Retinoic acid_SW 1088 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Retinoic acid perturbation in SW 1088 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Retinoic acid_SW 1088 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FN1 fibronectin 1 0.0998791
CDH13 cadherin 13 0.0947126
COL6A3 collagen, type VI, alpha 3 0.0919357
IGFBP3 insulin-like growth factor binding protein 3 0.0900953
COL5A1 collagen, type V, alpha 1 0.0820754
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0787995
NRXN3 neurexin 3 0.0671241
VEGFC vascular endothelial growth factor C 0.0649549
FNDC3B fibronectin type III domain containing 3B 0.062914
TRIO trio Rho guanine nucleotide exchange factor 0.0612925
PRELID2 PRELI domain containing 2 0.0590957
HMGA2 high mobility group AT-hook 2 0.0556716
RAD51B RAD51 paralog B 0.0537684
MYH9 myosin, heavy chain 9, non-muscle 0.0534322
GLIS3 GLIS family zinc finger 3 0.0512629
TNS3 tensin 3 0.0511297
EXT1 exostosin glycosyltransferase 1 0.0509873
PSD3 pleckstrin and Sec7 domain containing 3 0.0507231
ZSWIM6 zinc finger, SWIM-type containing 6 0.0499291
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.0479181
DPYD dihydropyrimidine dehydrogenase 0.0476527
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0474816
FNIP1 folliculin interacting protein 1 0.0467983
TTC3 tetratricopeptide repeat domain 3 0.0466231
MACF1 microtubule-actin crosslinking factor 1 0.0461711
LOXL2 lysyl oxidase-like 2 0.0451676
COL6A1 collagen, type VI, alpha 1 0.0447388
CXCL8 chemokine (C-X-C motif) ligand 8 0.0441639
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0437129
IGFBP7 insulin-like growth factor binding protein 7 0.0433596
CDK13 cyclin-dependent kinase 13 0.0432483
FBXL7 F-box and leucine-rich repeat protein 7 0.0425787
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) 0.0423662
SPTBN1 spectrin, beta, non-erythrocytic 1 0.042022
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0417821
HYCC1 hyccin PI4KA lipid kinase complex subunit 1 0.0414113
EGFR epidermal growth factor receptor 0.0407462
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A 0.040545
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) 0.0404362
KYNU kynureninase 0.0397902
SMYD3 SET and MYND domain containing 3 0.0394625
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0387928
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0381551
ATXN1 ataxin 1 0.0371317
RUNX1 runt-related transcription factor 1 0.0367524
INTS6 integrator complex subunit 6 0.0364873
GOLGB1 golgin B1 0.0361891
LAMB1 laminin, beta 1 0.0359324
PDLIM5 PDZ and LIM domain 5 0.0349662
LHFPL2 lipoma HMGIC fusion partner-like 2 0.0345462
COL7A1 collagen, type VII, alpha 1 0.0334302
GLS2 glutaminase 2 (liver, mitochondrial) 0.0330591
MICAL3 microtubule associated monooxygenase, calponin and LIM domain containing 3 0.0330488
SDK1 sidekick cell adhesion molecule 1 0.0320974
COL1A1 collagen, type I, alpha 1 0.0320816
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 0.0317927
RBFOX2 RNA binding protein, fox-1 homolog (C. elegans) 2 0.0314946
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.031461
MAML2 mastermind-like 2 (Drosophila) 0.0314056
DIAPH3 diaphanous-related formin 3 0.0313576
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 0.0312621
TGFBI transforming growth factor, beta-induced, 68kDa 0.0311929
VCL vinculin 0.030864
PDXDC1 pyridoxal-dependent decarboxylase domain containing 1 0.0306697
YEATS2 YEATS domain containing 2 0.0304056
RBMS3 RNA binding motif, single stranded interacting protein 3 0.0303463
CSMD2 CUB and Sushi multiple domains 2 0.0300359
AFF3 AF4/FMR2 family, member 3 0.0287832
UBAP2 ubiquitin associated protein 2 0.0285323
COL6A2 collagen, type VI, alpha 2 0.0279784
ANTXR2 anthrax toxin receptor 2 0.0278817
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0277937
ACTN1 actinin, alpha 1 0.0277275
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A 0.0274901
ITGB3BP integrin beta 3 binding protein (beta3-endonexin) 0.026894
GSE1 Gse1 coiled-coil protein 0.0268837
NAV1 neuron navigator 1 0.0266019
WNT5A wingless-type MMTV integration site family, member 5A 0.0265321
DST dystonin 0.0261061
SCLT1 sodium channel and clathrin linker 1 0.0259978
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0258129
FLNA filamin A, alpha 0.0257326
CCND1 cyclin D1 0.0256899
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) 0.0255083
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6 0.0254788
TENM3 teneurin transmembrane protein 3 0.025294
NRDC nardilysin convertase 0.0252921
ALK anaplastic lymphoma receptor tyrosine kinase 0.0252648
MYO10 myosin X 0.0252421
CDK14 cyclin-dependent kinase 14 0.0249283
ZBTB20 zinc finger and BTB domain containing 20 0.0248778
PRKCA protein kinase C, alpha 0.0248483
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0246797
SETBP1 SET binding protein 1 0.0244876
LPP LIM domain containing preferred translocation partner in lipoma 0.0239313
