Retinoic acid_H4 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Retinoic acid perturbation in H4 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Retinoic acid_H4 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
IGFBP3 insulin-like growth factor binding protein 3 0.280615
COL6A3 collagen, type VI, alpha 3 0.213052
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.208123
GNPDA1 glucosamine-6-phosphate deaminase 1 0.045824
ZC3HAV1 zinc finger CCCH-type, antiviral 1 0.0455452
TIMP3 TIMP metallopeptidase inhibitor 3 0.038739
HYCC1 hyccin PI4KA lipid kinase complex subunit 1 0.036771
PTCHD4 patched domain containing 4 0.0364058
SQSTM1 sequestosome 1 0.0331846
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A 0.0326235
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 0.030391
FTL ferritin, light polypeptide 0.0301418
HILPDA hypoxia inducible lipid droplet-associated 0.0300045
ANXA2 annexin A2 0.029265
FTH1 ferritin, heavy polypeptide 1 0.0292525
AHNAK AHNAK nucleoprotein 0.0283676
WARS1 tryptophanyl-tRNA synthetase 1 0.0250508
VCL vinculin 0.0245939
GDF15 growth differentiation factor 15 0.0229204
JUN jun proto-oncogene 0.0225153
NALF1 NALCN channel auxiliary factor 1 0.0219653
HDAC9 histone deacetylase 9 0.0212766
ZSWIM6 zinc finger, SWIM-type containing 6 0.0210714
FAM13A family with sequence similarity 13, member A 0.0209671
CADM1 cell adhesion molecule 1 0.0205999
RIGI RNA sensor RIG-I 0.0205575
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.0202163
IER3 immediate early response 3 0.0199117
GRB10 growth factor receptor-bound protein 10 0.0195012
BZW2 basic leucine zipper and W2 domains 2 0.0192315
CALR calreticulin 0.0188136
TENT5A terminal nucleotidyltransferase 5A 0.018794
PDE4D phosphodiesterase 4D, cAMP-specific 0.018592
ANTXR1 anthrax toxin receptor 1 0.0184798
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0184769
HIP1 huntingtin interacting protein 1 0.0180686
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 0.0178213
AHR aryl hydrocarbon receptor 0.0168736
KYNU kynureninase 0.0168438
FN1 fibronectin 1 0.0166201
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0166101
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0162479
LYPD6B LY6/PLAUR domain containing 6B 0.0152683
MYLK myosin light chain kinase 0.0149292
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1 0.0146864
PFKFB4 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 0.014585
RPN2 ribophorin II 0.0143836
DGKI diacylglycerol kinase, iota 0.0143662
IARS1 isoleucyl-tRNA synthetase 1 0.0140807
FLRT2 fibronectin leucine rich transmembrane protein 2 0.0139765
NCOA7 nuclear receptor coactivator 7 0.0137908
CD109 CD109 molecule 0.0136107
CTBP2 C-terminal binding protein 2 0.0136095
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.0135366
ADGRA3 adhesion G protein-coupled receptor A3 0.013444
TUBB tubulin, beta class I 0.0134186
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A 0.0132138
UBASH3B ubiquitin associated and SH3 domain containing B 0.0131666
PLEC plectin 0.0131472
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.01305
FAM53C family with sequence similarity 53, member C 0.0128853
NCOA3 nuclear receptor coactivator 3 0.0128594
FNIP1 folliculin interacting protein 1 0.0128564
FGF13 fibroblast growth factor 13 0.0128502
SP4 Sp4 transcription factor 0.012667
KDM4B lysine (K)-specific demethylase 4B 0.0123402
FAM20C family with sequence similarity 20, member C 0.0123248
EGR1 early growth response 1 0.0122766
C1S complement component 1, s subcomponent 0.0122604
SH3KBP1 SH3-domain kinase binding protein 1 0.012243
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 0.0122368
IGFBP5 insulin-like growth factor binding protein 5 0.0121586
WLS wntless Wnt ligand secretion mediator 0.0120036
PDIA4 protein disulfide isomerase family A, member 4 0.0119462
INTS6 integrator complex subunit 6 0.0119229
CCDC102B coiled-coil domain containing 102B 0.0117351
SLC38A1 solute carrier family 38, member 1 0.0116794
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1 0.0116035
UGDH UDP-glucose 6-dehydrogenase 0.0115718
RTN3 reticulon 3 0.0114932
SPMIP6 sperm microtubule inner protein 6 0.0114616
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) 0.0114375
MAP3K13 mitogen-activated protein kinase kinase kinase 13 0.0114353
RAB7A RAB7A, member RAS oncogene family 0.0114156
ADIPOR2 adiponectin receptor 2 0.0113776
FBXL7 F-box and leucine-rich repeat protein 7 0.0113511
AADAC arylacetamide deacetylase 0.0112354
ARF1 ADP-ribosylation factor 1 0.0110013
AOPEP aminopeptidase O (putative) 0.0109821
COL12A1 collagen, type XII, alpha 1 0.0109674
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0109573
MRTFA myocardin related transcription factor A 0.0108291
OASL 2'-5'-oligoadenylate synthetase-like 0.0107624
DDIT4 DNA-damage-inducible transcript 4 0.0107611
PRSS23 protease, serine, 23 0.0107598
RHEB Ras homolog enriched in brain 0.0107343
HBP1 HMG-box transcription factor 1 0.0107138
CFAP44 cilia and flagella associated protein 44 0.0106876
ATF3 activating transcription factor 3 0.0106206
