Retinoic acid_CFPAC-1 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Retinoic acid perturbation in CFPAC-1 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Retinoic acid_CFPAC-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FNDC3B fibronectin type III domain containing 3B 0.0547553
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0499791
NRIP1 nuclear receptor interacting protein 1 0.0421266
NAMPT nicotinamide phosphoribosyltransferase 0.0331858
TSC22D2 TSC22 domain family, member 2 0.0319984
EFNA5 ephrin-A5 0.0302815
SAMD4A sterile alpha motif domain containing 4A 0.0291447
FAM3C family with sequence similarity 3, member C 0.0279221
PTPN14 protein tyrosine phosphatase, non-receptor type 14 0.0268135
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0253028
TGM2 transglutaminase 2 0.0247177
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.024576
TRIO trio Rho guanine nucleotide exchange factor 0.0245403
SMAD3 SMAD family member 3 0.023692
HELZ helicase with zinc finger 0.0232635
ANKRD11 ankyrin repeat domain 11 0.0231411
RUNX1 runt-related transcription factor 1 0.0229775
GPCPD1 glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) 0.0229172
FAM13A family with sequence similarity 13, member A 0.0212562
KMT2E lysine (K)-specific methyltransferase 2E 0.0210025
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0205552
MYOF myoferlin 0.0197273
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.019649
CCNY cyclin Y 0.0188222
ELL2 elongation factor, RNA polymerase II, 2 0.0178666
PPARD peroxisome proliferator-activated receptor delta 0.0167855
EXT1 exostosin glycosyltransferase 1 0.0164382
PDZD8 PDZ domain containing 8 0.0164321
OGA O-GlcNAcase 0.0163761
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0162624
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0161609
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0161469
STRN3 striatin, calmodulin binding protein 3 0.0161051
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.0159448
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0158527
BICC1 BicC family RNA binding protein 1 0.0157843
SPAG9 sperm associated antigen 9 0.0157799
APP amyloid beta (A4) precursor protein 0.01571
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.0156158
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.0155827
EHF ets homologous factor 0.0151916
DOCK5 dedicator of cytokinesis 5 0.0151017
CHD1 chromodomain helicase DNA binding protein 1 0.0149912
MYO1E myosin IE 0.0143958
CCNL1 cyclin L1 0.0142892
SUCO SUN domain containing ossification factor 0.0139859
JAK1 Janus kinase 1 0.0139452
EPAS1 endothelial PAS domain protein 1 0.0138684
SLC35F5 solute carrier family 35, member F5 0.0138308
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.013582
CD2AP CD2-associated protein 0.0135254
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0135198
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0135058
PIP4K2A phosphatidylinositol-5-phosphate 4-kinase, type II, alpha 0.0131764
ZSWIM6 zinc finger, SWIM-type containing 6 0.0131716
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0129423
HOOK2 hook microtubule-tethering protein 2 0.0127756
CANX calnexin 0.0127147
CTBP2 C-terminal binding protein 2 0.0126119
PRELID2 PRELI domain containing 2 0.0124551
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) 0.0123985
TTC3 tetratricopeptide repeat domain 3 0.0122302
KYNU kynureninase 0.0121378
CTNND1 catenin (cadherin-associated protein), delta 1 0.0120727
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0120557
AHR aryl hydrocarbon receptor 0.0120231
KDM3A lysine (K)-specific demethylase 3A 0.0119841
TOP1 topoisomerase (DNA) I 0.0119019
KANSL1 KAT8 regulatory NSL complex subunit 1 0.0118506
PHLDB2 pleckstrin homology-like domain, family B, member 2 0.011746
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0117026
RIMKLB ribosomal modification protein rimK-like family member B 0.0116569
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.0115767
ZFC3H1 zinc finger, C3H1-type containing 0.0114878
PAPOLA poly(A) polymerase alpha 0.0114538
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.0109944
MYO1B myosin IB 0.0109799
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) 0.0109504
HKDC1 hexokinase domain containing 1 0.0108715
TFG TRK-fused gene 0.010848
CDC73 cell division cycle 73 0.0108352
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0107981
CNOT1 CCR4-NOT transcription complex, subunit 1 0.010681
NAV2 neuron navigator 2 0.0106707
CLIP4 CAP-GLY domain containing linker protein family, member 4 0.0106608
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 0.0105845
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0104968
ERRFI1 ERBB receptor feedback inhibitor 1 0.0104794
WWTR1 WW domain containing transcription regulator 1 0.0104777
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0104534
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 0.0104406
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.010384
RAB1A RAB1A, member RAS oncogene family 0.0103717
