Retinoic acid_NCI-H2030 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Retinoic acid perturbation in NCI-H2030 cell line (Tahoe Therapeutics)
Similar Terms
Downloads & Tools

Genes

200 genes differentially expressed following the Retinoic acid_NCI-H2030 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
GRAMD1B GRAM domain containing 1B 0.189485
PDE4D phosphodiesterase 4D, cAMP-specific 0.160117
PM20D1 peptidase M20 domain containing 1 0.124719
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) 0.123646
THSD4 thrombospondin, type I, domain containing 4 0.102719
DOCK4 dedicator of cytokinesis 4 0.0944793
FTH1 ferritin, heavy polypeptide 1 0.0913137
FNDC3B fibronectin type III domain containing 3B 0.0671279
SMOC1 SPARC related modular calcium binding 1 0.0620102
SAMD4A sterile alpha motif domain containing 4A 0.0540645
ARHGAP26 Rho GTPase activating protein 26 0.0504032
DST dystonin 0.0502838
WWOX WW domain containing oxidoreductase 0.0487557
MAML3 mastermind-like 3 (Drosophila) 0.0480297
SVIL supervillin 0.0460207
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0450912
PHLDB2 pleckstrin homology-like domain, family B, member 2 0.0441364
NEGR1 neuronal growth regulator 1 0.0435161
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0419182
PDLIM5 PDZ and LIM domain 5 0.0418398
TPM3 tropomyosin 3 0.0414769
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.0399963
VPS13B vacuolar protein sorting 13 homolog B (yeast) 0.0397587
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.03938
RAD51B RAD51 paralog B 0.0346991
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0345025
GLIS3 GLIS family zinc finger 3 0.0344588
FMNL2 formin-like 2 0.0343508
MACF1 microtubule-actin crosslinking factor 1 0.034326
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0341779
KYNU kynureninase 0.0338729
MCL1 myeloid cell leukemia 1 0.0335411
DOCK5 dedicator of cytokinesis 5 0.0334858
TTC28 tetratricopeptide repeat domain 28 0.0333666
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0328728
BICC1 BicC family RNA binding protein 1 0.0312083
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0311086
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.0310876
CMIP c-Maf inducing protein 0.0308672
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0300233
PTPRG protein tyrosine phosphatase, receptor type, G 0.0299654
KTN1 kinectin 1 (kinesin receptor) 0.0297691
MSN moesin 0.0291378
CCNL1 cyclin L1 0.0290819
UTRN utrophin 0.0290645
EFNA5 ephrin-A5 0.0288565
SHANK2 SH3 and multiple ankyrin repeat domains 2 0.0286531
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 0.0284442
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0284316
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0278863
BRD2 bromodomain containing 2 0.0263797
PDE10A phosphodiesterase 10A 0.0262912
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0262032
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.026026
HDAC9 histone deacetylase 9 0.025892
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0254325
PLS3 plastin 3 0.0252088
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.02424
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 0.0241981
TBC1D5 TBC1 domain family, member 5 0.0240629
NTN4 netrin 4 0.0240027
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0238016
EDIL3 EGF-like repeats and discoidin I-like domains 3 0.0235918
GALNT2 polypeptide N-acetylgalactosaminyltransferase 2 0.0234637
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0229848
PCBP2 poly(rC) binding protein 2 0.0229667
IL6 interleukin 6 0.0228184
SFPQ splicing factor proline/glutamine-rich 0.0226643
NR4A2 nuclear receptor subfamily 4, group A, member 2 0.0226332
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.0223428
GLS2 glutaminase 2 (liver, mitochondrial) 0.0217369
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) 0.0213361
TRAPPC9 trafficking protein particle complex 9 0.021039
POTEF POTE ankyrin domain family, member F 0.0209013
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) 0.0208678
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0204708
FOS FBJ murine osteosarcoma viral oncogene homolog 0.0204518
ZBTB20 zinc finger and BTB domain containing 20 0.0203885
FAM107B family with sequence similarity 107, member B 0.0203523
LRMDA leucine rich melanocyte differentiation associated 0.0202793
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 0.0202176
SIK3 SIK family kinase 3 0.0201409
RTN4 reticulon 4 0.0201338
SMYD3 SET and MYND domain containing 3 0.0200271
VEGFC vascular endothelial growth factor C 0.0199268
IGFBP3 insulin-like growth factor binding protein 3 0.019803
RABGAP1L RAB GTPase activating protein 1-like 0.0194594
BASP1 brain abundant, membrane attached signal protein 1 0.019409
MTHFD2L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2-like 0.0193946
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 0.0192482
FOXP1 forkhead box P1 0.0189962
LOC102724023 ES1 protein homolog, mitochondrial 0.0189737
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0189218
NEBL nebulette 0.018487
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0184245
TPM1 tropomyosin 1 (alpha) 0.0183579
FHIT fragile histidine triad 0.0183387
LDHA lactate dehydrogenase A 0.0182415
NBEAL1 neurobeachin-like 1 0.0182206
MYADM myeloid-associated differentiation marker 0.0181736

