Retinoic acid_HS-578T Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Retinoic acid perturbation in HS-578T cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Retinoic acid_HS-578T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
COL6A3 collagen, type VI, alpha 3 0.194469
CDH13 cadherin 13 0.148228
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 0.115753
PSD3 pleckstrin and Sec7 domain containing 3 0.0939003
FBN1 fibrillin 1 0.0863913
EXT1 exostosin glycosyltransferase 1 0.0775847
FNDC3B fibronectin type III domain containing 3B 0.0766464
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.070298
AHNAK AHNAK nucleoprotein 0.0692373
ZBTB20 zinc finger and BTB domain containing 20 0.0633469
ASPH aspartate beta-hydroxylase 0.0608197
LPP LIM domain containing preferred translocation partner in lipoma 0.053789
SMYD3 SET and MYND domain containing 3 0.0527744
PDLIM5 PDZ and LIM domain 5 0.0515045
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A 0.0510675
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0509472
ZFAND3 zinc finger, AN1-type domain 3 0.0501772
PTK2 protein tyrosine kinase 2 0.0499174
NKAIN3 Na+/K+ transporting ATPase interacting 3 0.0488212
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.048365
COL5A1 collagen, type V, alpha 1 0.0481175
VCL vinculin 0.0480657
PRELID2 PRELI domain containing 2 0.0460781
CADM1 cell adhesion molecule 1 0.0446777
NALF1 NALCN channel auxiliary factor 1 0.0439136
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0426446
ATXN1 ataxin 1 0.0424709
CLIC4 chloride intracellular channel 4 0.0415647
ZSWIM6 zinc finger, SWIM-type containing 6 0.040917
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.04001
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 0.0398669
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0397616
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) 0.0395956
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0394357
GRB10 growth factor receptor-bound protein 10 0.0385445
TRIO trio Rho guanine nucleotide exchange factor 0.0383148
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 0.0375022
ZCCHC7 zinc finger, CCHC domain containing 7 0.0374964
MACF1 microtubule-actin crosslinking factor 1 0.0365339
ZC3HAV1 zinc finger CCCH-type, antiviral 1 0.0363294
GSK3B glycogen synthase kinase 3 beta 0.0358846
CAMTA1 calmodulin binding transcription activator 1 0.0355628
TRPS1 trichorhinophalangeal syndrome I 0.0351891
COL7A1 collagen, type VII, alpha 1 0.034963
MBNL1 muscleblind-like splicing regulator 1 0.0346551
LHFPL2 lipoma HMGIC fusion partner-like 2 0.0344895
PDIA5 protein disulfide isomerase family A, member 5 0.0341527
DPYD dihydropyrimidine dehydrogenase 0.0340261
UBR4 ubiquitin protein ligase E3 component n-recognin 4 0.0338428
DOCK5 dedicator of cytokinesis 5 0.0338378
ANKRD11 ankyrin repeat domain 11 0.0336231
HMGA2 high mobility group AT-hook 2 0.033573
PLEC plectin 0.032903
HDAC9 histone deacetylase 9 0.0328629
GLIS3 GLIS family zinc finger 3 0.0321589
VMP1 vacuole membrane protein 1 0.0320265
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.0318148
INTS6 integrator complex subunit 6 0.0310478
EEF2 eukaryotic translation elongation factor 2 0.0301247
HDLBP high density lipoprotein binding protein 0.0294517
ARHGAP35 Rho GTPase activating protein 35 0.0290777
HMCN1 hemicentin 1 0.0287285
SPDYA speedy/RINGO cell cycle regulator family member A 0.0285162
NAV2 neuron navigator 2 0.0283937
PTPRG protein tyrosine phosphatase, receptor type, G 0.0283498
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0282057
CALR calreticulin 0.028062
FNIP1 folliculin interacting protein 1 0.027986
CDK13 cyclin-dependent kinase 13 0.0279399
ATP13A3 ATPase type 13A3 0.0278522
COG5 component of oligomeric golgi complex 5 0.027759
HYCC1 hyccin PI4KA lipid kinase complex subunit 1 0.027703
IQGAP1 IQ motif containing GTPase activating protein 1 0.0274934
TTC3 tetratricopeptide repeat domain 3 0.0272035
SEC61A1 Sec61 alpha 1 subunit (S. cerevisiae) 0.0270065
AGO2 argonaute RISC catalytic component 2 0.0266726
ZNF644 zinc finger protein 644 0.0262239
IARS1 isoleucyl-tRNA synthetase 1 0.0262195
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.0261406
RIGI RNA sensor RIG-I 0.0255739
UBC ubiquitin C 0.0255635
KLF12 Kruppel-like factor 12 0.0254764
VEGFC vascular endothelial growth factor C 0.0254185
CNTN5 contactin 5 0.0254149
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 0.0252906
FMNL2 formin-like 2 0.0252424
CALU calumenin 0.0245331
EDIL3 EGF-like repeats and discoidin I-like domains 3 0.0244588
VPS13B vacuolar protein sorting 13 homolog B (yeast) 0.0243498
PICALM phosphatidylinositol binding clathrin assembly protein 0.0243095
TBC1D22A TBC1 domain family, member 22A 0.0239882
BRIP1 BRCA1 interacting protein C-terminal helicase 1 0.0236332
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1 0.0231729
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0229489
RAD51B RAD51 paralog B 0.0229071
TFG TRK-fused gene 0.022803
NEK10 NIMA-related kinase 10 0.0226953
