Retinoic acid_MIA PaCa-2 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Retinoic acid perturbation in MIA PaCa-2 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Retinoic acid_MIA PaCa-2 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PSD3 pleckstrin and Sec7 domain containing 3 0.184947
DST dystonin 0.152318
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.111241
DPYD dihydropyrimidine dehydrogenase 0.0958705
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0869791
TP63 tumor protein p63 0.085619
RAD51B RAD51 paralog B 0.0854328
NPAS2 neuronal PAS domain protein 2 0.0839552
CADM2 cell adhesion molecule 2 0.0811413
VCL vinculin 0.0727096
BCAR3 breast cancer anti-estrogen resistance 3 0.0675023
DLG1 discs, large homolog 1 (Drosophila) 0.0671028
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3 0.0665496
RUNX1 runt-related transcription factor 1 0.0639432
PRELID2 PRELI domain containing 2 0.0635963
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0625574
FTH1 ferritin, heavy polypeptide 1 0.0620554
BIRC3 baculoviral IAP repeat containing 3 0.0598065
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A 0.0559645
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 0.0534872
ADGRG6 adhesion G protein-coupled receptor G6 0.0525731
EXOC4 exocyst complex component 4 0.0523114
GNGT1 guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1 0.0521727
CD44 CD44 molecule (Indian blood group) 0.0509763
SMYD3 SET and MYND domain containing 3 0.0495548
GCLM glutamate-cysteine ligase, modifier subunit 0.0485634
CDK6 cyclin-dependent kinase 6 0.0475875
DNER delta/notch-like EGF repeat containing 0.0466029
CMIP c-Maf inducing protein 0.0455706
SYNE2 spectrin repeat containing, nuclear envelope 2 0.0448179
MT2A metallothionein 2A 0.0444773
ZDHHC14 zinc finger, DHHC-type containing 14 0.042818
DPH6 diphthamine biosynthesis 6 0.0423899
TNS3 tensin 3 0.0403894
OAS3 2'-5'-oligoadenylate synthetase 3, 100kDa 0.0386875
SDCCAG8 serologically defined colon cancer antigen 8 0.038353
H1-0 H1.0 linker histone 0.0381288
CEP128 centrosomal protein 128kDa 0.03716
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0367961
SMAD3 SMAD family member 3 0.0362465
FMNL2 formin-like 2 0.0361007
WWTR1 WW domain containing transcription regulator 1 0.0360362
HDAC9 histone deacetylase 9 0.035396
SVIL supervillin 0.0348331
RFFL ring finger and FYVE-like domain containing E3 ubiquitin protein ligase 0.0339626
RTTN rotatin 0.0336746
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.033447
SPIDR scaffolding protein involved in DNA repair 0.0333974
TSC22D1 TSC22 domain family, member 1 0.0333547
PLK2 polo-like kinase 2 0.0323562
IQCJ-SCHIP1 IQCJ-SCHIP1 readthrough 0.03215
EPHA4 EPH receptor A4 0.0318983
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 0.0318607
ENO1 enolase 1, (alpha) 0.0316424
ZBTB38 zinc finger and BTB domain containing 38 0.0312393
CHD9 chromodomain helicase DNA binding protein 9 0.0307806
VEGFC vascular endothelial growth factor C 0.0307661
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 0.030596
CUBN cubilin (intrinsic factor-cobalamin receptor) 0.0297234
NCEH1 neutral cholesterol ester hydrolase 1 0.0281996
TPRG1 tumor protein p63 regulated 1 0.028106
RNF213 ring finger protein 213 0.0279369
LPP LIM domain containing preferred translocation partner in lipoma 0.0278287
ECE1 endothelin converting enzyme 1 0.0273965
SQSTM1 sequestosome 1 0.0270998
TTC28 tetratricopeptide repeat domain 28 0.0269757
PMEPA1 prostate transmembrane protein, androgen induced 1 0.0264482
POLA1 polymerase (DNA directed), alpha 1, catalytic subunit 0.0264168
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0263658
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.0263015
PRKCE protein kinase C, epsilon 0.0261609
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.0259559
TBC1D5 TBC1 domain family, member 5 0.025773
HELLS helicase, lymphoid-specific 0.0256131
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4 0.025559
SP100 SP100 nuclear antigen 0.0255308
DNAH14 dynein, axonemal, heavy chain 14 0.0255255
OAS2 2'-5'-oligoadenylate synthetase 2, 69/71kDa 0.0241805
DEK DEK proto-oncogene 0.02417
NCAPG2 non-SMC condensin II complex, subunit G2 0.0241292
NEBL nebulette 0.0241073
USP11 ubiquitin specific peptidase 11 0.023692
BCAS3 breast carcinoma amplified sequence 3 0.0234106
FARS2 phenylalanyl-tRNA synthetase 2, mitochondrial 0.0232077
THSD4 thrombospondin, type I, domain containing 4 0.0230963
DIAPH3 diaphanous-related formin 3 0.0230039
DOCK1 dedicator of cytokinesis 1 0.0228593
MBNL1 muscleblind-like splicing regulator 1 0.0225326
F2R coagulation factor II (thrombin) receptor 0.0224757
ZSWIM6 zinc finger, SWIM-type containing 6 0.022348
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like 0.0222755
TGM2 transglutaminase 2 0.0222632
WARS1 tryptophanyl-tRNA synthetase 1 0.0220144
UTRN utrophin 0.0218664
FOXP1 forkhead box P1 0.0218539
FER fer (fps/fes related) tyrosine kinase 0.0216125
RAB27B RAB27B, member RAS oncogene family 0.0206096
