Retinoic acid_NCI-H1792 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Retinoic acid perturbation in NCI-H1792 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Retinoic acid_NCI-H1792 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1 0.152929
SDK1 sidekick cell adhesion molecule 1 0.150572
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.092362
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 0.0845121
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0830191
FAM20C family with sequence similarity 20, member C 0.0824093
CDH13 cadherin 13 0.0710104
CAMK1D calcium/calmodulin-dependent protein kinase ID 0.0681363
GRB10 growth factor receptor-bound protein 10 0.0662266
NAV2 neuron navigator 2 0.0595175
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0577022
INTS6 integrator complex subunit 6 0.0573358
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0560162
ADAMTS14 ADAM metallopeptidase with thrombospondin type 1 motif, 14 0.054078
MAML3 mastermind-like 3 (Drosophila) 0.0531478
MTSS1 metastasis suppressor 1 0.0517803
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0493555
HMGA2 high mobility group AT-hook 2 0.0486007
GALNT18 polypeptide N-acetylgalactosaminyltransferase 18 0.0449248
SEPTIN9 septin 9 0.043713
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 0.0417873
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.0412856
AADAC arylacetamide deacetylase 0.0370246
MACF1 microtubule-actin crosslinking factor 1 0.0360704
PRELID2 PRELI domain containing 2 0.0357068
TGFB1 transforming growth factor, beta 1 0.0355672
PDLIM5 PDZ and LIM domain 5 0.0353601
EXT1 exostosin glycosyltransferase 1 0.0344274
ATXN1 ataxin 1 0.0342471
NRG1 neuregulin 1 0.0342112
EFNA5 ephrin-A5 0.0339556
MEF2A myocyte enhancer factor 2A 0.0336714
ZSWIM6 zinc finger, SWIM-type containing 6 0.0330014
CDK14 cyclin-dependent kinase 14 0.0327172
LRMDA leucine rich melanocyte differentiation associated 0.03195
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0315169
ASPH aspartate beta-hydroxylase 0.0315152
NPAS2 neuronal PAS domain protein 2 0.0305717
NLK nemo-like kinase 0.0305318
RARB retinoic acid receptor, beta 0.0300806
DTNA dystrobrevin, alpha 0.0298277
COL7A1 collagen, type VII, alpha 1 0.0297255
DIP2C DIP2 disco-interacting protein 2 homolog C (Drosophila) 0.0286185
GREB1L growth regulation by estrogen in breast cancer-like 0.0285535
RAI14 retinoic acid induced 14 0.0284321
TRIO trio Rho guanine nucleotide exchange factor 0.02794
ZNF638 zinc finger protein 638 0.0279289
PRKCA protein kinase C, alpha 0.027625
LHFPL2 lipoma HMGIC fusion partner-like 2 0.0275463
ASCC3 activating signal cointegrator 1 complex subunit 3 0.027339
IFI44L interferon-induced protein 44-like 0.0271906
CTBP2 C-terminal binding protein 2 0.0261399
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0258996
LOXL2 lysyl oxidase-like 2 0.0257285
PTK2 protein tyrosine kinase 2 0.0256724
EFCAB13 EF-hand calcium binding domain 13 0.0256569
WLS wntless Wnt ligand secretion mediator 0.0256037
RCOR1 REST corepressor 1 0.0255442
PTPRB protein tyrosine phosphatase, receptor type, B 0.0254316
FBN1 fibrillin 1 0.0250372
CUX1 cut-like homeobox 1 0.0248042
GLCCI1 glucocorticoid induced 1 0.0244413
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 0.0243426
MSRB3 methionine sulfoxide reductase B3 0.0236952
NHSL1 NHS-like 1 0.0234876