decreased expression

Symbol Name Standardized Value
MT2A metallothionein 2A -0.288326
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.151334
VIM vimentin -0.140693
TMSB10 thymosin beta 10 -0.12771
PTMA prothymosin, alpha -0.115801
AKAP12 A kinase (PRKA) anchor protein 12 -0.106042
EIF1 eukaryotic translation initiation factor 1 -0.102229
RPL23 ribosomal protein L23 -0.0944004
TPT1 tumor protein, translationally-controlled 1 -0.0865389
RPL19 ribosomal protein L19 -0.0845017
IER3 immediate early response 3 -0.0831211
TFPI2 tissue factor pathway inhibitor 2 -0.0655235
C15ORF48 chromosome 15 open reading frame 48 -0.0636721
RPS21 ribosomal protein S21 -0.0626429
RPL35A ribosomal protein L35a -0.0619544
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0611992
RPS8 ribosomal protein S8 -0.0561721
RPLP1 ribosomal protein, large, P1 -0.0515928
TM4SF1 transmembrane 4 L six family member 1 -0.051487
AHNAK AHNAK nucleoprotein -0.0504497
RPS29 ribosomal protein S29 -0.0503846
S100A10 S100 calcium binding protein A10 -0.0484318
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0469801
RPS6 ribosomal protein S6 -0.0465241
ACTG1 actin gamma 1 -0.0455537
RPL31 ribosomal protein L31 -0.0455156
CAVIN1 caveolae associated protein 1 -0.0440361
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -0.0439398
RPS24 ribosomal protein S24 -0.0425362
RPL34 ribosomal protein L34 -0.0424146
RPS23 ribosomal protein S23 -0.0419153
RPS25 ribosomal protein S25 -0.041707
RPL36 ribosomal protein L36 -0.0415311
FTL ferritin, light polypeptide -0.0415123
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.04023
RPS27A ribosomal protein S27a -0.0401537
SERF2 small EDRK-rich factor 2 -0.039921
RPL38 ribosomal protein L38 -0.0380807
SF3B2 splicing factor 3b, subunit 2, 145kDa -0.0355942
RPL37A ribosomal protein L37a -0.0353712
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0348767
RPS19 ribosomal protein S19 -0.0347502
RPS11 ribosomal protein S11 -0.0345049
RPL26 ribosomal protein L26 -0.0337014
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0334814
RAD21 RAD21 homolog (S. pombe) -0.0327899
RPS15 ribosomal protein S15 -0.0324168
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon -0.0323027
KDM3A lysine (K)-specific demethylase 3A -0.0318345
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0312321
MYL12B myosin, light chain 12B, regulatory -0.0311159
RPLP2 ribosomal protein, large, P2 -0.0308085
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0307408
LGALS1 lectin, galactoside-binding, soluble, 1 -0.0306077
KPNB1 karyopherin (importin) beta 1 -0.0291957
AP2B1 adaptor-related protein complex 2, beta 1 subunit -0.0291578
RPL12 ribosomal protein L12 -0.0290814
RBM39 RNA binding motif protein 39 -0.0284981
BHLHE40 basic helix-loop-helix family, member e40 -0.028313
KLF6 Kruppel-like factor 6 -0.0281625
NAP1L1 nucleosome assembly protein 1-like 1 -0.0280776
S100A6 S100 calcium binding protein A6 -0.0279975
RSL1D1 ribosomal L1 domain containing 1 -0.0279299
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.0274992
RPL4 ribosomal protein L4 -0.0268066
RPL11 ribosomal protein L11 -0.026688
RPS27 ribosomal protein S27 -0.0263817
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 -0.0261372
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0251146
HLA-E major histocompatibility complex, class I, E -0.0245209
PPIB peptidylprolyl isomerase B (cyclophilin B) -0.0244621
SLC38A2 solute carrier family 38, member 2 -0.024151
RPL8 ribosomal protein L8 -0.0239223
RPLP0 ribosomal protein, large, P0 -0.0238517
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0236165
PFDN2 prefoldin subunit 2 -0.0235749
MAPK8 mitogen-activated protein kinase 8 -0.0233892
FUS FUS RNA binding protein -0.0228145
ATP5F1E ATP synthase F1 subunit epsilon -0.0226506
HLA-B major histocompatibility complex, class I, B -0.0225011
GLG1 golgi glycoprotein 1 -0.022303
CANX calnexin -0.0221865
HMGB1 high mobility group box 1 -0.0220824
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa -0.0217939
RPL32 ribosomal protein L32 -0.0217086
RPL7 ribosomal protein L7 -0.0216863
RPS17 ribosomal protein S17 -0.0214055
SLC38A1 solute carrier family 38, member 1 -0.0213314
GNAS GNAS complex locus -0.021245
CCT5 chaperonin containing TCP1, subunit 5 (epsilon) -0.0212265
SRP14 signal recognition particle 14kDa (homologous Alu RNA binding protein) -0.0212138
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa -0.0211414
H1-0 H1.0 linker histone -0.0210253
RPL37 ribosomal protein L37 -0.0208956
RPS10 ribosomal protein S10 -0.0207902
YME1L1 YME1-like 1 ATPase -0.0205968
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -0.0205661
RPL10A ribosomal protein L10a -0.0204549
GARS1 glycyl-tRNA synthetase 1 -0.0203712
ANXA2 annexin A2 -0.0201272