Retinoic acid_Hs 766T Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Retinoic acid perturbation in Hs 766T cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Retinoic acid_Hs 766T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
TIMP3 TIMP metallopeptidase inhibitor 3 0.116744
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.112689
PDE4D phosphodiesterase 4D, cAMP-specific 0.103725
SLC35F3 solute carrier family 35, member F3 0.100375
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 0.0971014
MTSS1 metastasis suppressor 1 0.0952438
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0833224
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3 0.0671322
RAI14 retinoic acid induced 14 0.0631455
PTK2 protein tyrosine kinase 2 0.0603495
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0603486
LMO7 LIM domain 7 0.0559693
ANO1 anoctamin 1, calcium activated chloride channel 0.0557542
ST3GAL6 ST3 beta-galactoside alpha-2,3-sialyltransferase 6 0.054913
PALM2AKAP2 PALM2 and AKAP2 fusion 0.0542242
DOK5 docking protein 5 0.0525123
MSN moesin 0.052042
RAD51B RAD51 paralog B 0.0465186
ABI3BP ABI family, member 3 (NESH) binding protein 0.0456372
NAV2 neuron navigator 2 0.0442643
RNF217 ring finger protein 217 0.0439444
MACF1 microtubule-actin crosslinking factor 1 0.0438854
LAMC2 laminin, gamma 2 0.0422919
NRIP1 nuclear receptor interacting protein 1 0.0420075
IFI44L interferon-induced protein 44-like 0.0401825
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0400061
BCAR3 breast cancer anti-estrogen resistance 3 0.038934
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase) 0.0384747
MBOAT2 membrane bound O-acyltransferase domain containing 2 0.0382694
DPYD dihydropyrimidine dehydrogenase 0.0372703
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 0.0372291
FRMD6 FERM domain containing 6 0.0361342
UTRN utrophin 0.0354409
CALB1 calbindin 1, 28kDa 0.0354092
AKAP13 A kinase (PRKA) anchor protein 13 0.035143
KCNK1 potassium channel, two pore domain subfamily K, member 1 0.0343104
HMGA2 high mobility group AT-hook 2 0.0341285
PDLIM5 PDZ and LIM domain 5 0.0333774
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0332681
TGM2 transglutaminase 2 0.0331344
PCDH1 protocadherin 1 0.0327929
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0322405
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0319861
ABLIM3 actin binding LIM protein family, member 3 0.0317976
PLS3 plastin 3 0.0312599
RABGAP1L RAB GTPase activating protein 1-like 0.0309675
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 0.0305822
PSD3 pleckstrin and Sec7 domain containing 3 0.0303888
EFNA5 ephrin-A5 0.0303602
SULF2 sulfatase 2 0.0302456
EGFR epidermal growth factor receptor 0.0297217
THSD4 thrombospondin, type I, domain containing 4 0.0291147
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.0284577
GRB10 growth factor receptor-bound protein 10 0.0283544
INTS6 integrator complex subunit 6 0.0283219
NCOR2 nuclear receptor corepressor 2 0.0280973
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0280047
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 0.0277014
CDK6 cyclin-dependent kinase 6 0.0274798
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.026957
TENM4 teneurin transmembrane protein 4 0.0265239
HDAC9 histone deacetylase 9 0.0264031
RASAL2 RAS protein activator like 2 0.0262692
ALCAM activated leukocyte cell adhesion molecule 0.0258267
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0253542
LAMA5 laminin, alpha 5 0.0253304
COL5A1 collagen, type V, alpha 1 0.0250808
EXOC4 exocyst complex component 4 0.0250636
VEGFA vascular endothelial growth factor A 0.0248379
MEGF6 multiple EGF-like-domains 6 0.0248194
FAF1 Fas (TNFRSF6) associated factor 1 0.0247712
LRP1B low density lipoprotein receptor-related protein 1B 0.0245717
PPARG peroxisome proliferator-activated receptor gamma 0.0241688
ZSWIM6 zinc finger, SWIM-type containing 6 0.0241185
ATP9A ATPase, class II, type 9A 0.0236109
FTH1 ferritin, heavy polypeptide 1 0.023536
LPP LIM domain containing preferred translocation partner in lipoma 0.0232195
FNIP1 folliculin interacting protein 1 0.0231562
ZC3H12C zinc finger CCCH-type containing 12C 0.0231016
CUX1 cut-like homeobox 1 0.0224408
HSPH1 heat shock 105kDa/110kDa protein 1 0.0221449
CDCP1 CUB domain containing protein 1 0.0218132
SYNE2 spectrin repeat containing, nuclear envelope 2 0.0210568
CDKN2A cyclin-dependent kinase inhibitor 2A 0.0209824
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like 0.0209765
CSMD2 CUB and Sushi multiple domains 2 0.0208566
TPM3 tropomyosin 3 0.0207109
SOX5 SRY (sex determining region Y)-box 5 0.0203274
N4BP2L2 NEDD4 binding protein 2-like 2 0.0203076
SLCO4A1 solute carrier organic anion transporter family, member 4A1 0.0199164
MAML2 mastermind-like 2 (Drosophila) 0.0198501
SDCCAG8 serologically defined colon cancer antigen 8 0.0196461
ZEB1 zinc finger E-box binding homeobox 1 0.0195898
