Retinoic acid_J82 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Retinoic acid perturbation in J82 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Retinoic acid_J82 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
IGFBP3 insulin-like growth factor binding protein 3 0.132445
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.104924
UBA6 ubiquitin-like modifier activating enzyme 6 0.0792484
NAV2 neuron navigator 2 0.0778146
MSN moesin 0.0738211
PTK2 protein tyrosine kinase 2 0.0710424
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0691196
ERBIN erbb2 interacting protein 0.0655919
DLG1 discs, large homolog 1 (Drosophila) 0.0606937
FTH1 ferritin, heavy polypeptide 1 0.0565963
KTN1 kinectin 1 (kinesin receptor) 0.0523718
PICALM phosphatidylinositol binding clathrin assembly protein 0.0497319
ASPH aspartate beta-hydroxylase 0.0496055
FLNB filamin B, beta 0.0494386
TPM3 tropomyosin 3 0.0478076
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0477035
PTPN14 protein tyrosine phosphatase, non-receptor type 14 0.0476487
FOSL1 FOS-like antigen 1 0.0452207
VIM vimentin 0.0432981
PDLIM5 PDZ and LIM domain 5 0.0418914
DTNA dystrobrevin, alpha 0.0415898
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 0.0395061
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0388403
UGCG UDP-glucose ceramide glucosyltransferase 0.0383725
VEGFA vascular endothelial growth factor A 0.0378774
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.0371761
STC2 stanniocalcin 2 0.0364508
POTEF POTE ankyrin domain family, member F 0.0363081
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0359886
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0342509
SMAD3 SMAD family member 3 0.0339836
CCNY cyclin Y 0.0339001
AXL AXL receptor tyrosine kinase 0.0325188
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0319553
SYNE2 spectrin repeat containing, nuclear envelope 2 0.0317239
MACF1 microtubule-actin crosslinking factor 1 0.0316851
FAM120A family with sequence similarity 120A 0.0313123
TPD52 tumor protein D52 0.0311028
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0306807
ZSWIM6 zinc finger, SWIM-type containing 6 0.0302965
ZNF638 zinc finger protein 638 0.0301849
SEPTIN9 septin 9 0.0299022
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.0297987
PKM pyruvate kinase, muscle 0.0297559
MCL1 myeloid cell leukemia 1 0.0294809
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.0294773
RND3 Rho family GTPase 3 0.0289167
TPM1 tropomyosin 1 (alpha) 0.0284326
ADM adrenomedullin 0.0281386
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0279075
ATXN1 ataxin 1 0.0278256
MBNL1 muscleblind-like splicing regulator 1 0.0277939
RAD51B RAD51 paralog B 0.0275194
RASA2 RAS p21 protein activator 2 0.0274721
FNDC3B fibronectin type III domain containing 3B 0.0274277
FTL ferritin, light polypeptide 0.0270614
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.027034
SHB Src homology 2 domain containing adaptor protein B 0.0269819
KMT2C lysine (K)-specific methyltransferase 2C 0.026798
YEATS2 YEATS domain containing 2 0.0262325
SET SET nuclear proto-oncogene 0.0261498
GNPDA1 glucosamine-6-phosphate deaminase 1 0.0260647
WWOX WW domain containing oxidoreductase 0.0257953
PCBP2 poly(rC) binding protein 2 0.0257915
SETX senataxin 0.0257002
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0255078
STK4 serine/threonine kinase 4 0.0253941
NCOR2 nuclear receptor corepressor 2 0.0253281
JMJD1C jumonji domain containing 1C 0.0250433
FMNL2 formin-like 2 0.0249603
TIMP2 TIMP metallopeptidase inhibitor 2 0.0249028
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0248969
ADAM9 ADAM metallopeptidase domain 9 0.0248334
MYH9 myosin, heavy chain 9, non-muscle 0.0246735
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0246017
PACS1 phosphofurin acidic cluster sorting protein 1 0.0244145
CALD1 caldesmon 1 0.0243346
SH3RF1 SH3 domain containing ring finger 1 0.0239238
MYCBP2 MYC binding protein 2, E3 ubiquitin protein ligase 0.0237522
ENO2 enolase 2 (gamma, neuronal) 0.023749
AFF1 AF4/FMR2 family, member 1 0.0237125
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.023698
GSPT1 G1 to S phase transition 1 0.0236791
ECE1 endothelin converting enzyme 1 0.0232361
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0232313
BCAR3 breast cancer anti-estrogen resistance 3 0.0232085
ZBTB38 zinc finger and BTB domain containing 38 0.0231846
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0230438
HDGF hepatoma-derived growth factor 0.0227703
TAOK1 TAO kinase 1 0.0226478
TNIK TRAF2 and NCK interacting kinase 0.0226202
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0224521
SMYD3 SET and MYND domain containing 3 0.0224174
POLA1 polymerase (DNA directed), alpha 1, catalytic subunit 0.0223887
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.0223872
ATAD2 ATPase family, AAA domain containing 2 0.0223571
JARID2 jumonji, AT rich interactive domain 2 0.0222986
PLSCR1 phospholipid scramblase 1 0.0221903
SMC1A structural maintenance of chromosomes 1A 0.0221319
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.0221227

decreased expression

Symbol Name Standardized Value
NALF1 NALCN channel auxiliary factor 1 -0.203718
