Retinoic acid_SNU-1 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Retinoic acid perturbation in SNU-1 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Retinoic acid_SNU-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
VCL vinculin 0.112094
PDE4B phosphodiesterase 4B, cAMP-specific 0.103684
PDE4D phosphodiesterase 4D, cAMP-specific 0.0870073
HDAC9 histone deacetylase 9 0.0807262
EGFR epidermal growth factor receptor 0.0679976
SOX6 SRY (sex determining region Y)-box 6 0.0678866
PDGFC platelet derived growth factor C 0.0616021
NBEA neurobeachin 0.0594778
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0593977
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0593473
TXNRD1 thioredoxin reductase 1 0.0578618
ADAM10 ADAM metallopeptidase domain 10 0.0575867
ZEB1 zinc finger E-box binding homeobox 1 0.0551056
GLI2 GLI family zinc finger 2 0.045805
PYGB phosphorylase, glycogen; brain 0.0455015
GLI3 GLI family zinc finger 3 0.0415613
B3GALT1 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1 0.04068
PKM pyruvate kinase, muscle 0.0396903
AHCYL2 adenosylhomocysteinase-like 2 0.0367895
SPATS2L spermatogenesis associated, serine-rich 2-like 0.034917
TMEM65 transmembrane protein 65 0.0339708
BMP2K BMP2 inducible kinase 0.0308133
GCLM glutamate-cysteine ligase, modifier subunit 0.0302074
EFNA5 ephrin-A5 0.030025
PRELID2 PRELI domain containing 2 0.0297105
MAP3K14 mitogen-activated protein kinase kinase kinase 14 0.0293856
TGFBR3 transforming growth factor, beta receptor III 0.0289402
FOXP1 forkhead box P1 0.0287694
LOXL3 lysyl oxidase-like 3 0.0282475
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 0.0266455
TBC1D5 TBC1 domain family, member 5 0.0265078
TSC22D1 TSC22 domain family, member 1 0.0264726
TJP1 tight junction protein 1 0.02616
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0255761
SMYD3 SET and MYND domain containing 3 0.0252602
XKR6 XK, Kell blood group complex subunit-related family, member 6 0.02496
GSE1 Gse1 coiled-coil protein 0.0242708
SDK1 sidekick cell adhesion molecule 1 0.0241943
ZBTB20 zinc finger and BTB domain containing 20 0.0228613
CORO1C coronin, actin binding protein, 1C 0.0228082
SHC1 SHC (Src homology 2 domain containing) transforming protein 1 0.0225902
MACROD2 MACRO domain containing 2 0.0220656
PTPRG protein tyrosine phosphatase, receptor type, G 0.0220276
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.0220057
TTC28 tetratricopeptide repeat domain 28 0.0217855
MYO5C myosin VC 0.0216802
GPHN gephyrin 0.021645
PICALM phosphatidylinositol binding clathrin assembly protein 0.021329
CNOT6L CCR4-NOT transcription complex, subunit 6-like 0.02112
DPYD dihydropyrimidine dehydrogenase 0.020914
ECT2 epithelial cell transforming 2 0.0209011
NQO1 NAD(P)H dehydrogenase, quinone 1 0.0205763
PARD3B par-3 family cell polarity regulator beta 0.0202607
MINDY2 MINDY lysine 48 deubiquitinase 2 0.0201857
ZNF644 zinc finger protein 644 0.020157
ZNF608 zinc finger protein 608 0.0200617
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0200382
RAB27B RAB27B, member RAS oncogene family 0.0196761
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0193405
SMAD6 SMAD family member 6 0.0188786
EML4 echinoderm microtubule associated protein like 4 0.0185991
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.0185385
ALDH3A2 aldehyde dehydrogenase 3 family, member A2 0.0184788
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0182118
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) 0.0180818
EXOC4 exocyst complex component 4 0.0179258
FER fer (fps/fes related) tyrosine kinase 0.0179253
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2 0.0178061
FHAD1 forkhead-associated (FHA) phosphopeptide binding domain 1 0.0177617
ADNP activity-dependent neuroprotector homeobox 0.0176278
VPS13B vacuolar protein sorting 13 homolog B (yeast) 0.0176138
DDAH1 dimethylarginine dimethylaminohydrolase 1 0.0171171
EIF4B eukaryotic translation initiation factor 4B 0.0170191
NPAS2 neuronal PAS domain protein 2 0.0169917
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0167181
LPP LIM domain containing preferred translocation partner in lipoma 0.0166526
MYOF myoferlin 0.0165935
BCKDHB branched chain keto acid dehydrogenase E1, beta polypeptide 0.0165918
SRPK2 SRSF protein kinase 2 0.0165274
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box) 0.0162142
RPL3 ribosomal protein L3 0.0161422
KLC1 kinesin light chain 1 0.0159607
MKI67 marker of proliferation Ki-67 0.015954
PRUNE2 prune homolog 2 (Drosophila) 0.0159194
PPP1R9A protein phosphatase 1, regulatory subunit 9A 0.0157325
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0157179
PHF21A PHD finger protein 21A 0.0155723
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 0.0152129
LONRF2 LON peptidase N-terminal domain and ring finger 2 0.0151675
CCND1 cyclin D1 0.0151399
CACNB4 calcium channel, voltage-dependent, beta 4 subunit 0.0150609
