Retinoic acid_SNU-423 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Retinoic acid perturbation in SNU-423 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Retinoic acid_SNU-423 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
TRIO trio Rho guanine nucleotide exchange factor 0.160325
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.14634
PDE10A phosphodiesterase 10A 0.104317
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0953036
GRIN2A glutamate receptor, ionotropic, N-methyl D-aspartate 2A 0.0855236
IGFN1 immunoglobulin-like and fibronectin type III domain containing 1 0.0836901
COL6A3 collagen, type VI, alpha 3 0.08177
NDRG1 N-myc downstream regulated 1 0.0804123
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.072145
CADM1 cell adhesion molecule 1 0.0709189
NAV2 neuron navigator 2 0.0698048
VCAN versican 0.0691098
IQCJ-SCHIP1 IQCJ-SCHIP1 readthrough 0.0660051
ZMIZ1 zinc finger, MIZ-type containing 1 0.0656802
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.06566
IGFBP3 insulin-like growth factor binding protein 3 0.0647576
CDH13 cadherin 13 0.0632597
ASPH aspartate beta-hydroxylase 0.0618223
MYOF myoferlin 0.0607856
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 0.0588277
FMNL2 formin-like 2 0.055949
HDAC9 histone deacetylase 9 0.0555644
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0512351
SEPTIN9 septin 9 0.050676
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0479665
PRELID2 PRELI domain containing 2 0.0478182
MYH9 myosin, heavy chain 9, non-muscle 0.0473978
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0461302
VEGFA vascular endothelial growth factor A 0.0457882
FRMPD4 FERM and PDZ domain containing 4 0.0455603
AFF3 AF4/FMR2 family, member 3 0.0455491
MACF1 microtubule-actin crosslinking factor 1 0.0444645
UBA6 ubiquitin-like modifier activating enzyme 6 0.0438345
DLG1 discs, large homolog 1 (Drosophila) 0.0437137
ZHX2 zinc fingers and homeoboxes 2 0.0427426
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.041807
HELZ helicase with zinc finger 0.0413502
LDHA lactate dehydrogenase A 0.0411869
MSN moesin 0.0407114
FNIP1 folliculin interacting protein 1 0.0406229
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 0.0404566
PFKFB4 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 0.040361
BACE2 beta-site APP-cleaving enzyme 2 0.0394235
RUNX1 runt-related transcription factor 1 0.039166
SDK1 sidekick cell adhesion molecule 1 0.0391523
STC2 stanniocalcin 2 0.0390921
ENO1 enolase 1, (alpha) 0.0390391
COL5A1 collagen, type V, alpha 1 0.0382168
ATXN1 ataxin 1 0.0381272
SQSTM1 sequestosome 1 0.0376597
TNS3 tensin 3 0.0371114
CD109 CD109 molecule 0.0360906
ZNF292 zinc finger protein 292 0.0359693
DST dystonin 0.0358499
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0358094
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.0354317
ESYT2 extended synaptotagmin-like protein 2 0.0350823
PKM pyruvate kinase, muscle 0.0349806
HILPDA hypoxia inducible lipid droplet-associated 0.0348454
RAD51B RAD51 paralog B 0.0348338
EFNA5 ephrin-A5 0.0348264
CALR calreticulin 0.0346515
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0345266
MXI1 MAX interactor 1, dimerization protein 0.0343659
MMP12 matrix metallopeptidase 12 0.0338662
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase 0.0337178
BBX bobby sox homolog (Drosophila) 0.0334761
EPB41L2 erythrocyte membrane protein band 4.1-like 2 0.0334744
WWOX WW domain containing oxidoreductase 0.0331624
ADM adrenomedullin 0.0331212
RBMS3 RNA binding motif, single stranded interacting protein 3 0.0329826
TIMP2 TIMP metallopeptidase inhibitor 2 0.0329796
APLP2 amyloid beta (A4) precursor-like protein 2 0.032897
EGFR epidermal growth factor receptor 0.0327601
FTH1 ferritin, heavy polypeptide 1 0.0326536
DUSP10 dual specificity phosphatase 10 0.03174
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.031191
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.030753
PPARD peroxisome proliferator-activated receptor delta 0.0302401
ARFGEF3 ARFGEF family member 3 0.0295937
FNDC3B fibronectin type III domain containing 3B 0.0290548
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0288658
TTC3 tetratricopeptide repeat domain 3 0.0288595
IARS1 isoleucyl-tRNA synthetase 1 0.0287522
JARID2 jumonji, AT rich interactive domain 2 0.0284883
YEATS2 YEATS domain containing 2 0.0284691
RND3 Rho family GTPase 3 0.0284286
FBXO32 F-box protein 32 0.0282713
EPHA6 EPH receptor A6 0.0282056
PHF21A PHD finger protein 21A 0.02817
CEP250 centrosomal protein 250kDa 0.0280376
KDM2A lysine (K)-specific demethylase 2A 0.0278446
GOLGA4 golgin A4 0.0277414
FRMD4A FERM domain containing 4A 0.0276473
TMEM132D transmembrane protein 132D 0.0275786
MLPH melanophilin 0.0274879
PRKCE protein kinase C, epsilon 0.0270765
SLC8A1 solute carrier family 8 (sodium/calcium exchanger), member 1 0.0269632
