Retinoic acid_AN3 CA Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Retinoic acid perturbation in AN3 CA cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Retinoic acid_AN3 CA drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.129709
CADM2 cell adhesion molecule 2 0.12968
PRKG1 protein kinase, cGMP-dependent, type I 0.129439
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) 0.0823788
HMGA2 high mobility group AT-hook 2 0.0679883
TRIO trio Rho guanine nucleotide exchange factor 0.0591922
EGFR epidermal growth factor receptor 0.0585092
TSHZ2 teashirt zinc finger homeobox 2 0.0567362
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.055477
MYOF myoferlin 0.0482154
FNDC3B fibronectin type III domain containing 3B 0.0471121
AFF4 AF4/FMR2 family, member 4 0.0399126
GMDS GDP-mannose 4,6-dehydratase 0.0374862
FAM13A family with sequence similarity 13, member A 0.036492
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0364794
KAZN kazrin, periplakin interacting protein 0.0352019
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0342412
LPP LIM domain containing preferred translocation partner in lipoma 0.0339856
ZMIZ1 zinc finger, MIZ-type containing 1 0.0336461
NBEA neurobeachin 0.0325955
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0324116
IGF2R insulin-like growth factor 2 receptor 0.0312377
THSD4 thrombospondin, type I, domain containing 4 0.0311223
KDM4C lysine (K)-specific demethylase 4C 0.0301741
CTBP2 C-terminal binding protein 2 0.030017
FRMD6 FERM domain containing 6 0.0285448
ATP11A ATPase, class VI, type 11A 0.0275056
MBD5 methyl-CpG binding domain protein 5 0.027193
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0271815
PDE10A phosphodiesterase 10A 0.0267961
TRIM9 tripartite motif containing 9 0.0266238
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0258667
FLNB filamin B, beta 0.0256829
ZFHX3 zinc finger homeobox 3 0.0255968
NDRG1 N-myc downstream regulated 1 0.0253118
JMJD1C jumonji domain containing 1C 0.0232042
SMYD3 SET and MYND domain containing 3 0.0228623
MEIS2 Meis homeobox 2 0.0225517
EXOC4 exocyst complex component 4 0.0224272
DNAJB6 DnaJ (Hsp40) homolog, subfamily B, member 6 0.0222513
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.022051
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.021807
PARD3B par-3 family cell polarity regulator beta 0.0217866
ADIPOR2 adiponectin receptor 2 0.0215375
FMNL2 formin-like 2 0.0213281
EGLN1 egl-9 family hypoxia-inducible factor 1 0.0212464
SUPT3H suppressor of Ty 3 homolog (S. cerevisiae) 0.0210789
ANO6 anoctamin 6 0.0210397
PFKFB4 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 0.0209215
KDM5B lysine (K)-specific demethylase 5B 0.0208987
ARB2A ARB2 cotranscriptional regulator A 0.0208197
SHROOM3 shroom family member 3 0.0207326
JARID2 jumonji, AT rich interactive domain 2 0.0206493
FLNA filamin A, alpha 0.0205852
HSPH1 heat shock 105kDa/110kDa protein 1 0.0203276
ERC1 ELKS/RAB6-interacting/CAST family member 1 0.0202189
EXT1 exostosin glycosyltransferase 1 0.0199344
NCOR2 nuclear receptor corepressor 2 0.0198585
VPS13B vacuolar protein sorting 13 homolog B (yeast) 0.019678
EGR1 early growth response 1 0.0193335
CUX1 cut-like homeobox 1 0.0193
ASPH aspartate beta-hydroxylase 0.019062
ANK2 ankyrin 2, neuronal 0.0189616
HOOK2 hook microtubule-tethering protein 2 0.0189454
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0186216
ATP6V1H ATPase, H+ transporting, lysosomal 50/57kDa, V1 subunit H 0.0182474
TSC22D1 TSC22 domain family, member 1 0.0179582
PCM1 pericentriolar material 1 0.0175798
INO80 INO80 complex subunit 0.0175584
PLS3 plastin 3 0.0174205
INTS6 integrator complex subunit 6 0.0173611
FOXO3 forkhead box O3 0.0171705
HBP1 HMG-box transcription factor 1 0.0171421
AGO2 argonaute RISC catalytic component 2 0.0171081
KAT6B K(lysine) acetyltransferase 6B 0.0169724
ZNF407 zinc finger protein 407 0.0168021
GNPDA1 glucosamine-6-phosphate deaminase 1 0.0167814
VPS13D vacuolar protein sorting 13 homolog D (S. cerevisiae) 0.0166927
FNIP1 folliculin interacting protein 1 0.0165659
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.0165058
PHF21A PHD finger protein 21A 0.0164915
LATS2 large tumor suppressor kinase 2 0.0164609
DOCK4 dedicator of cytokinesis 4 0.016451
MSRB3 methionine sulfoxide reductase B3 0.0164037
HOOK3 hook microtubule-tethering protein 3 0.0163364
SEPTIN11 septin 11 0.0163205
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 0.0162063
TBC1D22A TBC1 domain family, member 22A 0.016162
AFF3 AF4/FMR2 family, member 3 0.0161388
SERTAD2 SERTA domain containing 2 0.0161324
FARS2 phenylalanyl-tRNA synthetase 2, mitochondrial 0.0159623
TTC3 tetratricopeptide repeat domain 3 0.015935
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0159084
RABGAP1L RAB GTPase activating protein 1-like 0.0158806
FOXN3 forkhead box N3 0.0158604
