Retinoic acid_C32 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Retinoic acid perturbation in C32 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Retinoic acid_C32 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
NLGN1 neuroligin 1 0.177401
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 0.167934
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.157944
GPC6 glypican 6 0.148975
MDGA2 MAM domain containing glycosylphosphatidylinositol anchor 2 0.142146
ASPH aspartate beta-hydroxylase 0.142109
IGFBP5 insulin-like growth factor binding protein 5 0.115316
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.103533
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0954134
CTTNBP2 cortactin binding protein 2 0.0821075
PFKFB4 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 0.0802537
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0795966
PCDH7 protocadherin 7 0.0792903
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0788827
PTK2 protein tyrosine kinase 2 0.0754496
SETBP1 SET binding protein 1 0.0702454
PPFIA4 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 4 0.0690564
ATXN1 ataxin 1 0.0681055
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0625062
NDRG1 N-myc downstream regulated 1 0.0623031
TIMP3 TIMP metallopeptidase inhibitor 3 0.059592
PRELID2 PRELI domain containing 2 0.0592871
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3 0.0592557
MAML3 mastermind-like 3 (Drosophila) 0.0527523
NBAS neuroblastoma amplified sequence 0.0518597
VGF VGF nerve growth factor inducible 0.0508551
MT2A metallothionein 2A 0.0500786
TRIM2 tripartite motif containing 2 0.0473628
TBC1D22A TBC1 domain family, member 22A 0.0462599
VIM vimentin 0.0435727
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1 0.0434298
KTN1 kinectin 1 (kinesin receptor) 0.0434181
ZMIZ1 zinc finger, MIZ-type containing 1 0.0433601
HILPDA hypoxia inducible lipid droplet-associated 0.0431774
TMEM178B transmembrane protein 178B 0.0418132
NAV1 neuron navigator 1 0.0412856
ESYT2 extended synaptotagmin-like protein 2 0.0408013
LEF1 lymphoid enhancer-binding factor 1 0.0407714
PTPRM protein tyrosine phosphatase, receptor type, M 0.040515
ZNF638 zinc finger protein 638 0.0399823
FRMD4A FERM domain containing 4A 0.0397607
CDK14 cyclin-dependent kinase 14 0.0395187
EXOC4 exocyst complex component 4 0.0392079
SMYD3 SET and MYND domain containing 3 0.0390515
LINGO2 leucine rich repeat and Ig domain containing 2 0.0383929
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0382055
UTRN utrophin 0.0373813
ENO1 enolase 1, (alpha) 0.0373697
FLNB filamin B, beta 0.0371796
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 0.0371144
ZNF704 zinc finger protein 704 0.0368819
SOX5 SRY (sex determining region Y)-box 5 0.0364889
RFX7 regulatory factor X, 7 0.0362407
FMNL2 formin-like 2 0.0361514
CENPF centromere protein F, 350/400kDa 0.0357097
LAMB1 laminin, beta 1 0.035567
TMTC2 transmembrane and tetratricopeptide repeat containing 2 0.03553
LRMDA leucine rich melanocyte differentiation associated 0.035405
CABIN1 calcineurin binding protein 1 0.035062
PDK3 pyruvate dehydrogenase kinase, isozyme 3 0.0348885
CTBP2 C-terminal binding protein 2 0.034527
KIRREL1 kirre like nephrin family adhesion molecule 1 0.0345136
ENO2 enolase 2 (gamma, neuronal) 0.0338222
PARVB parvin, beta 0.0337831
LARGE1 LARGE xylosyl- and glucuronyltransferase 1 0.0332869
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.033026
KDM4C lysine (K)-specific demethylase 4C 0.0329946
MACF1 microtubule-actin crosslinking factor 1 0.0324179
MARK3 MAP/microtubule affinity-regulating kinase 3 0.0320863
MRPS6 mitochondrial ribosomal protein S6 0.0318217
OSBPL10 oxysterol binding protein-like 10 0.0317644
LDHA lactate dehydrogenase A 0.0315696
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0312727
SAMD4A sterile alpha motif domain containing 4A 0.0309628
PKM pyruvate kinase, muscle 0.0306245
LMNA lamin A/C 0.0301935
RNF24 ring finger protein 24 0.0297927
KDM2A lysine (K)-specific demethylase 2A 0.0297805
SOX13 SRY (sex determining region Y)-box 13 0.0296225
ZBTB20 zinc finger and BTB domain containing 20 0.029391
HMGA2 high mobility group AT-hook 2 0.0293802
NEGR1 neuronal growth regulator 1 0.0293437
DST dystonin 0.0291698
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0288302
BCAS3 breast carcinoma amplified sequence 3 0.0286802
NAALADL2 N-acetylated alpha-linked acidic dipeptidase-like 2 0.028642
EYA1 EYA transcriptional coactivator and phosphatase 1 0.0285136
KDM2B lysine (K)-specific demethylase 2B 0.0284478
FBXL7 F-box and leucine-rich repeat protein 7 0.0284011
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1 0.0281901
RNASE12 ribonuclease, RNase A family, 12 (non-active) 0.0281753
TIMP2 TIMP metallopeptidase inhibitor 2 0.0280282
SNTB1 syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) 0.0276434
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 0.0272323
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase 0.0270275
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0268079
RBFOX2 RNA binding protein, fox-1 homolog (C. elegans) 2 0.0267644
FRYL FRY-like 0.0266567
CUX1 cut-like homeobox 1 0.0266034
SND1 staphylococcal nuclease and tudor domain containing 1 0.0266029

