Retinoic acid_NCI-H23 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Retinoic acid perturbation in NCI-H23 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Retinoic acid_NCI-H23 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
GRAMD1B GRAM domain containing 1B 0.172855
AKAP12 A kinase (PRKA) anchor protein 12 0.123474
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 0.114717
PDE4D phosphodiesterase 4D, cAMP-specific 0.107477
ERRFI1 ERBB receptor feedback inhibitor 1 0.100515
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0990258
THSD4 thrombospondin, type I, domain containing 4 0.0949039
KPNA4 karyopherin alpha 4 (importin alpha 3) 0.0923226
YBX3 Y box binding protein 3 0.0917765
PDE10A phosphodiesterase 10A 0.0848086
SYNE2 spectrin repeat containing, nuclear envelope 2 0.0809791
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0796176
IGF1R insulin-like growth factor 1 receptor 0.072005
MCL1 myeloid cell leukemia 1 0.0706023
DOCK5 dedicator of cytokinesis 5 0.0687665
OSMR oncostatin M receptor 0.0675614
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.0652308
RAD51B RAD51 paralog B 0.0642302
PHLDB2 pleckstrin homology-like domain, family B, member 2 0.0638997
CDK17 cyclin-dependent kinase 17 0.0628164
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 0.0624018
TPM3 tropomyosin 3 0.0612633
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.0611267
RIMS2 regulating synaptic membrane exocytosis 2 0.0596296
EML4 echinoderm microtubule associated protein like 4 0.0587581
TM4SF1 transmembrane 4 L six family member 1 0.0570151
EXOC4 exocyst complex component 4 0.0560115
FMNL2 formin-like 2 0.0547877
WWOX WW domain containing oxidoreductase 0.0543133
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0530612
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0502996
ATP11A ATPase, class VI, type 11A 0.0500762
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0475982
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.046613
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.045499
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 0.0444851
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 0.0439724
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) 0.043262
LATS2 large tumor suppressor kinase 2 0.0430965
RRM2 ribonucleotide reductase M2 0.0426367
IFI6 interferon, alpha-inducible protein 6 0.0413433
VCL vinculin 0.0409774
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0407228
BASP1 brain abundant, membrane attached signal protein 1 0.0401361
TPM4 tropomyosin 4 0.0400257
ELL2 elongation factor, RNA polymerase II, 2 0.0394173
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.039028
NR4A3 nuclear receptor subfamily 4, group A, member 3 0.0390025
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0387289
NF1 neurofibromin 1 0.0387093
HMGA2 high mobility group AT-hook 2 0.0380509
TRIP12 thyroid hormone receptor interactor 12 0.0378207
PARP14 poly (ADP-ribose) polymerase family, member 14 0.0372598
CALD1 caldesmon 1 0.0372325
FNDC3B fibronectin type III domain containing 3B 0.0366057
TXNRD1 thioredoxin reductase 1 0.0364983
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0357253
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0355565
IL6ST interleukin 6 signal transducer 0.0349865
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.0343423
YAP1 Yes-associated protein 1 0.0337496
EXT1 exostosin glycosyltransferase 1 0.0332924
VMP1 vacuole membrane protein 1 0.0330293
PDE4B phosphodiesterase 4B, cAMP-specific 0.0329584
ZSWIM6 zinc finger, SWIM-type containing 6 0.0327333
NLGN1 neuroligin 1 0.0320433
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0317513
NCOA7 nuclear receptor coactivator 7 0.0316865
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0315467
KTN1 kinectin 1 (kinesin receptor) 0.031451
JMJD1C jumonji domain containing 1C 0.0310118
MYH9 myosin, heavy chain 9, non-muscle 0.0309453
PLSCR1 phospholipid scramblase 1 0.0309286
PDLIM5 PDZ and LIM domain 5 0.0303388
SMYD3 SET and MYND domain containing 3 0.03004
PNPT1 polyribonucleotide nucleotidyltransferase 1 0.0296491
PRKCE protein kinase C, epsilon 0.0296222
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.0295842
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0295025
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide 0.0291227
SNAP25 synaptosomal-associated protein, 25kDa 0.0287184
ERC1 ELKS/RAB6-interacting/CAST family member 1 0.0287038
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0286413
CCND1 cyclin D1 0.0285219
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0284139
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 0.0283477
BIRC2 baculoviral IAP repeat containing 2 0.0282308
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0281676
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 0.0281084
DDAH1 dimethylarginine dimethylaminohydrolase 1 0.0281
MACF1 microtubule-actin crosslinking factor 1 0.0280666
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) 0.0278907
