Retinoic acid_LOX-IMVI Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Retinoic acid perturbation in LOX-IMVI cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Retinoic acid_LOX-IMVI drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
EFNA5 ephrin-A5 0.166848
ASPH aspartate beta-hydroxylase 0.125216
AKAP12 A kinase (PRKA) anchor protein 12 0.123794
NALF1 NALCN channel auxiliary factor 1 0.097802
NAV1 neuron navigator 1 0.0956227
PBX3 pre-B-cell leukemia homeobox 3 0.0913111
KIAA1549L KIAA1549-like 0.0790268
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0766301
MSN moesin 0.076334
MCL1 myeloid cell leukemia 1 0.0760574
GPC6 glypican 6 0.0757324
PTK2 protein tyrosine kinase 2 0.0740216
TRIO trio Rho guanine nucleotide exchange factor 0.0700189
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0666331
MYO10 myosin X 0.0658084
CDH13 cadherin 13 0.0649021
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.064529
PTPRD protein tyrosine phosphatase, receptor type, D 0.0641966
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0629604
FLNB filamin B, beta 0.0608179
SLC8A1 solute carrier family 8 (sodium/calcium exchanger), member 1 0.0596844
MACF1 microtubule-actin crosslinking factor 1 0.0586542
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0583648
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0546074
CHST11 carbohydrate (chondroitin 4) sulfotransferase 11 0.052923
SDCCAG8 serologically defined colon cancer antigen 8 0.051883
PTPRG protein tyrosine phosphatase, receptor type, G 0.0509697
KDM4C lysine (K)-specific demethylase 4C 0.0474397
RAD51B RAD51 paralog B 0.047412
FMNL2 formin-like 2 0.0471638
KIAA1217 KIAA1217 0.046696
ATXN1 ataxin 1 0.0444394
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0441995
SIPA1L3 signal-induced proliferation-associated 1 like 3 0.0432476
ITGA6 integrin, alpha 6 0.0409234
NRIP1 nuclear receptor interacting protein 1 0.0394212
DOCK5 dedicator of cytokinesis 5 0.0389784
HMGA2 high mobility group AT-hook 2 0.0386357
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0382678
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 0.037745
SAMD3 sterile alpha motif domain containing 3 0.0377335
ZSWIM6 zinc finger, SWIM-type containing 6 0.0375729
APLP2 amyloid beta (A4) precursor-like protein 2 0.0369607
PLEKHA5 pleckstrin homology domain containing, family A member 5 0.036607
GNPDA1 glucosamine-6-phosphate deaminase 1 0.0355899
PRELID2 PRELI domain containing 2 0.0352822
TPM3 tropomyosin 3 0.0352034
NCOR2 nuclear receptor corepressor 2 0.0351335
MAPKAP1 mitogen-activated protein kinase associated protein 1 0.0346823
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0346808
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0338293
EGFR epidermal growth factor receptor 0.0333438
NLGN1 neuroligin 1 0.0330353
HSPH1 heat shock 105kDa/110kDa protein 1 0.0316821
POTEF POTE ankyrin domain family, member F 0.0313421
SSH2 slingshot protein phosphatase 2 0.030988
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0303438
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 0.0303176
NDRG1 N-myc downstream regulated 1 0.0299692
PCBP2 poly(rC) binding protein 2 0.0299314
PKM pyruvate kinase, muscle 0.0294446
EXOC4 exocyst complex component 4 0.0292046
EGR1 early growth response 1 0.0292005
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1 0.0290902
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 0.0290847
SPATS2L spermatogenesis associated, serine-rich 2-like 0.0285226
LOXL2 lysyl oxidase-like 2 0.0284944
MBD5 methyl-CpG binding domain protein 5 0.0282828
PLEC plectin 0.027654
SUPT3H suppressor of Ty 3 homolog (S. cerevisiae) 0.02747
CMIP c-Maf inducing protein 0.0265955
LPP LIM domain containing preferred translocation partner in lipoma 0.0261972
ENO1 enolase 1, (alpha) 0.0260085
MAP2K1 mitogen-activated protein kinase kinase 1 0.025828
SMAD3 SMAD family member 3 0.0255985
TBC1D5 TBC1 domain family, member 5 0.0253947
ANO6 anoctamin 6 0.0251916
KLF12 Kruppel-like factor 12 0.0251238
RARB retinoic acid receptor, beta 0.0250458
ENO2 enolase 2 (gamma, neuronal) 0.0247962
MKI67 marker of proliferation Ki-67 0.0247664
JARID2 jumonji, AT rich interactive domain 2 0.0247538
PHACTR1 phosphatase and actin regulator 1 0.0246773
UBA6 ubiquitin-like modifier activating enzyme 6 0.0245128
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0239192
CENPF centromere protein F, 350/400kDa 0.0238525
PACS1 phosphofurin acidic cluster sorting protein 1 0.0237714
MYH9 myosin, heavy chain 9, non-muscle 0.0235725
MYCBP2 MYC binding protein 2, E3 ubiquitin protein ligase 0.0235588
INTS6 integrator complex subunit 6 0.0235319
TTC3 tetratricopeptide repeat domain 3 0.0235024
LIMCH1 LIM and calponin homology domains 1 0.0233281
PRKCE protein kinase C, epsilon 0.0230423
SHB Src homology 2 domain containing adaptor protein B 0.0226778
BABAM2 BRISC and BRCA1 A complex member 2 0.0220448
MLLT3 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3 0.0216568
