Retinoic acid_C-33 A Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Retinoic acid perturbation in C-33 A cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Retinoic acid_C-33 A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.175291
CTNNA2 catenin (cadherin-associated protein), alpha 2 0.157889
NEBL nebulette 0.107677
CTNNA3 catenin (cadherin-associated protein), alpha 3 0.0923945
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0884887
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0841392
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0729048
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.069854
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0660194
CENPF centromere protein F, 350/400kDa 0.0525477
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0488465
FMNL2 formin-like 2 0.0484716
DENND1A DENN/MADD domain containing 1A 0.0440469
TENM3 teneurin transmembrane protein 3 0.0432809
WLS wntless Wnt ligand secretion mediator 0.0421349
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.0408966
CENPE centromere protein E, 312kDa 0.0393324
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0393285
ZNF638 zinc finger protein 638 0.0385603
GNPDA1 glucosamine-6-phosphate deaminase 1 0.0359608
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0349201
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 0.0347902
SMYD3 SET and MYND domain containing 3 0.0333321
HMGA1 high mobility group AT-hook 1 0.0332885
ARHGAP32 Rho GTPase activating protein 32 0.0320617
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0307443
TTC28 tetratricopeptide repeat domain 28 0.0303531
HELLS helicase, lymphoid-specific 0.0300591
TRIO trio Rho guanine nucleotide exchange factor 0.0299418
RRM2 ribonucleotide reductase M2 0.0294155
CKAP5 cytoskeleton associated protein 5 0.0284292
SRSF1 serine/arginine-rich splicing factor 1 0.0282193
ARID2 AT rich interactive domain 2 (ARID, RFX-like) 0.0282111
HNRNPR heterogeneous nuclear ribonucleoprotein R 0.0278442
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) 0.0277458
HELZ helicase with zinc finger 0.0272451
CDH18 cadherin 18, type 2 0.0270517
RCOR1 REST corepressor 1 0.0269393
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase 0.026754
TXNRD1 thioredoxin reductase 1 0.0266946
BRWD1 bromodomain and WD repeat domain containing 1 0.0266863
MKI67 marker of proliferation Ki-67 0.0265518
ZNF609 zinc finger protein 609 0.0255946
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa 0.0253952
PTPRG protein tyrosine phosphatase, receptor type, G 0.0253212
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0253038
SFPQ splicing factor proline/glutamine-rich 0.0251199
SIK3 SIK family kinase 3 0.0246287
NCOR1 nuclear receptor corepressor 1 0.0244756
KTN1 kinectin 1 (kinesin receptor) 0.0243432
SMARCC1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1 0.0242381
RFX7 regulatory factor X, 7 0.0241949
RERE arginine-glutamic acid dipeptide (RE) repeats 0.024194
AUTS2 autism susceptibility candidate 2 0.024103
SUPT3H suppressor of Ty 3 homolog (S. cerevisiae) 0.0237236
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0236949
MACF1 microtubule-actin crosslinking factor 1 0.0235391
SPATS2 spermatogenesis associated, serine-rich 2 0.0234067
CUX1 cut-like homeobox 1 0.0232258
TBCD tubulin folding cofactor D 0.0231851
RAB11FIP3 RAB11 family interacting protein 3 (class II) 0.0230676
RCC1 regulator of chromosome condensation 1 0.0228035
UBE3C ubiquitin protein ligase E3C 0.0226961
ANP32E acidic (leucine-rich) nuclear phosphoprotein 32 family, member E 0.0220382
HP1BP3 heterochromatin protein 1, binding protein 3 0.0220348
DEK DEK proto-oncogene 0.0218147
TBC1D5 TBC1 domain family, member 5 0.0217742
ASPH aspartate beta-hydroxylase 0.0216998
RPS21 ribosomal protein S21 0.0215586
GYS1 glycogen synthase 1 (muscle) 0.0214443
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.0214053
VPS13A vacuolar protein sorting 13 homolog A (S. cerevisiae) 0.0213916
NFIA nuclear factor I/A 0.0213809
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.0212651
LRPPRC leucine-rich pentatricopeptide repeat containing 0.0211611
CNOT1 CCR4-NOT transcription complex, subunit 1 0.0211451
PIAS2 protein inhibitor of activated STAT, 2 0.0211073
RNASE12 ribonuclease, RNase A family, 12 (non-active) 0.0210864
PFKFB4 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 0.0209898
CABIN1 calcineurin binding protein 1 0.0209836
ANKRD1 ankyrin repeat domain 1 (cardiac muscle) 0.0208934
APLP2 amyloid beta (A4) precursor-like protein 2 0.0207923
ENO1 enolase 1, (alpha) 0.0205442
GSK3B glycogen synthase kinase 3 beta 0.0205019
KDM4B lysine (K)-specific demethylase 4B 0.0204261
KDM2A lysine (K)-specific demethylase 2A 0.020411
HNRNPM heterogeneous nuclear ribonucleoprotein M 0.0203545
PSPC1 paraspeckle component 1 0.0202373
GSE1 Gse1 coiled-coil protein 0.0202061
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0200624
ASXL2 additional sex combs like transcriptional regulator 2 0.0200589
PTK2 protein tyrosine kinase 2 0.0199853
NASP nuclear autoantigenic sperm protein (histone-binding) 0.0199807
WDPCP WD repeat containing planar cell polarity effector 0.0197919
SNX5 sorting nexin 5 0.0195931
