Retinoic acid_SHP-77 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Retinoic acid perturbation in SHP-77 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Retinoic acid_SHP-77 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
ADARB2 adenosine deaminase, RNA-specific, B2 (non-functional) 0.109001
MCL1 myeloid cell leukemia 1 0.0880771
SGIP1 SH3-domain GRB2-like (endophilin) interacting protein 1 0.0835667
NRG1 neuregulin 1 0.0768445
GPC6 glypican 6 0.0734329
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.067216
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.0611392
CAMK1D calcium/calmodulin-dependent protein kinase ID 0.0571782
STC1 stanniocalcin 1 0.0565953
RORA RAR-related orphan receptor A 0.0562562
IGFBP5 insulin-like growth factor binding protein 5 0.0504766
ASPH aspartate beta-hydroxylase 0.0484576
ESRRG estrogen-related receptor gamma 0.0457127
NBEA neurobeachin 0.0454419
MCTP1 multiple C2 domains, transmembrane 1 0.0443437
ST18 suppression of tumorigenicity 18, zinc finger 0.0412649
SNAP25 synaptosomal-associated protein, 25kDa 0.0408495
TSHZ2 teashirt zinc finger homeobox 2 0.0387786
EYA2 EYA transcriptional coactivator and phosphatase 2 0.0382062
ERRFI1 ERBB receptor feedback inhibitor 1 0.0381949
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0363721
ASIC2 acid sensing (proton gated) ion channel 2 0.0362875
NCKAP5 NCK-associated protein 5 0.0362392
STXBP5 syntaxin binding protein 5 (tomosyn) 0.0357352
EPHA6 EPH receptor A6 0.033879
SMOC1 SPARC related modular calcium binding 1 0.0317609
SDK1 sidekick cell adhesion molecule 1 0.0315377
EFNA5 ephrin-A5 0.0314399
DOCK5 dedicator of cytokinesis 5 0.0306979
CACNA1A calcium channel, voltage-dependent, P/Q type, alpha 1A subunit 0.030645
GRB10 growth factor receptor-bound protein 10 0.0302121
KCNB2 potassium channel, voltage gated Shab related subfamily B, member 2 0.0298664
BACE2 beta-site APP-cleaving enzyme 2 0.029469
NELL1 NEL-like 1 (chicken) 0.0293316
KCNMB3 potassium channel subfamily M regulatory beta subunit 3 0.0290057
KIF26B kinesin family member 26B 0.0287923
FNDC3A fibronectin type III domain containing 3A 0.0287436
MYCBP2 MYC binding protein 2, E3 ubiquitin protein ligase 0.0281983
NDRG1 N-myc downstream regulated 1 0.0279352
ARFGEF3 ARFGEF family member 3 0.0278783
DGKD diacylglycerol kinase, delta 130kDa 0.0276862
CNKSR3 CNKSR family member 3 0.0276294
MYH9 myosin, heavy chain 9, non-muscle 0.0273323
SETX senataxin 0.0270538
SVIL supervillin 0.0270351
NAV1 neuron navigator 1 0.0265899
NANOS1 nanos homolog 1 (Drosophila) 0.0264457
LCOR ligand dependent nuclear receptor corepressor 0.0252465
SMYD3 SET and MYND domain containing 3 0.0251688
ZSWIM6 zinc finger, SWIM-type containing 6 0.0241295
AUTS2 autism susceptibility candidate 2 0.0230783
MYT1L myelin transcription factor 1-like 0.0229998
SNTG1 syntrophin, gamma 1 0.0229906
SP100 SP100 nuclear antigen 0.0228747
COL22A1 collagen, type XXII, alpha 1 0.0226836
PAEP progestagen-associated endometrial protein 0.0225873
EXT1 exostosin glycosyltransferase 1 0.0225449
ZFHX3 zinc finger homeobox 3 0.0224645
SLC38A2 solute carrier family 38, member 2 0.0220936
INHBA inhibin, beta A 0.0213091
TRIM9 tripartite motif containing 9 0.0210836
ANKRD36C ankyrin repeat domain 36C 0.0208828
HOMER1 homer scaffolding protein 1 0.0205046
NAV2 neuron navigator 2 0.0202993
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0200759
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0199741
CDK13 cyclin-dependent kinase 13 0.0199429
TRAPPC9 trafficking protein particle complex 9 0.0198029
EGFR epidermal growth factor receptor 0.0197254
MSN moesin 0.0194082
FAM13A family with sequence similarity 13, member A 0.0189983
PRG2 proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein) 0.0188932
SCFD1 sec1 family domain containing 1 0.0188637
RIMS2 regulating synaptic membrane exocytosis 2 0.0187918
LINGO2 leucine rich repeat and Ig domain containing 2 0.0186552
ZBTB20 zinc finger and BTB domain containing 20 0.0184851
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.018464
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 0.0183254
PELI2 pellino E3 ubiquitin protein ligase family member 2 0.0180986
KLHL29 kelch-like family member 29 0.0179083
AP3B2 adaptor-related protein complex 3, beta 2 subunit 0.0178182
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0177547
ANKH ANKH inorganic pyrophosphate transport regulator 0.0175306
LRFN2 leucine rich repeat and fibronectin type III domain containing 2 0.0174328
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0173627
PALLD palladin, cytoskeletal associated protein 0.0173582
RNF144A ring finger protein 144A 0.0172984
SIK3 SIK family kinase 3 0.0171124
RIGI RNA sensor RIG-I 0.0171022
UBE2QL1 ubiquitin-conjugating enzyme E2Q family-like 1 0.016644
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 0.0165445
TRIP12 thyroid hormone receptor interactor 12 0.0164965
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0163081
IGFBP2 insulin-like growth factor binding protein 2, 36kDa 0.0160669
