Retinoic acid_AsPC-1 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Retinoic acid perturbation in AsPC-1 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Retinoic acid_AsPC-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
MBOAT2 membrane bound O-acyltransferase domain containing 2 0.0487255
IGFBP3 insulin-like growth factor binding protein 3 0.044131
SMAD3 SMAD family member 3 0.0382053
PSD3 pleckstrin and Sec7 domain containing 3 0.0352845
SGMS2 sphingomyelin synthase 2 0.0297988
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.029533
CHST11 carbohydrate (chondroitin 4) sulfotransferase 11 0.0288523
TGM2 transglutaminase 2 0.0261138
FNDC3B fibronectin type III domain containing 3B 0.0257342
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.025471
MSN moesin 0.0247185
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0233606
APLP2 amyloid beta (A4) precursor-like protein 2 0.0223408
PALM2AKAP2 PALM2 and AKAP2 fusion 0.0221972
MYH9 myosin, heavy chain 9, non-muscle 0.0217834
CCNY cyclin Y 0.0214223
ABTB3 ankyrin repeat and BTB domain containing 3 0.021363
NRIP1 nuclear receptor interacting protein 1 0.0204925
PPARD peroxisome proliferator-activated receptor delta 0.0199578
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0198558
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0198115
TPM3 tropomyosin 3 0.019757
MBNL1 muscleblind-like splicing regulator 1 0.0191972
FMNL2 formin-like 2 0.0189648
PICALM phosphatidylinositol binding clathrin assembly protein 0.0188515
GRB10 growth factor receptor-bound protein 10 0.0186854
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0186297
PLEC plectin 0.0183363
MCL1 myeloid cell leukemia 1 0.0175127
BMP6 bone morphogenetic protein 6 0.0168955
ATP13A3 ATPase type 13A3 0.0168076
PTK2 protein tyrosine kinase 2 0.0165828
MPRIP myosin phosphatase Rho interacting protein 0.0164345
RAI14 retinoic acid induced 14 0.0161696
TRIO trio Rho guanine nucleotide exchange factor 0.0161432
RUNX1 runt-related transcription factor 1 0.0159614
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 0.0157841
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0155435
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0154349
GDA guanine deaminase 0.0154014
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0151857
PCSK5 proprotein convertase subtilisin/kexin type 5 0.0151429
PIP4K2A phosphatidylinositol-5-phosphate 4-kinase, type II, alpha 0.0150665
CAMK1D calcium/calmodulin-dependent protein kinase ID 0.0147378
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0145367
FAM13A family with sequence similarity 13, member A 0.0145
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0141532
CLIP2 CAP-GLY domain containing linker protein 2 0.0138429
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0136785
FOSB FBJ murine osteosarcoma viral oncogene homolog B 0.0136325
WDR43 WD repeat domain 43 0.0136051
RNPS1 RNA binding protein S1, serine-rich domain 0.0136051
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0135856
NCEH1 neutral cholesterol ester hydrolase 1 0.0135817
GPCPD1 glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) 0.0133745
MAML2 mastermind-like 2 (Drosophila) 0.0133047
ANKRD11 ankyrin repeat domain 11 0.0131627
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0130314
CTBP2 C-terminal binding protein 2 0.0129788
CAPRIN2 caprin family member 2 0.0128765
PPP4R1 protein phosphatase 4, regulatory subunit 1 0.0128611
SEPTIN9 septin 9 0.0128024
NCOR2 nuclear receptor corepressor 2 0.0125231
AHR aryl hydrocarbon receptor 0.0123934
ANXA1 annexin A1 0.0122637
DSPP dentin sialophosphoprotein 0.012137
MED13L mediator complex subunit 13-like 0.0120436
HSPA8 heat shock 70kDa protein 8 0.0117741
OSBPL3 oxysterol binding protein-like 3 0.011728
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0117185
LMTK2 lemur tyrosine kinase 2 0.0116076
STK39 serine threonine kinase 39 0.0112664
UBA6 ubiquitin-like modifier activating enzyme 6 0.0111475
EIF4B eukaryotic translation initiation factor 4B 0.0111246
SIK3 SIK family kinase 3 0.0110867
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.0110495
RBM39 RNA binding motif protein 39 0.0110377
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.0110054
ZMIZ1 zinc finger, MIZ-type containing 1 0.0109397
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 0.0108655
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3 0.0108204
PTK2B protein tyrosine kinase 2 beta 0.010798
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0107465
ZEB1 zinc finger E-box binding homeobox 1 0.0107183
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.0106933
DIAPH1 diaphanous-related formin 1 0.0106802
RCOR1 REST corepressor 1 0.0106446
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 0.0106302
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2 0.010588
HNRNPA3 heterogeneous nuclear ribonucleoprotein A3 0.010532
PDIA6 protein disulfide isomerase family A, member 6 0.0104898
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4 0.0103705
PTPRJ protein tyrosine phosphatase, receptor type, J 0.0103182