PCM1 pericentriolar material 1 0.0195126
EHMT1 euchromatic histone-lysine N-methyltransferase 1 0.0193087
ZNF407 zinc finger protein 407 0.0192618
ZZZ3 zinc finger, ZZ-type containing 3 0.0191648
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0188007

decreased expression

Symbol Name Standardized Value
SEMA3D sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3D -0.124357
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0582211
CADM2 cell adhesion molecule 2 -0.0546331
TOX thymocyte selection-associated high mobility group box -0.054109
ADGRG6 adhesion G protein-coupled receptor G6 -0.0540322
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0505531
RAD51B RAD51 paralog B -0.0497288
RPS8 ribosomal protein S8 -0.0479788
RPLP1 ribosomal protein, large, P1 -0.0467216
EGR1 early growth response 1 -0.0442672
TPT1 tumor protein, translationally-controlled 1 -0.0386722
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0379496
JMJD1C jumonji domain containing 1C -0.0366379
EIF1 eukaryotic translation initiation factor 1 -0.0362383
CELF2 CUGBP, Elav-like family member 2 -0.0361711
NR2F1 nuclear receptor subfamily 2, group F, member 1 -0.0327591
B2M beta-2-microglobulin -0.0324773
SLF1 SMC5-SMC6 complex localization factor 1 -0.0321182
MCTP1 multiple C2 domains, transmembrane 1 -0.0315824
RPL31 ribosomal protein L31 -0.0312559
MAP3K14 mitogen-activated protein kinase kinase kinase 14 -0.0311359
GRID2 glutamate receptor, ionotropic, delta 2 -0.0307006
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0297709
ARB2A ARB2 cotranscriptional regulator A -0.0295859
RPL37A ribosomal protein L37a -0.0290148
RPS13 ribosomal protein S13 -0.0278227
RPL35A ribosomal protein L35a -0.027487
WDR45B WD repeat domain 45B -0.0270336
RPL13A ribosomal protein L13a -0.0262274
RPS23 ribosomal protein S23 -0.0260822
ZNF33A zinc finger protein 33A -0.0257291
PTMA prothymosin, alpha -0.0256216
RPL36 ribosomal protein L36 -0.0253645
RPL26 ribosomal protein L26 -0.024876
SHROOM3 shroom family member 3 -0.0246414
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.024594
FTL ferritin, light polypeptide -0.0245263
RHEB Ras homolog enriched in brain -0.0243173
RPS5 ribosomal protein S5 -0.0236687
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) -0.0235943
LOC112694756 uncharaterized LOC112694756 -0.0234891
RPL27A ribosomal protein L27a -0.0230738
ALDH7A1 aldehyde dehydrogenase 7 family, member A1 -0.0227229
RAP1B RAP1B, member of RAS oncogene family -0.0223075
RPS25 ribosomal protein S25 -0.0222751
RPS27 ribosomal protein S27 -0.0220705
RPS6 ribosomal protein S6 -0.0215761
NR5A2 nuclear receptor subfamily 5, group A, member 2 -0.0214057
RACK1 receptor for activated C kinase 1 -0.021325
RPL34 ribosomal protein L34 -0.0212767
RPS16 ribosomal protein S16 -0.0209958
H1-0 H1.0 linker histone -0.0209778
DLGAP1 discs, large (Drosophila) homolog-associated protein 1 -0.0209445
PDE4D phosphodiesterase 4D, cAMP-specific -0.020816
RPL38 ribosomal protein L38 -0.0207211
ZNF544 zinc finger protein 544 -0.0206271
CAVIN1 caveolae associated protein 1 -0.0204295
RPS19 ribosomal protein S19 -0.0201139
COL5A2 collagen, type V, alpha 2 -0.0200854
NFE2L2 nuclear factor, erythroid 2-like 2 -0.0199391
TMEM41B transmembrane protein 41B -0.0198971
SOX5 SRY (sex determining region Y)-box 5 -0.0195782
RPL37 ribosomal protein L37 -0.0195545
CASK calcium/calmodulin-dependent serine protein kinase (MAGUK family) -0.0192412
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -0.0192019
ACTG1 actin gamma 1 -0.0191987
PDIA3 protein disulfide isomerase family A, member 3 -0.0190558
VDAC1 voltage-dependent anion channel 1 -0.0189599
VMP1 vacuole membrane protein 1 -0.0189042
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0188764
UBE2E2 ubiquitin-conjugating enzyme E2E 2 -0.0188051
MAP3K2 mitogen-activated protein kinase kinase kinase 2 -0.0187829
TJP1 tight junction protein 1 -0.0187129
GOLGA4 golgin A4 -0.0186359
HHIP hedgehog interacting protein -0.0183795
EIF5B eukaryotic translation initiation factor 5B -0.0182718
RPS14 ribosomal protein S14 -0.0179951
LATS2 large tumor suppressor kinase 2 -0.0177424
PNRC1 proline-rich nuclear receptor coactivator 1 -0.0176981
RPL8 ribosomal protein L8 -0.0175808
EXT1 exostosin glycosyltransferase 1 -0.0174465
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) -0.0171207
DNAJC1 DnaJ (Hsp40) homolog, subfamily C, member 1 -0.0170821
MIMS1 mitochondrial inner membrane scaffold 1 -0.0170432
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0170151
RPL4 ribosomal protein L4 -0.0167613
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform -0.016279
RPS27A ribosomal protein S27a -0.0162056
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0161458
ATXN10 ataxin 10 -0.0161412
FOXO3 forkhead box O3 -0.016098
RPL15 ribosomal protein L15 -0.0160851
RLF rearranged L-myc fusion -0.0160692
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 -0.0160587
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0160102
CALR calreticulin -0.0158701
AHI1 Abelson helper integration site 1 -0.0158453
RPS29 ribosomal protein S29 -0.0158151
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein -0.015772
MAP1B microtubule-associated protein 1B -0.0157399