Retinoic acid_NCI-H661 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Retinoic acid perturbation in NCI-H661 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Retinoic acid_NCI-H661 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HDAC9 histone deacetylase 9 0.0914965
DST dystonin 0.0839653
TRIO trio Rho guanine nucleotide exchange factor 0.0700117
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) 0.0675616
ZFAND3 zinc finger, AN1-type domain 3 0.0624794
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0563885
HS3ST5 heparan sulfate (glucosamine) 3-O-sulfotransferase 5 0.055749
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.0534746
ANK2 ankyrin 2, neuronal 0.0518188
ADGRL3 adhesion G protein-coupled receptor L3 0.0460554
ZEB2 zinc finger E-box binding homeobox 2 0.0449913
ANKRD33B ankyrin repeat domain 33B 0.0425979
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A 0.0419695
TRPS1 trichorhinophalangeal syndrome I 0.0414144
GLS2 glutaminase 2 (liver, mitochondrial) 0.0405544
PARD3B par-3 family cell polarity regulator beta 0.0379245
PCLO piccolo presynaptic cytomatrix protein 0.035055
UTRN utrophin 0.0346173
KMT2C lysine (K)-specific methyltransferase 2C 0.0343924
SOX5 SRY (sex determining region Y)-box 5 0.0336481
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2 0.0331244
SAMD4A sterile alpha motif domain containing 4A 0.0308641
TENM3 teneurin transmembrane protein 3 0.0298905
RASAL2 RAS protein activator like 2 0.0298122
FIGN fidgetin 0.0295766
ZNF292 zinc finger protein 292 0.029479
KDM6A lysine (K)-specific demethylase 6A 0.0292625
CDC73 cell division cycle 73 0.0291906
RBMS3 RNA binding motif, single stranded interacting protein 3 0.0284544
ERBB4 erb-b2 receptor tyrosine kinase 4 0.0283451
FNDC3B fibronectin type III domain containing 3B 0.0281996
SMYD3 SET and MYND domain containing 3 0.0270966
FNIP1 folliculin interacting protein 1 0.0266611
PDGFC platelet derived growth factor C 0.0266024
NFIA nuclear factor I/A 0.026418
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0264161
CTBP2 C-terminal binding protein 2 0.026354
SPAG9 sperm associated antigen 9 0.026087
PARD3 par-3 family cell polarity regulator 0.025866
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box) 0.0256035
LIN28B lin-28 homolog B (C. elegans) 0.025465
PDE4D phosphodiesterase 4D, cAMP-specific 0.0254545
DNAH14 dynein, axonemal, heavy chain 14 0.0251349
USH2A Usher syndrome 2A (autosomal recessive, mild) 0.024952
SYT1 synaptotagmin I 0.0248673
APP amyloid beta (A4) precursor protein 0.0244152
NRIP1 nuclear receptor interacting protein 1 0.024363
ECT2 epithelial cell transforming 2 0.0243301
DSCAM Down syndrome cell adhesion molecule 0.023955
RIMS2 regulating synaptic membrane exocytosis 2 0.0238847
ZNF644 zinc finger protein 644 0.0235958
IGF1R insulin-like growth factor 1 receptor 0.0232902
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0232136
NPAS3 neuronal PAS domain protein 3 0.0231353
METAP2 methionyl aminopeptidase 2 0.0228853
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0226211
CDK6 cyclin-dependent kinase 6 0.0226031
MB21D2 Mab-21 domain containing 2 0.0225487
CTNNA2 catenin (cadherin-associated protein), alpha 2 0.0225235
IWS1 IWS1 homolog (S. cerevisiae) 0.0224462
ANKRD17 ankyrin repeat domain 17 0.0223107
FXR1 fragile X mental retardation, autosomal homolog 1 0.0221057
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0217541
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0216851
G2E3 G2/M-phase specific E3 ubiquitin protein ligase 0.0215841
SERTAD2 SERTA domain containing 2 0.0213719
CADM2 cell adhesion molecule 2 0.0212229
OPHN1 oligophrenin 1 0.021037
WDR33 WD repeat domain 33 0.0209335
ARL15 ADP-ribosylation factor-like 15 0.0208709
SORBS2 sorbin and SH3 domain containing 2 0.0207374
ZSWIM6 zinc finger, SWIM-type containing 6 0.0204278
PUM2 pumilio RNA-binding family member 2 0.0203922
RALGAPA1 Ral GTPase activating protein, alpha subunit 1 (catalytic) 0.0203187
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 0.0200206
ZFHX4 zinc finger homeobox 4 0.0199375
CELF2 CUGBP, Elav-like family member 2 0.0196362
NUP153 nucleoporin 153kDa 0.0195986
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0195779
SCFD1 sec1 family domain containing 1 0.0194397
AK1 adenylate kinase 1 0.0193891
ATP11B ATPase, class VI, type 11B 0.0193505
ANLN anillin, actin binding protein 0.0193375
ELF2 E74-like factor 2 (ets domain transcription factor) 0.019256
NCKAP1 NCK-associated protein 1 0.0189939
PICALM phosphatidylinositol binding clathrin assembly protein 0.0187821
USP12 ubiquitin specific peptidase 12 0.018772
MCTP1 multiple C2 domains, transmembrane 1 0.0187206
PTEN phosphatase and tensin homolog 0.0186017
TRA2A transformer 2 alpha homolog (Drosophila) 0.0185723
WDR26 WD repeat domain 26 0.0184463
KPNA1 karyopherin alpha 1 (importin alpha 5) 0.0183737
PRKD1 protein kinase D1 0.0182589
PUM1 pumilio RNA-binding family member 1 0.0180601
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.0180041
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 0.0178891
