Retinoic acid_HT-29 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Retinoic acid perturbation in HT-29 cell line (Tahoe Therapeutics)
Similar Terms
Downloads & Tools

Genes

200 genes differentially expressed following the Retinoic acid_HT-29 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
LMO7 LIM domain 7 0.2159
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 0.170662
EXT1 exostosin glycosyltransferase 1 0.122855
FTH1 ferritin, heavy polypeptide 1 0.106718
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0907317
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0891858
NTN4 netrin 4 0.0840152
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0784468
ATXN1 ataxin 1 0.0761123
ERRFI1 ERBB receptor feedback inhibitor 1 0.0759041
BCL2L1 BCL2-like 1 0.0725003
SMAD3 SMAD family member 3 0.0688446
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.06323
PDZD8 PDZ domain containing 8 0.0624493
ARHGAP29 Rho GTPase activating protein 29 0.0599658
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0582064
EPS8 epidermal growth factor receptor pathway substrate 8 0.0528059
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.051989
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0516659
FHL2 four and a half LIM domains 2 0.0510423
SPRED2 sprouty-related, EVH1 domain containing 2 0.0498254
DPP4 dipeptidyl-peptidase 4 0.0468356
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0445143
PDLIM5 PDZ and LIM domain 5 0.0440862
EZR ezrin 0.0435094
CTBP2 C-terminal binding protein 2 0.0419888
CCNYL1 cyclin Y-like 1 0.0413919
RPS8 ribosomal protein S8 0.0409468
HSD17B2 hydroxysteroid (17-beta) dehydrogenase 2 0.0405052
TJP1 tight junction protein 1 0.0399944
ZC3HAV1 zinc finger CCCH-type, antiviral 1 0.0392986
PELI1 pellino E3 ubiquitin protein ligase 1 0.0388342
FOXO1 forkhead box O1 0.0382837
AFF1 AF4/FMR2 family, member 1 0.0376644
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 0.0362258
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0358682
SPATS2L spermatogenesis associated, serine-rich 2-like 0.0356772
LCOR ligand dependent nuclear receptor corepressor 0.0355689
GCNT3 glucosaminyl (N-acetyl) transferase 3, mucin type 0.0348295
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0347183
KMT2E lysine (K)-specific methyltransferase 2E 0.0345699
RPS17 ribosomal protein S17 0.0329768
MYO5B myosin VB 0.0323871
FOSB FBJ murine osteosarcoma viral oncogene homolog B 0.0322919
DIAPH1 diaphanous-related formin 1 0.0320944
NEBL nebulette 0.0320899
UBN2 ubinuclein 2 0.0319287
PRKN parkin RBR E3 ubiquitin protein ligase 0.0318212
FNDC3B fibronectin type III domain containing 3B 0.0315586
RPS3 ribosomal protein S3 0.0314438
VCL vinculin 0.0306829
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0305279
VEGFA vascular endothelial growth factor A 0.029874
ARHGAP42 Rho GTPase activating protein 42 0.0297175
NCEH1 neutral cholesterol ester hydrolase 1 0.02944
MYO1E myosin IE 0.0294323
TMCO3 transmembrane and coiled-coil domains 3 0.0293535
TSPAN5 tetraspanin 5 0.0290213
FTL ferritin, light polypeptide 0.0287641
SIK3 SIK family kinase 3 0.0286318
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0283871
GAREM1 GRB2 associated regulator of MAPK1 subtype 1 0.028359
ACSL3 acyl-CoA synthetase long-chain family member 3 0.0282651
PCCA propionyl CoA carboxylase, alpha polypeptide 0.0280948