ANKRD36 ankyrin repeat domain 36 0.0239187
NECTIN3 nectin cell adhesion molecule 3 0.0239169
SND1 staphylococcal nuclease and tudor domain containing 1 0.0239089
ZMIZ1 zinc finger, MIZ-type containing 1 0.0236981
CDK6 cyclin-dependent kinase 6 0.0236753

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.239918
MT2A metallothionein 2A -0.209875
TMSB10 thymosin beta 10 -0.176781
VIM vimentin -0.111189
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0892916
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.086795
B2M beta-2-microglobulin -0.0857638
HLA-B major histocompatibility complex, class I, B -0.0813645
AKAP12 A kinase (PRKA) anchor protein 12 -0.0781714
ADM adrenomedullin -0.0734659
FTL ferritin, light polypeptide -0.0610863
PDIA3 protein disulfide isomerase family A, member 3 -0.0606628
RTN4 reticulon 4 -0.059412
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0578809
RPS6 ribosomal protein S6 -0.0577636
SPAG9 sperm associated antigen 9 -0.0496372
TPT1 tumor protein, translationally-controlled 1 -0.048123
MARCKS myristoylated alanine-rich protein kinase C substrate -0.047753
NDRG1 N-myc downstream regulated 1 -0.0463033
SDC4 syndecan 4 -0.0454353
H3-3B H3.3 histone B -0.0451703
RPL11 ribosomal protein L11 -0.0431155
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.042898
PRRC2C proline-rich coiled-coil 2C -0.0422742
RPL23 ribosomal protein L23 -0.0421134
RPLP1 ribosomal protein, large, P1 -0.0418063
UBC ubiquitin C -0.0407991
S100A6 S100 calcium binding protein A6 -0.0402702
PNRC1 proline-rich nuclear receptor coactivator 1 -0.040106
EIF1 eukaryotic translation initiation factor 1 -0.0399477
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -0.0398582
LGALS1 lectin, galactoside-binding, soluble, 1 -0.039474
HILPDA hypoxia inducible lipid droplet-associated -0.0393766
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0390648
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 -0.0390007
NAMPT nicotinamide phosphoribosyltransferase -0.0387953
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0387178
LOX lysyl oxidase -0.0384862
RPL35A ribosomal protein L35a -0.0383926
RPL19 ribosomal protein L19 -0.0378959
ESYT2 extended synaptotagmin-like protein 2 -0.0375865
RPL36 ribosomal protein L36 -0.036712
COL1A2 collagen, type I, alpha 2 -0.0363672
ARRDC3 arrestin domain containing 3 -0.035958
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0326367
RPS19 ribosomal protein S19 -0.0324413
ENO1 enolase 1, (alpha) -0.032068
ACBD3 acyl-CoA binding domain containing 3 -0.0320179
PKM pyruvate kinase, muscle -0.0312848
UGCG UDP-glucose ceramide glucosyltransferase -0.0311811
HLA-C major histocompatibility complex, class I, C -0.0309466
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 -0.0309388
RPS16 ribosomal protein S16 -0.0308691
WDR45B WD repeat domain 45B -0.0305046
KLF7 Kruppel-like factor 7 (ubiquitous) -0.0304901
H1-0 H1.0 linker histone -0.0301695
PPP1CB protein phosphatase 1, catalytic subunit, beta isozyme -0.0299455
RPL37A ribosomal protein L37a -0.0288726
RPS12 ribosomal protein S12 -0.0288137
PTMA prothymosin, alpha -0.0287995
PDE10A phosphodiesterase 10A -0.0286814
SOD2 superoxide dismutase 2, mitochondrial -0.0283653
ADAM9 ADAM metallopeptidase domain 9 -0.0281294
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0279788
ERC2 ELKS/RAB6-interacting/CAST family member 2 -0.0277882
GNAS GNAS complex locus -0.0275328
ZNF292 zinc finger protein 292 -0.0275259
GPC6 glypican 6 -0.0273738
CCNI cyclin I -0.0271552
NUCB2 nucleobindin 2 -0.0268501
UBE2D3 ubiquitin-conjugating enzyme E2D 3 -0.0263848
ANXA1 annexin A1 -0.0262452
CD109 CD109 molecule -0.0261775
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0260965
CD63 CD63 molecule -0.0260871
RPL12 ribosomal protein L12 -0.0259436
CD99 CD99 molecule -0.0254826
MAP4K5 mitogen-activated protein kinase kinase kinase kinase 5 -0.0250776
CNOT2 CCR4-NOT transcription complex, subunit 2 -0.0247507
EGR1 early growth response 1 -0.0244439
RPL31 ribosomal protein L31 -0.0241723
BHLHE40 basic helix-loop-helix family, member e40 -0.0241305
CSDE1 cold shock domain containing E1, RNA-binding -0.0238579
WTAP Wilms tumor 1 associated protein -0.0237708
RPL26 ribosomal protein L26 -0.0237038
RPLP0 ribosomal protein, large, P0 -0.0235881
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0235122
RAI14 retinoic acid induced 14 -0.0231145
RPS8 ribosomal protein S8 -0.0230423
LMAN1 lectin, mannose-binding, 1 -0.0228721
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit -0.0228647
PI3 peptidase inhibitor 3, skin-derived -0.0227766
RPS27A ribosomal protein S27a -0.0227181
RPL8 ribosomal protein L8 -0.0226552
RPS4X ribosomal protein S4, X-linked -0.0226057
PCBP2 poly(rC) binding protein 2 -0.0225914
RPS14 ribosomal protein S14 -0.0225741
TXNRD1 thioredoxin reductase 1 -0.0222588
WAC WW domain containing adaptor with coiled-coil -0.0219162
RPS11 ribosomal protein S11 -0.0218615