RFX3 regulatory factor X, 3 (influences HLA class II expression) 0.0178254
SMCHD1 structural maintenance of chromosomes flexible hinge domain containing 1 0.0176821
SEMA6A sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A 0.017568
ZNF608 zinc finger protein 608 0.017557

decreased expression

Symbol Name Standardized Value
VIM vimentin -0.219432
COL11A1 collagen, type XI, alpha 1 -0.180566
TMSB10 thymosin beta 10 -0.12058
PTMA prothymosin, alpha -0.117019
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.108693
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0940068
RPS16 ribosomal protein S16 -0.0919626
RPS6 ribosomal protein S6 -0.0916252
WSB1 WD repeat and SOCS box containing 1 -0.0899313
RPS8 ribosomal protein S8 -0.0716262
LDHA lactate dehydrogenase A -0.0689478
MDK midkine (neurite growth-promoting factor 2) -0.0669063
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0650736
ENO1 enolase 1, (alpha) -0.0641632
PGK1 phosphoglycerate kinase 1 -0.0627578
CDH10 cadherin 10, type 2 (T2-cadherin) -0.0595706
RPS12 ribosomal protein S12 -0.0568273
RPL35A ribosomal protein L35a -0.052036
ITGAV integrin, alpha V -0.0508561
GNAS GNAS complex locus -0.0501237
RPLP1 ribosomal protein, large, P1 -0.0496211
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0490057
ACTG1 actin gamma 1 -0.0484001
CDH6 cadherin 6, type 2, K-cadherin (fetal kidney) -0.0478044
TPT1 tumor protein, translationally-controlled 1 -0.0472679
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0469001
RPL37 ribosomal protein L37 -0.0464255
PDIA3 protein disulfide isomerase family A, member 3 -0.0461539
RPS19 ribosomal protein S19 -0.0452627
CALR calreticulin -0.0446665
GARS1 glycyl-tRNA synthetase 1 -0.0443152
SOX2 SRY (sex determining region Y)-box 2 -0.0440784
RPL11 ribosomal protein L11 -0.0435474
RPL23 ribosomal protein L23 -0.0428901
RPS13 ribosomal protein S13 -0.042044
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0416674
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 -0.0411335
COL1A2 collagen, type I, alpha 2 -0.0408413
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0395688
FTL ferritin, light polypeptide -0.0391002
RPL37A ribosomal protein L37a -0.0390493
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0388404
SNX6 sorting nexin 6 -0.0386161
H1-0 H1.0 linker histone -0.0385663
KTN1 kinectin 1 (kinesin receptor) -0.0382619
RPS27A ribosomal protein S27a -0.037693
CNRIP1 cannabinoid receptor interacting protein 1 -0.037365
RPL9 ribosomal protein L9 -0.0368193
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 -0.0362872
RPS3 ribosomal protein S3 -0.0345221
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein -0.0340184
RPL31 ribosomal protein L31 -0.0336214
RPL19 ribosomal protein L19 -0.0330743
RPL30 ribosomal protein L30 -0.032944
SFRP4 secreted frizzled-related protein 4 -0.032717
NACA nascent polypeptide-associated complex alpha subunit -0.0324705
RPS25 ribosomal protein S25 -0.0322313
RPL34 ribosomal protein L34 -0.032109
RPLP0 ribosomal protein, large, P0 -0.0311319
RPS29 ribosomal protein S29 -0.0310736
RPL5 ribosomal protein L5 -0.0310101
PHIP pleckstrin homology domain interacting protein -0.0306426
WASF2 WAS protein family, member 2 -0.0303936
EIF1 eukaryotic translation initiation factor 1 -0.0303755
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0299713
RPLP2 ribosomal protein, large, P2 -0.0299115
PFN1 profilin 1 -0.0297561
CALU calumenin -0.0294395
S100A9 S100 calcium binding protein A9 -0.0293624
PDIA6 protein disulfide isomerase family A, member 6 -0.0291053
RPL28 ribosomal protein L28 -0.0290775
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.028626
PCDH9 protocadherin 9 -0.0282481
LOC102724023 ES1 protein homolog, mitochondrial -0.0281873
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0279183
RPL26 ribosomal protein L26 -0.0278799
RAD51B RAD51 paralog B -0.0278677
SRRM2 serine/arginine repetitive matrix 2 -0.0277174
SSR3 signal sequence receptor, gamma (translocon-associated protein gamma) -0.0277118
RPL7A ribosomal protein L7a -0.0275096
MRPS6 mitochondrial ribosomal protein S6 -0.0273274
FN1 fibronectin 1 -0.0273196
RPL12 ribosomal protein L12 -0.0272138
LOC112694756 uncharaterized LOC112694756 -0.0268212
ISG15 ISG15 ubiquitin-like modifier -0.0261663
RACK1 receptor for activated C kinase 1 -0.0261094
EAPP E2F-associated phosphoprotein -0.0257611
RPS24 ribosomal protein S24 -0.0257546
YY1 YY1 transcription factor -0.0255727
DDIT4 DNA-damage-inducible transcript 4 -0.0254561
NCOR2 nuclear receptor corepressor 2 -0.0254322
RPL7 ribosomal protein L7 -0.0253545
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats -0.0253066
RPL36 ribosomal protein L36 -0.0252761
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 -0.0252565
NCAM2 neural cell adhesion molecule 2 -0.0250557
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1 -0.0249086
TPR translocated promoter region, nuclear basket protein -0.0249011
FBXO17 F-box protein 17 -0.0247326
LSM14A LSM14A, SCD6 homolog A (S. cerevisiae) -0.0247176