DSCAM Down syndrome cell adhesion molecule 0.0103223
RASA2 RAS p21 protein activator 2 0.0102488
EPS8 epidermal growth factor receptor pathway substrate 8 0.0102313
WARS1 tryptophanyl-tRNA synthetase 1 0.010195
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0101662
SLTM SAFB-like, transcription modulator 0.0101448
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0101331

decreased expression

Symbol Name Standardized Value
MT2A metallothionein 2A -0.106394
TMSB10 thymosin beta 10 -0.0913584
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0611639
LAMB3 laminin, beta 3 -0.0597925
IGFBP3 insulin-like growth factor binding protein 3 -0.0562475
HLA-B major histocompatibility complex, class I, B -0.0549033
KRT19 keratin 19, type I -0.0539748
B2M beta-2-microglobulin -0.0502678
IFI27 interferon, alpha-inducible protein 27 -0.0431995
EIF1 eukaryotic translation initiation factor 1 -0.0414525
RPL23 ribosomal protein L23 -0.0351592
MMP7 matrix metallopeptidase 7 -0.0349396
S100A6 S100 calcium binding protein A6 -0.0348555
HMGA1 high mobility group AT-hook 1 -0.0342713
MT1X metallothionein 1X -0.0335934
VIM vimentin -0.0303748
HLA-A major histocompatibility complex, class I, A -0.0303227
LAMA4 laminin, alpha 4 -0.0302121
FTL ferritin, light polypeptide -0.0297196
ISG15 ISG15 ubiquitin-like modifier -0.0293485
LAMC2 laminin, gamma 2 -0.0292343
RPLP1 ribosomal protein, large, P1 -0.0289885
TPT1 tumor protein, translationally-controlled 1 -0.0286215
RPL19 ribosomal protein L19 -0.0285053
RPL35A ribosomal protein L35a -0.027789
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0267743
RPS8 ribosomal protein S8 -0.0242736
PTMA prothymosin, alpha -0.0242683
POTEF POTE ankyrin domain family, member F -0.0229222
TPM4 tropomyosin 4 -0.0225992
APOL1 apolipoprotein L, 1 -0.0217588
RPS19 ribosomal protein S19 -0.0217206
C15ORF48 chromosome 15 open reading frame 48 -0.0216307
TMSB4X thymosin beta 4, X-linked -0.0215364
RPS6 ribosomal protein S6 -0.0213315
S100A10 S100 calcium binding protein A10 -0.0212461
ENO1 enolase 1, (alpha) -0.0210728
CP ceruloplasmin (ferroxidase) -0.0209742
ACTG1 actin gamma 1 -0.0208873
RPL34 ribosomal protein L34 -0.019814
LOC112694756 uncharaterized LOC112694756 -0.0193676
CSTB cystatin B (stefin B) -0.0192114
AKAP12 A kinase (PRKA) anchor protein 12 -0.0191424
RPS29 ribosomal protein S29 -0.0187968
RPS21 ribosomal protein S21 -0.0187508
RPS27 ribosomal protein S27 -0.0187229
DSG2 desmoglein 2 -0.0186745
NDRG1 N-myc downstream regulated 1 -0.0184849
SLC38A1 solute carrier family 38, member 1 -0.0178715
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0178708
F3 coagulation factor III (thromboplastin, tissue factor) -0.0171811
AHNAK AHNAK nucleoprotein -0.0170245
IFI6 interferon, alpha-inducible protein 6 -0.0169987
IFITM1 interferon induced transmembrane protein 1 -0.016384
RPL37A ribosomal protein L37a -0.016116
RPS23 ribosomal protein S23 -0.0159443
S100A11 S100 calcium binding protein A11 -0.0158397
CYBA cytochrome b-245, alpha polypeptide -0.015715
IFITM3 interferon induced transmembrane protein 3 -0.0155498
RPS14 ribosomal protein S14 -0.0153682
RPL9 ribosomal protein L9 -0.0151666
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 -0.0151126
EGR1 early growth response 1 -0.0149659
RPL31 ribosomal protein L31 -0.0149553
CNRIP1 cannabinoid receptor interacting protein 1 -0.0147036
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0145387
RPL11 ribosomal protein L11 -0.0145319
LCN2 lipocalin 2 -0.0142599
HLA-E major histocompatibility complex, class I, E -0.0139995
GNAS GNAS complex locus -0.0137911
PLAT plasminogen activator, tissue -0.0134464
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa -0.0132516
RPL37 ribosomal protein L37 -0.0130681
MEF2A myocyte enhancer factor 2A -0.0128187
CIB1 calcium and integrin binding 1 (calmyrin) -0.0127445
RPL28 ribosomal protein L28 -0.0126025
RPS25 ribosomal protein S25 -0.0125602
ITGA6 integrin, alpha 6 -0.0125366
SLCO3A1 solute carrier organic anion transporter family, member 3A1 -0.0122544
MMP14 matrix metallopeptidase 14 (membrane-inserted) -0.0121638
RPS27A ribosomal protein S27a -0.0121596
RPL8 ribosomal protein L8 -0.0121512
RPS17 ribosomal protein S17 -0.0117934
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase) -0.0117106
TAPBP TAP binding protein (tapasin) -0.011654
RPL12 ribosomal protein L12 -0.0116113
BLZF1 basic leucine zipper nuclear factor 1 -0.0115999
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle -0.0115464
RPLP2 ribosomal protein, large, P2 -0.0113988
PDE4D phosphodiesterase 4D, cAMP-specific -0.011295
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.011134
MDK midkine (neurite growth-promoting factor 2) -0.0110247
GCC2 GRIP and coiled-coil domain containing 2 -0.0109375
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0107567
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4 -0.0107091
RPL26 ribosomal protein L26 -0.0104153
SQSTM1 sequestosome 1 -0.0101585
AGRN agrin -0.0101473
RPS16 ribosomal protein S16 -0.0101388
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0100865