LRRC23 leucine rich repeat containing 23 0.0105703

decreased expression

Symbol Name Standardized Value
MT2A metallothionein 2A -0.160844
NDRG1 N-myc downstream regulated 1 -0.149056
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0923555
STC1 stanniocalcin 1 -0.0795161
NAMPT nicotinamide phosphoribosyltransferase -0.0726715
DGKD diacylglycerol kinase, delta 130kDa -0.0681485
RPS6 ribosomal protein S6 -0.0651702
FNDC3B fibronectin type III domain containing 3B -0.0627047
TXNIP thioredoxin interacting protein -0.0555325
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0552186
AKAP12 A kinase (PRKA) anchor protein 12 -0.0548962
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0538489
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0535809
RTN4 reticulon 4 -0.0530737
RPS2 ribosomal protein S2 -0.0524035
CD44 CD44 molecule (Indian blood group) -0.0497811
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0480238
ATP13A3 ATPase type 13A3 -0.0476858
MSN moesin -0.0458506
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 -0.0455294
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0454073
SMAD3 SMAD family member 3 -0.0447984
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0438162
CALD1 caldesmon 1 -0.0425952
TMSB10 thymosin beta 10 -0.0424396
ANKRD11 ankyrin repeat domain 11 -0.042429
VEGFA vascular endothelial growth factor A -0.0404955
VIM vimentin -0.0404557
EGFR epidermal growth factor receptor -0.0390554
ANKRD12 ankyrin repeat domain 12 -0.0382709
TRIO trio Rho guanine nucleotide exchange factor -0.037854
ERRFI1 ERBB receptor feedback inhibitor 1 -0.037615
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -0.0371759
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0370334
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0364975
ASPH aspartate beta-hydroxylase -0.0361039
DTNA dystrobrevin, alpha -0.0356965
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 -0.0354456
AVL9 AVL9 homolog (S. cerevisiase) -0.0347143
RFX8 RFX family member 8, lacking RFX DNA binding domain -0.0345702
NF1 neurofibromin 1 -0.0343651
ANTXR2 anthrax toxin receptor 2 -0.0342063
GOLGB1 golgin B1 -0.033582
GOLGA4 golgin A4 -0.0335814
TGFBI transforming growth factor, beta-induced, 68kDa -0.0332658
USP34 ubiquitin specific peptidase 34 -0.0329209
DLG1 discs, large homolog 1 (Drosophila) -0.0324701
UBA6 ubiquitin-like modifier activating enzyme 6 -0.0315484
AKAP9 A kinase (PRKA) anchor protein 9 -0.0313336
OSMR oncostatin M receptor -0.0312841
NPC1 Niemann-Pick disease, type C1 -0.0312834
ELL2 elongation factor, RNA polymerase II, 2 -0.0312259
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0309352
HIPK2 homeodomain interacting protein kinase 2 -0.0308981
SBF2 SET binding factor 2 -0.0307808
COG5 component of oligomeric golgi complex 5 -0.0303824
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0302552
PTPN14 protein tyrosine phosphatase, non-receptor type 14 -0.0297832
SPRED1 sprouty-related, EVH1 domain containing 1 -0.029645
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0292799
GLIS3 GLIS family zinc finger 3 -0.0288983
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.0280925
ACBD3 acyl-CoA binding domain containing 3 -0.0280551
PKM pyruvate kinase, muscle -0.0280094
ZNF292 zinc finger protein 292 -0.0277598
TNIP1 TNFAIP3 interacting protein 1 -0.027628
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0271939
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.027073
POTEF POTE ankyrin domain family, member F -0.0268616
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0265329
BIRC6 baculoviral IAP repeat containing 6 -0.02652
SETD5 SET domain containing 5 -0.0264858
RNF216 ring finger protein 216 -0.0264451
PRRC2C proline-rich coiled-coil 2C -0.0264344
MAST4 microtubule associated serine/threonine kinase family member 4 -0.0263883
ANKRD17 ankyrin repeat domain 17 -0.0259759
TXNRD1 thioredoxin reductase 1 -0.0258185
RPS23 ribosomal protein S23 -0.0253932
SAMD4A sterile alpha motif domain containing 4A -0.025339
RPL9 ribosomal protein L9 -0.0248338
PLAUR plasminogen activator, urokinase receptor -0.0247912
IQCJ-SCHIP1 IQCJ-SCHIP1 readthrough -0.0245683
YBX3 Y box binding protein 3 -0.0245166
PDE4B phosphodiesterase 4B, cAMP-specific -0.0241081
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0241059
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 -0.0238938
BOD1L1 biorientation of chromosomes in cell division 1-like 1 -0.0237932
TLN1 talin 1 -0.0237914
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0234684
RARS1 arginyl-tRNA synthetase 1 -0.023357
FRMD6 FERM domain containing 6 -0.0232235
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0231757
ACTR2 ARP2 actin-related protein 2 homolog (yeast) -0.0230779
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 -0.023061
HSPA8 heat shock 70kDa protein 8 -0.022999
NAV2 neuron navigator 2 -0.0229827
PTMA prothymosin, alpha -0.0229145
ZNF148 zinc finger protein 148 -0.022529
MYH9 myosin, heavy chain 9, non-muscle -0.0224079
TM9SF3 transmembrane 9 superfamily member 3 -0.0224058