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0194432
BACE2 beta-site APP-cleaving enzyme 2 0.0193631
SIK3 SIK family kinase 3 0.0189688
MYO10 myosin X 0.0187897
SPIRE1 spire-type actin nucleation factor 1 0.0187801
KIAA1671 KIAA1671 0.0187719
UBA6 ubiquitin-like modifier activating enzyme 6 0.0186542

decreased expression

Symbol Name Standardized Value
FLNB filamin B, beta -0.17908
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.176191
TMSB10 thymosin beta 10 -0.116956
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.102793
KRT17 keratin 17, type I -0.102232
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0925466
CLU clusterin -0.091652
LMNA lamin A/C -0.0905169
PTMA prothymosin, alpha -0.08271
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.080615
LOC112694756 uncharaterized LOC112694756 -0.0786512
S100A10 S100 calcium binding protein A10 -0.0782358
H1-0 H1.0 linker histone -0.0736028
AHNAK AHNAK nucleoprotein -0.0716685
NAMPT nicotinamide phosphoribosyltransferase -0.0714421
RPS21 ribosomal protein S21 -0.0709828
ANXA2 annexin A2 -0.0703275
ANKRD33B ankyrin repeat domain 33B -0.0694899
TMSB4X thymosin beta 4, X-linked -0.0689729
EMP1 epithelial membrane protein 1 -0.0686567
NDRG1 N-myc downstream regulated 1 -0.0655641
PGK1 phosphoglycerate kinase 1 -0.0598261
FOXO1 forkhead box O1 -0.0564397
GNAS GNAS complex locus -0.0553174
KRT6A keratin 6A, type II -0.054235
CUL4B cullin 4B -0.0540369
TRIO trio Rho guanine nucleotide exchange factor -0.0533838
OGA O-GlcNAcase -0.053168
RBM39 RNA binding motif protein 39 -0.052971
STC1 stanniocalcin 1 -0.0524347
FN1 fibronectin 1 -0.0521996
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0509452
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) -0.0508621
SEC31A SEC31 homolog A (S. cerevisiae) -0.0500193
CANX calnexin -0.0489607
NCOA3 nuclear receptor coactivator 3 -0.0489518
YBX3 Y box binding protein 3 -0.0479845
FSCN1 fascin actin-bundling protein 1 -0.0478408
ENO1 enolase 1, (alpha) -0.0470775
CAVIN1 caveolae associated protein 1 -0.0469742
B2M beta-2-microglobulin -0.0465855
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0463491
GOLGA4 golgin A4 -0.0455193
MT2A metallothionein 2A -0.0453756
BCL2L1 BCL2-like 1 -0.0451393
NRG1 neuregulin 1 -0.0448889
MORF4L2 mortality factor 4 like 2 -0.0444487
COPB1 coatomer protein complex, subunit beta 1 -0.0443473
EIF1 eukaryotic translation initiation factor 1 -0.0439242
NEK7 NIMA-related kinase 7 -0.0437378
KDM3A lysine (K)-specific demethylase 3A -0.0435019
ANLN anillin, actin binding protein -0.0419866
CD44 CD44 molecule (Indian blood group) -0.0419419
SQLE squalene epoxidase -0.0415584
CAV1 caveolin 1, caveolae protein, 22kDa -0.0415159
RPLP1 ribosomal protein, large, P1 -0.0408728
MINDY2 MINDY lysine 48 deubiquitinase 2 -0.0402898
SLC45A4 solute carrier family 45, member 4 -0.04023
IFITM3 interferon induced transmembrane protein 3 -0.0401674
RPL11 ribosomal protein L11 -0.0401575
ARF1 ADP-ribosylation factor 1 -0.0400913
WASF2 WAS protein family, member 2 -0.0399188
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0398442
ALDH3A1 aldehyde dehydrogenase 3 family, member A1 -0.0392955
RPLP2 ribosomal protein, large, P2 -0.0390779
ITCH itchy E3 ubiquitin protein ligase -0.0390704
CTNND1 catenin (cadherin-associated protein), delta 1 -0.0383399
VCL vinculin -0.0381439
S100A6 S100 calcium binding protein A6 -0.0380423
RPS6 ribosomal protein S6 -0.0378628
PJA2 praja ring finger 2, E3 ubiquitin protein ligase -0.0378251
ERC2 ELKS/RAB6-interacting/CAST family member 2 -0.0376728
PALLD palladin, cytoskeletal associated protein -0.0373354
DUSP6 dual specificity phosphatase 6 -0.0363808
LDHA lactate dehydrogenase A -0.0362511
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.0357998
S100A2 S100 calcium binding protein A2 -0.0355297
RPL8 ribosomal protein L8 -0.0354847
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0352865
EPHA2 EPH receptor A2 -0.0345705
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0345454
RAD21 RAD21 homolog (S. pombe) -0.0342598
SPAG9 sperm associated antigen 9 -0.0341763
SF3B2 splicing factor 3b, subunit 2, 145kDa -0.034075
LMAN1 lectin, mannose-binding, 1 -0.0339776
SERINC3 serine incorporator 3 -0.0334984
RPL12 ribosomal protein L12 -0.033215
HDLBP high density lipoprotein binding protein -0.0332029
SEMA4B sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B -0.0329414
LGALS1 lectin, galactoside-binding, soluble, 1 -0.0328003
PTPN13 protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase) -0.0326349
CALU calumenin -0.0325719
CD99 CD99 molecule -0.0325144
CEMIP cell migration inducing protein, hyaluronan binding -0.0324878
OSMR oncostatin M receptor -0.0324479
ANXA1 annexin A1 -0.032379
TKT transketolase -0.0320675
HLA-E major histocompatibility complex, class I, E -0.0319527
KRT14 keratin 14, type I -0.0318924
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0317345