Retinoic acid_LoVo Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Retinoic acid perturbation in LoVo cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Retinoic acid_LoVo drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.136482
FAT1 FAT atypical cadherin 1 0.106312
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 0.0748705
TXNRD1 thioredoxin reductase 1 0.0720869
MYO1E myosin IE 0.0654897
PTPRG protein tyrosine phosphatase, receptor type, G 0.0591966
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 0.0584884
EEF2 eukaryotic translation elongation factor 2 0.056513
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0535038
LOC105378220 macrophage receptor MARCO-like 0.0508678
PDE4D phosphodiesterase 4D, cAMP-specific 0.0507274
PKP2 plakophilin 2 0.0466448
MUC13 mucin 13, cell surface associated 0.0444698
ASPH aspartate beta-hydroxylase 0.0403986
RPL13A ribosomal protein L13a 0.0396383
RIMKLB ribosomal modification protein rimK-like family member B 0.0394563
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0388362
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0380902
TMTC2 transmembrane and tetratricopeptide repeat containing 2 0.0376795
TRIM2 tripartite motif containing 2 0.0369806
EXT1 exostosin glycosyltransferase 1 0.0356674
PCBP2 poly(rC) binding protein 2 0.0348147
MT2A metallothionein 2A 0.034213
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0331984
CENPF centromere protein F, 350/400kDa 0.0331354
MKI67 marker of proliferation Ki-67 0.0327594
WWOX WW domain containing oxidoreductase 0.0321475
RNF145 ring finger protein 145 0.0298317
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.029503
PHLPP1 PH domain and leucine rich repeat protein phosphatase 1 0.0290245
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0286307
WWC1 WW and C2 domain containing 1 0.0285158
EGR1 early growth response 1 0.0283495
ATXN1 ataxin 1 0.0276869
ERRFI1 ERBB receptor feedback inhibitor 1 0.0275122
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0274832
VCL vinculin 0.027043
ARL15 ADP-ribosylation factor-like 15 0.0266602
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0266212
PRELID2 PRELI domain containing 2 0.0265323
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0258408
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 0.0254264
FOXP1 forkhead box P1 0.0254239
MYOF myoferlin 0.0253736
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.0251829
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0251218
PDZD8 PDZ domain containing 8 0.0249868
NCOA7 nuclear receptor coactivator 7 0.0248721
RPL3 ribosomal protein L3 0.0247353
DUSP4 dual specificity phosphatase 4 0.0245875
MLLT3 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3 0.0245549
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 0.0245478
ENO1 enolase 1, (alpha) 0.023555
SQSTM1 sequestosome 1 0.0235083
PARD3B par-3 family cell polarity regulator beta 0.0232309
FBXL17 F-box and leucine-rich repeat protein 17 0.0224865
MX1 MX dynamin-like GTPase 1 0.0223872
RFX3 regulatory factor X, 3 (influences HLA class II expression) 0.0221355
NR4A1 nuclear receptor subfamily 4, group A, member 1 0.0218033
NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta 0.0216009
WARS1 tryptophanyl-tRNA synthetase 1 0.0213127
PLEKHG1 pleckstrin homology domain containing, family G (with RhoGef domain) member 1 0.0211968
EPS8 epidermal growth factor receptor pathway substrate 8 0.02118
CEMIP cell migration inducing protein, hyaluronan binding 0.0211072
RNF43 ring finger protein 43 0.0210526
AHCYL2 adenosylhomocysteinase-like 2 0.0204214
APLP2 amyloid beta (A4) precursor-like protein 2 0.0202096
CCSER1 coiled-coil serine-rich protein 1 0.0201871
FTH1 ferritin, heavy polypeptide 1 0.020053
RPL5 ribosomal protein L5 0.0198321
TC2N tandem C2 domains, nuclear 0.0197747
LGR4 leucine-rich repeat containing G protein-coupled receptor 4 0.019768
SLCO1B3 solute carrier organic anion transporter family, member 1B3 0.019631
PCM1 pericentriolar material 1 0.0195212
ANP32B acidic (leucine-rich) nuclear phosphoprotein 32 family, member B 0.0195042
SMYD3 SET and MYND domain containing 3 0.0193244
SH3RF2 SH3 domain containing ring finger 2 0.0193018
EPB41L2 erythrocyte membrane protein band 4.1-like 2 0.0191534
EFNA5 ephrin-A5 0.0188415
EIF1 eukaryotic translation initiation factor 1 0.0188379
RPL21 ribosomal protein L21 0.0188197
ASNS asparagine synthetase (glutamine-hydrolyzing) 0.0185476
PTPRK protein tyrosine phosphatase, receptor type, K 0.0185066
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.0183934
ANK3 ankyrin 3, node of Ranvier (ankyrin G) 0.0183415
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.018327
WNK1 WNK lysine deficient protein kinase 1 0.0182965
ANKRD11 ankyrin repeat domain 11 0.0181047
ROCK2 Rho-associated, coiled-coil containing protein kinase 2 0.0180469
RIGI RNA sensor RIG-I 0.0180187
MPP2 membrane protein, palmitoylated 2 (MAGUK p55 subfamily member 2) 0.0179744
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0179402
ARHGAP42 Rho GTPase activating protein 42 0.0177109
SAMD5 sterile alpha motif domain containing 5 0.0175735
