Retinoic acid_BT-474 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Retinoic acid perturbation in BT-474 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Retinoic acid_BT-474 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
NCOA3 nuclear receptor coactivator 3 0.0381836
INTS6 integrator complex subunit 6 0.0260839
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.0190053
NRIP1 nuclear receptor interacting protein 1 0.0183532
PDLIM5 PDZ and LIM domain 5 0.0156783
RPS6KB1 ribosomal protein S6 kinase, 70kDa, polypeptide 1 0.0154994
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0149972
UNC13B unc-13 homolog B (C. elegans) 0.0138154
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0137374
ACSL3 acyl-CoA synthetase long-chain family member 3 0.013686
ADARB1 adenosine deaminase, RNA-specific, B1 0.0135651
ARHGAP26 Rho GTPase activating protein 26 0.0134817
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0131187
LPP LIM domain containing preferred translocation partner in lipoma 0.0130652
SRSF1 serine/arginine-rich splicing factor 1 0.0129103
PLSCR2 phospholipid scramblase 2 0.012559
STXBP4 syntaxin binding protein 4 0.0124625
KRT86 keratin 86, type II 0.0119687
LHFPL2 lipoma HMGIC fusion partner-like 2 0.0118303
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.0113701
FAM219A family with sequence similarity 219, member A 0.0110221
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit 0.0109986
VCL vinculin 0.0109589
VIPR2 vasoactive intestinal peptide receptor 2 0.0109254
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0108192
POLD3 polymerase (DNA-directed), delta 3, accessory subunit 0.0108109
RCOR1 REST corepressor 1 0.0104913
FGB fibrinogen beta chain 0.0101432
MAPK8 mitogen-activated protein kinase 8 0.00997944
UQCC1 ubiquinol-cytochrome c reductase complex assembly factor 1 0.00973432
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0095543
BAZ1A bromodomain adjacent to zinc finger domain, 1A 0.00937949
NEK7 NIMA-related kinase 7 0.00931395
PPME1 protein phosphatase methylesterase 1 0.00913197
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.00894202
ANKRD11 ankyrin repeat domain 11 0.00892228
PNN pinin, desmosome associated protein 0.00875664
AHCTF1 AT hook containing transcription factor 1 0.00857443
DENND5A DENN/MADD domain containing 5A 0.00850385
ZSWIM6 zinc finger, SWIM-type containing 6 0.00845626
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.00839865
DSCAM Down syndrome cell adhesion molecule 0.00823562
RBM33 RNA binding motif protein 33 0.00813044
FAM168A family with sequence similarity 168, member A 0.00811049
JAK1 Janus kinase 1 0.00800471
DHRS3 dehydrogenase/reductase (SDR family) member 3 0.00796586
CCNY cyclin Y 0.00792655
GRB10 growth factor receptor-bound protein 10 0.00770428
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.00768751
TUFT1 tuftelin 1 0.00768061
HOMER1 homer scaffolding protein 1 0.00761118
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1 0.00760058
BZW1 basic leucine zipper and W2 domains 1 0.00757357
RYK receptor-like tyrosine kinase 0.00752361
DENND1A DENN/MADD domain containing 1A 0.00747666
FNIP1 folliculin interacting protein 1 0.00745247
SAMD4A sterile alpha motif domain containing 4A 0.00744592
GNPDA1 glucosamine-6-phosphate deaminase 1 0.00740158
USP15 ubiquitin specific peptidase 15 0.00734934
HSPA8 heat shock 70kDa protein 8 0.00732392
CNOT4 CCR4-NOT transcription complex, subunit 4 0.00730748
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.00723369
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.00721485
PUM2 pumilio RNA-binding family member 2 0.00717431
EFNA5 ephrin-A5 0.00712971
SMCHD1 structural maintenance of chromosomes flexible hinge domain containing 1 0.0069693
POU2F1 POU class 2 homeobox 1 0.00689654
DOCK5 dedicator of cytokinesis 5 0.00687031
ATAD2 ATPase family, AAA domain containing 2 0.00681798
CNOT1 CCR4-NOT transcription complex, subunit 1 0.00681629
NABP1 nucleic acid binding protein 1 0.00680007
TRA2B transformer 2 beta homolog (Drosophila) 0.00678641
G2E3 G2/M-phase specific E3 ubiquitin protein ligase 0.00674293
CEMIP cell migration inducing protein, hyaluronan binding 0.00669693
NPTN neuroplastin 0.00668143
KAT6A K(lysine) acetyltransferase 6A 0.00667069
TANC1 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1 0.00665526
ANKRD17 ankyrin repeat domain 17 0.00665475
MACF1 microtubule-actin crosslinking factor 1 0.00655961
PSME4 proteasome (prosome, macropain) activator subunit 4 0.00648433
ATF6 activating transcription factor 6 0.00647479
LARP4B La ribonucleoprotein domain family, member 4B 0.00639661
NCAPG2 non-SMC condensin II complex, subunit G2 0.00638704
AFDN afadin, adherens junction formation factor 0.00637835
CMSS1 cms1 ribosomal small subunit homolog (yeast) 0.0063711
FOXJ3 forkhead box J3 0.00628941
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.00625901
SIK3 SIK family kinase 3 0.0061917
MCU mitochondrial calcium uniporter 0.00599057
ELOF1 elongation factor 1 homolog (S. cerevisiae) 0.00596889
ASXL1 additional sex combs like transcriptional regulator 1 0.00595584
UBAP2L ubiquitin associated protein 2-like 0.00591509
TRA2A transformer 2 alpha homolog (Drosophila) 0.00582805
MED13L mediator complex subunit 13-like 0.00582755
