Retinoic acid_LS 180 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Retinoic acid perturbation in LS 180 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Retinoic acid_LS 180 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 0.226513
CEMIP cell migration inducing protein, hyaluronan binding 0.165697
FAT1 FAT atypical cadherin 1 0.122494
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0799904
TRIM2 tripartite motif containing 2 0.0782409
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 0.077112
GMDS GDP-mannose 4,6-dehydratase 0.0731465
CADPS Ca++-dependent secretion activator 0.07123
FTH1 ferritin, heavy polypeptide 1 0.0704868
RNF43 ring finger protein 43 0.0674363
TNS4 tensin 4 0.0613879
GPHN gephyrin 0.0559317
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.0446431
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 0.0444019
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0440681
NEBL nebulette 0.0413853
VMP1 vacuole membrane protein 1 0.0406421
VCL vinculin 0.040491
CD44 CD44 molecule (Indian blood group) 0.0400641
PDLIM5 PDZ and LIM domain 5 0.0395581
EPS8 epidermal growth factor receptor pathway substrate 8 0.0380126
UBE2H ubiquitin-conjugating enzyme E2H 0.0374419
CEMIP2 cell migration inducing hyaluronidase 2 0.037027
MYO1E myosin IE 0.0363171
PDZD8 PDZ domain containing 8 0.0356998
SLCO1B3 solute carrier organic anion transporter family, member 1B3 0.0355093
ANKRD17 ankyrin repeat domain 17 0.0349274
RNF145 ring finger protein 145 0.0340109
PELI1 pellino E3 ubiquitin protein ligase 1 0.033937
PTBP3 polypyrimidine tract binding protein 3 0.0334662
EREG epiregulin 0.0333971
LMO7 LIM domain 7 0.032687
MACF1 microtubule-actin crosslinking factor 1 0.0318383
CDH17 cadherin 17, LI cadherin (liver-intestine) 0.0315653
ARHGAP26 Rho GTPase activating protein 26 0.0315386
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme 0.0315086
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.0309998
TPM3 tropomyosin 3 0.0308706
GAREM1 GRB2 associated regulator of MAPK1 subtype 1 0.0307734
CENPF centromere protein F, 350/400kDa 0.0307675
NRXN3 neurexin 3 0.0302269
LGR4 leucine-rich repeat containing G protein-coupled receptor 4 0.0301451
ETNK1 ethanolamine kinase 1 0.0298575
ABHD2 abhydrolase domain containing 2 0.0297905
MED13L mediator complex subunit 13-like 0.0294982
ARL15 ADP-ribosylation factor-like 15 0.0292388
USP6NL USP6 N-terminal like 0.0292271
ITGA6 integrin, alpha 6 0.0290173
CNOT1 CCR4-NOT transcription complex, subunit 1 0.0289743
PTPRG protein tyrosine phosphatase, receptor type, G 0.0288811
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0283076
SOX9 SRY (sex determining region Y)-box 9 0.0280924
CD46 CD46 molecule, complement regulatory protein 0.027524
COG5 component of oligomeric golgi complex 5 0.0273835
AKAP13 A kinase (PRKA) anchor protein 13 0.0272825
NCEH1 neutral cholesterol ester hydrolase 1 0.0271681
SHROOM3 shroom family member 3 0.027122
LDHA lactate dehydrogenase A 0.0270747
PRAG1 PEAK1 related, kinase-activating pseudokinase 1 0.0269357
GSK3B glycogen synthase kinase 3 beta 0.0268884
TGFBR3 transforming growth factor, beta receptor III 0.0266723
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0265927
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 0.0265073
ARHGAP32 Rho GTPase activating protein 32 0.0261451
ANK3 ankyrin 3, node of Ranvier (ankyrin G) 0.0256587
PLS1 plastin 1 0.0254203
PUM2 pumilio RNA-binding family member 2 0.0253577
MYH9 myosin, heavy chain 9, non-muscle 0.025284
EEF2 eukaryotic translation elongation factor 2 0.0251936
CTBP2 C-terminal binding protein 2 0.0247444
MACC1 metastasis associated in colon cancer 1 0.0246858
FBXW7 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase 0.0243706
UBR3 ubiquitin protein ligase E3 component n-recognin 3 (putative) 0.0242775
FOXO1 forkhead box O1 0.0240569
PSME4 proteasome (prosome, macropain) activator subunit 4 0.0237619
DPY19L1 dpy-19-like 1 (C. elegans) 0.0237041
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0235964
CLTC clathrin, heavy chain (Hc) 0.023445
RPL3 ribosomal protein L3 0.0233597
RAB10 RAB10, member RAS oncogene family 0.0232454
TBC1D5 TBC1 domain family, member 5 0.0232448
ECT2 epithelial cell transforming 2 0.0231944
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 0.0231193
METTL15 methyltransferase like 15 0.0228902
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0228101
MUC13 mucin 13, cell surface associated 0.0226674
MBNL1 muscleblind-like splicing regulator 1 0.0225725
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0223479
NOSTRIN nitric oxide synthase trafficking 0.0223072
PARD3B par-3 family cell polarity regulator beta 0.0222446
NAALADL2 N-acetylated alpha-linked acidic dipeptidase-like 2 0.0221319
ZFAND3 zinc finger, AN1-type domain 3 0.0220122
NALF1 NALCN channel auxiliary factor 1 0.0219804
ZNRF3 zinc and ring finger 3 0.021727
