Retinoic acid_HEC-1-A Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Retinoic acid perturbation in HEC-1-A cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Retinoic acid_HEC-1-A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PRELID2 PRELI domain containing 2 0.0862043
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0649541
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0528313
MACROD2 MACRO domain containing 2 0.047249
RAD51B RAD51 paralog B 0.0453987
FNDC3B fibronectin type III domain containing 3B 0.0419937
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0419794
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0415166
ASPH aspartate beta-hydroxylase 0.0407519
WWOX WW domain containing oxidoreductase 0.037382
SMAD3 SMAD family member 3 0.036385
FHIT fragile histidine triad 0.0355406
ATXN1 ataxin 1 0.0337869
VCL vinculin 0.0329934
SMYD3 SET and MYND domain containing 3 0.0324061
OSBPL10 oxysterol binding protein-like 10 0.0309475
ANKRD36 ankyrin repeat domain 36 0.0286909
LPP LIM domain containing preferred translocation partner in lipoma 0.02802
TBC1D5 TBC1 domain family, member 5 0.0271694
NRIP1 nuclear receptor interacting protein 1 0.0269977
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.0257646
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) 0.0256527
SVIL supervillin 0.0243977
BBS9 Bardet-Biedl syndrome 9 0.024243
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 0.0242009
RUNX1 runt-related transcription factor 1 0.0233912
ZNF638 zinc finger protein 638 0.0227841
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0225626
TRIO trio Rho guanine nucleotide exchange factor 0.0221754
ZSWIM6 zinc finger, SWIM-type containing 6 0.0212021
PAX8 paired box 8 0.0205767
HMGA2 high mobility group AT-hook 2 0.0204689
ZBTB20 zinc finger and BTB domain containing 20 0.0204087
ITGB8 integrin, beta 8 0.0203799
PCSK5 proprotein convertase subtilisin/kexin type 5 0.0203314
DIAPH3 diaphanous-related formin 3 0.0199121
INTS6 integrator complex subunit 6 0.0195088
FNIP1 folliculin interacting protein 1 0.0191145
TJP1 tight junction protein 1 0.0190898
EGFR epidermal growth factor receptor 0.019088
TMTC2 transmembrane and tetratricopeptide repeat containing 2 0.0189498
SMC4 structural maintenance of chromosomes 4 0.0187721
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.0182869
GSK3B glycogen synthase kinase 3 beta 0.0182266
WWC1 WW and C2 domain containing 1 0.0179819
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0179271
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0177984
TTC3 tetratricopeptide repeat domain 3 0.0176802
CEP128 centrosomal protein 128kDa 0.0174711
SUMF1 sulfatase modifying factor 1 0.017229
EXOC4 exocyst complex component 4 0.0171666
PDE4D phosphodiesterase 4D, cAMP-specific 0.0171014
METTL15 methyltransferase like 15 0.0167615
EXT1 exostosin glycosyltransferase 1 0.0161245
PICALM phosphatidylinositol binding clathrin assembly protein 0.0161187
PARD3B par-3 family cell polarity regulator beta 0.0161148
CHST15 carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15 0.0161128
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0160293
RABGAP1L RAB GTPase activating protein 1-like 0.0160141
KDM6A lysine (K)-specific demethylase 6A 0.0159364
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0157621
LINGO2 leucine rich repeat and Ig domain containing 2 0.0154077
PTPRK protein tyrosine phosphatase, receptor type, K 0.015322
KDM4C lysine (K)-specific demethylase 4C 0.0152075
MPRIP myosin phosphatase Rho interacting protein 0.0151678
KIAA1328 KIAA1328 0.0151655
NCEH1 neutral cholesterol ester hydrolase 1 0.0149033
RNF213 ring finger protein 213 0.0149033
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0148977
RALGAPA2 Ral GTPase activating protein, alpha subunit 2 (catalytic) 0.0148953
RFC3 replication factor C (activator 1) 3, 38kDa 0.014742
TRAPPC9 trafficking protein particle complex 9 0.0147409
ERBIN erbb2 interacting protein 0.0147352
DIAPH1 diaphanous-related formin 1 0.0145309
SLC35F5 solute carrier family 35, member F5 0.0143554
DOCK1 dedicator of cytokinesis 1 0.014346
PATJ PATJ crumbs cell polarity complex component 0.0141541
ATXN7 ataxin 7 0.0141452
MYEOV myeloma overexpressed 0.0140642
NFIB nuclear factor I/B 0.0140291
MBNL1 muscleblind-like splicing regulator 1 0.0140259
USP34 ubiquitin specific peptidase 34 0.0139831
MYO9A myosin IXA 0.0139594
SEPTIN9 septin 9 0.0139518
FLNA filamin A, alpha 0.0139426
ECT2 epithelial cell transforming 2 0.0137152
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0136035
MYCBP2 MYC binding protein 2, E3 ubiquitin protein ligase 0.0135461
MBD5 methyl-CpG binding domain protein 5 0.0135102
ANXA11 annexin A11 0.0134492
OGDH oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide) 0.013436