DHRS3 dehydrogenase/reductase (SDR family) member 3 0.0231914
FN1 fibronectin 1 0.0231224
PMEPA1 prostate transmembrane protein, androgen induced 1 0.0228293
PFKFB4 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 0.0227137
HDAC4 histone deacetylase 4 0.0225638
UBE2E2 ubiquitin-conjugating enzyme E2E 2 0.0225603
MECOM MDS1 and EVI1 complex locus 0.0223032
ZFYVE28 zinc finger, FYVE domain containing 28 0.0220387
RASAL2 RAS protein activator like 2 0.0218052
DLG1 discs, large homolog 1 (Drosophila) 0.0214142
RIMS2 regulating synaptic membrane exocytosis 2 0.0213477
PYGL phosphorylase, glycogen, liver 0.0210937
SYT1 synaptotagmin I 0.0210606
SLIT2 slit homolog 2 (Drosophila) 0.0210003
GLS2 glutaminase 2 (liver, mitochondrial) 0.0209349
OXR1 oxidation resistance 1 0.0208484
IGF1R insulin-like growth factor 1 receptor 0.0207806
TRIOBP TRIO and F-actin binding protein 0.0207021
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) 0.0205996
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0204655
JARID2 jumonji, AT rich interactive domain 2 0.0203807
PRH1 proline-rich protein HaeIII subfamily 1 0.0203329
NAV1 neuron navigator 1 0.0202861
CACNA2D3 calcium channel, voltage-dependent, alpha 2/delta subunit 3 0.0202616
NCOR2 nuclear receptor corepressor 2 0.02025
PEAK1 pseudopodium-enriched atypical kinase 1 0.0201446
NEBL nebulette 0.0200609
GYS1 glycogen synthase 1 (muscle) 0.0200579
HDAC9 histone deacetylase 9 0.0199805
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0197987
ARFGEF3 ARFGEF family member 3 0.0197165
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.0195289
ANKRD36 ankyrin repeat domain 36 0.019474
DENND1A DENN/MADD domain containing 1A 0.0193342
ZMIZ1 zinc finger, MIZ-type containing 1 0.0190008

decreased expression

Symbol Name Standardized Value
NAMPT nicotinamide phosphoribosyltransferase -0.239936
CD44 CD44 molecule (Indian blood group) -0.152723
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.102352
OSMR oncostatin M receptor -0.0952047
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.0939279
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0794506
FNDC3B fibronectin type III domain containing 3B -0.0768293
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0692187
RBM39 RNA binding motif protein 39 -0.0614582
ELL2 elongation factor, RNA polymerase II, 2 -0.0596722
GOLGA4 golgin A4 -0.0593311
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0528229
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) -0.0523229
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.051032
NCOA7 nuclear receptor coactivator 7 -0.0509831
VIM vimentin -0.0504337
NPC1 Niemann-Pick disease, type C1 -0.0486556
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 -0.047768
RAB27B RAB27B, member RAS oncogene family -0.0473647
KYNU kynureninase -0.046464
PDE4D phosphodiesterase 4D, cAMP-specific -0.0456166
LMAN1 lectin, mannose-binding, 1 -0.0425162
ZEB2 zinc finger E-box binding homeobox 2 -0.0399604
C15ORF48 chromosome 15 open reading frame 48 -0.0394614
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0394488
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0390133
BASP1 brain abundant, membrane attached signal protein 1 -0.0386914
MT2A metallothionein 2A -0.0373673
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0363746
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0363659
TMSB10 thymosin beta 10 -0.0359973
