Retinoic acid_NCI-H2347 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Retinoic acid perturbation in NCI-H2347 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Retinoic acid_NCI-H2347 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FNDC3B fibronectin type III domain containing 3B 0.107408
TRIO trio Rho guanine nucleotide exchange factor 0.105908
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.104175
GRB10 growth factor receptor-bound protein 10 0.0977149
SAMD4A sterile alpha motif domain containing 4A 0.0910019
EXT1 exostosin glycosyltransferase 1 0.0888245
TSC22D2 TSC22 domain family, member 2 0.0847474
PLEC plectin 0.077029
LIMCH1 LIM and calponin homology domains 1 0.0734103
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0701226
LAMB3 laminin, beta 3 0.067907
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.0643936
ZSWIM6 zinc finger, SWIM-type containing 6 0.0596975
AHNAK AHNAK nucleoprotein 0.0560132
PPARD peroxisome proliferator-activated receptor delta 0.0538936
FLNB filamin B, beta 0.0530974
AKAP13 A kinase (PRKA) anchor protein 13 0.0527894
CTBP2 C-terminal binding protein 2 0.0506996
SMAD3 SMAD family member 3 0.0503015
MBOAT2 membrane bound O-acyltransferase domain containing 2 0.0501886
UBE2H ubiquitin-conjugating enzyme E2H 0.0494995
PDLIM5 PDZ and LIM domain 5 0.0477019
MSI2 musashi RNA-binding protein 2 0.0473926
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 0.0468527
PPP1R13B protein phosphatase 1, regulatory subunit 13B 0.0466117
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0442454
LPP LIM domain containing preferred translocation partner in lipoma 0.0432458
MICAL3 microtubule associated monooxygenase, calponin and LIM domain containing 3 0.0430177
RALGPS2 Ral GEF with PH domain and SH3 binding motif 2 0.0429527
LHFPL2 lipoma HMGIC fusion partner-like 2 0.0403182
CTNND1 catenin (cadherin-associated protein), delta 1 0.0398943
AFF4 AF4/FMR2 family, member 4 0.0396893
RAI14 retinoic acid induced 14 0.0394281
OGA O-GlcNAcase 0.0393238
DUSP10 dual specificity phosphatase 10 0.0388909
NRIP1 nuclear receptor interacting protein 1 0.038194
RCOR1 REST corepressor 1 0.0380179
SERINC5 serine incorporator 5 0.0376064
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0364772
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0357574
TUFT1 tuftelin 1 0.0357164
ANKRD11 ankyrin repeat domain 11 0.035052
PTK2 protein tyrosine kinase 2 0.0347913
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0342084
ANKRD17 ankyrin repeat domain 17 0.0331383
FBXO32 F-box protein 32 0.0329911
TJP2 tight junction protein 2 0.0322806
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.0322721
MYO1E myosin IE 0.0322582
SH3RF1 SH3 domain containing ring finger 1 0.0308044
USP53 ubiquitin specific peptidase 53 0.0305815
WSB1 WD repeat and SOCS box containing 1 0.0301333
VCL vinculin 0.0300647
UPP1 uridine phosphorylase 1 0.0298993
MACF1 microtubule-actin crosslinking factor 1 0.0294528
SPSB1 splA/ryanodine receptor domain and SOCS box containing 1 0.0290252
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.0289595
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0289565
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.0284483
NIPBL Nipped-B homolog (Drosophila) 0.0281368
PGBD5 piggyBac transposable element derived 5 0.0278194
SDC4 syndecan 4 0.0276417
IGFBP3 insulin-like growth factor binding protein 3 0.0276086
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0271831
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.0271419
MYO6 myosin VI 0.0269325
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0265957
AGO2 argonaute RISC catalytic component 2 0.0264813
NAV2 neuron navigator 2 0.0263354
PSD3 pleckstrin and Sec7 domain containing 3 0.026266
MAP1B microtubule-associated protein 1B 0.0262284
UBE2E1 ubiquitin-conjugating enzyme E2E 1 0.0261306
OCLN occludin 0.0261005
KLF7 Kruppel-like factor 7 (ubiquitous) 0.0260278
SEMA3B sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B 0.0259913
FGD4 FYVE, RhoGEF and PH domain containing 4 0.0259553
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0259513
FNIP1 folliculin interacting protein 1 0.0256568
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b 0.0256039
RAD51B RAD51 paralog B 0.0253683
AHNAK2 AHNAK nucleoprotein 2 0.0252642
RAB7A RAB7A, member RAS oncogene family 0.0252231
UGDH UDP-glucose 6-dehydrogenase 0.0250573
SH3KBP1 SH3-domain kinase binding protein 1 0.0246693
ST14 suppression of tumorigenicity 14 (colon carcinoma) 0.0244815
GNPDA1 glucosamine-6-phosphate deaminase 1 0.0243105
FBXL2 F-box and leucine-rich repeat protein 2 0.02423
STRN3 striatin, calmodulin binding protein 3 0.0240721
ARHGAP5 Rho GTPase activating protein 5 0.0239531
GOLGB1 golgin B1 0.0237065
SHB Src homology 2 domain containing adaptor protein B 0.0235403
RBM47 RNA binding motif protein 47 0.023453
AFF1 AF4/FMR2 family, member 1 0.0234144
BASP1 brain abundant, membrane attached signal protein 1 0.0233973
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0230581