NUP58 nucleoporin 58 0.0102858
QKI QKI, KH domain containing, RNA binding 0.0102584
ADGRE5 adhesion G protein-coupled receptor E5 0.0102333
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma 0.0102328
MYOF myoferlin 0.0101739
SEC24A SEC24 family member A 0.0101003
CORO1C coronin, actin binding protein, 1C 0.010025

decreased expression

Symbol Name Standardized Value
TMSB10 thymosin beta 10 -0.304918
ARPC1B actin related protein 2/3 complex, subunit 1B, 41kDa -0.230111
TPT1 tumor protein, translationally-controlled 1 -0.182478
LAMB3 laminin, beta 3 -0.179852
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 -0.147419
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.121081
F3 coagulation factor III (thromboplastin, tissue factor) -0.112385
VIM vimentin -0.100514
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0928197
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0888029
FTL ferritin, light polypeptide -0.0879338
ARPC1A actin related protein 2/3 complex, subunit 1A, 41kDa -0.0850578
B2M beta-2-microglobulin -0.0840854
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0838478
PTMA prothymosin, alpha -0.0797419
DHRS9 dehydrogenase/reductase (SDR family) member 9 -0.0785499
LMO7 LIM domain 7 -0.0784585
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0753262
KLK10 kallikrein-related peptidase 10 -0.0716343
MUC17 mucin 17, cell surface associated -0.0674441
S100A10 S100 calcium binding protein A10 -0.065266
LAMC2 laminin, gamma 2 -0.0615155
TMBIM1 transmembrane BAX inhibitor motif containing 1 -0.0604195
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.058616
RPL35A ribosomal protein L35a -0.0580113
CD59 CD59 molecule, complement regulatory protein -0.0567861
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa -0.0565205
S100A11 S100 calcium binding protein A11 -0.0556329
TXNIP thioredoxin interacting protein -0.0536702
EIF1 eukaryotic translation initiation factor 1 -0.053039
RPS21 ribosomal protein S21 -0.0523054
RPL12 ribosomal protein L12 -0.0518429
HMGA1 high mobility group AT-hook 1 -0.0513229
RPL34 ribosomal protein L34 -0.0510045
RPL23 ribosomal protein L23 -0.0508471
PGK1 phosphoglycerate kinase 1 -0.049943
RPL31 ribosomal protein L31 -0.0494121
TPM4 tropomyosin 4 -0.0487083
RPLP2 ribosomal protein, large, P2 -0.0475127
UBC ubiquitin C -0.0474563
RPS8 ribosomal protein S8 -0.0471294
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0468601
PLAUR plasminogen activator, urokinase receptor -0.045811
TM4SF1 transmembrane 4 L six family member 1 -0.0457893
RPL37A ribosomal protein L37a -0.0451514
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0450016
S100A6 S100 calcium binding protein A6 -0.0448922
RPL8 ribosomal protein L8 -0.0440937
POTEF POTE ankyrin domain family, member F -0.043145
ACTG1 actin gamma 1 -0.0431191
SACK1A scaffolding CK1 anchoring protein A -0.0429524
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0424885
NPSR1 neuropeptide S receptor 1 -0.0421287
GNAS GNAS complex locus -0.0419967
RPLP1 ribosomal protein, large, P1 -0.0417418
RPL26 ribosomal protein L26 -0.041687
KLF6 Kruppel-like factor 6 -0.041082
PRSS3 protease, serine, 3 -0.0409126
PERP PERP, TP53 apoptosis effector -0.0404361
RPS13 ribosomal protein S13 -0.0399102
ASPH aspartate beta-hydroxylase -0.0396614
SDC4 syndecan 4 -0.0393284
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5 -0.0393049
S100A4 S100 calcium binding protein A4 -0.0393008
RPL11 ribosomal protein L11 -0.0392198
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.039206
RPL30 ribosomal protein L30 -0.0391829
LY6E lymphocyte antigen 6 complex, locus E -0.0391318
SLC35F3 solute carrier family 35, member F3 -0.0388974
KCNK1 potassium channel, two pore domain subfamily K, member 1 -0.0388787
CAP1 CAP, adenylate cyclase-associated protein 1 (yeast) -0.0386917
RPS3 ribosomal protein S3 -0.0381043
RPL37 ribosomal protein L37 -0.0379124
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0374582
MXD1 MAX dimerization protein 1 -0.0373086
RPS24 ribosomal protein S24 -0.036944
RPS6 ribosomal protein S6 -0.036465
RPS25 ribosomal protein S25 -0.0359464
ANXA2 annexin A2 -0.0350911
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) -0.0350292
AKAP9 A kinase (PRKA) anchor protein 9 -0.0349171
RPS27A ribosomal protein S27a -0.0342051
LOC112694756 uncharaterized LOC112694756 -0.0338448
SP100 SP100 nuclear antigen -0.033374
IFI6 interferon, alpha-inducible protein 6 -0.033334
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -0.0331481
UBE2B ubiquitin-conjugating enzyme E2B -0.0327158
RRBP1 ribosome binding protein 1 -0.032706
MIDN midnolin -0.0319218
RPS23 ribosomal protein S23 -0.0311578
MYL12B myosin, light chain 12B, regulatory -0.0311306
PTPRR protein tyrosine phosphatase, receptor type, R -0.0303786
CHCHD2 coiled-coil-helix-coiled-coil-helix domain containing 2 -0.0302855
CD2AP CD2-associated protein -0.0301413
PRRC2C proline-rich coiled-coil 2C -0.0296955
CD63 CD63 molecule -0.0295286
RPS14 ribosomal protein S14 -0.0294379
RPL9 ribosomal protein L9 -0.0292823
RPS27 ribosomal protein S27 -0.0290205
RPL32 ribosomal protein L32 -0.0288495