MACC1 metastasis associated in colon cancer 1 0.0134035
CTBP2 C-terminal binding protein 2 0.0133955
ADARB1 adenosine deaminase, RNA-specific, B1 0.0133496
TMCC1 transmembrane and coiled-coil domain family 1 0.0132813
DOCK5 dedicator of cytokinesis 5 0.0132366
CBX5 chromobox homolog 5 0.0129793
DENND1A DENN/MADD domain containing 1A 0.0128371
ARID1B AT rich interactive domain 1B (SWI1-like) 0.0127365
ANO6 anoctamin 6 0.0126493

decreased expression

Symbol Name Standardized Value
MT2A metallothionein 2A -0.101883
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0994681
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0949512
TPT1 tumor protein, translationally-controlled 1 -0.0743612
TMSB10 thymosin beta 10 -0.0723708
RPS6 ribosomal protein S6 -0.06795
FTL ferritin, light polypeptide -0.0614062
ACTG1 actin gamma 1 -0.0591795
PTMA prothymosin, alpha -0.0567618
TMSB4X thymosin beta 4, X-linked -0.0539096
B2M beta-2-microglobulin -0.0533619
RPL23 ribosomal protein L23 -0.0497309
IGFBP3 insulin-like growth factor binding protein 3 -0.0488162
RPL12 ribosomal protein L12 -0.0486229
KRT7 keratin 7, type II -0.0479208
RPL35A ribosomal protein L35a -0.0473974
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0472481
RPL19 ribosomal protein L19 -0.0457936
RPS8 ribosomal protein S8 -0.0447752
EIF1 eukaryotic translation initiation factor 1 -0.0427214
ENO1 enolase 1, (alpha) -0.0420125
LAMB3 laminin, beta 3 -0.0400014
RPL34 ribosomal protein L34 -0.0387767
ANXA2 annexin A2 -0.037478
HMGA1 high mobility group AT-hook 1 -0.0369342
RACK1 receptor for activated C kinase 1 -0.0368316
GOLGA4 golgin A4 -0.0362956
RPL32 ribosomal protein L32 -0.0357805
TPM4 tropomyosin 4 -0.0335896
LDHA lactate dehydrogenase A -0.0331976
AHNAK AHNAK nucleoprotein -0.0320009
RPL31 ribosomal protein L31 -0.0316991
RPS19 ribosomal protein S19 -0.0315679
RPS14 ribosomal protein S14 -0.0305802
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0290866
DSG2 desmoglein 2 -0.0290698
RSL1D1 ribosomal L1 domain containing 1 -0.0284282
S100A10 S100 calcium binding protein A10 -0.0282344
RPLP1 ribosomal protein, large, P1 -0.0278027
RPL8 ribosomal protein L8 -0.0268449
TPI1 triosephosphate isomerase 1 -0.0259971
RPLP0 ribosomal protein, large, P0 -0.0255179
PKM pyruvate kinase, muscle -0.0247724
LMAN1 lectin, mannose-binding, 1 -0.0247482
CANX calnexin -0.0244998
UPP1 uridine phosphorylase 1 -0.0243693
RPL35 ribosomal protein L35 -0.0241132
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon -0.0238559
RPS3 ribosomal protein S3 -0.0236344
CALR calreticulin -0.0235258
RPS27A ribosomal protein S27a -0.0235018
S100A6 S100 calcium binding protein A6 -0.0234329
RPS16 ribosomal protein S16 -0.0233012
RPL26 ribosomal protein L26 -0.0230778
RPLP2 ribosomal protein, large, P2 -0.0229178
H1-0 H1.0 linker histone -0.0229143
CCND1 cyclin D1 -0.0227844
RPL5 ribosomal protein L5 -0.0227482
APP amyloid beta (A4) precursor protein -0.0225949
RPS24 ribosomal protein S24 -0.0225337
LOC112694756 uncharaterized LOC112694756 -0.0217767
RPL11 ribosomal protein L11 -0.0217039
MATR3 matrin 3 -0.0212047
EMP1 epithelial membrane protein 1 -0.0210447
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -0.0209612
GNAS GNAS complex locus -0.0209305
FAM162A family with sequence similarity 162, member A -0.0207754
RPL28 ribosomal protein L28 -0.0207305
RPL15 ribosomal protein L15 -0.020659
RPL7A ribosomal protein L7a -0.020649
RPS12 ribosomal protein S12 -0.0204953
RPL18 ribosomal protein L18 -0.0204583
YBX1 Y box binding protein 1 -0.0202768
EEF2 eukaryotic translation elongation factor 2 -0.019866
RPS13 ribosomal protein S13 -0.0197279
TKT transketolase -0.0193632
CSDE1 cold shock domain containing E1, RNA-binding -0.019339
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0193377
RPS5 ribosomal protein S5 -0.0192803
RPS27 ribosomal protein S27 -0.0192099
TUBB tubulin, beta class I -0.0191994
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0190893
PGK1 phosphoglycerate kinase 1 -0.0190791
RPS23 ribosomal protein S23 -0.0189651
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0189348
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36 -0.0185784
WDR45B WD repeat domain 45B -0.0183073
KDM3A lysine (K)-specific demethylase 3A -0.0181946
EPCAM epithelial cell adhesion molecule -0.0175081
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0174624
RPS25 ribosomal protein S25 -0.01734
KRT18 keratin 18, type I -0.0170875
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha -0.0170619
RPS29 ribosomal protein S29 -0.016996
RPS11 ribosomal protein S11 -0.0169539
SEPTIN7 septin 7 -0.0169523
ARF1 ADP-ribosylation factor 1 -0.0169326
BHLHE40 basic helix-loop-helix family, member e40 -0.0168535
EIF4A2 eukaryotic translation initiation factor 4A2 -0.0168467
RPL14 ribosomal protein L14 -0.016781