Retinoic acid_HCT15 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Retinoic acid perturbation in HCT15 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Retinoic acid_HCT15 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.179451
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.113715
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.108258
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0640158
PRELID2 PRELI domain containing 2 0.0610246
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0594952
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0556632
AHNAK AHNAK nucleoprotein 0.0524553
NDRG1 N-myc downstream regulated 1 0.0508764
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0502248
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0446484
TBC1D22A TBC1 domain family, member 22A 0.0443233
TOP2A topoisomerase (DNA) II alpha 170kDa 0.043275
PTMA prothymosin, alpha 0.041858
UBA6 ubiquitin-like modifier activating enzyme 6 0.037707
MKI67 marker of proliferation Ki-67 0.037426
FHIT fragile histidine triad 0.0370306
PCM1 pericentriolar material 1 0.0369326
SEC24D SEC24 family member D 0.0355416
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0347783
OGA O-GlcNAcase 0.0337658
FAM168A family with sequence similarity 168, member A 0.0337142
SOS1 son of sevenless homolog 1 (Drosophila) 0.033516
KIF5B kinesin family member 5B 0.0333114
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.0331941
PDIA3 protein disulfide isomerase family A, member 3 0.0329952
USP37 ubiquitin specific peptidase 37 0.0318459
PFKFB4 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 0.0318398
ZNF148 zinc finger protein 148 0.0314773
TPM3 tropomyosin 3 0.0314658
HELZ helicase with zinc finger 0.031422
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0310988
CANX calnexin 0.030422
TMF1 TATA element modulatory factor 1 0.030302
SMYD3 SET and MYND domain containing 3 0.0299431
KDM2A lysine (K)-specific demethylase 2A 0.0281456
RAB1A RAB1A, member RAS oncogene family 0.0281278
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0277096
SETD5 SET domain containing 5 0.0276978
ZNF292 zinc finger protein 292 0.0276196
MATR3 matrin 3 0.0260098
SPAG9 sperm associated antigen 9 0.0259575
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0259522
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0252689
ESYT2 extended synaptotagmin-like protein 2 0.0252443
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa 0.0252431
CENPF centromere protein F, 350/400kDa 0.0251083
MED13 mediator complex subunit 13 0.024725
RNMT RNA (guanine-7-) methyltransferase 0.0245003
EGLN1 egl-9 family hypoxia-inducible factor 1 0.0240083
ERRFI1 ERBB receptor feedback inhibitor 1 0.0239746
LMAN1 lectin, mannose-binding, 1 0.0238853
KDM3A lysine (K)-specific demethylase 3A 0.0238019
TRA2A transformer 2 alpha homolog (Drosophila) 0.0236275
KPNB1 karyopherin (importin) beta 1 0.0233213
HSPA8 heat shock 70kDa protein 8 0.0229654
SEC31A SEC31 homolog A (S. cerevisiae) 0.0228757
ERO1B endoplasmic reticulum oxidoreductase 1 beta 0.0227323
ZC3H11A zinc finger CCCH-type containing 11A 0.0227031
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 0.0226358
NF1 neurofibromin 1 0.0226169
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 0.0224712
WDPCP WD repeat containing planar cell polarity effector 0.0224118
GOLGA4 golgin A4 0.0222375
ZNF638 zinc finger protein 638 0.0221891
ANKRD11 ankyrin repeat domain 11 0.0221812
FAT1 FAT atypical cadherin 1 0.0221127
BRD2 bromodomain containing 2 0.0217349
DDIT4 DNA-damage-inducible transcript 4 0.0216023
FUS FUS RNA binding protein 0.0215431
FBXO11 F-box protein 11 0.0214951
MAPK1IP1L mitogen-activated protein kinase 1 interacting protein 1-like 0.0213489
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0211319
CSNK1A1 casein kinase 1, alpha 1 0.0211179
IQGAP1 IQ motif containing GTPase activating protein 1 0.0209459
MYH9 myosin, heavy chain 9, non-muscle 0.0208573
COPA coatomer protein complex, subunit alpha 0.0208297
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0207735
RBM39 RNA binding motif protein 39 0.0207131
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa 0.0207106
EPRS1 glutamyl-prolyl-tRNA synthetase 1 0.020679
LASP1 LIM and SH3 protein 1 0.0206563
COPB1 coatomer protein complex, subunit beta 1 0.0205085
FNBP1L formin binding protein 1-like 0.0204779
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase 0.0204053
PKM pyruvate kinase, muscle 0.0202417
DSPP dentin sialophosphoprotein 0.0202292
TFG TRK-fused gene 0.0201415
HNRNPDL heterogeneous nuclear ribonucleoprotein D-like 0.020012
PELI1 pellino E3 ubiquitin protein ligase 1 0.0198606
RNF24 ring finger protein 24 0.0198484
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.0197899
LCOR ligand dependent nuclear receptor corepressor 0.0197327
MARCHF6 membrane associated ring-CH-type finger 6 0.0197124
TXNIP thioredoxin interacting protein 0.0196721
