Retinoic acid_NCI-H596 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Retinoic acid perturbation in NCI-H596 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Retinoic acid_NCI-H596 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PDE10A phosphodiesterase 10A 0.354091
PDE4D phosphodiesterase 4D, cAMP-specific 0.16438
PSD3 pleckstrin and Sec7 domain containing 3 0.137909
SMYD3 SET and MYND domain containing 3 0.137787
RORA RAR-related orphan receptor A 0.137576
NALF1 NALCN channel auxiliary factor 1 0.133933
GPC6 glypican 6 0.119431
VGF VGF nerve growth factor inducible 0.114369
CDH13 cadherin 13 0.114336
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A 0.111395
EFNA5 ephrin-A5 0.110092
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) 0.104559
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.0993144
EXT1 exostosin glycosyltransferase 1 0.0902853
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) 0.0845953
NKD1 naked cuticle homolog 1 (Drosophila) 0.0828304
SGIP1 SH3-domain GRB2-like (endophilin) interacting protein 1 0.074843
MYCBP2 MYC binding protein 2, E3 ubiquitin protein ligase 0.0678178
PUM2 pumilio RNA-binding family member 2 0.0638736
SYT1 synaptotagmin I 0.0615268
TENM3 teneurin transmembrane protein 3 0.0608514
ASPH aspartate beta-hydroxylase 0.0591859
TOP1 topoisomerase (DNA) I 0.0568552
SPTBN1 spectrin, beta, non-erythrocytic 1 0.055468
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0542233
PTK2 protein tyrosine kinase 2 0.0523994
GLIS3 GLIS family zinc finger 3 0.0519421
NDRG1 N-myc downstream regulated 1 0.0516801
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0516784
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0502251
TRIO trio Rho guanine nucleotide exchange factor 0.0491489
DST dystonin 0.0486628
FLNB filamin B, beta 0.0459114
NAP1L1 nucleosome assembly protein 1-like 1 0.0452871
MBD5 methyl-CpG binding domain protein 5 0.0438785
NAV2 neuron navigator 2 0.0423038
NABP1 nucleic acid binding protein 1 0.0421912
STC1 stanniocalcin 1 0.0386957
OGA O-GlcNAcase 0.0386709
IGF2 insulin-like growth factor 2 0.0383926
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.0382038
SEPTIN9 septin 9 0.0373178
PRELID2 PRELI domain containing 2 0.0370836
FBXO11 F-box protein 11 0.0368218
INTS6 integrator complex subunit 6 0.0364599
KDM3B lysine (K)-specific demethylase 3B 0.0354231
UBE2H ubiquitin-conjugating enzyme E2H 0.0347637
KDM4C lysine (K)-specific demethylase 4C 0.0336467
BIRC6 baculoviral IAP repeat containing 6 0.0331622
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0320621
ALCAM activated leukocyte cell adhesion molecule 0.0315677
PGK1 phosphoglycerate kinase 1 0.0311031
TBC1D22A TBC1 domain family, member 22A 0.0307729
CMIP c-Maf inducing protein 0.0304811
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.02975
APLP2 amyloid beta (A4) precursor-like protein 2 0.0295144
TAS2R14 taste receptor, type 2, member 14 0.0288067
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 0.0285189
NCOA3 nuclear receptor coactivator 3 0.0278268
FNIP1 folliculin interacting protein 1 0.0266671
USP34 ubiquitin specific peptidase 34 0.0266507
MED13 mediator complex subunit 13 0.0255827
NCOR1 nuclear receptor corepressor 1 0.0254465
ARHGAP32 Rho GTPase activating protein 32 0.0251011
ZNF292 zinc finger protein 292 0.0250406
YAP1 Yes-associated protein 1 0.0246917
AKAP9 A kinase (PRKA) anchor protein 9 0.0241963
NEBL nebulette 0.0240893
CUL3 cullin 3 0.0232017
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0222847
AHNAK AHNAK nucleoprotein 0.0220559
APP amyloid beta (A4) precursor protein 0.0209582
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.020755
EZR ezrin 0.020492
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0192117
WWC1 WW and C2 domain containing 1 0.0191225
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 0.0189842
ZFAND3 zinc finger, AN1-type domain 3 0.0183984
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.0171223
CERS6 ceramide synthase 6 0.0170789
CANX calnexin 0.0166429
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) 0.016137
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0152209
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0135273
SDK1 sidekick cell adhesion molecule 1 0.0133668
COL5A2 collagen, type V, alpha 2 0.013315
NAMPT nicotinamide phosphoribosyltransferase 0.0128622
ATF3 activating transcription factor 3 0.0126581
ELL2 elongation factor, RNA polymerase II, 2 0.0125719
ZSWIM6 zinc finger, SWIM-type containing 6 0.0123653
ANKRD17 ankyrin repeat domain 17 0.0122022
PRRC2C proline-rich coiled-coil 2C 0.0119255
SYNGAP1 synaptic Ras GTPase activating protein 1 0.0114146
KMT2C lysine (K)-specific methyltransferase 2C 0.0113113
PDGFA platelet-derived growth factor alpha polypeptide 0.0110462
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0109366
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0105306
RABGAP1L RAB GTPase activating protein 1-like 0.0104851
RUNX1 runt-related transcription factor 1 0.0102476
BACE2 beta-site APP-cleaving enzyme 2 0.00970707

decreased expression