TENM2 teneurin transmembrane protein 2 0.0212701
USP34 ubiquitin specific peptidase 34 0.0212193
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0212102
RPTOR regulatory associated protein of MTOR, complex 1 0.0210602

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.470669
TMSB10 thymosin beta 10 -0.0922092
EIF1 eukaryotic translation initiation factor 1 -0.0793018
LOC112694756 uncharaterized LOC112694756 -0.0680489
YBX3 Y box binding protein 3 -0.0679341
RAD21 RAD21 homolog (S. pombe) -0.0664825
ACTG1 actin gamma 1 -0.0639975
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0593316
FTL ferritin, light polypeptide -0.0583037
NAMPT nicotinamide phosphoribosyltransferase -0.0553359
KYNU kynureninase -0.0546786
RPL23 ribosomal protein L23 -0.0546303
ENKUR enkurin, TRPC channel interacting protein -0.0539198
DTNA dystrobrevin, alpha -0.0529898
FRMD6 FERM domain containing 6 -0.0525427
KDM3A lysine (K)-specific demethylase 3A -0.0522212
CFAP251 cilia and flagella associated protein 251 -0.0520244
RBM39 RNA binding motif protein 39 -0.0489127
VIM vimentin -0.0466737
WDR43 WD repeat domain 43 -0.0457379
SPAG9 sperm associated antigen 9 -0.0454706
OSMR oncostatin M receptor -0.0445764
CALD1 caldesmon 1 -0.0437682
MARCHF6 membrane associated ring-CH-type finger 6 -0.0430452
ELL2 elongation factor, RNA polymerase II, 2 -0.0407893
RPS19 ribosomal protein S19 -0.040617
EIF4A1 eukaryotic translation initiation factor 4A1 -0.0405172
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0403649
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0401317
MCTP1 multiple C2 domains, transmembrane 1 -0.0400743
CDK17 cyclin-dependent kinase 17 -0.0391246
ZNF207 zinc finger protein 207 -0.0390788
ANXA2 annexin A2 -0.0376393
KLF6 Kruppel-like factor 6 -0.0375092
PNISR PNN-interacting serine/arginine-rich protein -0.0366524
RPL26 ribosomal protein L26 -0.0365227
RPS6 ribosomal protein S6 -0.0363864
WDR45B WD repeat domain 45B -0.0361544
MMP12 matrix metallopeptidase 12 -0.0361339
BTG1 B-cell translocation gene 1, anti-proliferative -0.0359915
H1-0 H1.0 linker histone -0.0356838
WSB1 WD repeat and SOCS box containing 1 -0.0352855
RPL32 ribosomal protein L32 -0.0351814
RPL30 ribosomal protein L30 -0.0348182
RPLP1 ribosomal protein, large, P1 -0.0347164
NF1 neurofibromin 1 -0.0345725
RPL12 ribosomal protein L12 -0.0342856
TSC22D2 TSC22 domain family, member 2 -0.034105
ATP13A3 ATPase type 13A3 -0.0340139
GNAS GNAS complex locus -0.0335289
PAWR PRKC, apoptosis, WT1, regulator -0.0330701
RPL8 ribosomal protein L8 -0.0329725
ERBIN erbb2 interacting protein -0.0324349
MT2A metallothionein 2A -0.0320153
USP15 ubiquitin specific peptidase 15 -0.0316205
EIF3E eukaryotic translation initiation factor 3, subunit E -0.0315368
RPLP0 ribosomal protein, large, P0 -0.0315311
ADAM9 ADAM metallopeptidase domain 9 -0.0314519
UBR5 ubiquitin protein ligase E3 component n-recognin 5 -0.030833
RPL36 ribosomal protein L36 -0.0305941
NUP58 nucleoporin 58 -0.0303602
RPL19 ribosomal protein L19 -0.0297837
APP amyloid beta (A4) precursor protein -0.0297803
EPB41L2 erythrocyte membrane protein band 4.1-like 2 -0.029726
RPS24 ribosomal protein S24 -0.0295506
LMAN1 lectin, mannose-binding, 1 -0.0292494
TPT1 tumor protein, translationally-controlled 1 -0.0289714
CAMK2D calcium/calmodulin-dependent protein kinase II delta -0.0289492
HAS2 hyaluronan synthase 2 -0.0288963
ABI1 abl-interactor 1 -0.0287812
RPL34 ribosomal protein L34 -0.028745
RPL35A ribosomal protein L35a -0.0287298
TXNRD1 thioredoxin reductase 1 -0.0287244
ZNF217 zinc finger protein 217 -0.0286633
RLF rearranged L-myc fusion -0.0284873
ANKRD28 ankyrin repeat domain 28 -0.0284452
EIF3H eukaryotic translation initiation factor 3, subunit H -0.0284298
CMSS1 cms1 ribosomal small subunit homolog (yeast) -0.0282964
UGCG UDP-glucose ceramide glucosyltransferase -0.0279799
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0279158
MAP3K2 mitogen-activated protein kinase kinase kinase 2 -0.027784
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0276949
PAN3 PAN3 poly(A) specific ribonuclease subunit -0.0276026
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0274385
RAB3GAP1 RAB3 GTPase activating protein subunit 1 (catalytic) -0.0273714
RPL11 ribosomal protein L11 -0.0271584
WDR26 WD repeat domain 26 -0.026588
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0265809
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0264465
LIMA1 LIM domain and actin binding 1 -0.0261562
TFRC transferrin receptor -0.0260036
IFI16 interferon, gamma-inducible protein 16 -0.0255208
CANX calnexin -0.0253043
CNOT2 CCR4-NOT transcription complex, subunit 2 -0.0252753
NPC1 Niemann-Pick disease, type C1 -0.0250542
LATS2 large tumor suppressor kinase 2 -0.0250493
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0250119
PNRC1 proline-rich nuclear receptor coactivator 1 -0.0245768
SERINC1 serine incorporator 1 -0.0244901
ZFR zinc finger RNA binding protein -0.0241938