BMP5 bone morphogenetic protein 5 0.0274002
CACNA2D1 calcium channel, voltage-dependent, alpha 2/delta subunit 1 0.0269992
BMAL2 basic helix-loop-helix ARNT like 2 0.0267724
STC1 stanniocalcin 1 0.0267566
SSH2 slingshot protein phosphatase 2 0.0264637
ADAR adenosine deaminase, RNA-specific 0.0264002
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0263816
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0263166

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.217433
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.150409
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.107722
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0990214
TMSB10 thymosin beta 10 -0.0710019
RPL26 ribosomal protein L26 -0.0591871
RPS21 ribosomal protein S21 -0.058622
RPL23 ribosomal protein L23 -0.0566191
TFPI2 tissue factor pathway inhibitor 2 -0.0561902
RPS19 ribosomal protein S19 -0.0551272
RPL35A ribosomal protein L35a -0.0538086
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.0504105
RPL37A ribosomal protein L37a -0.0472701
RPL37 ribosomal protein L37 -0.0471454
CANX calnexin -0.0462654
RPS27 ribosomal protein S27 -0.0450113
RPS8 ribosomal protein S8 -0.0442097
RPL34 ribosomal protein L34 -0.0422455
RPLP1 ribosomal protein, large, P1 -0.0420805
RPL12 ribosomal protein L12 -0.0417368
PTMA prothymosin, alpha -0.0416226
RPS3 ribosomal protein S3 -0.0396851
EIF1 eukaryotic translation initiation factor 1 -0.039333
TPT1 tumor protein, translationally-controlled 1 -0.0375926
GOLGA4 golgin A4 -0.0366152
VIM vimentin -0.03592
COPA coatomer protein complex, subunit alpha -0.0352895
RPL32 ribosomal protein L32 -0.0352743
EEF2 eukaryotic translation elongation factor 2 -0.035029
RPL19 ribosomal protein L19 -0.0338893
RPS15 ribosomal protein S15 -0.0337594
RPLP2 ribosomal protein, large, P2 -0.0336453
GARS1 glycyl-tRNA synthetase 1 -0.0314344
NAP1L1 nucleosome assembly protein 1-like 1 -0.0313576
RPL5 ribosomal protein L5 -0.0303506
KDM3A lysine (K)-specific demethylase 3A -0.029981
RPS27A ribosomal protein S27a -0.0295414
RPL11 ribosomal protein L11 -0.0295174
RPL36 ribosomal protein L36 -0.0294236
RPL8 ribosomal protein L8 -0.0293847
ZCCHC7 zinc finger, CCHC domain containing 7 -0.028943
RPL31 ribosomal protein L31 -0.028919
RPS29 ribosomal protein S29 -0.028762
RPS24 ribosomal protein S24 -0.0286547
GOLGB1 golgin B1 -0.0280645
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 -0.0273121
RPS4X ribosomal protein S4, X-linked -0.0270953
RPS6 ribosomal protein S6 -0.0265325
MYL12B myosin, light chain 12B, regulatory -0.0261828
RPS14 ribosomal protein S14 -0.0261316
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0258698
PREPL prolyl endopeptidase-like -0.0258067
KDM4B lysine (K)-specific demethylase 4B -0.0246285
SRP72 signal recognition particle 72kDa -0.0246162
PDIA4 protein disulfide isomerase family A, member 4 -0.0242795
RPS25 ribosomal protein S25 -0.0237841
TMEM263 transmembrane protein 263 -0.023395
WSB1 WD repeat and SOCS box containing 1 -0.0233215
BBX bobby sox homolog (Drosophila) -0.0226753
COPB2 coatomer protein complex, subunit beta 2 (beta prime) -0.0223652
LMAN1 lectin, mannose-binding, 1 -0.0223482
SHANK2 SH3 and multiple ankyrin repeat domains 2 -0.0220432
ACSL3 acyl-CoA synthetase long-chain family member 3 -0.0214961
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0212099
RPS23 ribosomal protein S23 -0.0211423
RPL18 ribosomal protein L18 -0.0209105
RPL28 ribosomal protein L28 -0.0208696
RPL35 ribosomal protein L35 -0.0208031
FTL ferritin, light polypeptide -0.0207336
EGR1 early growth response 1 -0.0204616
RPL38 ribosomal protein L38 -0.0204166
EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3 -0.0202267
PCLO piccolo presynaptic cytomatrix protein -0.0202222
RPS13 ribosomal protein S13 -0.0200339
MON2 MON2 homolog (S. cerevisiae) -0.0194015
RACK1 receptor for activated C kinase 1 -0.0190714
ZFR zinc finger RNA binding protein -0.0188403
WASF2 WAS protein family, member 2 -0.018749
RPS10 ribosomal protein S10 -0.0185319
OGA O-GlcNAcase -0.0183457
ATXN2 ataxin 2 -0.0183161
NACA nascent polypeptide-associated complex alpha subunit -0.0181095
CALR calreticulin -0.0179525
LRRC23 leucine rich repeat containing 23 -0.0178567
KRT18 keratin 18, type I -0.0178202
RAB1A RAB1A, member RAS oncogene family -0.0176028
ACBD3 acyl-CoA binding domain containing 3 -0.017466
RPS17 ribosomal protein S17 -0.0173789
H1-0 H1.0 linker histone -0.017356
RPL36A ribosomal protein L36a -0.0170786
TRPC4AP transient receptor potential cation channel, subfamily C, member 4 associated protein -0.0170041
SRP54 signal recognition particle 54kDa -0.0169247
RPS20 ribosomal protein S20 -0.016829
UBE2V1 ubiquitin-conjugating enzyme E2 variant 1 -0.0165697
RPL27 ribosomal protein L27 -0.0164628
FBXO11 F-box protein 11 -0.0164029
PPP4R3B protein phosphatase 4 regulatory subunit 3B -0.0163241
RPL9 ribosomal protein L9 -0.0160576
HMGA1 high mobility group AT-hook 1 -0.0160251
AEBP2 AE binding protein 2 -0.0159234