decreased expression

Symbol Name Standardized Value
FMN1 formin 1 -0.150752
NAMPT nicotinamide phosphoribosyltransferase -0.14997
FN1 fibronectin 1 -0.13295
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.126445
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0947557
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0824005
CDC73 cell division cycle 73 -0.0719154
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.0714198
IGFBP3 insulin-like growth factor binding protein 3 -0.0679495
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0596789
PI15 peptidase inhibitor 15 -0.0589325
TNNC1 troponin C type 1 (slow) -0.0577441
NPC1 Niemann-Pick disease, type C1 -0.0537168
VCL vinculin -0.0518547
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.0508916
IFI16 interferon, gamma-inducible protein 16 -0.050841
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0492839
MKLN1 muskelin 1, intracellular mediator containing kelch motifs -0.048239
BRAF B-Raf proto-oncogene, serine/threonine kinase -0.0462783
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 -0.0446422
AKAP12 A kinase (PRKA) anchor protein 12 -0.0426144
UBE2H ubiquitin-conjugating enzyme E2H -0.0417396
RAD21 RAD21 homolog (S. pombe) -0.040982
NCOA7 nuclear receptor coactivator 7 -0.0407599
RTN4 reticulon 4 -0.0407055
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.040683
HBP1 HMG-box transcription factor 1 -0.0401815
A2M alpha-2-macroglobulin -0.0397247
HMCN1 hemicentin 1 -0.0395601
RNF145 ring finger protein 145 -0.0387194
PAN3 PAN3 poly(A) specific ribonuclease subunit -0.0385221
ZNF292 zinc finger protein 292 -0.0372497
INPP5F inositol polyphosphate-5-phosphatase F -0.0371809
EPS8 epidermal growth factor receptor pathway substrate 8 -0.0366832
CPEB2 cytoplasmic polyadenylation element binding protein 2 -0.0355192
CAPZA2 capping protein (actin filament) muscle Z-line, alpha 2 -0.0350228
LOC112694756 uncharaterized LOC112694756 -0.0348843
NEK7 NIMA-related kinase 7 -0.0339992
ARHGAP5 Rho GTPase activating protein 5 -0.0338573
ICAM1 intercellular adhesion molecule 1 -0.0334204
PNPLA8 patatin-like phospholipase domain containing 8 -0.0328933
COL19A1 collagen, type XIX, alpha 1 -0.0322763
RHEB Ras homolog enriched in brain -0.0319576
AHR aryl hydrocarbon receptor -0.0315891
MITF microphthalmia-associated transcription factor -0.0315773
PPP2CA protein phosphatase 2, catalytic subunit, alpha isozyme -0.030971
WSB1 WD repeat and SOCS box containing 1 -0.0308159
ZKSCAN1 zinc finger with KRAB and SCAN domains 1 -0.030665
APP amyloid beta (A4) precursor protein -0.0305245
SPRED1 sprouty-related, EVH1 domain containing 1 -0.0298008
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0294326
RBM33 RNA binding motif protein 33 -0.0293852
ANKRD28 ankyrin repeat domain 28 -0.0291941
RBM39 RNA binding motif protein 39 -0.0284153
SPRED2 sprouty-related, EVH1 domain containing 2 -0.0281757
SYPL1 synaptophysin-like 1 -0.0276383
BHLHE40 basic helix-loop-helix family, member e40 -0.0275651
RPS6KA3 ribosomal protein S6 kinase, 90kDa, polypeptide 3 -0.0275084
BIRC2 baculoviral IAP repeat containing 2 -0.0270646
EGLN1 egl-9 family hypoxia-inducible factor 1 -0.0265529
RHOA ras homolog family member A -0.0260157
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.0258981
ACSL3 acyl-CoA synthetase long-chain family member 3 -0.0254718
ZFAND6 zinc finger, AN1-type domain 6 -0.0253444
CUL3 cullin 3 -0.0249799
MRTFA myocardin related transcription factor A -0.02488
MBNL2 muscleblind-like splicing regulator 2 -0.0245318
NFE2L2 nuclear factor, erythroid 2-like 2 -0.0244632
PUM1 pumilio RNA-binding family member 1 -0.0244041
SERINC1 serine incorporator 1 -0.024148
SRPK2 SRSF protein kinase 2 -0.0240245
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit -0.0240045
RAP1B RAP1B, member of RAS oncogene family -0.0236206
MT1X metallothionein 1X -0.0232486
RHOJ ras homolog family member J -0.0231678
LUC7L2 LUC7-like 2 (S. cerevisiae) -0.0231258
EWSR1 EWS RNA-binding protein 1 -0.0230415
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 -0.0225928
G3BP1 GTPase activating protein (SH3 domain) binding protein 1 -0.0225904
FOXJ3 forkhead box J3 -0.0219738
KBTBD2 kelch repeat and BTB (POZ) domain containing 2 -0.0218517
SBF2 SET binding factor 2 -0.0217768
AHNAK AHNAK nucleoprotein -0.0217364
ODR4 odr-4 GPCR localization factor homolog -0.0217357
GDF15 growth differentiation factor 15 -0.0217118
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) -0.0215942
ST3GAL6 ST3 beta-galactoside alpha-2,3-sialyltransferase 6 -0.0215661
WDR45B WD repeat domain 45B -0.0213655
RAD23B RAD23 homolog B (S. cerevisiae) -0.0209352
PJA2 praja ring finger 2, E3 ubiquitin protein ligase -0.0206282
CTNND1 catenin (cadherin-associated protein), delta 1 -0.0205338
SDC2 syndecan 2 -0.02044
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0201544
TMEM87A transmembrane protein 87A -0.020096
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36 -0.0199926
MAP3K2 mitogen-activated protein kinase kinase kinase 2 -0.0199369
UBC ubiquitin C -0.019605
MTPN myotrophin -0.0194922
ANXA2 annexin A2 -0.0194776
WWTR1 WW domain containing transcription regulator 1 -0.0193289