SOD2 superoxide dismutase 2, mitochondrial 0.0226677
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 0.0223286
GNAI3 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3 0.0221286

decreased expression

Symbol Name Standardized Value
MT2A metallothionein 2A -0.282886
NDRG1 N-myc downstream regulated 1 -0.274074
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.244955
TGFBI transforming growth factor, beta-induced, 68kDa -0.106412
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.103085
VEGFA vascular endothelial growth factor A -0.10217
CD44 CD44 molecule (Indian blood group) -0.0925116
RPS6 ribosomal protein S6 -0.0867541
FTL ferritin, light polypeptide -0.0802488
IGFBP3 insulin-like growth factor binding protein 3 -0.0740631
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.073762
IER3 immediate early response 3 -0.0707451
STC1 stanniocalcin 1 -0.0700873
RPS2 ribosomal protein S2 -0.068556
B2M beta-2-microglobulin -0.0659897
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.0637243
LGALS1 lectin, galactoside-binding, soluble, 1 -0.0635447
S100A9 S100 calcium binding protein A9 -0.0610575
VIM vimentin -0.0605574
EIF1 eukaryotic translation initiation factor 1 -0.0588706
RPS8 ribosomal protein S8 -0.0585678
RPL35A ribosomal protein L35a -0.0575261
PTMA prothymosin, alpha -0.0549651
HILPDA hypoxia inducible lipid droplet-associated -0.0522417
HLA-B major histocompatibility complex, class I, B -0.0521459
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0515558
TMSB10 thymosin beta 10 -0.0491
MT1X metallothionein 1X -0.0454073
LOXL2 lysyl oxidase-like 2 -0.0452027
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0419843
F3 coagulation factor III (thromboplastin, tissue factor) -0.0401618
RPL11 ribosomal protein L11 -0.0400911
RPL7 ribosomal protein L7 -0.0397291
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0397053
RPL37A ribosomal protein L37a -0.0389561
MTSS1 metastasis suppressor 1 -0.0382762
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0379263
ADM adrenomedullin -0.0374627
IGFBP7 insulin-like growth factor binding protein 7 -0.0364161
ARRDC3 arrestin domain containing 3 -0.0363438
BHLHE40 basic helix-loop-helix family, member e40 -0.0358293
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.035719
ALCAM activated leukocyte cell adhesion molecule -0.0356314
RPS19 ribosomal protein S19 -0.0355547
TPT1 tumor protein, translationally-controlled 1 -0.0352165
RPLP2 ribosomal protein, large, P2 -0.0351072
COL1A2 collagen, type I, alpha 2 -0.0339972
RPS12 ribosomal protein S12 -0.0338081
RPL12 ribosomal protein L12 -0.0337669
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0325321
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0323736
LTBP1 latent transforming growth factor beta binding protein 1 -0.0323211
RPL30 ribosomal protein L30 -0.0321568
RPL19 ribosomal protein L19 -0.0320773
RPS13 ribosomal protein S13 -0.0318242
CENPF centromere protein F, 350/400kDa -0.0315931
ELL2 elongation factor, RNA polymerase II, 2 -0.0311083
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 -0.0300324
IFI6 interferon, alpha-inducible protein 6 -0.0295176
RPL36 ribosomal protein L36 -0.0291906
RPLP1 ribosomal protein, large, P1 -0.0291474
TIMP1 TIMP metallopeptidase inhibitor 1 -0.0290889
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0288607
RPL28 ribosomal protein L28 -0.0288202
ACTG1 actin gamma 1 -0.0288012
RPL5 ribosomal protein L5 -0.0287383
RPS14 ribosomal protein S14 -0.0287375
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0271555
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.027146
S100A10 S100 calcium binding protein A10 -0.0265607
HLA-A major histocompatibility complex, class I, A -0.0261097
HAS2 hyaluronan synthase 2 -0.0260755
KMT2E lysine (K)-specific methyltransferase 2E -0.0260076
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0258232
RLF rearranged L-myc fusion -0.0256989
FAM162A family with sequence similarity 162, member A -0.0255307
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.025528
RPL9 ribosomal protein L9 -0.0254223
NAMPT nicotinamide phosphoribosyltransferase -0.0253653
RPL37 ribosomal protein L37 -0.0244847
POTEF POTE ankyrin domain family, member F -0.0244317
H3-3B H3.3 histone B -0.0241419
ECE1 endothelin converting enzyme 1 -0.0237737
IRF1 interferon regulatory factor 1 -0.0236408
RPL26 ribosomal protein L26 -0.0233804
LDHA lactate dehydrogenase A -0.0231201
RACK1 receptor for activated C kinase 1 -0.0230896
DEPP1 DEPP autophagy regulator 1 -0.0229291
ZNF292 zinc finger protein 292 -0.0228537
LOC102724023 ES1 protein homolog, mitochondrial -0.0228384
RPL32 ribosomal protein L32 -0.0227801
RPL23 ribosomal protein L23 -0.0226198
RPS3 ribosomal protein S3 -0.0223916
UGCG UDP-glucose ceramide glucosyltransferase -0.02229
RPL34 ribosomal protein L34 -0.0217919
TNIP1 TNFAIP3 interacting protein 1 -0.0216412
RPL8 ribosomal protein L8 -0.0213473
PNRC1 proline-rich nuclear receptor coactivator 1 -0.0212787
RPS16 ribosomal protein S16 -0.0212286
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 -0.0211517