GOLGB1 golgin B1 0.0159577
CEMIP cell migration inducing protein, hyaluronan binding 0.0159426
EGLN3 egl-9 family hypoxia-inducible factor 3 0.0159152
WLS wntless Wnt ligand secretion mediator 0.0158535
PARM1 prostate androgen-regulated mucin-like protein 1 0.0158212
IVNS1ABP influenza virus NS1A binding protein 0.0155866

decreased expression

Symbol Name Standardized Value
PTMA prothymosin, alpha -0.204703
TENM1 teneurin transmembrane protein 1 -0.135293
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0980379
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0897081
CALCA calcitonin-related polypeptide alpha -0.0891592
CENPF centromere protein F, 350/400kDa -0.0703679
FTL ferritin, light polypeptide -0.0669465
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.065893
RPS6 ribosomal protein S6 -0.0587349
SINHCAF SIN3-HDAC complex associated factor -0.0560802
RPS21 ribosomal protein S21 -0.054236
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0538962
RAD21 RAD21 homolog (S. pombe) -0.0525508
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0524318
RPS3 ribosomal protein S3 -0.0524073
RPL26 ribosomal protein L26 -0.0500033
MKI67 marker of proliferation Ki-67 -0.047945
NCOR1 nuclear receptor corepressor 1 -0.0464661
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0455999
PEG10 paternally expressed 10 -0.0454169
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0431072
RPS8 ribosomal protein S8 -0.0428436
RPL23 ribosomal protein L23 -0.0410628
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0408277
MT2A metallothionein 2A -0.0402117
RPL8 ribosomal protein L8 -0.0398715
EIF4A1 eukaryotic translation initiation factor 4A1 -0.039076
NIPSNAP2 nipsnap homolog 2 -0.0389756
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0380955
MIS18BP1 MIS18 binding protein 1 -0.0373035
NFIA nuclear factor I/A -0.0372968
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.036834
S100A9 S100 calcium binding protein A9 -0.0361852
RPLP1 ribosomal protein, large, P1 -0.0352844
RPL35 ribosomal protein L35 -0.0345586
SF3B2 splicing factor 3b, subunit 2, 145kDa -0.034432
ENO1 enolase 1, (alpha) -0.0342962
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) -0.034257
RPL11 ribosomal protein L11 -0.0341672
RPS16 ribosomal protein S16 -0.0339065
TXNRD1 thioredoxin reductase 1 -0.0333104
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0331042
MATR3 matrin 3 -0.0329843
RPS27 ribosomal protein S27 -0.0325796
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0323055
RPS27A ribosomal protein S27a -0.0321907
GNAS GNAS complex locus -0.0319953
RPL7 ribosomal protein L7 -0.0317551
SYT1 synaptotagmin I -0.0316778
G2E3 G2/M-phase specific E3 ubiquitin protein ligase -0.0316669
H1-0 H1.0 linker histone -0.0315158
NAMPT nicotinamide phosphoribosyltransferase -0.0314305
ATP5F1E ATP synthase F1 subunit epsilon -0.0303001
RPL32 ribosomal protein L32 -0.0299674
RTN4 reticulon 4 -0.0294925
YBX1 Y box binding protein 1 -0.0294261
RPLP0 ribosomal protein, large, P0 -0.0292554
RPL19 ribosomal protein L19 -0.0292095
TUBB tubulin, beta class I -0.0290668
RPS23 ribosomal protein S23 -0.0288424
UBB ubiquitin B -0.0287843
STMN1 stathmin 1 -0.0286691
RPL12 ribosomal protein L12 -0.0286255
HMGB2 high mobility group box 2 -0.028248
RPL36 ribosomal protein L36 -0.0281561
ZNF292 zinc finger protein 292 -0.0277047
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) -0.027419
NIPBL Nipped-B homolog (Drosophila) -0.0266836
RPL5 ribosomal protein L5 -0.0266298
RPL37 ribosomal protein L37 -0.0261509
LOC112694756 uncharaterized LOC112694756 -0.0260689
PCCA propionyl CoA carboxylase, alpha polypeptide -0.0260644
RPS19 ribosomal protein S19 -0.0255001
CCDC88A coiled-coil domain containing 88A -0.0252556
KPNB1 karyopherin (importin) beta 1 -0.0251356
RPL35A ribosomal protein L35a -0.0250744
TPT1 tumor protein, translationally-controlled 1 -0.0249942
RPL37A ribosomal protein L37a -0.0248909
SMC4 structural maintenance of chromosomes 4 -0.0248083
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 -0.0247696
PRKDC protein kinase, DNA-activated, catalytic polypeptide -0.0246237
RPL38 ribosomal protein L38 -0.0242286
TPX2 TPX2, microtubule-associated -0.024212
NAP1L1 nucleosome assembly protein 1-like 1 -0.0242024
RPL30 ribosomal protein L30 -0.0240915
RPS25 ribosomal protein S25 -0.0240474
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0240115
NUF2 NUF2, NDC80 kinetochore complex component -0.0238912
RPL34 ribosomal protein L34 -0.0237489
PJA2 praja ring finger 2, E3 ubiquitin protein ligase -0.0235638
TMSB10 thymosin beta 10 -0.0234854
DEK DEK proto-oncogene -0.0234324
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit -0.0233786
CKAP5 cytoskeleton associated protein 5 -0.0233571
FOXC1 forkhead box C1 -0.0233144
PBK PDZ binding kinase -0.0233131
XPO1 exportin 1 -0.0232406
VGF VGF nerve growth factor inducible -0.0231746
SET SET nuclear proto-oncogene -0.0231022
EIF1 eukaryotic translation initiation factor 1 -0.0230945