Retinoic acid_CHP-212 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Retinoic acid perturbation in CHP-212 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Retinoic acid_CHP-212 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
VCL vinculin 0.202992
TLE4 transducin-like enhancer of split 4 0.177432
AKAP12 A kinase (PRKA) anchor protein 12 0.117436
ZSWIM6 zinc finger, SWIM-type containing 6 0.114902
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.095986
PLAT plasminogen activator, tissue 0.0806784
THSD4 thrombospondin, type I, domain containing 4 0.0647475
FAM13A family with sequence similarity 13, member A 0.0579547
EGR1 early growth response 1 0.0575036
PBX1 pre-B-cell leukemia homeobox 1 0.0541872
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.0530071
PEAK1 pseudopodium-enriched atypical kinase 1 0.0502769
MYO1E myosin IE 0.0482529
PTPRM protein tyrosine phosphatase, receptor type, M 0.0476646
VMP1 vacuole membrane protein 1 0.047296
FNDC3A fibronectin type III domain containing 3A 0.0469319
SLIT2 slit homolog 2 (Drosophila) 0.0462374
SIK2 salt-inducible kinase 2 0.0453484
NRIP1 nuclear receptor interacting protein 1 0.0453161
PTPRD protein tyrosine phosphatase, receptor type, D 0.0448621
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0443152
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0442791
KIAA1217 KIAA1217 0.0434744
LINGO2 leucine rich repeat and Ig domain containing 2 0.0432193
TMTC2 transmembrane and tetratricopeptide repeat containing 2 0.0427528
VEGFA vascular endothelial growth factor A 0.0416056
RIGI RNA sensor RIG-I 0.0414476
PDE3A phosphodiesterase 3A, cGMP-inhibited 0.0414081
FERMT2 fermitin family member 2 0.0413091
NR4A3 nuclear receptor subfamily 4, group A, member 3 0.0410048
AUTS2 autism susceptibility candidate 2 0.0408941
PLPP1 phospholipid phosphatase 1 0.0407574
PDE10A phosphodiesterase 10A 0.0404064
TIMP2 TIMP metallopeptidase inhibitor 2 0.0402937
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) 0.0402339
MCL1 myeloid cell leukemia 1 0.0401036
PDLIM5 PDZ and LIM domain 5 0.0399629
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0392659
ZMIZ1 zinc finger, MIZ-type containing 1 0.0390592
INTS6 integrator complex subunit 6 0.0387962
FAM107B family with sequence similarity 107, member B 0.0384711
PSD3 pleckstrin and Sec7 domain containing 3 0.0382449
SOX9 SRY (sex determining region Y)-box 9 0.0380401
PCBP2 poly(rC) binding protein 2 0.0375505
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) 0.0374618
DHRS3 dehydrogenase/reductase (SDR family) member 3 0.0363784
NCOR2 nuclear receptor corepressor 2 0.0358834
ADGRB3 adhesion G protein-coupled receptor B3 0.0346942
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1 0.0342427
MYCN v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog 0.0340411
MRTFA myocardin related transcription factor A 0.0339753
GLI3 GLI family zinc finger 3 0.0337983
HOMER1 homer scaffolding protein 1 0.0335068
THBS1 thrombospondin 1 0.0333776
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.033156
EXT1 exostosin glycosyltransferase 1 0.0331292
PTPRE protein tyrosine phosphatase, receptor type, E 0.0322222
FMN1 formin 1 0.0321994
TPM1 tropomyosin 1 (alpha) 0.0321664
HILPDA hypoxia inducible lipid droplet-associated 0.0320147
RAB7A RAB7A, member RAS oncogene family 0.031978
IGFBP5 insulin-like growth factor binding protein 5 0.0317691
KDM4C lysine (K)-specific demethylase 4C 0.0315126
