Retinoic acid_RKO Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Retinoic acid perturbation in RKO cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Retinoic acid_RKO drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FLNB filamin B, beta 0.142446
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.10239
PHC2 polyhomeotic homolog 2 (Drosophila) 0.0812353
ARHGAP22 Rho GTPase activating protein 22 0.074008
SGMS2 sphingomyelin synthase 2 0.0687089
ANK2 ankyrin 2, neuronal 0.0662467
RAD51B RAD51 paralog B 0.0605797
FHIT fragile histidine triad 0.0582263
MAPKAP1 mitogen-activated protein kinase associated protein 1 0.0580639
NAV2 neuron navigator 2 0.0545395
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0491738
FRMD6 FERM domain containing 6 0.0489886
AKAP12 A kinase (PRKA) anchor protein 12 0.0465952
PBX3 pre-B-cell leukemia homeobox 3 0.0455069
ZEB1 zinc finger E-box binding homeobox 1 0.0438651
GFPT2 glutamine-fructose-6-phosphate transaminase 2 0.0418418
CDC27 cell division cycle 27 0.0395488
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0395384
NAV3 neuron navigator 3 0.0395038
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1 0.039268
CD68 CD68 molecule 0.0384829
MCL1 myeloid cell leukemia 1 0.0379091
AGO2 argonaute RISC catalytic component 2 0.0370012
ENTPD7 ectonucleoside triphosphate diphosphohydrolase 7 0.0368081
DGKI diacylglycerol kinase, iota 0.0367731
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.0359814
CORO1C coronin, actin binding protein, 1C 0.0356857
ASPH aspartate beta-hydroxylase 0.0354971
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0351064
LRMDA leucine rich melanocyte differentiation associated 0.0347477
BNC2 basonuclin 2 0.0336495
EXT1 exostosin glycosyltransferase 1 0.0334256
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0325176
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.0325097
ELL2 elongation factor, RNA polymerase II, 2 0.0318931
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0316123
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type 0.0298627
IQCJ-SCHIP1 IQCJ-SCHIP1 readthrough 0.0295439
JMJD1C jumonji domain containing 1C 0.0294197
HMGA2 high mobility group AT-hook 2 0.029301
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0292915
EFL1 elongation factor like GTPase 1 0.0290072
EFNB2 ephrin-B2 0.0288325
ZNF438 zinc finger protein 438 0.0286977
ZBTB38 zinc finger and BTB domain containing 38 0.0285586
EXOC4 exocyst complex component 4 0.0285575
MYC v-myc avian myelocytomatosis viral oncogene homolog 0.0282492
UPP1 uridine phosphorylase 1 0.0273614
GALNT18 polypeptide N-acetylgalactosaminyltransferase 18 0.0272982
NSMCE2 non-SMC element 2, MMS21 homolog (S. cerevisiae) 0.0270786
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0267378
PTPN1 protein tyrosine phosphatase, non-receptor type 1 0.0264077
MACF1 microtubule-actin crosslinking factor 1 0.0263808
WDR43 WD repeat domain 43 0.0255946
NRIP1 nuclear receptor interacting protein 1 0.0250341
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 0.0249129
PPP1R9A protein phosphatase 1, regulatory subunit 9A 0.024443
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0240008
PNPT1 polyribonucleotide nucleotidyltransferase 1 0.0234276
MYCBP2 MYC binding protein 2, E3 ubiquitin protein ligase 0.0234112
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0233623
DIAPH2 diaphanous-related formin 2 0.0232105
TSC22D2 TSC22 domain family, member 2 0.0225497
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1 0.0217454
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0215033
FOSL1 FOS-like antigen 1 0.0214484
RPL3 ribosomal protein L3 0.0212275
MYH9 myosin, heavy chain 9, non-muscle 0.0212241
PKM pyruvate kinase, muscle 0.0211979
ABTB3 ankyrin repeat and BTB domain containing 3 0.0211225
TMEM156 transmembrane protein 156 0.0210358
GATAD2A GATA zinc finger domain containing 2A 0.0210023
CEP250 centrosomal protein 250kDa 0.0209944
RCOR1 REST corepressor 1 0.020732
CENPF centromere protein F, 350/400kDa 0.020552
ZZZ3 zinc finger, ZZ-type containing 3 0.0204281
CALB2 calbindin 2 0.0199036
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.0198791
SUPT3H suppressor of Ty 3 homolog (S. cerevisiae) 0.0197011
DHX9 DEAH (Asp-Glu-Ala-His) box helicase 9 0.0195957
VPS13B vacuolar protein sorting 13 homolog B (yeast) 0.0195366
NEMP2 nuclear envelope integral membrane protein 2 0.0194907
MX1 MX dynamin-like GTPase 1 0.0194652
ADTRP androgen-dependent TFPI-regulating protein 0.0194416
RGS4 regulator of G-protein signaling 4 0.0193083
TBC1D5 TBC1 domain family, member 5 0.019295
RRM2 ribonucleotide reductase M2 0.0190558
KLF12 Kruppel-like factor 12 0.0187348
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.0187327
SHC1 SHC (Src homology 2 domain containing) transforming protein 1 0.0183385
FAM120A family with sequence similarity 120A 0.0181222
TCF12 transcription factor 12 0.0181214
CMSS1 cms1 ribosomal small subunit homolog (yeast) 0.017796
