Retinoic acid_COLO 205 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Retinoic acid perturbation in COLO 205 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Retinoic acid_COLO 205 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
LMO7 LIM domain 7 0.174315
SMAD3 SMAD family member 3 0.131534
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.122241
SPTBN1 spectrin, beta, non-erythrocytic 1 0.106586
AKAP13 A kinase (PRKA) anchor protein 13 0.102325
LRCH1 leucine-rich repeats and calponin homology (CH) domain containing 1 0.0993645
DNAJC15 DnaJ (Hsp40) homolog, subfamily C, member 15 0.0920648
MACC1 metastasis associated in colon cancer 1 0.0810976
SIPA1L2 signal-induced proliferation-associated 1 like 2 0.0797531
MAN1A1 mannosidase, alpha, class 1A, member 1 0.0749803
MYO1E myosin IE 0.0686962
NRIP1 nuclear receptor interacting protein 1 0.0669513
LCN2 lipocalin 2 0.0629035
SHB Src homology 2 domain containing adaptor protein B 0.0610625
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0573342
BCL2L1 BCL2-like 1 0.0552097
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 0.0550946
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 0.0541173
TMTC2 transmembrane and tetratricopeptide repeat containing 2 0.0525163
ANXA2 annexin A2 0.050679
ETV6 ets variant 6 0.0504782
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 0.0489017
CHST11 carbohydrate (chondroitin 4) sulfotransferase 11 0.0480281
VCL vinculin 0.0476605
ASPH aspartate beta-hydroxylase 0.0464691
N4BP2L2 NEDD4 binding protein 2-like 2 0.0442924
STK24 serine/threonine kinase 24 0.0439674
ERBIN erbb2 interacting protein 0.0434016
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0429578
ADAM10 ADAM metallopeptidase domain 10 0.0429297
TJP1 tight junction protein 1 0.0429162
DIAPH1 diaphanous-related formin 1 0.0424067
FTH1 ferritin, heavy polypeptide 1 0.0423469
ERN1 endoplasmic reticulum to nucleus signaling 1 0.0392533
YAP1 Yes-associated protein 1 0.0389992
EPS8 epidermal growth factor receptor pathway substrate 8 0.0388933
LPP LIM domain containing preferred translocation partner in lipoma 0.0380315
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0377653
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0368402
IFNGR1 interferon gamma receptor 1 0.036541
VMP1 vacuole membrane protein 1 0.0363074
MCTP1 multiple C2 domains, transmembrane 1 0.0359194
PRSS22 protease, serine, 22 0.035078
XDH xanthine dehydrogenase 0.0350051
C6ORF132 chromosome 6 open reading frame 132 0.0348206
MPRIP myosin phosphatase Rho interacting protein 0.0345462
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0341911
KYNU kynureninase 0.0340433
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.0337265
BAIAP2L1 BAI1-associated protein 2-like 1 0.033463
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0333634
OAS3 2'-5'-oligoadenylate synthetase 3, 100kDa 0.0328584
DUSP10 dual specificity phosphatase 10 0.0322122
MCL1 myeloid cell leukemia 1 0.0318371
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0316469
PKM pyruvate kinase, muscle 0.0313639
CTBP2 C-terminal binding protein 2 0.0313009
FNDC3A fibronectin type III domain containing 3A 0.0311217
EREG epiregulin 0.0308979
SPRED1 sprouty-related, EVH1 domain containing 1 0.0305022
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3 0.0304625
EML4 echinoderm microtubule associated protein like 4 0.0302197
SIK3 SIK family kinase 3 0.0299868
DIP2B DIP2 disco-interacting protein 2 homolog B (Drosophila) 0.0299683
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 0.0299455
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0297286
TM4SF19 transmembrane 4 L six family member 19 0.0294635
ZNF292 zinc finger protein 292 0.0288603
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box) 0.0287371
HKDC1 hexokinase domain containing 1 0.0282147
ST14 suppression of tumorigenicity 14 (colon carcinoma) 0.0281655
CLOCK clock circadian regulator 0.0281301
SRRM2 serine/arginine repetitive matrix 2 0.0280158
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 0.0278398
ELOF1 elongation factor 1 homolog (S. cerevisiae) 0.0276031
PADI1 peptidyl arginine deiminase, type I 0.0275929
EZR ezrin 0.027334
CXCL8 chemokine (C-X-C motif) ligand 8 0.0268496
MTUS1 microtubule associated tumor suppressor 1 0.0267796
CCNL1 cyclin L1 0.026656
LIMA1 LIM domain and actin binding 1 0.0266277
DPP4 dipeptidyl-peptidase 4 0.0264022
TXNRD1 thioredoxin reductase 1 0.0263149
DUSP16 dual specificity phosphatase 16 0.0260973
PDZD8 PDZ domain containing 8 0.0258649
AREG amphiregulin 0.0245525
RDH10 retinol dehydrogenase 10 (all-trans) 0.0244276
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0241932
SLK STE20-like kinase 0.0232076
TRIM2 tripartite motif containing 2 0.0231532
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0230212
MYO5B myosin VB 0.022786
EPB41L1 erythrocyte membrane protein band 4.1-like 1 0.0227762
FAT1 FAT atypical cadherin 1 0.0226959
DST dystonin 0.0226528
APP amyloid beta (A4) precursor protein 0.0226119
RFFL ring finger and FYVE-like domain containing E3 ubiquitin protein ligase 0.0224856
PDLIM5 PDZ and LIM domain 5 0.0224527
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0224434
AFF4 AF4/FMR2 family, member 4 0.0223386

decreased expression

Symbol Name Standardized Value
