Retinoic acid_SK-MEL-2 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Retinoic acid perturbation in SK-MEL-2 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Retinoic acid_SK-MEL-2 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
VIM vimentin 0.117727
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.102597
LINGO2 leucine rich repeat and Ig domain containing 2 0.0893445
FNDC3B fibronectin type III domain containing 3B 0.0808118
ASPH aspartate beta-hydroxylase 0.048924
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.0465491
SPAG9 sperm associated antigen 9 0.0430876
PPFIA1 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 0.0386925
JMJD1C jumonji domain containing 1C 0.0377811
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0374622
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0363037
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0346317
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0344218
HDAC9 histone deacetylase 9 0.0337472
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.0335803
CTTN cortactin 0.0329777
PFKFB4 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 0.0327716
IGFBP3 insulin-like growth factor binding protein 3 0.0324546
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0320776
MSN moesin 0.0317649
AFDN afadin, adherens junction formation factor 0.0315791
PRELID2 PRELI domain containing 2 0.0311232
PTK2 protein tyrosine kinase 2 0.0310955
FMNL2 formin-like 2 0.0310106
RB1CC1 RB1-inducible coiled-coil 1 0.0306421
MED13 mediator complex subunit 13 0.030466
BIRC6 baculoviral IAP repeat containing 6 0.0301924
RUNX1 runt-related transcription factor 1 0.029815
AKT3 v-akt murine thymoma viral oncogene homolog 3 0.0297052
ZFAND3 zinc finger, AN1-type domain 3 0.0294044
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.028829
OGA O-GlcNAcase 0.0284501
TRIP12 thyroid hormone receptor interactor 12 0.0283408
MAP4 microtubule-associated protein 4 0.0277739
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0274766
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0271941
NOTCH2 notch 2 0.0271685
ANKRD11 ankyrin repeat domain 11 0.0271346
FRMD5 FERM domain containing 5 0.0268989
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0266341
SREBF2 sterol regulatory element binding transcription factor 2 0.0266132
ATXN1 ataxin 1 0.0265401
MED13L mediator complex subunit 13-like 0.0263563
GOLGB1 golgin B1 0.0262526
KDM3A lysine (K)-specific demethylase 3A 0.0261699
TXNRD1 thioredoxin reductase 1 0.0261069
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0260491
AFF4 AF4/FMR2 family, member 4 0.0260371
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0259427
ELL2 elongation factor, RNA polymerase II, 2 0.0256019
NF1 neurofibromin 1 0.0245806
CDK6 cyclin-dependent kinase 6 0.0240038
FAM13B family with sequence similarity 13, member B 0.023941
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0239242
CLINT1 clathrin interactor 1 0.0239089
COG5 component of oligomeric golgi complex 5 0.0238011
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0234087
FNIP1 folliculin interacting protein 1 0.0233918
SMAD3 SMAD family member 3 0.0232251
KMT2C lysine (K)-specific methyltransferase 2C 0.0230445
PGK1 phosphoglycerate kinase 1 0.0230309
BBX bobby sox homolog (Drosophila) 0.0228808
KMT2E lysine (K)-specific methyltransferase 2E 0.0228467
MDGA2 MAM domain containing glycosylphosphatidylinositol anchor 2 0.0228297
PJA2 praja ring finger 2, E3 ubiquitin protein ligase 0.0226232