GLCCI1 glucocorticoid induced 1 0.0311097
TRA2A transformer 2 alpha homolog (Drosophila) 0.0307579
MX2 MX dynamin-like GTPase 2 0.0307461
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2 0.029854
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 0.0292398
DUSP10 dual specificity phosphatase 10 0.0291786
PCM1 pericentriolar material 1 0.0291678
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) 0.0289002
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) 0.0288879
IGF2 insulin-like growth factor 2 0.0288659
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0285782
RARA retinoic acid receptor, alpha 0.0283994
PAPOLA poly(A) polymerase alpha 0.0283722
DKK2 dickkopf WNT signaling pathway inhibitor 2 0.0283656
CCNL1 cyclin L1 0.0282107
KCNT2 potassium channel, sodium activated subfamily T, member 2 0.0281051
PFKFB4 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 0.0280714
ASPH aspartate beta-hydroxylase 0.0280232
KLF7 Kruppel-like factor 7 (ubiquitous) 0.0280111
KDM2A lysine (K)-specific demethylase 2A 0.0273006
ZCCHC7 zinc finger, CCHC domain containing 7 0.0271427
ZNF148 zinc finger protein 148 0.0268651
RBFOX2 RNA binding protein, fox-1 homolog (C. elegans) 2 0.0267967
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.0267091
LGR5 leucine-rich repeat containing G protein-coupled receptor 5 0.0266142
CPED1 cadherin-like and PC-esterase domain containing 1 0.0266103
NPAS2 neuronal PAS domain protein 2 0.0265598
EPC2 enhancer of polycomb homolog 2 (Drosophila) 0.0265197
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 0.0264125
RCOR1 REST corepressor 1 0.0263787
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.0263442
EFNA5 ephrin-A5 0.0262867
CTNND1 catenin (cadherin-associated protein), delta 1 0.0261154
MAPK10 mitogen-activated protein kinase 10 0.0260429
DNM3 dynamin 3 0.0260151
ERBIN erbb2 interacting protein 0.025897
AKAP9 A kinase (PRKA) anchor protein 9 0.0258525

decreased expression

Symbol Name Standardized Value
DDX1 DEAD (Asp-Glu-Ala-Asp) box helicase 1 -0.292291
NRG1 neuregulin 1 -0.142671
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.103823
PTMA prothymosin, alpha -0.103646
COL3A1 collagen, type III, alpha 1 -0.102387
COL1A1 collagen, type I, alpha 1 -0.0997253
VIM vimentin -0.0944711
SYT1 synaptotagmin I -0.0764886
CADM2 cell adhesion molecule 2 -0.0716005
RPS6 ribosomal protein S6 -0.0615773
RPS24 ribosomal protein S24 -0.0590232
RPL23 ribosomal protein L23 -0.05787
RPL38 ribosomal protein L38 -0.0565982
AHNAK AHNAK nucleoprotein -0.0554783
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.0513032
PCDH9 protocadherin 9 -0.050065
TPT1 tumor protein, translationally-controlled 1 -0.0500355
EIF1 eukaryotic translation initiation factor 1 -0.0500065
RAD21 RAD21 homolog (S. pombe) -0.049054
TRIB2 tribbles pseudokinase 2 -0.049001
GNAS GNAS complex locus -0.0484747
SPAG9 sperm associated antigen 9 -0.0480318
PRRC2C proline-rich coiled-coil 2C -0.0471557
RPL4 ribosomal protein L4 -0.0467839
NAMPT nicotinamide phosphoribosyltransferase -0.0459568
H3-3B H3.3 histone B -0.0452944
CSDE1 cold shock domain containing E1, RNA-binding -0.0450033
CD36 CD36 molecule (thrombospondin receptor) -0.0441494
RPLP1 ribosomal protein, large, P1 -0.0441239
LPIN1 lipin 1 -0.0423634
AOPEP aminopeptidase O (putative) -0.0410475
RPL35A ribosomal protein L35a -0.0405911
SOS1 son of sevenless homolog 1 (Drosophila) -0.0402578
