Retinoic acid_Panc 03.27 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Retinoic acid perturbation in Panc 03.27 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Retinoic acid_Panc 03.27 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
NRIP1 nuclear receptor interacting protein 1 0.151724
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0927644
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0881153
SMAD3 SMAD family member 3 0.083822
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0725926
ARHGAP26 Rho GTPase activating protein 26 0.0725771
MACF1 microtubule-actin crosslinking factor 1 0.0694531
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.069028
MUC4 mucin 4, cell surface associated 0.0653488
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.0604144
ZSWIM6 zinc finger, SWIM-type containing 6 0.0593514
ETV6 ets variant 6 0.0574759
RAD51B RAD51 paralog B 0.053455
MACC1 metastasis associated in colon cancer 1 0.0494579
EFNA5 ephrin-A5 0.0480509
SEPTIN9 septin 9 0.0460471
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0455463
PLSCR1 phospholipid scramblase 1 0.0438909
TGM2 transglutaminase 2 0.0406571
TJP1 tight junction protein 1 0.0404364
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0397215
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 0.0385272
PLAT plasminogen activator, tissue 0.0380556
HDAC9 histone deacetylase 9 0.0373441
GMDS GDP-mannose 4,6-dehydratase 0.037076
APLP2 amyloid beta (A4) precursor-like protein 2 0.0362539
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 0.0358083
TNIP1 TNFAIP3 interacting protein 1 0.0343676
FHIT fragile histidine triad 0.0337871
ANXA11 annexin A11 0.0329143
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0325059
LPP LIM domain containing preferred translocation partner in lipoma 0.0320797
SKAP2 src kinase associated phosphoprotein 2 0.0320481
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 0.0318004
SAMD12 sterile alpha motif domain containing 12 0.0306835
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.0302562
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 0.0301392
TRAPPC9 trafficking protein particle complex 9 0.0297143
PCLO piccolo presynaptic cytomatrix protein 0.0293599
GPHN gephyrin 0.0290603
TNFAIP2 tumor necrosis factor, alpha-induced protein 2 0.0288321
DHRS3 dehydrogenase/reductase (SDR family) member 3 0.0282291
LATS2 large tumor suppressor kinase 2 0.0280915
MX1 MX dynamin-like GTPase 1 0.0280575
SLC35F3 solute carrier family 35, member F3 0.0277205
TRIO trio Rho guanine nucleotide exchange factor 0.0277185
MTAP methylthioadenosine phosphorylase 0.0276119
VPS13B vacuolar protein sorting 13 homolog B (yeast) 0.0269224
MEIS2 Meis homeobox 2 0.0268051
MYH9 myosin, heavy chain 9, non-muscle 0.026671
LCN2 lipocalin 2 0.0258604
SGMS2 sphingomyelin synthase 2 0.0255201
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0252299
CMSS1 cms1 ribosomal small subunit homolog (yeast) 0.02515
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0244957
TAS2R14 taste receptor, type 2, member 14 0.0243476
DOCK1 dedicator of cytokinesis 1 0.0238735
TRIM44 tripartite motif containing 44 0.0237486
SMC1A structural maintenance of chromosomes 1A 0.0237394
ZBTB20 zinc finger and BTB domain containing 20 0.0234784
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 0.0229047
MGST1 microsomal glutathione S-transferase 1 0.0228037
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0227365
CDK6 cyclin-dependent kinase 6 0.0226937
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.02264
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 0.0226378
EGFR epidermal growth factor receptor 0.0224817
HSPA8 heat shock 70kDa protein 8 0.0222186
ANK3 ankyrin 3, node of Ranvier (ankyrin G) 0.0217646
FAF1 Fas (TNFRSF6) associated factor 1 0.0216828
RABGAP1L RAB GTPase activating protein 1-like 0.0216341
RUNX1 runt-related transcription factor 1 0.0214263
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0210607
ST3GAL1 ST3 beta-galactoside alpha-2,3-sialyltransferase 1 0.0207821
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.0205757
DIAPH1 diaphanous-related formin 1 0.0205693
NFIB nuclear factor I/B 0.020527
CASK calcium/calmodulin-dependent serine protein kinase (MAGUK family) 0.0202411
CTBP2 C-terminal binding protein 2 0.0202338
ENO1 enolase 1, (alpha) 0.0199412
MX2 MX dynamin-like GTPase 2 0.019922
SPECC1L sperm antigen with calponin homology and coiled-coil domains 1-like 0.0199087
FLNA filamin A, alpha 0.0198834
SIK3 SIK family kinase 3 0.0198253
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0198126
CEP128 centrosomal protein 128kDa 0.0198013
WNK1 WNK lysine deficient protein kinase 1 0.0194908
MECOM MDS1 and EVI1 complex locus 0.0192756
SYNE2 spectrin repeat containing, nuclear envelope 2 0.0192737
TGFB2 transforming growth factor, beta 2 0.0192713
APP amyloid beta (A4) precursor protein 0.0191576
IQCJ-SCHIP1 IQCJ-SCHIP1 readthrough 0.0191447
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0191419
MYEOV myeloma overexpressed 0.0190807