EIF1 eukaryotic translation initiation factor 1 -0.0349123
COL12A1 collagen, type XII, alpha 1 -0.0348494
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0344822
ZMYND8 zinc finger, MYND-type containing 8 -0.0344138
KDM2A lysine (K)-specific demethylase 2A -0.0339636
SYAP1 synapse associated protein 1 -0.0333009
SOD2 superoxide dismutase 2, mitochondrial -0.0328088
SLC38A1 solute carrier family 38, member 1 -0.0327455
ATP13A3 ATPase type 13A3 -0.0325369
PRRC2C proline-rich coiled-coil 2C -0.0314772
KDM3A lysine (K)-specific demethylase 3A -0.0313881
LOX lysyl oxidase -0.0310854
SBF2 SET binding factor 2 -0.0309995
RNF24 ring finger protein 24 -0.0306572
CTNND1 catenin (cadherin-associated protein), delta 1 -0.0305019
PID1 phosphotyrosine interaction domain containing 1 -0.0304047
DPYSL3 dihydropyrimidinase-like 3 -0.0301526
SPRED2 sprouty-related, EVH1 domain containing 2 -0.0298831
HAS2 hyaluronan synthase 2 -0.0297072
PJA2 praja ring finger 2, E3 ubiquitin protein ligase -0.0292216
CANX calnexin -0.0291559
OGA O-GlcNAcase -0.0290817
KLF6 Kruppel-like factor 6 -0.029028
IER3 immediate early response 3 -0.0289702
AKAP9 A kinase (PRKA) anchor protein 9 -0.0280672
TNNC1 troponin C type 1 (slow) -0.027893
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0275335
YBX3 Y box binding protein 3 -0.0270637
CNOT2 CCR4-NOT transcription complex, subunit 2 -0.0265234
ETV6 ets variant 6 -0.026064
SPAG9 sperm associated antigen 9 -0.0255325
MAP3K5 mitogen-activated protein kinase kinase kinase 5 -0.0253309
ANKRD28 ankyrin repeat domain 28 -0.0251336
RNF149 ring finger protein 149 -0.0245978
CDK17 cyclin-dependent kinase 17 -0.0243221
RB1CC1 RB1-inducible coiled-coil 1 -0.0242906
MAP3K2 mitogen-activated protein kinase kinase kinase 2 -0.0242733
EGR1 early growth response 1 -0.0242488
HEG1 heart development protein with EGF-like domains 1 -0.0237993
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0236637
CDH2 cadherin 2, type 1, N-cadherin (neuronal) -0.0235175
PRKCSH protein kinase C substrate 80K-H -0.0234897
DAAM1 dishevelled associated activator of morphogenesis 1 -0.0234145
MON2 MON2 homolog (S. cerevisiae) -0.0234085
ZNF292 zinc finger protein 292 -0.0232044
EREG epiregulin -0.0226811
CDCP1 CUB domain containing protein 1 -0.0226317
MORF4L2 mortality factor 4 like 2 -0.0217548
NF1 neurofibromin 1 -0.0217132
GCC2 GRIP and coiled-coil domain containing 2 -0.0215645
UGCG UDP-glucose ceramide glucosyltransferase -0.0214689
CXCL5 chemokine (C-X-C motif) ligand 5 -0.0214575
MIS18BP1 MIS18 binding protein 1 -0.0213344
RBM25 RNA binding motif protein 25 -0.0212139
YME1L1 YME1-like 1 ATPase -0.0211871
IL1R1 interleukin 1 receptor, type I -0.0211041
KMT2C lysine (K)-specific methyltransferase 2C -0.0210612
KLF7 Kruppel-like factor 7 (ubiquitous) -0.0210264
DOCK4 dedicator of cytokinesis 4 -0.020912
KIF5B kinesin family member 5B -0.0207641
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0207084
ACTR2 ARP2 actin-related protein 2 homolog (yeast) -0.0204999
RPLP1 ribosomal protein, large, P1 -0.0204848
DNAJC1 DnaJ (Hsp40) homolog, subfamily C, member 1 -0.020281
MINDY2 MINDY lysine 48 deubiquitinase 2 -0.0202705
GALNT2 polypeptide N-acetylgalactosaminyltransferase 2 -0.0200744
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha -0.0194723
ZFP91 ZFP91 zinc finger protein -0.0193922
NPEPPS aminopeptidase puromycin sensitive -0.0193401