NALF1 NALCN channel auxiliary factor 1 -0.0391722
CEP95 centrosomal protein 95kDa -0.039096
ADGRG6 adhesion G protein-coupled receptor G6 -0.0375576
RPL19 ribosomal protein L19 -0.0374731
BIRC6 baculoviral IAP repeat containing 6 -0.0365072
DNAH14 dynein, axonemal, heavy chain 14 -0.0360596
NME2 NME/NM23 nucleoside diphosphate kinase 2 -0.0354255
ANGPT1 angiopoietin 1 -0.0348557
PRKDC protein kinase, DNA-activated, catalytic polypeptide -0.0345734
ZNF804A zinc finger protein 804A -0.0334534
RPL35 ribosomal protein L35 -0.0324531
HMGB2 high mobility group box 2 -0.0323817
RPLP0 ribosomal protein, large, P0 -0.0319474
RPL26 ribosomal protein L26 -0.0316576
MATR3 matrin 3 -0.0312868
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.0311833
EIF3A eukaryotic translation initiation factor 3, subunit A -0.0309151
FKBP10 FK506 binding protein 10, 65 kDa -0.0307878
MIB1 mindbomb E3 ubiquitin protein ligase 1 -0.0306757
IRF2BP2 interferon regulatory factor 2 binding protein 2 -0.030674
IFI16 interferon, gamma-inducible protein 16 -0.0305762
LMNA lamin A/C -0.0301278
GPC5 glypican 5 -0.03004
TNPO1 transportin 1 -0.0298726
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0297866
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.029752
UNC5C unc-5 homolog C (C. elegans) -0.0295616
IGF1R insulin-like growth factor 1 receptor -0.029461
IQGAP1 IQ motif containing GTPase activating protein 1 -0.0294246
ITFG1 integrin alpha FG-GAP repeat containing 1 -0.029362
SMARCC1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1 -0.0292994
RO60 Ro60, Y RNA binding protein -0.0292944
FOXK2 forkhead box K2 -0.0292638
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 -0.0291178
PRR11 proline rich 11 -0.0290471
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0290296
EIF4A1 eukaryotic translation initiation factor 4A1 -0.0290063
GARS1 glycyl-tRNA synthetase 1 -0.0287799
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0282041
PLEKHA5 pleckstrin homology domain containing, family A member 5 -0.0280773
KPNB1 karyopherin (importin) beta 1 -0.0278607
IARS1 isoleucyl-tRNA synthetase 1 -0.0277483
DSCAM Down syndrome cell adhesion molecule -0.0277387
SEC23A Sec23 homolog A (S. cerevisiae) -0.027499
HAND2 heart and neural crest derivatives expressed 2 -0.0274858
PRKRIP1 PRKR interacting protein 1 (IL11 inducible) -0.0271176
CDH2 cadherin 2, type 1, N-cadherin (neuronal) -0.0269161
ACTG1 actin gamma 1 -0.0267928
UBE2D3 ubiquitin-conjugating enzyme E2D 3 -0.0266952
UBE2O ubiquitin-conjugating enzyme E2O -0.026496
VPS54 vacuolar protein sorting 54 homolog (S. cerevisiae) -0.0264913
HDLBP high density lipoprotein binding protein -0.0263813
RPL34 ribosomal protein L34 -0.0262932
SEC63 SEC63 homolog (S. cerevisiae) -0.0261006
GNA13 guanine nucleotide binding protein (G protein), alpha 13 -0.0260703
USP3 ubiquitin specific peptidase 3 -0.0259821
TMSB10 thymosin beta 10 -0.0258467
ZMYM2 zinc finger, MYM-type 2 -0.0256431
KIF5B kinesin family member 5B -0.0255182
FBXW7 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase -0.0254502
ANKS1B ankyrin repeat and sterile alpha motif domain containing 1B -0.0248431
PCNX1 pecanex 1 -0.0247515
TUBB tubulin, beta class I -0.0245672
FUBP3 far upstream element (FUSE) binding protein 3 -0.0241627
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0240508
KLHL5 kelch-like family member 5 -0.0239881
CDC27 cell division cycle 27 -0.0239773