IPO9 importin 9 0.0205777
ANTXR2 anthrax toxin receptor 2 0.0201903
DIAPH1 diaphanous-related formin 1 0.0201018

decreased expression

Symbol Name Standardized Value
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.187604
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.147408
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.139223
ERRFI1 ERBB receptor feedback inhibitor 1 -0.116355
TPT1 tumor protein, translationally-controlled 1 -0.113886
PTMA prothymosin, alpha -0.109916
TMSB4X thymosin beta 4, X-linked -0.0916063
TM4SF1 transmembrane 4 L six family member 1 -0.0885507
TXNRD1 thioredoxin reductase 1 -0.0825059
TMSB10 thymosin beta 10 -0.0820415
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0784191
RPL26 ribosomal protein L26 -0.0774764
RAI1 retinoic acid induced 1 -0.0772475
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0771554
SPAG9 sperm associated antigen 9 -0.0739747
RPL35A ribosomal protein L35a -0.0639161
RPS6 ribosomal protein S6 -0.0624817
RPS8 ribosomal protein S8 -0.062065
WSB1 WD repeat and SOCS box containing 1 -0.0620565
CANX calnexin -0.0617018
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0590214
RPL12 ribosomal protein L12 -0.0581258
SLC38A2 solute carrier family 38, member 2 -0.0575225
USP34 ubiquitin specific peptidase 34 -0.0573498
ARHGAP5 Rho GTPase activating protein 5 -0.0562105
KDM3A lysine (K)-specific demethylase 3A -0.0550784
EIF1 eukaryotic translation initiation factor 1 -0.0530462
GARS1 glycyl-tRNA synthetase 1 -0.0510733
HSPA9 heat shock 70kDa protein 9 (mortalin) -0.0508153
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha -0.0494479
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0476267
RPS24 ribosomal protein S24 -0.046252
RPL36A ribosomal protein L36a -0.0457186
ADAM17 ADAM metallopeptidase domain 17 -0.0451431
RPL37A ribosomal protein L37a -0.044405
TMEM41B transmembrane protein 41B -0.0443794
RPS2 ribosomal protein S2 -0.0441246
RPL34 ribosomal protein L34 -0.0436091
NUP58 nucleoporin 58 -0.0432796
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0416311
ZNF217 zinc finger protein 217 -0.0411772
RPS3 ribosomal protein S3 -0.0409201
NAMPT nicotinamide phosphoribosyltransferase -0.0400557
MAP1LC3B microtubule-associated protein 1 light chain 3 beta -0.039889
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0390017
MT1X metallothionein 1X -0.0387991
NAP1L1 nucleosome assembly protein 1-like 1 -0.0384436
PRRC2C proline-rich coiled-coil 2C -0.0382026
RPL38 ribosomal protein L38 -0.0375566
RPS27A ribosomal protein S27a -0.0373673
CENPF centromere protein F, 350/400kDa -0.0372577
HSPA8 heat shock 70kDa protein 8 -0.0366937
HLA-B major histocompatibility complex, class I, B -0.0366446
RPL23 ribosomal protein L23 -0.0365713
KLF6 Kruppel-like factor 6 -0.0360345
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0351241
RPL37 ribosomal protein L37 -0.0348294
RPS21 ribosomal protein S21 -0.0342131
RPL31 ribosomal protein L31 -0.0337238
ZMYND8 zinc finger, MYND-type containing 8 -0.033689
RPS23 ribosomal protein S23 -0.0336405
RPS19 ribosomal protein S19 -0.0333702
SET SET nuclear proto-oncogene -0.0329996
HMGA1 high mobility group AT-hook 1 -0.0329676
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0329165
RBM39 RNA binding motif protein 39 -0.0325921
EIF4A1 eukaryotic translation initiation factor 4A1 -0.0325642
RPS13 ribosomal protein S13 -0.0324576
YBX3 Y box binding protein 3 -0.0308993
RPS25 ribosomal protein S25 -0.0308165
HOOK2 hook microtubule-tethering protein 2 -0.0305155
POTEF POTE ankyrin domain family, member F -0.0302447
ZEB1 zinc finger E-box binding homeobox 1 -0.0300958
RACK1 receptor for activated C kinase 1 -0.0294244
AP2B1 adaptor-related protein complex 2, beta 1 subunit -0.029369
EIF3A eukaryotic translation initiation factor 3, subunit A -0.0289614
CSDE1 cold shock domain containing E1, RNA-binding -0.0287751
RPL18 ribosomal protein L18 -0.0287674
PDIA6 protein disulfide isomerase family A, member 6 -0.0287012
MARCHF6 membrane associated ring-CH-type finger 6 -0.0286111
UPP1 uridine phosphorylase 1 -0.0285215
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0283859
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 -0.0280605
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0274428
SEC24A SEC24 family member A -0.0272587
TXNIP thioredoxin interacting protein -0.0268708
RPS12 ribosomal protein S12 -0.0265753
RPL7A ribosomal protein L7a -0.0264521
TOMM20 translocase of outer mitochondrial membrane 20 homolog (yeast) -0.0263513
WDR45B WD repeat domain 45B -0.0262413
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.0260737
RPL9 ribosomal protein L9 -0.0258895
AHNAK AHNAK nucleoprotein -0.0257383
GOLT1B golgi transport 1B -0.0256251
RPL19 ribosomal protein L19 -0.025538
PJA2 praja ring finger 2, E3 ubiquitin protein ligase -0.0254235
UBC ubiquitin C -0.0250926
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36 -0.024907
ANKHD1 ankyrin repeat and KH domain containing 1 -0.0248515
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 -0.0247639