TMTC2 transmembrane and tetratricopeptide repeat containing 2 0.0217077
STT3B STT3B, subunit of the oligosaccharyltransferase complex (catalytic) 0.0215447
DSPP dentin sialophosphoprotein 0.0214682
DNAJC15 DnaJ (Hsp40) homolog, subfamily C, member 15 0.0213225
NEK7 NIMA-related kinase 7 0.0209439
LURAP1L leucine rich adaptor protein 1-like 0.0208636

decreased expression

Symbol Name Standardized Value
TMSB10 thymosin beta 10 -0.226015
TPT1 tumor protein, translationally-controlled 1 -0.220381
PTMA prothymosin, alpha -0.205071
RPS6 ribosomal protein S6 -0.14807
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.132608
NPSR1 neuropeptide S receptor 1 -0.125249
RPL35A ribosomal protein L35a -0.0917405
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0855801
NDRG1 N-myc downstream regulated 1 -0.0827314
MUC5AC mucin 5AC, oligomeric mucus/gel-forming -0.079992
S100A6 S100 calcium binding protein A6 -0.0787344
FLNB filamin B, beta -0.0719205
RPL34 ribosomal protein L34 -0.0714517
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0706146
RPS19 ribosomal protein S19 -0.0664354
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0567082
ACTG1 actin gamma 1 -0.0559597
GCC2 GRIP and coiled-coil domain containing 2 -0.0551703
RPL26 ribosomal protein L26 -0.0537133
RPLP2 ribosomal protein, large, P2 -0.0525738
RPLP1 ribosomal protein, large, P1 -0.0523122
MT2A metallothionein 2A -0.052096
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5 -0.0520489
RPL9 ribosomal protein L9 -0.0518806
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0514172
TFF1 trefoil factor 1 -0.0508572
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0492257
RPS8 ribosomal protein S8 -0.0486774
RPS24 ribosomal protein S24 -0.0484633
RPL37A ribosomal protein L37a -0.0473325
FTL ferritin, light polypeptide -0.0455717
RPL31 ribosomal protein L31 -0.0447684
RPS12 ribosomal protein S12 -0.0445879
MUC17 mucin 17, cell surface associated -0.0445319
TPM4 tropomyosin 4 -0.0442987
RPL36 ribosomal protein L36 -0.0441503
AGR2 anterior gradient 2 -0.0440701
SOX4 SRY (sex determining region Y)-box 4 -0.0431144
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0429175
RPS27A ribosomal protein S27a -0.0420335
RPS21 ribosomal protein S21 -0.0418775
TFF3 trefoil factor 3 (intestinal) -0.0414575
EZR ezrin -0.0409966
ALCAM activated leukocyte cell adhesion molecule -0.0394464
RPL37 ribosomal protein L37 -0.0388885
ESYT2 extended synaptotagmin-like protein 2 -0.0385207
RPL23 ribosomal protein L23 -0.0382462
ONECUT3 one cut homeobox 3 -0.0382184
RPL12 ribosomal protein L12 -0.0381732
RPS13 ribosomal protein S13 -0.0371581
RPL7A ribosomal protein L7a -0.0370063
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0365623
RPS25 ribosomal protein S25 -0.0363931
BACE2 beta-site APP-cleaving enzyme 2 -0.0362037
LMNA lamin A/C -0.0360166
AHNAK AHNAK nucleoprotein -0.0352339
RPS27 ribosomal protein S27 -0.0347654
IER3 immediate early response 3 -0.0345097
RPS6KA5 ribosomal protein S6 kinase, 90kDa, polypeptide 5 -0.0338363
RPS14 ribosomal protein S14 -0.0334573
SLC35F3 solute carrier family 35, member F3 -0.0325757
HMGA1 high mobility group AT-hook 1 -0.0323734
B2M beta-2-microglobulin -0.0322151
BCAT1 branched chain amino-acid transaminase 1, cytosolic -0.032007
GNAS GNAS complex locus -0.031871
RPS23 ribosomal protein S23 -0.0310357
GRB10 growth factor receptor-bound protein 10 -0.0310076
EIF1 eukaryotic translation initiation factor 1 -0.0309649
RALGPS2 Ral GEF with PH domain and SH3 binding motif 2 -0.0305772
MUC6 mucin 6, oligomeric mucus/gel-forming -0.0305021
RPL19 ribosomal protein L19 -0.0299695
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0299232
RPL8 ribosomal protein L8 -0.0298312
RPL32 ribosomal protein L32 -0.0292531
LGALS3 lectin, galactoside-binding, soluble, 3 -0.0287299
RPS29 ribosomal protein S29 -0.0283443
S100P S100 calcium binding protein P -0.0282909
CSTB cystatin B (stefin B) -0.028112
RPL27A ribosomal protein L27a -0.0280139
RPS16 ribosomal protein S16 -0.0278054
BTG1 B-cell translocation gene 1, anti-proliferative -0.0277256
RPL30 ribosomal protein L30 -0.0276889
KLK10 kallikrein-related peptidase 10 -0.0272277
KPNB1 karyopherin (importin) beta 1 -0.0267897
ZBTB7A zinc finger and BTB domain containing 7A -0.0266671
RPLP0 ribosomal protein, large, P0 -0.0264647
PPARG peroxisome proliferator-activated receptor gamma -0.0264472
ITGB4 integrin, beta 4 -0.0262447
RPL36A ribosomal protein L36a -0.0259793
LAMB3 laminin, beta 3 -0.0259574
RPL18 ribosomal protein L18 -0.0259033
RPL38 ribosomal protein L38 -0.0257097
GREB1L growth regulation by estrogen in breast cancer-like -0.0257052
FERMT1 fermitin family member 1 -0.0246686
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0238582
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -0.023168
FBXO11 F-box protein 11 -0.0229602
RIN2 Ras and Rab interactor 2 -0.022959
HMGB1 high mobility group box 1 -0.0229381
KLF6 Kruppel-like factor 6 -0.0227513