RASA2 RAS p21 protein activator 2 0.0177784
SMARCC1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1 0.0177318
KRIT1 KRIT1, ankyrin repeat containing 0.0176812
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.0174801
GTPBP4 GTP binding protein 4 0.0172876
RABGAP1L RAB GTPase activating protein 1-like 0.0172251
CPQ carboxypeptidase Q 0.0172115

decreased expression

Symbol Name Standardized Value
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.234237
MT2A metallothionein 2A -0.101971
ACTG1 actin gamma 1 -0.0931065
RPS27A ribosomal protein S27a -0.0874191
RPS6 ribosomal protein S6 -0.0873876
TMSB10 thymosin beta 10 -0.0859851
RPL12 ribosomal protein L12 -0.083776
TPT1 tumor protein, translationally-controlled 1 -0.0836461
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0809249
RPL23 ribosomal protein L23 -0.0791847
RPL7A ribosomal protein L7a -0.0702666
UBC ubiquitin C -0.070238
RPLP1 ribosomal protein, large, P1 -0.0699655
RPL26 ribosomal protein L26 -0.0674609
RPS8 ribosomal protein S8 -0.0669068
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0650127
RPL37A ribosomal protein L37a -0.0649939
NAP1L1 nucleosome assembly protein 1-like 1 -0.0633183
RAD21 RAD21 homolog (S. pombe) -0.0617434
RPL8 ribosomal protein L8 -0.0607129
RPS19 ribosomal protein S19 -0.0605857
EIF1 eukaryotic translation initiation factor 1 -0.0604081
RPL35A ribosomal protein L35a -0.0603881
RPS21 ribosomal protein S21 -0.0589206
RPL34 ribosomal protein L34 -0.0581639
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0570931
PTMA prothymosin, alpha -0.0566058
RPS24 ribosomal protein S24 -0.0557802
RPL30 ribosomal protein L30 -0.0536256
RPLP2 ribosomal protein, large, P2 -0.0534772
RPL32 ribosomal protein L32 -0.0534126
RPL9 ribosomal protein L9 -0.0521087
JUN jun proto-oncogene -0.0510622
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -0.0503387
RPL31 ribosomal protein L31 -0.0489327
RPL7 ribosomal protein L7 -0.0479882
HDAC9 histone deacetylase 9 -0.0472117
RPS3 ribosomal protein S3 -0.0469667
GNAS GNAS complex locus -0.0461343
KDM3A lysine (K)-specific demethylase 3A -0.0452447
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0447549
RBM25 RNA binding motif protein 25 -0.0445967
RPS12 ribosomal protein S12 -0.0445226
NIPBL Nipped-B homolog (Drosophila) -0.0443179
RPL11 ribosomal protein L11 -0.0418395
SSR3 signal sequence receptor, gamma (translocon-associated protein gamma) -0.0398866
RPS13 ribosomal protein S13 -0.03974
RPL19 ribosomal protein L19 -0.039656
RPL36 ribosomal protein L36 -0.0384411
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) -0.0382709
RPS25 ribosomal protein S25 -0.0382386
RPL36A ribosomal protein L36a -0.037485
RPS16 ribosomal protein S16 -0.0365315
OGA O-GlcNAcase -0.0364176
LOC112694756 uncharaterized LOC112694756 -0.0356774
GARS1 glycyl-tRNA synthetase 1 -0.0355546
ZFAND3 zinc finger, AN1-type domain 3 -0.0352682
RBM39 RNA binding motif protein 39 -0.0350675
LAMB3 laminin, beta 3 -0.0347513
RPL5 ribosomal protein L5 -0.0341026
RPS4X ribosomal protein S4, X-linked -0.033645
PNISR PNN-interacting serine/arginine-rich protein -0.0333793
RRBP1 ribosome binding protein 1 -0.0328112
CALU calumenin -0.0319892
CANX calnexin -0.0319742
RPL35 ribosomal protein L35 -0.0318742
EEF2 eukaryotic translation elongation factor 2 -0.0316016
AHNAK AHNAK nucleoprotein -0.0315743
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa -0.0310902
STAU1 staufen double-stranded RNA binding protein 1 -0.0310569
RPS29 ribosomal protein S29 -0.0310056
PHIP pleckstrin homology domain interacting protein -0.0309752
PRRC2C proline-rich coiled-coil 2C -0.0309584
WSB1 WD repeat and SOCS box containing 1 -0.030427
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0303918
TOP1 topoisomerase (DNA) I -0.0302975
RPL18 ribosomal protein L18 -0.0301113
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.0300676
RPL28 ribosomal protein L28 -0.0298336
RPS27 ribosomal protein S27 -0.0296919
NABP1 nucleic acid binding protein 1 -0.0291436
RPS5 ribosomal protein S5 -0.0287379
USP34 ubiquitin specific peptidase 34 -0.0287328
S100A9 S100 calcium binding protein A9 -0.0285516
TEX10 testis expressed 10 -0.0283042
TM9SF3 transmembrane 9 superfamily member 3 -0.0282129
RPS15 ribosomal protein S15 -0.0276242
RPS11 ribosomal protein S11 -0.0276017
CELF1 CUGBP, Elav-like family member 1 -0.0275054
FTL ferritin, light polypeptide -0.0272874
TPM4 tropomyosin 4 -0.0271125
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 -0.0269704
RPS20 ribosomal protein S20 -0.0268913
B2M beta-2-microglobulin -0.0264539
EIF2S2 eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa -0.0263917
EIF4A1 eukaryotic translation initiation factor 4A1 -0.0260265
CAP1 CAP, adenylate cyclase-associated protein 1 (yeast) -0.0254206
HLA-C major histocompatibility complex, class I, C -0.0252182
EEF1D eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein) -0.0249879
RPL38 ribosomal protein L38 -0.0248893