MBNL2 muscleblind-like splicing regulator 2 0.0280126
ADGRG6 adhesion G protein-coupled receptor G6 0.0279839
ROCK2 Rho-associated, coiled-coil containing protein kinase 2 0.0279585
TXNRD1 thioredoxin reductase 1 0.0278826
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 0.0277414
PDIA4 protein disulfide isomerase family A, member 4 0.0273357
SEC31A SEC31 homolog A (S. cerevisiae) 0.0266056
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 0.026355
PGCKA1 PDCD10 and GCKIII kinases associated 1 0.0263194
JMY junction mediating and regulatory protein, p53 cofactor 0.0260156
RPS25 ribosomal protein S25 0.0258268
KDM6A lysine (K)-specific demethylase 6A 0.0257866
KTN1 kinectin 1 (kinesin receptor) 0.0256865
LIMA1 LIM domain and actin binding 1 0.0252203
LATS2 large tumor suppressor kinase 2 0.024866
EREG epiregulin 0.0247205
HKDC1 hexokinase domain containing 1 0.0241383
DUSP16 dual specificity phosphatase 16 0.0239536
UBE2R2 ubiquitin-conjugating enzyme E2R 2 0.0236782
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 0.0236271
FAM13A family with sequence similarity 13, member A 0.0235214
RPS13 ribosomal protein S13 0.0234982
PDE10A phosphodiesterase 10A 0.0233987
SH3KBP1 SH3-domain kinase binding protein 1 0.0233063
ARHGAP23 Rho GTPase activating protein 23 0.0232452
AREG amphiregulin 0.0227752
LPIN2 lipin 2 0.0226583
LURAP1L leucine rich adaptor protein 1-like 0.0226502
CLIC5 chloride intracellular channel 5 0.0226238
SGMS2 sphingomyelin synthase 2 0.0224089
PICALM phosphatidylinositol binding clathrin assembly protein 0.0223649
ACVR1 activin A receptor, type I 0.0221877
GLCCI1 glucocorticoid induced 1 0.0220354
ITPRID2 ITPR interacting domain containing 2 0.0219905
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3 0.0219454
DST dystonin 0.0218747

decreased expression

Symbol Name Standardized Value
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5 -0.188652
AHNAK AHNAK nucleoprotein -0.16409
SLC45A4 solute carrier family 45, member 4 -0.144824
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.129678
GMDS GDP-mannose 4,6-dehydratase -0.123736
LAMA4 laminin, alpha 4 -0.112738
NDRG1 N-myc downstream regulated 1 -0.111499
DIAPH2 diaphanous-related formin 2 -0.100644
ANXA2 annexin A2 -0.0997472
KRT8 keratin 8, type II -0.0965855
NAALADL2 N-acetylated alpha-linked acidic dipeptidase-like 2 -0.0925859
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.084701
SAMD12 sterile alpha motif domain containing 12 -0.0835473
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 -0.0803298
MYH14 myosin, heavy chain 14, non-muscle -0.0758538
KRT20 keratin 20, type I -0.0693922
JUN jun proto-oncogene -0.0675656
ACTN4 actinin, alpha 4 -0.0667927
PRELID2 PRELI domain containing 2 -0.065962
TPT1 tumor protein, translationally-controlled 1 -0.0621992
NECTIN2 nectin cell adhesion molecule 2 -0.0603652
FRY furry homolog (Drosophila) -0.0596304
RAD21 RAD21 homolog (S. pombe) -0.0586537
EGR1 early growth response 1 -0.0575838
GSN gelsolin -0.0553183
TFRC transferrin receptor -0.0549021
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.0531328
KLF10 Kruppel-like factor 10 -0.0530442
MCL1 myeloid cell leukemia 1 -0.048047
CAPN8 calpain 8 -0.0459355
ADARB1 adenosine deaminase, RNA-specific, B1 -0.043974
TMSB10 thymosin beta 10 -0.0432337
CCSER1 coiled-coil serine-rich protein 1 -0.0424642