TNIK TRAF2 and NCK interacting kinase 0.026783
PSD3 pleckstrin and Sec7 domain containing 3 0.0267649

decreased expression

Symbol Name Standardized Value
NAMPT nicotinamide phosphoribosyltransferase -0.12832
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.123584
VCL vinculin -0.115041
VIM vimentin -0.110142
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.0960139
FN1 fibronectin 1 -0.0946779
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0897943
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.0845478
TMSB10 thymosin beta 10 -0.0829696
HLA-B major histocompatibility complex, class I, B -0.0828605
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0756756
BICC1 BicC family RNA binding protein 1 -0.0736706
TPT1 tumor protein, translationally-controlled 1 -0.0650574
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0594998
EIF1 eukaryotic translation initiation factor 1 -0.0589309
AKAP12 A kinase (PRKA) anchor protein 12 -0.0563107
MT2A metallothionein 2A -0.056117
KYNU kynureninase -0.0490963
RPL23 ribosomal protein L23 -0.0487959
OSMR oncostatin M receptor -0.0481823
RPS24 ribosomal protein S24 -0.0455807
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 -0.0447631
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0447473
KLF6 Kruppel-like factor 6 -0.0438487
GNAS GNAS complex locus -0.0433869
ELL2 elongation factor, RNA polymerase II, 2 -0.043355
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0432118
NABP1 nucleic acid binding protein 1 -0.0427155
ACSL4 acyl-CoA synthetase long-chain family member 4 -0.0406936
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 -0.040615
SLC38A2 solute carrier family 38, member 2 -0.0403108
EGR1 early growth response 1 -0.0401788
THBS1 thrombospondin 1 -0.0391179
SDC4 syndecan 4 -0.0390375
PNRC1 proline-rich nuclear receptor coactivator 1 -0.0385114
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0384685
RPL35A ribosomal protein L35a -0.0383887
PALLD palladin, cytoskeletal associated protein -0.0379061
GLIS3 GLIS family zinc finger 3 -0.037375
AHNAK AHNAK nucleoprotein -0.0357109
RPS6 ribosomal protein S6 -0.0351388
TUBB tubulin, beta class I -0.0349322
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0336767
MKI67 marker of proliferation Ki-67 -0.0325484
RPL26 ribosomal protein L26 -0.0320446
RTN4 reticulon 4 -0.0312714
RPL32 ribosomal protein L32 -0.0309526
RPL19 ribosomal protein L19 -0.0309235
RPS21 ribosomal protein S21 -0.0308823
TMSB4X thymosin beta 4, X-linked -0.0307464
RPS4X ribosomal protein S4, X-linked -0.0297237
RPL36A ribosomal protein L36a -0.0293321
SOD2 superoxide dismutase 2, mitochondrial -0.0293029
ANXA2 annexin A2 -0.0292916
RPL12 ribosomal protein L12 -0.0285763
LOC112694756 uncharaterized LOC112694756 -0.0281939
PAPPA pregnancy-associated plasma protein A, pappalysin 1 -0.0281627
RPLP1 ribosomal protein, large, P1 -0.0280138
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II -0.027944
NCOA7 nuclear receptor coactivator 7 -0.0278448
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0275102
TNNC1 troponin C type 1 (slow) -0.0270687
RACK1 receptor for activated C kinase 1 -0.0269742
CENPF centromere protein F, 350/400kDa -0.0268916
SERINC1 serine incorporator 1 -0.0266218
DIAPH3 diaphanous-related formin 3 -0.0264253
ARHGAP5 Rho GTPase activating protein 5 -0.0264152
ANLN anillin, actin binding protein -0.0263145
DENND5A DENN/MADD domain containing 5A -0.0259636
KPNB1 karyopherin (importin) beta 1 -0.0253468
TMEM41B transmembrane protein 41B -0.0250479
UBC ubiquitin C -0.0248487
RPL35 ribosomal protein L35 -0.0247939
FTL ferritin, light polypeptide -0.0246871
BCAR3 breast cancer anti-estrogen resistance 3 -0.0240972
RPL34 ribosomal protein L34 -0.0238439
RPLP0 ribosomal protein, large, P0 -0.0235185
SLC38A1 solute carrier family 38, member 1 -0.0235091
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa -0.0234944
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0233297
ZNF217 zinc finger protein 217 -0.0230387
HDAC8 histone deacetylase 8 -0.0229427
VMP1 vacuole membrane protein 1 -0.0229135
ACTG1 actin gamma 1 -0.0228658
RAD21 RAD21 homolog (S. pombe) -0.0226458
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0224991
KLF7 Kruppel-like factor 7 (ubiquitous) -0.0224389
COL1A1 collagen, type I, alpha 1 -0.022337
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0220721
BASP1 brain abundant, membrane attached signal protein 1 -0.0218696
EHBP1 EH domain binding protein 1 -0.0218652
RPL36 ribosomal protein L36 -0.0217117
STK17A serine/threonine kinase 17a -0.0216784
IL6 interleukin 6 -0.0216505
KIF4A kinesin family member 4A -0.0216342
COL1A2 collagen, type I, alpha 2 -0.0215932
RPLP2 ribosomal protein, large, P2 -0.0215635
IFI6 interferon, alpha-inducible protein 6 -0.0215279
DCBLD1 discoidin, CUB and LCCL domain containing 1 -0.0214348
CAVIN1 caveolae associated protein 1 -0.0210133