Retinoic acid_HepG2/C3A Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Retinoic acid perturbation in HepG2/C3A cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Retinoic acid_HepG2/C3A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
SAMD4A sterile alpha motif domain containing 4A 0.0511206
SVIL supervillin 0.0423988
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0414502
LRMDA leucine rich melanocyte differentiation associated 0.0326674
FNDC3B fibronectin type III domain containing 3B 0.0276987
TNS1 tensin 1 0.0271866
SMAD3 SMAD family member 3 0.0253545
DNAH17 dynein, axonemal, heavy chain 17 0.0248164
TRIO trio Rho guanine nucleotide exchange factor 0.023501
APOB apolipoprotein B 0.0232382
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) 0.0227949
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0222468
ATXN1 ataxin 1 0.0218188
DOCK4 dedicator of cytokinesis 4 0.0209705
VMP1 vacuole membrane protein 1 0.02052
AFDN afadin, adherens junction formation factor 0.0204145
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 0.0196716
MACF1 microtubule-actin crosslinking factor 1 0.0188395
FAT1 FAT atypical cadherin 1 0.0179498
UBR4 ubiquitin protein ligase E3 component n-recognin 4 0.0175935
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0174671
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 0.0173316
BCL2L1 BCL2-like 1 0.0167842
IGFBP1 insulin-like growth factor binding protein 1 0.0167132
GPC6 glypican 6 0.0167092
RALGAPA2 Ral GTPase activating protein, alpha subunit 2 (catalytic) 0.0166128
NRIP1 nuclear receptor interacting protein 1 0.0165847
PDLIM5 PDZ and LIM domain 5 0.0164199
YAP1 Yes-associated protein 1 0.0157491
MYH9 myosin, heavy chain 9, non-muscle 0.0155609
SPATS2L spermatogenesis associated, serine-rich 2-like 0.0155185
DST dystonin 0.0149519
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0148673
NKD1 naked cuticle homolog 1 (Drosophila) 0.0146197
TPM1 tropomyosin 1 (alpha) 0.0140833
PPARD peroxisome proliferator-activated receptor delta 0.0140437
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0139611
TNS3 tensin 3 0.0139557
DIAPH1 diaphanous-related formin 1 0.0136681
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0136229
RUNX1 runt-related transcription factor 1 0.0134543
DOCK5 dedicator of cytokinesis 5 0.0131136
LCOR ligand dependent nuclear receptor corepressor 0.0129362
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0127753
KYNU kynureninase 0.0127559
RAI14 retinoic acid induced 14 0.0127421
GPAM glycerol-3-phosphate acyltransferase, mitochondrial 0.0126138
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) 0.0125393
SEPTIN9 septin 9 0.0124141
GK glycerol kinase 0.0123207
PSME4 proteasome (prosome, macropain) activator subunit 4 0.0121587
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0118788
CEMIP2 cell migration inducing hyaluronidase 2 0.0117853
FARP1 FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived) 0.0116976
PRAG1 PEAK1 related, kinase-activating pseudokinase 1 0.0116572
JMJD1C jumonji domain containing 1C 0.0116512
ACTR3 ARP3 actin-related protein 3 homolog (yeast) 0.0114759
DIP2B DIP2 disco-interacting protein 2 homolog B (Drosophila) 0.0114207
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0113636
ANO6 anoctamin 6 0.0112053
EIF4B eukaryotic translation initiation factor 4B 0.0109435
PKP4 plakophilin 4 0.0108807
SHB Src homology 2 domain containing adaptor protein B 0.010813
USP6NL USP6 N-terminal like 0.0107933
ADAM9 ADAM metallopeptidase domain 9 0.01075
MYO1B myosin IB 0.010589
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.010571
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0105525
UBASH3B ubiquitin associated and SH3 domain containing B 0.0104902
SKIL SKI-like proto-oncogene 0.0103868
SESTD1 SEC14 and spectrin domains 1 0.0103702
MSI2 musashi RNA-binding protein 2 0.0103085
SFPQ splicing factor proline/glutamine-rich 0.0103059
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.0102664
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 0.0101872
VPS13B vacuolar protein sorting 13 homolog B (yeast) 0.010062
ENAH enabled homolog (Drosophila) 0.0100278
ITGAV integrin, alpha V 0.00988762
FAM135A family with sequence similarity 135, member A 0.00984886
ZNF638 zinc finger protein 638 0.00984103
ITCH itchy E3 ubiquitin protein ligase 0.00980065
MBNL1 muscleblind-like splicing regulator 1 0.00977322
RPL3 ribosomal protein L3 0.00965214
IGF1R insulin-like growth factor 1 receptor 0.00961219
MAML2 mastermind-like 2 (Drosophila) 0.00957714
WWTR1 WW domain containing transcription regulator 1 0.0095042
NBAS neuroblastoma amplified sequence 0.0093774
ABTB3 ankyrin repeat and BTB domain containing 3 0.00937458
LRRTM4 leucine rich repeat transmembrane neuronal 4 0.00937399
TBC1D22A TBC1 domain family, member 22A 0.00935931
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.0093399
FKTN fukutin 0.00933107
PTK2 protein tyrosine kinase 2 0.00927904