EXOC4 exocyst complex component 4 -0.040979
WASF2 WAS protein family, member 2 -0.0406529
ACACA acetyl-CoA carboxylase alpha -0.0390468
SQSTM1 sequestosome 1 -0.0389979
RRBP1 ribosome binding protein 1 -0.0385456
RBM39 RNA binding motif protein 39 -0.03842
PARP4 poly (ADP-ribose) polymerase family, member 4 -0.0379471
JUP junction plakoglobin -0.0376289
PGK1 phosphoglycerate kinase 1 -0.0375848
GARS1 glycyl-tRNA synthetase 1 -0.0370772
ITPKC inositol-trisphosphate 3-kinase C -0.0364359
ZBTB20 zinc finger and BTB domain containing 20 -0.0364082
FOS FBJ murine osteosarcoma viral oncogene homolog -0.0363437
SEMA4B sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B -0.0363148
NF1 neurofibromin 1 -0.0362396
POF1B premature ovarian failure, 1B -0.0361473
THOC2 THO complex 2 -0.0359969
SDCBP syndecan binding protein (syntenin) -0.0357831
CBL Cbl proto-oncogene, E3 ubiquitin protein ligase -0.0357762
MAML2 mastermind-like 2 (Drosophila) -0.0357275
DGKH diacylglycerol kinase, eta -0.0355533
RNF213 ring finger protein 213 -0.0352183
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.0348385
ZMYND8 zinc finger, MYND-type containing 8 -0.0346419
IRF1 interferon regulatory factor 1 -0.0345778
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0344862
MMP7 matrix metallopeptidase 7 -0.0342007
LDHA lactate dehydrogenase A -0.0341288
PATJ PATJ crumbs cell polarity complex component -0.0334753
NIBAN2 niban apoptosis regulator 2 -0.0325246
FARP1 FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived) -0.0321587
ASPH aspartate beta-hydroxylase -0.0320797
CAMK2D calcium/calmodulin-dependent protein kinase II delta -0.0318685
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa -0.0317407
TM9SF3 transmembrane 9 superfamily member 3 -0.031481
KLF3 Kruppel-like factor 3 (basic) -0.0311703
NPSR1 neuropeptide S receptor 1 -0.031159
MUC13 mucin 13, cell surface associated -0.0307902
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3 -0.0304997
PTK2 protein tyrosine kinase 2 -0.0295488
PTPRH protein tyrosine phosphatase, receptor type, H -0.0295288
DSPP dentin sialophosphoprotein -0.0294285
IGF1R insulin-like growth factor 1 receptor -0.0290699
PRKCA protein kinase C, alpha -0.0287996
DLG1 discs, large homolog 1 (Drosophila) -0.028528
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0283324
CAMKMT calmodulin-lysine N-methyltransferase -0.0283114
ANKHD1 ankyrin repeat and KH domain containing 1 -0.0278178
ITGA6 integrin, alpha 6 -0.0278083
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.0275201
PERP PERP, TP53 apoptosis effector -0.0271271
RPS21 ribosomal protein S21 -0.0270928
ITGA1 integrin, alpha 1 -0.0268792
ZNF207 zinc finger protein 207 -0.0268083
INTS6 integrator complex subunit 6 -0.0266851
DDIT3 DNA-damage-inducible transcript 3 -0.0264719
CCDC91 coiled-coil domain containing 91 -0.0263974
TRPS1 trichorhinophalangeal syndrome I -0.0262732
SPDYA speedy/RINGO cell cycle regulator family member A -0.0261193
PPP1R10 protein phosphatase 1, regulatory subunit 10 -0.0261143
KLF5 Kruppel-like factor 5 (intestinal) -0.0260647
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein -0.0257876
PAN3 PAN3 poly(A) specific ribonuclease subunit -0.0257771
USP34 ubiquitin specific peptidase 34 -0.0257455
MKI67 marker of proliferation Ki-67 -0.0255857
MECOM MDS1 and EVI1 complex locus -0.0254545
KRT19 keratin 19, type I -0.0254418