HLA-B major histocompatibility complex, class I, B -0.174135
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.171094
MT2A metallothionein 2A -0.111557
ABI3BP ABI family, member 3 (NESH) binding protein -0.0938382
GLIS3 GLIS family zinc finger 3 -0.074689
AHNAK AHNAK nucleoprotein -0.0630375
HLA-C major histocompatibility complex, class I, C -0.056842
TMSB4X thymosin beta 4, X-linked -0.055481
EXT1 exostosin glycosyltransferase 1 -0.0547522
MT1X metallothionein 1X -0.0520615
PLCB4 phospholipase C, beta 4 -0.0509562
FN1 fibronectin 1 -0.04968
SOD2 superoxide dismutase 2, mitochondrial -0.04788
FSTL1 follistatin-like 1 -0.0476683
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.0461745
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0459902
TUBB tubulin, beta class I -0.0438226
LOC112694756 uncharaterized LOC112694756 -0.0424151
SEC61A1 Sec61 alpha 1 subunit (S. cerevisiae) -0.0408456
CTSD cathepsin D -0.0404714
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A -0.0394412
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0385731
GNAS GNAS complex locus -0.038222
CUL4B cullin 4B -0.0373405
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2 -0.037122
RAD21 RAD21 homolog (S. pombe) -0.0368935
SLC12A8 solute carrier family 12, member 8 -0.0350117
CCBE1 collagen and calcium binding EGF domains 1 -0.034204
CANX calnexin -0.0341343
LAMP1 lysosomal-associated membrane protein 1 -0.033651
F3 coagulation factor III (thromboplastin, tissue factor) -0.0336021
SULF1 sulfatase 1 -0.0335873
HLA-A major histocompatibility complex, class I, A -0.0333027
ARF1 ADP-ribosylation factor 1 -0.032551
OSMR oncostatin M receptor -0.0325315
TGFB2 transforming growth factor, beta 2 -0.032141
TPT1 tumor protein, translationally-controlled 1 -0.0313312
ZNF841 zinc finger protein 841 -0.0311483
POSTN periostin, osteoblast specific factor -0.0307961
IFI6 interferon, alpha-inducible protein 6 -0.0305448
SPDYA speedy/RINGO cell cycle regulator family member A -0.0298929
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) -0.029522
RPL26 ribosomal protein L26 -0.0295219
PHACTR1 phosphatase and actin regulator 1 -0.0293051
TMEM263 transmembrane protein 263 -0.0292931
CAVIN1 caveolae associated protein 1 -0.0292736
ANKRD10 ankyrin repeat domain 10 -0.0292026
SENP5 SUMO1/sentrin specific peptidase 5 -0.0288991
ADARB1 adenosine deaminase, RNA-specific, B1 -0.0268305
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0267502
LYPD6B LY6/PLAUR domain containing 6B -0.0266826
DIAPH3 diaphanous-related formin 3 -0.0262983
NAMPT nicotinamide phosphoribosyltransferase -0.0256545
NABP1 nucleic acid binding protein 1 -0.0253778
COL5A1 collagen, type V, alpha 1 -0.0253012
E2F3 E2F transcription factor 3 -0.0251836
MORF4L2 mortality factor 4 like 2 -0.025053
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.0249966
COL5A2 collagen, type V, alpha 2 -0.0246821
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0237001
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 -0.0236898
PTPN1 protein tyrosine phosphatase, non-receptor type 1 -0.0235738
EIF4A1 eukaryotic translation initiation factor 4A1 -0.0234686
ACSL4 acyl-CoA synthetase long-chain family member 4 -0.0232357
TNS3 tensin 3 -0.0229537
RPS21 ribosomal protein S21 -0.0227599
DIS3 DIS3 exosome endoribonuclease and 3'-5' exoribonuclease -0.0226106
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 -0.0225167
FRMD6 FERM domain containing 6 -0.0222101
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36 -0.0220819
KLF6 Kruppel-like factor 6 -0.0220149
TMSB10 thymosin beta 10 -0.0219355
CSE1L CSE1 chromosome segregation 1-like (yeast) -0.0219323
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 -0.0217252
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0216103
COPB1 coatomer protein complex, subunit beta 1 -0.0214921
HMGB1 high mobility group box 1 -0.0214637
ZEB2 zinc finger E-box binding homeobox 2 -0.0214335
ZNF804A zinc finger protein 804A -0.0212071
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.0210175
RBM39 RNA binding motif protein 39 -0.0210009
TRIO trio Rho guanine nucleotide exchange factor -0.0207627
ANKUB1 ankyrin repeat and ubiquitin domain containing 1 -0.0203049
MARCHF6 membrane associated ring-CH-type finger 6 -0.019269
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0189707
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0188411
HEG1 heart development protein with EGF-like domains 1 -0.0184079
SCFD2 sec1 family domain containing 2 -0.0183463
PPP2CA protein phosphatase 2, catalytic subunit, alpha isozyme -0.0183434
PARD3B par-3 family cell polarity regulator beta -0.0183221
SERINC1 serine incorporator 1 -0.0183026
OLR1 oxidized low density lipoprotein (lectin-like) receptor 1 -0.0181436
MON2 MON2 homolog (S. cerevisiae) -0.0180744
SEC31A SEC31 homolog A (S. cerevisiae) -0.0179542
EIF1 eukaryotic translation initiation factor 1 -0.0178868
ANKLE2 ankyrin repeat and LEM domain containing 2 -0.0178809
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3 -0.0178525
MYL12B myosin, light chain 12B, regulatory -0.0177591
STARD13 StAR-related lipid transfer (START) domain containing 13 -0.0177587