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0187119
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) 0.0185913
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0185171
ZBTB38 zinc finger and BTB domain containing 38 0.018487
SHROOM3 shroom family member 3 0.018444
SPIDR scaffolding protein involved in DNA repair 0.0183747

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.251246
PTMA prothymosin, alpha -0.214102
TMSB10 thymosin beta 10 -0.154421
NDRG1 N-myc downstream regulated 1 -0.145277
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.11159
TPT1 tumor protein, translationally-controlled 1 -0.101676
TMSB4X thymosin beta 4, X-linked -0.0968171
FN1 fibronectin 1 -0.0879053
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0877418
RPL35A ribosomal protein L35a -0.085445
RPL23 ribosomal protein L23 -0.0846995
NPEPPS aminopeptidase puromycin sensitive -0.079207
LMO7 LIM domain 7 -0.0751644
TXNIP thioredoxin interacting protein -0.0729448
LY6E lymphocyte antigen 6 complex, locus E -0.0718355
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0692143
F3 coagulation factor III (thromboplastin, tissue factor) -0.068592
AHNAK AHNAK nucleoprotein -0.0678423
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0676903
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0613846
CD2AP CD2-associated protein -0.0609068
MEF2A myocyte enhancer factor 2A -0.0585168
S100A6 S100 calcium binding protein A6 -0.0583422
UGCG UDP-glucose ceramide glucosyltransferase -0.0577442
RPS6 ribosomal protein S6 -0.0568343
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0553859
EIF1 eukaryotic translation initiation factor 1 -0.0546876
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0513032
PGK1 phosphoglycerate kinase 1 -0.0509471
CD47 CD47 molecule -0.0508289
LAMB3 laminin, beta 3 -0.0507355
WSB1 WD repeat and SOCS box containing 1 -0.0501858
TPI1 triosephosphate isomerase 1 -0.0490094
RPLP1 ribosomal protein, large, P1 -0.0480937
RPS19 ribosomal protein S19 -0.0479508
KRT17 keratin 17, type I -0.0476214
KDM3A lysine (K)-specific demethylase 3A -0.0469653
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0468067
ANXA2 annexin A2 -0.046193
FTL ferritin, light polypeptide -0.0458885
RPS21 ribosomal protein S21 -0.0451385
NT5C2 5'-nucleotidase, cytosolic II -0.0446045
TSC22D2 TSC22 domain family, member 2 -0.0442855
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.0433145
OGA O-GlcNAcase -0.0431963
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0422223
RPL8 ribosomal protein L8 -0.0419599
SOX4 SRY (sex determining region Y)-box 4 -0.0416416
S100A10 S100 calcium binding protein A10 -0.0411688
CANX calnexin -0.040852
RPL34 ribosomal protein L34 -0.0405959
HMGA1 high mobility group AT-hook 1 -0.0400898
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36 -0.0395194
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 -0.0391687
FTH1 ferritin, heavy polypeptide 1 -0.0387149
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0386852
TMEM123 transmembrane protein 123 -0.0380392
DDIT4 DNA-damage-inducible transcript 4 -0.037532
GNAS GNAS complex locus -0.0371407
PICALM phosphatidylinositol binding clathrin assembly protein -0.0370739
KLF6 Kruppel-like factor 6 -0.0365779
ANLN anillin, actin binding protein -0.0365386
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.0362282
RPS24 ribosomal protein S24 -0.0361027
CAV1 caveolin 1, caveolae protein, 22kDa -0.0359879
RIOK3 RIO kinase 3 -0.0358304
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0357202
MBOAT2 membrane bound O-acyltransferase domain containing 2 -0.035615
RPL19 ribosomal protein L19 -0.0353308
KDM2A lysine (K)-specific demethylase 2A -0.035262
HLA-B major histocompatibility complex, class I, B -0.0350184
WDR45B WD repeat domain 45B -0.0349605
ANXA1 annexin A1 -0.0348756
ESYT2 extended synaptotagmin-like protein 2 -0.0347444
RLF rearranged L-myc fusion -0.0345629
LGALS3 lectin, galactoside-binding, soluble, 3 -0.0345269
FCHSD2 FCH and double SH3 domains 2 -0.0344811
RPL32 ribosomal protein L32 -0.0343509
EMP1 epithelial membrane protein 1 -0.0341118
RPS13 ribosomal protein S13 -0.0341032
RBM39 RNA binding motif protein 39 -0.0340756
HLA-A major histocompatibility complex, class I, A -0.0336071
RPL12 ribosomal protein L12 -0.0334303
RPS14 ribosomal protein S14 -0.0331601
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific ) -0.0330359
DAPK1 death-associated protein kinase 1 -0.032902
SULF2 sulfatase 2 -0.0327852
GOLGA4 golgin A4 -0.0323531
PTBP3 polypyrimidine tract binding protein 3 -0.0322706
SETD5 SET domain containing 5 -0.0322614
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.0321022
LDHA lactate dehydrogenase A -0.0319871
RPL36 ribosomal protein L36 -0.0319373
S100A11 S100 calcium binding protein A11 -0.0318657
ARHGEF3 Rho guanine nucleotide exchange factor (GEF) 3 -0.0317012
RPS25 ribosomal protein S25 -0.0316199
KMT2E lysine (K)-specific methyltransferase 2E -0.0311597
FNBP1L formin binding protein 1-like -0.030979
IFITM3 interferon induced transmembrane protein 3 -0.03093
RPS23 ribosomal protein S23 -0.0307968