COG6 component of oligomeric golgi complex 6 0.0196094
KDM5B lysine (K)-specific demethylase 5B 0.0195914
AKAP10 A kinase (PRKA) anchor protein 10 0.0195337
LOC112694756 uncharaterized LOC112694756 0.019502
SUCO SUN domain containing ossification factor 0.0193709

decreased expression

Symbol Name Standardized Value
TPT1 tumor protein, translationally-controlled 1 -0.11956
RPS6 ribosomal protein S6 -0.103899
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.090858
TMSB10 thymosin beta 10 -0.0763734
EGR1 early growth response 1 -0.0747042
RPL26 ribosomal protein L26 -0.0581961
RPL34 ribosomal protein L34 -0.054238
RPL35A ribosomal protein L35a -0.0518431
SLC38A2 solute carrier family 38, member 2 -0.0492427
MIDN midnolin -0.0486588
RPS8 ribosomal protein S8 -0.046853
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 -0.0443377
RPLP2 ribosomal protein, large, P2 -0.0437261
S100A10 S100 calcium binding protein A10 -0.0428657
SERINC5 serine incorporator 5 -0.0402607
RPL37A ribosomal protein L37a -0.0400669
SPDYA speedy/RINGO cell cycle regulator family member A -0.0399566
RPL12 ribosomal protein L12 -0.0380803
RPL23 ribosomal protein L23 -0.037606
PATJ PATJ crumbs cell polarity complex component -0.0366448
RPL36 ribosomal protein L36 -0.0365178
RPS13 ribosomal protein S13 -0.0356972
EIF1 eukaryotic translation initiation factor 1 -0.0355603
HMGA1 high mobility group AT-hook 1 -0.0351482
RPS21 ribosomal protein S21 -0.0339354
RPS19 ribosomal protein S19 -0.0334956
RPL31 ribosomal protein L31 -0.0330768
PTPRK protein tyrosine phosphatase, receptor type, K -0.0330218
RPS12 ribosomal protein S12 -0.0323822
RPS3 ribosomal protein S3 -0.03181
RPL18 ribosomal protein L18 -0.0317699
RACK1 receptor for activated C kinase 1 -0.0305099
RPL19 ribosomal protein L19 -0.0303674
RPL11 ribosomal protein L11 -0.0302169
RPL37 ribosomal protein L37 -0.0284729
RPS27 ribosomal protein S27 -0.0283691
TENM3 teneurin transmembrane protein 3 -0.0283384
RAD51B RAD51 paralog B -0.0279997
ANKRD17 ankyrin repeat domain 17 -0.0279414
ACACA acetyl-CoA carboxylase alpha -0.0274286
IFITM3 interferon induced transmembrane protein 3 -0.0267057
ZCCHC7 zinc finger, CCHC domain containing 7 -0.0266242
RPS17 ribosomal protein S17 -0.0264873
EHBP1 EH domain binding protein 1 -0.0259491
SCFD2 sec1 family domain containing 2 -0.0253588
FAF1 Fas (TNFRSF6) associated factor 1 -0.0251039
RPL8 ribosomal protein L8 -0.0250968
S100A9 S100 calcium binding protein A9 -0.0249619
ABCG1 ATP-binding cassette, sub-family G (WHITE), member 1 -0.0249098
RPLP1 ribosomal protein, large, P1 -0.0248686
ACSL3 acyl-CoA synthetase long-chain family member 3 -0.024792
RPS24 ribosomal protein S24 -0.0247537
RPS10 ribosomal protein S10 -0.0245669
RPL27 ribosomal protein L27 -0.024556
RPL9 ribosomal protein L9 -0.0245551
KRT18 keratin 18, type I -0.0245336
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 -0.024432
RPL32 ribosomal protein L32 -0.0242566
RPL7A ribosomal protein L7a -0.0237524
FTL ferritin, light polypeptide -0.0234596
RPS15 ribosomal protein S15 -0.0231974
KRT8 keratin 8, type II -0.023089
RPL28 ribosomal protein L28 -0.023079
SLCO1B3-SLCO1B7 SLCO1B3-SLCO1B7 readthrough -0.0228541
HPCAL1 hippocalcin-like 1 -0.022739
VMP1 vacuole membrane protein 1 -0.02272
PTPN4 protein tyrosine phosphatase, non-receptor type 4 (megakaryocyte) -0.022495
LOC102724023 ES1 protein homolog, mitochondrial -0.0222992
CCDC138 coiled-coil domain containing 138 -0.0221614
RPS11 ribosomal protein S11 -0.0221
POTEF POTE ankyrin domain family, member F -0.0213842
HLA-B major histocompatibility complex, class I, B -0.0213491
LRBA LPS-responsive vesicle trafficking, beach and anchor containing -0.0212222
RPL7 ribosomal protein L7 -0.020967
RPS27A ribosomal protein S27a -0.0209632
CELF1 CUGBP, Elav-like family member 1 -0.0208848
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0208252
AHI1 Abelson helper integration site 1 -0.0205901
RSL1D1 ribosomal L1 domain containing 1 -0.020589
TNS4 tensin 4 -0.0205743
RPL5 ribosomal protein L5 -0.020422
ATF4 activating transcription factor 4 -0.0203052
RPLP0 ribosomal protein, large, P0 -0.0203027
NT5C2 5'-nucleotidase, cytosolic II -0.0201143
SLCO1B3 solute carrier organic anion transporter family, member 1B3 -0.0199818
RPL36A ribosomal protein L36a -0.0197889
TCF12 transcription factor 12 -0.0197088
RSF1 remodeling and spacing factor 1 -0.0196912
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 -0.0194925
NAP1L1 nucleosome assembly protein 1-like 1 -0.0192663
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0191509
RPS14 ribosomal protein S14 -0.0190898
SERF2 small EDRK-rich factor 2 -0.0188976
PABPN1 poly(A) binding protein, nuclear 1 -0.0188604
RPL27A ribosomal protein L27a -0.018828
RIGI RNA sensor RIG-I -0.0188077
YBX3 Y box binding protein 3 -0.0186574
UBE2E2 ubiquitin-conjugating enzyme E2E 2 -0.0184457
MYOF myoferlin -0.0182524
RPS5 ribosomal protein S5 -0.0182344