101346
CEMIP2 cell migration inducing hyaluronidase 2 0.0100428
CNOT1 CCR4-NOT transcription complex, subunit 1 0.00986334
ACTR3 ARP3 actin-related protein 3 homolog (yeast) 0.00977328
RBPMS RNA binding protein with multiple splicing 0.00972744
INTS6 integrator complex subunit 6 0.00963663
TSC22D2 TSC22 domain family, member 2 0.00959348
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.00950522
EIF4B eukaryotic translation initiation factor 4B 0.00936025
LAMA5 laminin, alpha 5 0.00933965
SKIL SKI-like proto-oncogene 0.00918707
RUNX1 runt-related transcription factor 1 0.00913553
CCNY cyclin Y 0.00911338
TMTC2 transmembrane and tetratricopeptide repeat containing 2 0.00911099
KLF7 Kruppel-like factor 7 (ubiquitous) 0.0090957
CTBP2 C-terminal binding protein 2 0.00892902
SIK3 SIK family kinase 3 0.00891721
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.00889401
RNPS1 RNA binding protein S1, serine-rich domain 0.00888504
BRD2 bromodomain containing 2 0.00887974
UBA6 ubiquitin-like modifier activating enzyme 6 0.00879585
RALGAPA2 Ral GTPase activating protein, alpha subunit 2 (catalytic) 0.00876885
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.00871433
VMP1 vacuole membrane protein 1 0.00864285
MAFK v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog K 0.00850343
ZNF146 zinc finger protein 146 0.00850035
KTN1 kinectin 1 (kinesin receptor) 0.00847863
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.00845816

decreased expression

Symbol Name Standardized Value
TMSB10 thymosin beta 10 -0.264208
VIM vimentin -0.149745
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.14901
MT2A metallothionein 2A -0.121774
AKAP12 A kinase (PRKA) anchor protein 12 -0.100884
ACTG1 actin gamma 1 -0.100869
NDRG1 N-myc downstream regulated 1 -0.0998887
MT1X metallothionein 1X -0.0921811
TPT1 tumor protein, translationally-controlled 1 -0.0813955
BASP1 brain abundant, membrane attached signal protein 1 -0.0801263
IGFBP4 insulin-like growth factor binding protein 4 -0.0785032
EIF1 eukaryotic translation initiation factor 1 -0.0777225
S100A6 S100 calcium binding protein A6 -0.071869
RPS19 ribosomal protein S19 -0.0715256
RPLP1 ribosomal protein, large, P1 -0.0657017
PTMA prothymosin, alpha -0.0646518
ANXA2 annexin A2 -0.0643611
PDE4D phosphodiesterase 4D, cAMP-specific -0.0640378
AKR1C2 aldo-keto reductase family 1, member C2 -0.0623799
FTL ferritin, light polypeptide -0.0609855
TM4SF1 transmembrane 4 L six family member 1 -0.0587665
RPS24 ribosomal protein S24 -0.0566448
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0547192
STC1 stanniocalcin 1 -0.0523278
RPL23 ribosomal protein L23 -0.0512794
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.0495835
CA12 carbonic anhydrase XII -0.0492425
RPL26 ribosomal protein L26 -0.0480477
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.0478795
KLF6 Kruppel-like factor 6 -0.0460591
S100A10 S100 calcium binding protein A10 -0.0451304
RPS16 ribosomal protein S16 -0.0443
RPS6 ribosomal protein S6 -0.0442466
ASPH aspartate beta-hydroxylase -0.0433213
IGFBP3 insulin-like growth factor binding protein 3 -0.0425641
KRT81 keratin 81, type II -0.0420097
AHNAK AHNAK nucleoprotein -0.0419918
OSMR oncostatin M receptor -0.040456
PAPPA pregnancy-associated plasma protein A, pappalysin 1 -0.0378048
RPL12 ribosomal protein L12 -0.0372216
RPL19 ribosomal protein L19 -0.0370605
EIF4A1 eukaryotic translation initiation factor 4A1 -0.0364681
LMNA lamin A/C -0.0353951
RPL35A ribosomal protein L35a -0.0348407
THSD4 thrombospondin, type I, domain containing 4 -0.0346421
RPS27A ribosomal protein S27a -0.0324879
EFNA5 ephrin-A5 -0.031624
RPL32 ribosomal protein L32 -0.0313619
RPLP0 ribosomal protein, large, P0 -0.0313538
RPL34 ribosomal protein L34 -0.0308037
RPS21 ribosomal protein S21 -0.0301109
RRBP1 ribosome binding protein 1 -0.030042
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 -0.0298652
GRB10 growth factor receptor-bound protein 10 -0.0287667
TMSB4X thymosin beta 4, X-linked -0.0287518
RPS13 ribosomal protein S13 -0.0284459
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0283994
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) -0.028341
RPLP2 ribosomal protein, large, P2 -0.0283402
EGR1 early growth response 1 -0.028294
ZMYND8 zinc finger, MYND-type containing 8 -0.0278146
PNRC1 proline-rich nuclear receptor coactivator 1 -0.0276808
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0276342
BTG1 B-cell translocation gene 1, anti-proliferative -0.0268985
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0266787
EHBP1 EH domain binding protein 1 -0.02659
KYNU kynureninase -0.0265561
RPS8 ribosomal protein S8 -0.0263304
RPL18 ribosomal protein L18 -0.0261911
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0257444
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0256797
RPL36A ribosomal protein L36a -0.0254305
MAML3 mastermind-like 3 (Drosophila) -0.0250837
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0249157
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0248331
ANXA4 annexin A4 -0.0247477
RNF213 ring finger protein 213 -0.0246037
MARCKS myristoylated alanine-rich protein kinase C substrate -0.024327
RPL28 ribosomal protein L28 -0.0241697
SEMA4B sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B -0.0241678
IGFBP1 insulin-like growth factor binding protein 1 -0.0240837
CAVIN1 caveolae associated protein 1 -0.0239893
ARL4C ADP-ribosylation factor-like 4C -0.0238197
IFI6 interferon, alpha-inducible protein 6 -0.0236209
RPL37A ribosomal protein L37a -0.0235823
KPNB1 karyopherin (importin) beta 1 -0.0234358
PRKCA protein kinase C, alpha -0.0229558
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 -0.0229089
RPL31 ribosomal protein L31 -0.0228023
PFN1 profilin 1 -0.0227172
HMGA2 high mobility group AT-hook 2 -0.0221635
NAP1L1 nucleosome assembly protein 1-like 1 -0.0219481
RPL8 ribosomal protein L8 -0.0217818
RPS11 ribosomal protein S11 -0.0216221
UBC ubiquitin C -0.021531
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0213538
TPI1 triosephosphate isomerase 1 -0.0213362
CCDC88A coiled-coil domain containing 88A -0.0212736
RPS5 ribosomal protein S5 -0.0210682
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0209519