GLS2 glutaminase 2 (liver, mitochondrial) 0.0157576
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0157135
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.015699
GTF2IRD1 GTF2I repeat domain containing 1 0.0156611
LPIN2 lipin 2 0.0155975

decreased expression

Symbol Name Standardized Value
VIM vimentin -0.116548
MT2A metallothionein 2A -0.116466
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.113775
MEST mesoderm specific transcript -0.105331
RPS6 ribosomal protein S6 -0.102353
PTMA prothymosin, alpha -0.0971701
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0736631
RPS2 ribosomal protein S2 -0.0725413
CENPF centromere protein F, 350/400kDa -0.0717231
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0686545
PEG10 paternally expressed 10 -0.0681951
ZNF292 zinc finger protein 292 -0.0671754
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0640039
MGP matrix Gla protein -0.0632862
RPL34 ribosomal protein L34 -0.0610866
HMGB2 high mobility group box 2 -0.0602141
TMSB4X thymosin beta 4, X-linked -0.0533163
RPS24 ribosomal protein S24 -0.0532488
RPL26 ribosomal protein L26 -0.053061
RPS12 ribosomal protein S12 -0.0526468
PRRC2C proline-rich coiled-coil 2C -0.0521328
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0511622
SOX4 SRY (sex determining region Y)-box 4 -0.0490824
RPS23 ribosomal protein S23 -0.0490209
RPS8 ribosomal protein S8 -0.0485541
RPL11 ribosomal protein L11 -0.0474181
RPS19 ribosomal protein S19 -0.0470394
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0462734
RPL19 ribosomal protein L19 -0.0442631
RPLP0 ribosomal protein, large, P0 -0.0440691
RPL23 ribosomal protein L23 -0.0438043
CALR calreticulin -0.043438
RPLP1 ribosomal protein, large, P1 -0.0426707
RPLP2 ribosomal protein, large, P2 -0.0419915
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.041533
QKI QKI, KH domain containing, RNA binding -0.0415157
RPL12 ribosomal protein L12 -0.0412945
RPL7 ribosomal protein L7 -0.0400284
RPS27A ribosomal protein S27a -0.0392982
HMGA1 high mobility group AT-hook 1 -0.0392364
RAD21 RAD21 homolog (S. pombe) -0.0389793
MEOX2 mesenchyme homeobox 2 -0.037961
MIS18BP1 MIS18 binding protein 1 -0.0372492
RPS14 ribosomal protein S14 -0.0371815
PHIP pleckstrin homology domain interacting protein -0.0370375
RPL37A ribosomal protein L37a -0.0367636
NAP1L1 nucleosome assembly protein 1-like 1 -0.0367385
TPX2 TPX2, microtubule-associated -0.0358341
RPL37 ribosomal protein L37 -0.0358139
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0357415
RPL36 ribosomal protein L36 -0.0354279
RACK1 receptor for activated C kinase 1 -0.034939
TM9SF3 transmembrane 9 superfamily member 3 -0.0349121
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0348192
MATR3 matrin 3 -0.0342611
RPS3 ribosomal protein S3 -0.034146
RPS4X ribosomal protein S4, X-linked -0.0341195
DNAJC1 DnaJ (Hsp40) homolog, subfamily C, member 1 -0.0340177
RPS13 ribosomal protein S13 -0.0338424
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0336126
MKI67 marker of proliferation Ki-67 -0.0335768
EEF2 eukaryotic translation elongation factor 2 -0.0333376
RPS10 ribosomal protein S10 -0.0328064
COL1A2 collagen, type I, alpha 2 -0.0324983
PNISR PNN-interacting serine/arginine-rich protein -0.03246
CENPE centromere protein E, 312kDa -0.0318595
PDIA6 protein disulfide isomerase family A, member 6 -0.0306827
IER3 immediate early response 3 -0.0306607
ITGAV integrin, alpha V -0.0304308
WBP11 WW domain binding protein 11 -0.0303356
SEPTIN7 septin 7 -0.030224
PELI1 pellino E3 ubiquitin protein ligase 1 -0.0300814
RPL32 ribosomal protein L32 -0.0300693
RPS25 ribosomal protein S25 -0.0298586
RBM25 RNA binding motif protein 25 -0.0295688
B2M beta-2-microglobulin -0.0294706
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 -0.029412
CANX calnexin -0.0291364
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0290434
SQSTM1 sequestosome 1 -0.0290026
KIF11 kinesin family member 11 -0.0289177
TPT1 tumor protein, translationally-controlled 1 -0.0288804
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0286982
RPL7A ribosomal protein L7a -0.0284291
ARHGAP21 Rho GTPase activating protein 21 -0.0282352
S100A9 S100 calcium binding protein A9 -0.028179
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) -0.0281316
SET SET nuclear proto-oncogene -0.028101
RPS21 ribosomal protein S21 -0.02763
PCBP2 poly(rC) binding protein 2 -0.0276269
LMO4 LIM domain only 4 -0.0274276
IRF2BP2 interferon regulatory factor 2 binding protein 2 -0.0272831
RPS17 ribosomal protein S17 -0.0272258
RPL31 ribosomal protein L31 -0.0271944
TUBB tubulin, beta class I -0.0270565
RPL5 ribosomal protein L5 -0.0267546
BCOR BCL6 corepressor -0.026684
RPS16 ribosomal protein S16 -0.0266606
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0266479
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) -0.0265618