TPT1 tumor protein, translationally-controlled 1 -0.167183
NPSR1 neuropeptide S receptor 1 -0.136185
ZMYND8 zinc finger, MYND-type containing 8 -0.120631
GMDS GDP-mannose 4,6-dehydratase -0.0980936
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0932944
XAF1 XIAP associated factor 1 -0.0838031
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0800453
HLA-B major histocompatibility complex, class I, B -0.0797483
ARHGAP26 Rho GTPase activating protein 26 -0.0780692
LYZ lysozyme -0.0722335
TRIO trio Rho guanine nucleotide exchange factor -0.0722035
PTMA prothymosin, alpha -0.0710021
EPSTI1 epithelial stromal interaction 1 (breast) -0.0691047
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid) -0.0646052
H1-0 H1.0 linker histone -0.0621092
NDRG1 N-myc downstream regulated 1 -0.0614179
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 -0.0593565
MAML2 mastermind-like 2 (Drosophila) -0.0559904
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0544684
IGF1R insulin-like growth factor 1 receptor -0.0539695
SYNE2 spectrin repeat containing, nuclear envelope 2 -0.0537473
EGLN3 egl-9 family hypoxia-inducible factor 3 -0.0534272
AHNAK AHNAK nucleoprotein -0.0529488
BTBD9 BTB (POZ) domain containing 9 -0.0510967
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 -0.0489598
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0478328
MUC20 mucin 20, cell surface associated -0.0452564
SSH2 slingshot protein phosphatase 2 -0.0452223
TSHZ2 teashirt zinc finger homeobox 2 -0.0448344
PLSCR2 phospholipid scramblase 2 -0.0446643
CSTPP1 centriolar satellite-associated tubulin polyglutamylase complex regulator 1 -0.0439906
SP100 SP100 nuclear antigen -0.0425463
B2M beta-2-microglobulin -0.0424951
ZKSCAN1 zinc finger with KRAB and SCAN domains 1 -0.0422114
TMSB10 thymosin beta 10 -0.0418069
SLC44A1 solute carrier family 44 (choline transporter), member 1 -0.0402784
TFRC transferrin receptor -0.0390051
TXNIP thioredoxin interacting protein -0.0387691
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.0379279
JUN jun proto-oncogene -0.0370335
RRBP1 ribosome binding protein 1 -0.0364966
DSCAML1 Down syndrome cell adhesion molecule like 1 -0.0363087
FMN1 formin 1 -0.0353446
RPL35A ribosomal protein L35a -0.0352718
MBNL2 muscleblind-like splicing regulator 2 -0.0343092
RPL34 ribosomal protein L34 -0.0342399
WSB1 WD repeat and SOCS box containing 1 -0.0338974
EPCAM epithelial cell adhesion molecule -0.03366
PGK1 phosphoglycerate kinase 1 -0.0332409
PERP PERP, TP53 apoptosis effector -0.0327998
ARHGEF38 Rho guanine nucleotide exchange factor (GEF) 38 -0.032707
GRIN2B glutamate receptor, ionotropic, N-methyl D-aspartate 2B -0.0326011
RPL23 ribosomal protein L23 -0.0316609
PATJ PATJ crumbs cell polarity complex component -0.0313922
RBM39 RNA binding motif protein 39 -0.0309016
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0299764
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble) -0.0297111
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0295033
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0294983
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17 -0.0291792
NT5C3A 5'-nucleotidase, cytosolic IIIA -0.0289383
NCOA7 nuclear receptor coactivator 7 -0.0289272
HLA-C major histocompatibility complex, class I, C -0.0287305
PARP4 poly (ADP-ribose) polymerase family, member 4 -0.0286834
SQSTM1 sequestosome 1 -0.0283276
LDLRAD4 low density lipoprotein receptor class A domain containing 4 -0.0280624
RAD51B RAD51 paralog B -0.0276331
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0275457
CCDC146 coiled-coil domain containing 146 -0.0270455
PPARGC1A peroxisome proliferator-activated receptor gamma, coactivator 1 alpha -0.0270363
NCOR1 nuclear receptor corepressor 1 -0.0266979
NAALADL2 N-acetylated alpha-linked acidic dipeptidase-like 2 -0.0265748
PTGR1 prostaglandin reductase 1 -0.0264889
VOPP1 vesicular, overexpressed in cancer, prosurvival protein 1 -0.0262849
STK39 serine threonine kinase 39 -0.0258881
EIF1 eukaryotic translation initiation factor 1 -0.0257422
ZBTB20 zinc finger and BTB domain containing 20 -0.0256413
MPHOSPH8 M-phase phosphoprotein 8 -0.0255617
SORBS1 sorbin and SH3 domain containing 1 -0.0255369
ZMYM2 zinc finger, MYM-type 2 -0.0254854
VDAC1 voltage-dependent anion channel 1 -0.0254774
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10 -0.0254378
IGFBP3 insulin-like growth factor binding protein 3 -0.0250552
WDR45B WD repeat domain 45B -0.0247179
LLGL2 lethal giant larvae homolog 2 (Drosophila) -0.0245976
ITGA1 integrin, alpha 1 -0.0245346
RPS24 ribosomal protein S24 -0.0243801
PLSCR1 phospholipid scramblase 1 -0.0241622
MAP3K20 mitogen-activated protein kinase kinase kinase 20 -0.0241597
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2 -0.0241449
IFI6 interferon, alpha-inducible protein 6 -0.0239416
ABLIM1 actin binding LIM protein 1 -0.0234227
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0232724
PTPRF protein tyrosine phosphatase, receptor type, F -0.0229208
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0227148
CANX calnexin -0.0226407
CSTB cystatin B (stefin B) -0.0224887
LCORL ligand dependent nuclear receptor corepressor-like -0.0221675
KDM3A lysine (K)-specific demethylase 3A -0.0221133
ZNF518A zinc finger protein 518A -0.0218611