PPP1R13B protein phosphatase 1, regulatory subunit 13B 0.00579844
MYO1E myosin IE 0.00578571
GALNT18 polypeptide N-acetylgalactosaminyltransferase 18 0.00578361
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa 0.00577231
MNAT1 MNAT CDK-activating kinase assembly factor 1 0.00576114
STK4 serine/threonine kinase 4 0.00573902

decreased expression

Symbol Name Standardized Value
RPL23 ribosomal protein L23 -0.210032
RPL19 ribosomal protein L19 -0.150348
ZMYND8 zinc finger, MYND-type containing 8 -0.109671
FTH1 ferritin, heavy polypeptide 1 -0.0783956
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0729661
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0672803
PTMA prothymosin, alpha -0.065869
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -0.0658245
TMSB10 thymosin beta 10 -0.0494482
ACACA acetyl-CoA carboxylase alpha -0.0484204
ASPH aspartate beta-hydroxylase -0.0476926
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0460754
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0448734
ACSS2 acyl-CoA synthetase short-chain family member 2 -0.0442771
RPL35A ribosomal protein L35a -0.0426731
ERBB2 erb-b2 receptor tyrosine kinase 2 -0.0370624
RARRES1 retinoic acid receptor responder (tazarotene induced) 1 -0.0368079
LASP1 LIM and SH3 protein 1 -0.0363084
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.036301
ACTG1 actin gamma 1 -0.0360229
SLC38A1 solute carrier family 38, member 1 -0.0355079
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3 -0.0348015
TRPS1 trichorhinophalangeal syndrome I -0.0321658
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.030084
POTEF POTE ankyrin domain family, member F -0.0291286
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0290327
LOC102724023 ES1 protein homolog, mitochondrial -0.0288562
KRT19 keratin 19, type I -0.0285218
TMSB4X thymosin beta 4, X-linked -0.027833
IGFBP5 insulin-like growth factor binding protein 5 -0.0273358
MUC6 mucin 6, oligomeric mucus/gel-forming -0.0260745
DSTN destrin (actin depolymerizing factor) -0.0258974
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.025856
S100A9 S100 calcium binding protein A9 -0.0254036
ENO1 enolase 1, (alpha) -0.0249108
DYNLRB1 dynein, light chain, roadblock-type 1 -0.024855
RPS6 ribosomal protein S6 -0.0242765
CCND1 cyclin D1 -0.0238677
MLLT6 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 6 -0.0236276
FADS2 fatty acid desaturase 2 -0.0235629
RAB22A RAB22A, member RAS oncogene family -0.0234358
CCNI cyclin I -0.0233812
CATSPERB catsper channel auxiliary subunit beta -0.0232898
PKM pyruvate kinase, muscle -0.0232061
RPL12 ribosomal protein L12 -0.023095
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0230312
VMP1 vacuole membrane protein 1 -0.0227991
RPS19 ribosomal protein S19 -0.02277
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0224201
S100A14 S100 calcium binding protein A14 -0.0223646
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) -0.0219668
TPM4 tropomyosin 4 -0.0216683
B2M beta-2-microglobulin -0.0215998
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0212679
MDK midkine (neurite growth-promoting factor 2) -0.0212241
GNAS GNAS complex locus -0.0206246
RPL8 ribosomal protein L8 -0.0205258
RPS3 ribosomal protein S3 -0.0205031
LOC112694756 uncharaterized LOC112694756 -0.0200431
RPL35 ribosomal protein L35 -0.0200397
OSMR oncostatin M receptor -0.0194546
S100A8 S100 calcium binding protein A8 -0.0193904
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.0193336
NDRG1 N-myc downstream regulated 1 -0.0193258
AHNAK AHNAK nucleoprotein -0.0192403
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0190562
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0189703
S100A6 S100 calcium binding protein A6 -0.0189418
RPLP1 ribosomal protein, large, P1 -0.0188957
MYL12B myosin, light chain 12B, regulatory -0.0187471
LDHA lactate dehydrogenase A -0.0187235
ANKRD12 ankyrin repeat domain 12 -0.0186112
ZNF652 zinc finger protein 652 -0.0184764
UGCG UDP-glucose ceramide glucosyltransferase -0.0184296
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0184287
IFI6 interferon, alpha-inducible protein 6 -0.0184196
CBX3 chromobox homolog 3 -0.0183819
LMNA lamin A/C -0.0182797
GRB7 growth factor receptor-bound protein 7 -0.0182723
TMEM123 transmembrane protein 123 -0.018147
TMC5 transmembrane channel-like 5 -0.0181208
INSIG1 insulin induced gene 1 -0.0181161
NCOA6 nuclear receptor coactivator 6 -0.0178065
RNF19A ring finger protein 19A, RBR E3 ubiquitin protein ligase -0.0178038
LMAN1 lectin, mannose-binding, 1 -0.0177701
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0177459
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C -0.0177144
SMIM14 small integral membrane protein 14 -0.0174936
DSPP dentin sialophosphoprotein -0.017388
TMEM165 transmembrane protein 165 -0.0172392
PDIA3 protein disulfide isomerase family A, member 3 -0.0171345
DUSP4 dual specificity phosphatase 4 -0.016961
RPL28 ribosomal protein L28 -0.0169136
PFN1 profilin 1 -0.0168357
FASN fatty acid synthase -0.0166205
GSK3B glycogen synthase kinase 3 beta -0.0164148
BPTF bromodomain PHD finger transcription factor -0.0163775
THSD4 thrombospondin, type I, domain containing 4 -0.0161011
TMEM45B transmembrane protein 45B -0.0159572
PRRC2C proline-rich coiled-coil 2C -0.0158528