Symbol Name Standardized Value
EGFR epidermal growth factor receptor -0.148755
ARID2 AT rich interactive domain 2 (ARID, RFX-like) -0.147265
PTMA prothymosin, alpha -0.138906
TMSB10 thymosin beta 10 -0.137632
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.114817
LPP LIM domain containing preferred translocation partner in lipoma -0.113559
ITGA6 integrin, alpha 6 -0.111826
FN1 fibronectin 1 -0.108173
RPS6 ribosomal protein S6 -0.0999449
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 -0.0996138
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0981827
MYO10 myosin X -0.0971319
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0952544
PATJ PATJ crumbs cell polarity complex component -0.0947713
SLTM SAFB-like, transcription modulator -0.0883888
KPNB1 karyopherin (importin) beta 1 -0.0810483
RPLP1 ribosomal protein, large, P1 -0.0808345
MCL1 myeloid cell leukemia 1 -0.0760883
MT2A metallothionein 2A -0.0754506
TXNIP thioredoxin interacting protein -0.0751042
ANKRD12 ankyrin repeat domain 12 -0.0739494
FOXP1 forkhead box P1 -0.073053
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type -0.0725691
ENO1 enolase 1, (alpha) -0.0711162
ANXA2 annexin A2 -0.0702102
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0698327
PRKCA protein kinase C, alpha -0.062811
THSD4 thrombospondin, type I, domain containing 4 -0.0625434
ANKRD11 ankyrin repeat domain 11 -0.0607182
KTN1 kinectin 1 (kinesin receptor) -0.060622
KANSL1 KAT8 regulatory NSL complex subunit 1 -0.0601598
UBE2E1 ubiquitin-conjugating enzyme E2E 1 -0.0580791
FNDC3B fibronectin type III domain containing 3B -0.0565779
RPL23 ribosomal protein L23 -0.0559739
ANKHD1 ankyrin repeat and KH domain containing 1 -0.0515272
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) -0.0489187
LMO7 LIM domain 7 -0.0456942
RAD51B RAD51 paralog B -0.0442755
ANKRD28 ankyrin repeat domain 28 -0.0428563
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3 -0.0426945
CNKSR3 CNKSR family member 3 -0.0426339
LIMS1 LIM and senescent cell antigen-like domains 1 -0.0426025
CEMIP cell migration inducing protein, hyaluronan binding -0.0416706
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0410999
TTC3 tetratricopeptide repeat domain 3 -0.0409437
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0403251
COL6A3 collagen, type VI, alpha 3 -0.0371017
RPS8 ribosomal protein S8 -0.0366536
RPS12 ribosomal protein S12 -0.0362236
DSCAM Down syndrome cell adhesion molecule -0.0357827
LCOR ligand dependent nuclear receptor corepressor -0.0353364
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0338871
NIPBL Nipped-B homolog (Drosophila) -0.032963
GLG1 golgi glycoprotein 1 -0.0329467
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 -0.0325256
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0317501
DOCK4 dedicator of cytokinesis 4 -0.030975
MACF1 microtubule-actin crosslinking factor 1 -0.0307576
AKAP12 A kinase (PRKA) anchor protein 12 -0.0304859
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0297086
ANO6 anoctamin 6 -0.0286299
RPS25 ribosomal protein S25 -0.0277756
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0269723
BCLAF1 BCL2-associated transcription factor 1 -0.0252949
PSEN1 presenilin 1 -0.0250841
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 -0.0250384
RPL12 ribosomal protein L12 -0.0229437
ARID1B AT rich interactive domain 1B (SWI1-like) -0.0223448
AFDN afadin, adherens junction formation factor -0.0222001
SBF2 SET binding factor 2 -0.0216212
MED13L mediator complex subunit 13-like -0.0212873
SETD5 SET domain containing 5 -0.021071
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0207988
PARD3 par-3 family cell polarity regulator -0.0206376
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0203796
MAML2 mastermind-like 2 (Drosophila) -0.0202095
RPS19 ribosomal protein S19 -0.0195745
NRIP1 nuclear receptor interacting protein 1 -0.0193761
TPT1 tumor protein, translationally-controlled 1 -0.0193051
VIM vimentin -0.0186521
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa -0.0176826
PPP6R3 protein phosphatase 6, regulatory subunit 3 -0.0173067
YES1 YES proto-oncogene 1, Src family tyrosine kinase -0.0165957
RNF213 ring finger protein 213 -0.0165806
RAP1B RAP1B, member of RAS oncogene family -0.0158653
EEF2 eukaryotic translation elongation factor 2 -0.015208
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0141038
ESYT2 extended synaptotagmin-like protein 2 -0.013344
SMAD3 SMAD family member 3 -0.0128584
RSF1 remodeling and spacing factor 1 -0.0122997
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0122469
BTBD9 BTB (POZ) domain containing 9 -0.0121871
SLC38A2 solute carrier family 38, member 2 -0.0113334
PTPRM protein tyrosine phosphatase, receptor type, M -0.0110191
PCCA propionyl CoA carboxylase, alpha polypeptide -0.0108611
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa -0.0106966
ADNP activity-dependent neuroprotector homeobox -0.0105169
N4BP2L2 NEDD4 binding protein 2-like 2 -0.010429
PTPRG protein tyrosine phosphatase, receptor type, G -0.00803924
DPYSL2 dihydropyrimidinase-like 2 -0.00791458