IGFN1 immunoglobulin-like and fibronectin type III domain containing 1 0.0225681
SEC31A SEC31 homolog A (S. cerevisiae) 0.0223395
TFG TRK-fused gene 0.0221858
LDHA lactate dehydrogenase A 0.022064
FOXO3 forkhead box O3 0.0219633
GSK3B glycogen synthase kinase 3 beta 0.0219523
TRPC4AP transient receptor potential cation channel, subfamily C, member 4 associated protein 0.0217711
NKTR natural killer cell triggering receptor 0.0217599
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0217531
MAN2A1 mannosidase, alpha, class 2A, member 1 0.021739
BCKDHB branched chain keto acid dehydrogenase E1, beta polypeptide 0.0217107
LAMP2 lysosomal-associated membrane protein 2 0.0216671
CTBP2 C-terminal binding protein 2 0.0215281
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0214705
ITCH itchy E3 ubiquitin protein ligase 0.0214035
ATP13A3 ATPase type 13A3 0.0213341
SETD5 SET domain containing 5 0.0213313
HELZ helicase with zinc finger 0.0212871
CD44 CD44 molecule (Indian blood group) 0.0212454
CLIP4 CAP-GLY domain containing linker protein family, member 4 0.0212163
TRIM33 tripartite motif containing 33 0.0211145
MARK3 MAP/microtubule affinity-regulating kinase 3 0.021106
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) 0.0210231
TASOR2 transcription activation suppressor family member 2 0.0209904
ANKRD1 ankyrin repeat domain 1 (cardiac muscle) 0.0209373
B2M beta-2-microglobulin 0.0209015
ESYT2 extended synaptotagmin-like protein 2 0.0209004
GLS2 glutaminase 2 (liver, mitochondrial) 0.0208451
CAMTA1 calmodulin binding transcription activator 1 0.0208406
ACTG1 actin gamma 1 0.0208024
RTN4 reticulon 4 0.0208006
ANKIB1 ankyrin repeat and IBR domain containing 1 0.0207318
KPNB1 karyopherin (importin) beta 1 0.0207205
AKAP13 A kinase (PRKA) anchor protein 13 0.0206827
ELF2 E74-like factor 2 (ets domain transcription factor) 0.0206818

decreased expression

Symbol Name Standardized Value
LSAMP limbic system-associated membrane protein -0.185997
FRMD4A FERM domain containing 4A -0.105901
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 -0.105497
NRG3 neuregulin 3 -0.0831912
NLGN1 neuroligin 1 -0.0813275
MT2A metallothionein 2A -0.0486728
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0450605
TNNC1 troponin C type 1 (slow) -0.0441249
CHST11 carbohydrate (chondroitin 4) sulfotransferase 11 -0.039049
FN1 fibronectin 1 -0.0385657
AKAP12 A kinase (PRKA) anchor protein 12 -0.0296091
LEF1 lymphoid enhancer-binding factor 1 -0.0240714
CNIH3 cornichon family AMPA receptor auxiliary protein 3 -0.0213306
LINC02798 long intergenic non-protein coding RNA 2798 -0.0195199
SLC39A11 solute carrier family 39, member 11 -0.0187635
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) -0.0183533
BCAS3 breast carcinoma amplified sequence 3 -0.018235
HMGA1 high mobility group AT-hook 1 -0.0176574
ZBTB20 zinc finger and BTB domain containing 20 -0.0172776
HLA-A major histocompatibility complex, class I, A -0.0155948
HPSE2 heparanase 2 (inactive) -0.0149402
TYR tyrosinase -0.0149328
CTSL cathepsin L -0.0148015
LDLRAD3 low density lipoprotein receptor class A domain containing 3 -0.0147863
AEBP2 AE binding protein 2 -0.014145
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0140017
TPT1 tumor protein, translationally-controlled 1 -0.0139783
DIP2C DIP2 disco-interacting protein 2 homolog C (Drosophila) -0.0137575
MCTP2 multiple C2 domains, transmembrane 2 -0.0134279
OSBPL5 oxysterol binding protein-like 5 -0.0133603