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) 0.0227964
BCL2L1 BCL2-like 1 0.0227499
FBXO34 F-box protein 34 0.0226837
JARID2 jumonji, AT rich interactive domain 2 0.0226555
H1-0 H1.0 linker histone 0.0224876

decreased expression

Symbol Name Standardized Value
FN1 fibronectin 1 -0.22577
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.14711
PTMA prothymosin, alpha -0.140769
POTEF POTE ankyrin domain family, member F -0.136467
ASPH aspartate beta-hydroxylase -0.117961
NDRG1 N-myc downstream regulated 1 -0.106132
NAMPT nicotinamide phosphoribosyltransferase -0.0945116
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0885483
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0840915
FTL ferritin, light polypeptide -0.0822144
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0790239
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0756936
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0733122
RPS2 ribosomal protein S2 -0.0708519
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0696511
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0669417
DSTN destrin (actin depolymerizing factor) -0.0630063
ACTG1 actin gamma 1 -0.0600492
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0599444
S100A6 S100 calcium binding protein A6 -0.0598418
LAMC2 laminin, gamma 2 -0.058628
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.051658
EIF1 eukaryotic translation initiation factor 1 -0.0510337
RACK1 receptor for activated C kinase 1 -0.0505797
RPS8 ribosomal protein S8 -0.0492354
RPS3 ribosomal protein S3 -0.0483549
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0481218
UBC ubiquitin C -0.047962
RPS6 ribosomal protein S6 -0.0471334
GOLGA4 golgin A4 -0.0469933
HSPA8 heat shock 70kDa protein 8 -0.0463135
LDHA lactate dehydrogenase A -0.0449387
HNRNPDL heterogeneous nuclear ribonucleoprotein D-like -0.0445467
RPS13 ribosomal protein S13 -0.0445281
RPL7 ribosomal protein L7 -0.0433618
SET SET nuclear proto-oncogene -0.0433021
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0429801
RPS12 ribosomal protein S12 -0.0424486
TFG TRK-fused gene -0.0415514
SLC38A1 solute carrier family 38, member 1 -0.040395
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.0401499
CCNL1 cyclin L1 -0.0400329
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa -0.0398833
RPL37A ribosomal protein L37a -0.0391922
TMSB4X thymosin beta 4, X-linked -0.039061
PAPOLA poly(A) polymerase alpha -0.0385252
TPM4 tropomyosin 4 -0.0383111
RPL9 ribosomal protein L9 -0.03805
TPM3 tropomyosin 3 -0.0380205
RPL15 ribosomal protein L15 -0.0366175
MSMO1 methylsterol monooxygenase 1 -0.0364761
HDGF hepatoma-derived growth factor -0.03617
RPL11 ribosomal protein L11 -0.0336925
EPCAM epithelial cell adhesion molecule -0.0336226
MAL2 mal, T-cell differentiation protein 2 (gene/pseudogene) -0.0336123
RPS27A ribosomal protein S27a -0.0332336
ATP5F1B ATP synthase F1 subunit beta -0.0322649
DDIT4 DNA-damage-inducible transcript 4 -0.0321671
RPS17 ribosomal protein S17 -0.0320726
HMGB2 high mobility group box 2 -0.0319952
CENPF centromere protein F, 350/400kDa -0.0317725
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0317475
RPLP0 ribosomal protein, large, P0 -0.0309266
CNBP CCHC-type zinc finger, nucleic acid binding protein -0.0307638
RPS25 ribosomal protein S25 -0.0306229
GOLT1B golgi transport 1B -0.0296362
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha -0.029589
TPT1 tumor protein, translationally-controlled 1 -0.0295743
LDHB lactate dehydrogenase B -0.0289405
TXNRD1 thioredoxin reductase 1 -0.0287193
CD47 CD47 molecule -0.0284768
RPS14 ribosomal protein S14 -0.0283846
MAP4K5 mitogen-activated protein kinase kinase kinase kinase 5 -0.0283309
ISG15 ISG15 ubiquitin-like modifier -0.0282582
TUBA1B tubulin, alpha 1b -0.0277878
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 -0.027762
TKT transketolase -0.0275308
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like -0.0273763
RBM3 RNA binding motif (RNP1, RRM) protein 3 -0.0271695
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0269044
RPS23 ribosomal protein S23 -0.0267289
PKM pyruvate kinase, muscle -0.0265169
G3BP2 GTPase activating protein (SH3 domain) binding protein 2 -0.0263496
PGK1 phosphoglycerate kinase 1 -0.026283
H3-3B H3.3 histone B -0.0262526
ERRFI1 ERBB receptor feedback inhibitor 1 -0.026161
BRD2 bromodomain containing 2 -0.0256507
EEF2 eukaryotic translation elongation factor 2 -0.0256177
MKI67 marker of proliferation Ki-67 -0.0254526
ANLN anillin, actin binding protein -0.0253138
MBNL1 muscleblind-like splicing regulator 1 -0.0250569
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 -0.0250564
RPL30 ribosomal protein L30 -0.0247635
UBA6 ubiquitin-like modifier activating enzyme 6 -0.0247568
SMC4 structural maintenance of chromosomes 4 -0.0245643
STARD4 StAR-related lipid transfer (START) domain containing 4 -0.0244072
CCND1 cyclin D1 -0.0243791
PEG10 paternally expressed 10 -0.024306
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha -0.0241138
RPL37 ribosomal protein L37 -0.0238712