LARGE1 LARGE xylosyl- and glucuronyltransferase 1 0.0175341
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.0175063
PHF14 PHD finger protein 14 0.0174439
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) 0.017289
CCPG1 cell cycle progression 1 0.0171197
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.016798

decreased expression

Symbol Name Standardized Value
TPT1 tumor protein, translationally-controlled 1 -0.260668
RPS6 ribosomal protein S6 -0.121317
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.110199
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.104378
RPL34 ribosomal protein L34 -0.099766
TMSB10 thymosin beta 10 -0.0975707
PTMA prothymosin, alpha -0.0922818
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5 -0.0812863
RPL35A ribosomal protein L35a -0.0715998
FLNB filamin B, beta -0.0715096
RPLP1 ribosomal protein, large, P1 -0.0695458
GMDS GDP-mannose 4,6-dehydratase -0.0675443
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 -0.0670932
RPS6KA5 ribosomal protein S6 kinase, 90kDa, polypeptide 5 -0.0652951
RPL31 ribosomal protein L31 -0.0636943
RPS8 ribosomal protein S8 -0.0626269
F3 coagulation factor III (thromboplastin, tissue factor) -0.0591473
RPS21 ribosomal protein S21 -0.057886
RPS24 ribosomal protein S24 -0.0565619
RPL37A ribosomal protein L37a -0.0552678
HLA-B major histocompatibility complex, class I, B -0.0543523
RPS25 ribosomal protein S25 -0.0534686
RPL26 ribosomal protein L26 -0.0526553
TSPAN8 tetraspanin 8 -0.051515
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.0507206
S100A6 S100 calcium binding protein A6 -0.0505943
DSPP dentin sialophosphoprotein -0.0500464
GOLGA4 golgin A4 -0.0488486
NPSR1 neuropeptide S receptor 1 -0.0476764
UBE2H ubiquitin-conjugating enzyme E2H -0.046702
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0466225
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0463875
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5 -0.044879
CALB1 calbindin 1, 28kDa -0.044733
MCU mitochondrial calcium uniporter -0.0435543
ESYT2 extended synaptotagmin-like protein 2 -0.0428622
RRBP1 ribosome binding protein 1 -0.0424711
CANX calnexin -0.0415607
MPRIP myosin phosphatase Rho interacting protein -0.0414303
RPLP2 ribosomal protein, large, P2 -0.0402277
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.0388275
PERP PERP, TP53 apoptosis effector -0.0386642
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0382342
PDIA3 protein disulfide isomerase family A, member 3 -0.0372724
FRMD5 FERM domain containing 5 -0.0369778
KRT19 keratin 19, type I -0.0360632
SVIL supervillin -0.0355455
RPL36 ribosomal protein L36 -0.0352543
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) -0.0348913
ACTN4 actinin, alpha 4 -0.0348409
HDLBP high density lipoprotein binding protein -0.0342479
MSI2 musashi RNA-binding protein 2 -0.0342093
LAMB3 laminin, beta 3 -0.0340193
CALU calumenin -0.0340179
EZR ezrin -0.0339862
RREB1 ras responsive element binding protein 1 -0.0336522
RPS27A ribosomal protein S27a -0.0335191
RPL11 ribosomal protein L11 -0.033518
AGR2 anterior gradient 2 -0.0331134
RAB1A RAB1A, member RAS oncogene family -0.0329733
ZFP36L2 ZFP36 ring finger protein-like 2 -0.0329412
RPL37 ribosomal protein L37 -0.0324679
RPL27A ribosomal protein L27a -0.0321157
RBM25 RNA binding motif protein 25 -0.031987
COBL cordon-bleu WH2 repeat protein -0.0313407
DSG2 desmoglein 2 -0.0312362
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0308893
SEC31A SEC31 homolog A (S. cerevisiae) -0.0306847
ACSL3 acyl-CoA synthetase long-chain family member 3 -0.0306413
RPL36A ribosomal protein L36a -0.0306062
ZCCHC7 zinc finger, CCHC domain containing 7 -0.0304499
NT5C2 5'-nucleotidase, cytosolic II -0.0303711
PIK3AP1 phosphoinositide-3-kinase adaptor protein 1 -0.0302647
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.029923
KRT18 keratin 18, type I -0.029896
NPEPPS aminopeptidase puromycin sensitive -0.0298626
IFI27 interferon, alpha-inducible protein 27 -0.0295542
FERMT1 fermitin family member 1 -0.0292133
DIAPH1 diaphanous-related formin 1 -0.0291371
CUX1 cut-like homeobox 1 -0.0288061
LAMA4 laminin, alpha 4 -0.0287641
SLMAP sarcolemma associated protein -0.0286583
MBOAT2 membrane bound O-acyltransferase domain containing 2 -0.0284836
RPS13 ribosomal protein S13 -0.028417
MYH14 myosin, heavy chain 14, non-muscle -0.028343
RALA v-ral simian leukemia viral oncogene homolog A (ras related) -0.0276814
RPS19 ribosomal protein S19 -0.0275973
AOPEP aminopeptidase O (putative) -0.0275081
COG5 component of oligomeric golgi complex 5 -0.0274846
PTPRR protein tyrosine phosphatase, receptor type, R -0.0273272
RPL8 ribosomal protein L8 -0.0272563
OSBPL3 oxysterol binding protein-like 3 -0.0270666
MUC2 mucin 2, oligomeric mucus/gel-forming -0.027036
LAMC2 laminin, gamma 2 -0.0270251
RPS14 ribosomal protein S14 -0.026951
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha -0.026886
BIRC6 baculoviral IAP repeat containing 6 -0.0265457
BAIAP2L1 BAI1-associated protein 2-like 1 -0.0263053
COL17A1 collagen, type XVII, alpha 1 -0.0260744
FOXO3 forkhead box O3 -0.0260459