ARHGAP9 Rho GTPase activating protein 9 0.00923845
RASA2 RAS p21 protein activator 2 0.00922882
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 0.00915882
KPNA4 karyopherin alpha 4 (importin alpha 3) 0.00914458
CHST15 carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15 0.00908399
ERRFI1 ERBB receptor feedback inhibitor 1 0.00903236
PTP4A1 protein tyrosine phosphatase type IVA, member 1 0.00892032

decreased expression

Symbol Name Standardized Value
IGF2 insulin-like growth factor 2 -0.682976
TPT1 tumor protein, translationally-controlled 1 -0.153351
APOA2 apolipoprotein A-II -0.120398
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.105044
MT2A metallothionein 2A -0.0971286
AKAP12 A kinase (PRKA) anchor protein 12 -0.0884391
TMSB10 thymosin beta 10 -0.087713
RPS24 ribosomal protein S24 -0.0774197
GPC3 glypican 3 -0.0744253
ENO1 enolase 1, (alpha) -0.0734402
RPL11 ribosomal protein L11 -0.073234
RPS8 ribosomal protein S8 -0.0687406
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0662817
RPL37A ribosomal protein L37a -0.062496
RPL35A ribosomal protein L35a -0.0622955
RPS6 ribosomal protein S6 -0.0614457
FTL ferritin, light polypeptide -0.0609819
TM4SF1 transmembrane 4 L six family member 1 -0.0599736
AHSG alpha-2-HS-glycoprotein -0.057827
SLC38A2 solute carrier family 38, member 2 -0.0572726
HMGA1 high mobility group AT-hook 1 -0.0571038
RPLP1 ribosomal protein, large, P1 -0.051888
RPL34 ribosomal protein L34 -0.051059
RPS12 ribosomal protein S12 -0.0507595
RPS27A ribosomal protein S27a -0.0499135
RPS21 ribosomal protein S21 -0.0496028
RPL26 ribosomal protein L26 -0.047078
RPLP0 ribosomal protein, large, P0 -0.0467548
RPL23 ribosomal protein L23 -0.0465121
RPL31 ribosomal protein L31 -0.0450703
RPL12 ribosomal protein L12 -0.0420921
CP ceruloplasmin (ferroxidase) -0.0418435
ASPH aspartate beta-hydroxylase -0.0412548
RPL9 ribosomal protein L9 -0.0405901
GNAS GNAS complex locus -0.0400383
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 -0.0389037
RPS19 ribosomal protein S19 -0.0379793
APOE apolipoprotein E -0.0369989
NDRG1 N-myc downstream regulated 1 -0.036734
PLIN2 perilipin 2 -0.0366992
RPLP2 ribosomal protein, large, P2 -0.0365846
ACSL4 acyl-CoA synthetase long-chain family member 4 -0.0364985
PTMA prothymosin, alpha -0.0363426
RPS13 ribosomal protein S13 -0.0342736
EIF1 eukaryotic translation initiation factor 1 -0.0342501
AMBP alpha-1-microglobulin/bikunin precursor -0.0339015
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0335406
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0333079
RPS3 ribosomal protein S3 -0.0321895
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0313327
RPL5 ribosomal protein L5 -0.0306647
RPL37 ribosomal protein L37 -0.0303403
RPS14 ribosomal protein S14 -0.0302747
B2M beta-2-microglobulin -0.0301659
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.0299821
FN1 fibronectin 1 -0.0299463
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0288371
RACK1 receptor for activated C kinase 1 -0.0288195
TIMP1 TIMP metallopeptidase inhibitor 1 -0.0287111
ZMYND8 zinc finger, MYND-type containing 8 -0.0285155
RPS5 ribosomal protein S5 -0.0282793
PTTG1IP pituitary tumor-transforming 1 interacting protein -0.0281527
S100A9 S100 calcium binding protein A9 -0.0280201
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -0.0278507
RPS23 ribosomal protein S23 -0.0277208
ISG15 ISG15 ubiquitin-like modifier -0.0274328
RPL32 ribosomal protein L32 -0.0272304
RPS29 ribosomal protein S29 -0.0267469
IFITM1 interferon induced transmembrane protein 1 -0.026405
ACTG1 actin gamma 1 -0.0261639
STAU1 staufen double-stranded RNA binding protein 1 -0.0258134
RPS25 ribosomal protein S25 -0.0253968
IRF2BP2 interferon regulatory factor 2 binding protein 2 -0.0253219
RPL38 ribosomal protein L38 -0.0250509
RPL19 ribosomal protein L19 -0.024829
NAP1L1 nucleosome assembly protein 1-like 1 -0.0247825
LDHA lactate dehydrogenase A -0.0245898
ETFB electron-transfer-flavoprotein, beta polypeptide -0.023958
SDC4 syndecan 4 -0.0239186
TPM4 tropomyosin 4 -0.0225253
EGR1 early growth response 1 -0.0224995
NPR2 natriuretic peptide receptor 2 -0.0224943
PTPRF protein tyrosine phosphatase, receptor type, F -0.0222811
IFI6 interferon, alpha-inducible protein 6 -0.0222557
RPL28 ribosomal protein L28 -0.0220486
APOA1 apolipoprotein A-I -0.0218963
RPS16 ribosomal protein S16 -0.0214913
RPS10 ribosomal protein S10 -0.0213764
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3 -0.021075
TRIM26 tripartite motif containing 26 -0.021022
RPL10A ribosomal protein L10a -0.0208745
KDM3A lysine (K)-specific demethylase 3A -0.0208214
HLA-A major histocompatibility complex, class I, A -0.0204726
PRRC2C proline-rich coiled-coil 2C -0.0202834
PERP PERP, TP53 apoptosis effector -0.0201947
RPL7A ribosomal protein L7a -0.0201064
RPS11 ribosomal protein S11 -0.0200517
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0200179
S100A6 S100 calcium binding protein A6 -0.0200074
RPL30 ribosomal protein L30 -0.0199979