PIWIL1 piwi-like RNA-mediated gene silencing 1 0.0149224
IBTK inhibitor of Bruton agammaglobulinemia tyrosine kinase 0.0148416
ZNF438 zinc finger protein 438 0.0148406
FCHSD2 FCH and double SH3 domains 2 0.014826
DOCK3 dedicator of cytokinesis 3 0.0146882
RTN4 reticulon 4 0.0146066
FAM91A1 family with sequence similarity 91, member A1 0.0145846
CDK14 cyclin-dependent kinase 14 0.0145262
BLTP1 bridge-like lipid transfer protein family member 1 0.0145087

decreased expression

Symbol Name Standardized Value
PTMA prothymosin, alpha -0.352023
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.266702
TPT1 tumor protein, translationally-controlled 1 -0.139127
RPS6 ribosomal protein S6 -0.121602
RPS8 ribosomal protein S8 -0.109007
RPL35A ribosomal protein L35a -0.094174
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0822625
RPL31 ribosomal protein L31 -0.0752616
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0721185
RPL23 ribosomal protein L23 -0.0717771
RPL34 ribosomal protein L34 -0.0677807
TMSB10 thymosin beta 10 -0.0671954
RPL37A ribosomal protein L37a -0.0662903
RPL9 ribosomal protein L9 -0.0661197
RPS19 ribosomal protein S19 -0.0645543
RPLP1 ribosomal protein, large, P1 -0.0638346
RPLP2 ribosomal protein, large, P2 -0.061869
RPL26 ribosomal protein L26 -0.059848
RPS3 ribosomal protein S3 -0.0588661
RPS23 ribosomal protein S23 -0.0583352
RPS12 ribosomal protein S12 -0.0577097
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0576436
RPS25 ribosomal protein S25 -0.0575235
RPS27A ribosomal protein S27a -0.0566804
RPL12 ribosomal protein L12 -0.0539355
RPL19 ribosomal protein L19 -0.0531541
ARL4C ADP-ribosylation factor-like 4C -0.0524374
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0520324
RPS13 ribosomal protein S13 -0.0508388
B2M beta-2-microglobulin -0.0469901
NAP1L1 nucleosome assembly protein 1-like 1 -0.0463619
ACTG1 actin gamma 1 -0.0458624
EIF1 eukaryotic translation initiation factor 1 -0.0453811
RPL11 ribosomal protein L11 -0.0450575
RPS21 ribosomal protein S21 -0.0443578
S100A9 S100 calcium binding protein A9 -0.0443466
RPL7A ribosomal protein L7a -0.0436725
S100A6 S100 calcium binding protein A6 -0.0436641
FTL ferritin, light polypeptide -0.0421997
RPL36 ribosomal protein L36 -0.0414782
WSB1 WD repeat and SOCS box containing 1 -0.0412581
RPL32 ribosomal protein L32 -0.0412426
RPS24 ribosomal protein S24 -0.0412411
RPL5 ribosomal protein L5 -0.0406296
RACK1 receptor for activated C kinase 1 -0.0395092
RPS14 ribosomal protein S14 -0.0388291
CPED1 cadherin-like and PC-esterase domain containing 1 -0.0371347
UBC ubiquitin C -0.0369509
RPL7 ribosomal protein L7 -0.0354685
RPS27 ribosomal protein S27 -0.0351044
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0344938
RPS11 ribosomal protein S11 -0.0340828
VIM vimentin -0.0338957
RPS16 ribosomal protein S16 -0.0329556
RPL8 ribosomal protein L8 -0.0326266
RPL36A ribosomal protein L36a -0.0321068
RPLP0 ribosomal protein, large, P0 -0.0320274
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.031397
RPS29 ribosomal protein S29 -0.0313307
RPS10 ribosomal protein S10 -0.0307886
RPS17 ribosomal protein S17 -0.0302245
HSPB1 heat shock 27kDa protein 1 -0.0298237
PFN1 profilin 1 -0.0296133
RPL37 ribosomal protein L37 -0.0294049
RPL27A ribosomal protein L27a -0.0291742
NACA nascent polypeptide-associated complex alpha subunit -0.0290381
RPL30 ribosomal protein L30 -0.0288781
TPI1 triosephosphate isomerase 1 -0.0286245
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0279498
ENO2 enolase 2 (gamma, neuronal) -0.0275376
EIF4A1 eukaryotic translation initiation factor 4A1 -0.0268968
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0263955
RPL18 ribosomal protein L18 -0.0263493
S100A10 S100 calcium binding protein A10 -0.0258844
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0258664
TMSB4X thymosin beta 4, X-linked -0.0253498
ENO1 enolase 1, (alpha) -0.0251191
RPL28 ribosomal protein L28 -0.0247504
RPL15 ribosomal protein L15 -0.024454
FN1 fibronectin 1 -0.0240607
RPS15 ribosomal protein S15 -0.0240321
GOLGA4 golgin A4 -0.0239697
LOC102724023 ES1 protein homolog, mitochondrial -0.0239433
RPS5 ribosomal protein S5 -0.0236513
MYL12B myosin, light chain 12B, regulatory -0.023647
RPL13A ribosomal protein L13a -0.0235039
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -0.0234685
MT2A metallothionein 2A -0.0234486
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0234037
NDRG1 N-myc downstream regulated 1 -0.0230112
COX4I1 cytochrome c oxidase subunit IV isoform 1 -0.022343
RPL10A ribosomal protein L10a -0.0214791
GNAS GNAS complex locus -0.021441
RPS4X ribosomal protein S4, X-linked -0.0210946
UQCRB ubiquinol-cytochrome c reductase binding protein -0.020934
RPL35 ribosomal protein L35 -0.020728
RPS20 ribosomal protein S20 -0.0206859
EBNA1BP2 EBNA1 binding protein 2 -0.0206706
ASCC3 activating signal cointegrator 1 complex subunit 3 -0.020619
CCNI cyclin I -0.0203927