MEIS2 Meis homeobox 2 -0.0132755
ICAM1 intercellular adhesion molecule 1 -0.0130375
L3MBTL4 l(3)mbt-like 4 (Drosophila) -0.0128805
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0126651
RPTOR regulatory associated protein of MTOR, complex 1 -0.0125672
RPL27A ribosomal protein L27a -0.0124649
EHBP1 EH domain binding protein 1 -0.0121908
RPL23 ribosomal protein L23 -0.0121456
DNAH14 dynein, axonemal, heavy chain 14 -0.0116325
PMEL premelanosome protein -0.0116033
TMSB10 thymosin beta 10 -0.0115413
KIAA1549L KIAA1549-like -0.0113735
ARPC1B actin related protein 2/3 complex, subunit 1B, 41kDa -0.0112093
RNF213 ring finger protein 213 -0.0109533
TENM3 teneurin transmembrane protein 3 -0.0106865
EXOC4 exocyst complex component 4 -0.0106337
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 -0.0105728
NHSL1 NHS-like 1 -0.0104245
RFX3 regulatory factor X, 3 (influences HLA class II expression) -0.0103789
EIF1 eukaryotic translation initiation factor 1 -0.0103308
ST6GAL1 ST6 beta-galactosamide alpha-2,6-sialyltranferase 1 -0.0102511
LRRC23 leucine rich repeat containing 23 -0.0101715
SUCLG2 succinate-CoA ligase, GDP-forming, beta subunit -0.0101036
PDE10A phosphodiesterase 10A -0.0101019
C10ORF90 chromosome 10 open reading frame 90 -0.010049
DPP6 dipeptidyl-peptidase 6 -0.0100137
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.00987252
CPED1 cadherin-like and PC-esterase domain containing 1 -0.00983429
RPL31 ribosomal protein L31 -0.00975393
HDAC4 histone deacetylase 4 -0.00968284
RPS2 ribosomal protein S2 -0.00938774
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) -0.0092677
GALNT18 polypeptide N-acetylgalactosaminyltransferase 18 -0.0092405
SLC30A9 solute carrier family 30 (zinc transporter), member 9 -0.00921045
IGF2 insulin-like growth factor 2 -0.00917223
ADAM19 ADAM metallopeptidase domain 19 -0.00908028
USP40 ubiquitin specific peptidase 40 -0.00897178
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa -0.0089568
SVIL supervillin -0.00895476
PRDM7 PR domain containing 7 -0.00892466
FCRLA Fc receptor-like A -0.00890221
MT1X metallothionein 1X -0.0088186
RPL12 ribosomal protein L12 -0.0088141
IGF1R insulin-like growth factor 1 receptor -0.00873947
ANGPTL4 angiopoietin-like 4 -0.00867638
S100A13 S100 calcium binding protein A13 -0.0086756
RPL18 ribosomal protein L18 -0.00863229
ZNF717 zinc finger protein 717 -0.00857177
ARNT2 aryl-hydrocarbon receptor nuclear translocator 2 -0.00855934
DISC1 disrupted in schizophrenia 1 -0.00854473
ATP11A ATPase, class VI, type 11A -0.00847996
PRG2 proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein) -0.00834988
MSI2 musashi RNA-binding protein 2 -0.00833802
HIPK2 homeodomain interacting protein kinase 2 -0.00830738
AFG2A AFG2 AAA ATPase homolog A -0.00830402
RPL34 ribosomal protein L34 -0.00822227
KCNN2 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 2 -0.0082152
CDH13 cadherin 13 -0.00816427
ZNF121 zinc finger protein 121 -0.00807856
CDIN1 CDAN1 interacting nuclease 1 -0.00806344
VEZF1 vascular endothelial zinc finger 1 -0.00806249
LOXL2 lysyl oxidase-like 2 -0.00800191
NPAS2 neuronal PAS domain protein 2 -0.00800059
PHF14 PHD finger protein 14 -0.00795276
HIBADH 3-hydroxyisobutyrate dehydrogenase -0.00786049
FGF13 fibroblast growth factor 13 -0.0078314
RASA3 RAS p21 protein activator 3 -0.00776081
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 -0.00763822
SCFD2 sec1 family domain containing 2 -0.00762427
ENTHD1 ENTH domain containing 1 -0.00758418