Retinoic acid_SW 1271 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Retinoic acid perturbation in SW 1271 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Retinoic acid_SW 1271 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0428967
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0348586
FMNL2 formin-like 2 0.0328781
ZSWIM6 zinc finger, SWIM-type containing 6 0.0307594
SMAD3 SMAD family member 3 0.0271747
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0248124
INTS6 integrator complex subunit 6 0.0215233
ANO6 anoctamin 6 0.0208457
CEMIP2 cell migration inducing hyaluronidase 2 0.0205113
EGFR epidermal growth factor receptor 0.0203824
RIGI RNA sensor RIG-I 0.0202823
ATXN1 ataxin 1 0.0202585
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.0199817
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0199173
FAM13A family with sequence similarity 13, member A 0.0194812
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0190429
CCNY cyclin Y 0.0186251
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 0.0183124
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0180302
GLS2 glutaminase 2 (liver, mitochondrial) 0.0178896
FNDC3B fibronectin type III domain containing 3B 0.0176313
YAP1 Yes-associated protein 1 0.0175143
PLEC plectin 0.0171928
ASPH aspartate beta-hydroxylase 0.0168101
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0166262
UBQLN1 ubiquilin 1 0.0156415
TPD52 tumor protein D52 0.0155943
AHNAK AHNAK nucleoprotein 0.015215
GPC5 glypican 5 0.0145118
HIVEP1 human immunodeficiency virus type I enhancer binding protein 1 0.0143714
APP amyloid beta (A4) precursor protein 0.01412
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 0.0139969
NGLY1 N-glycanase 1 0.0138233
CNOT12 CCR4-NOT transcription complex subunit 12 0.0137969
PAPOLA poly(A) polymerase alpha 0.0134632
MACF1 microtubule-actin crosslinking factor 1 0.0134306
PRELID2 PRELI domain containing 2 0.013402
MBNL2 muscleblind-like splicing regulator 2 0.013366
SKIL SKI-like proto-oncogene 0.0132001
CPEB2 cytoplasmic polyadenylation element binding protein 2 0.0124584
ASCC3 activating signal cointegrator 1 complex subunit 3 0.0122429
TRA2A transformer 2 alpha homolog (Drosophila) 0.0122297
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0120102
ARHGAP26 Rho GTPase activating protein 26 0.0119626
FOXO1 forkhead box O1 0.0117589
CRYBG3 beta-gamma crystallin domain containing 3 0.0114122
FCHO2 FCH domain only 2 0.0114039
SLC20A1 solute carrier family 20 (phosphate transporter), member 1 0.0113939
TSC22D2 TSC22 domain family, member 2 0.0113366
DIAPH1 diaphanous-related formin 1 0.011273
SH3RF1 SH3 domain containing ring finger 1 0.0112173
OXSR1 oxidative stress responsive 1 0.0109421
RUNX1 runt-related transcription factor 1 0.0108787
APLP2 amyloid beta (A4) precursor-like protein 2 0.0108655
ZEB1 zinc finger E-box binding homeobox 1 0.0108651
SUPT3H suppressor of Ty 3 homolog (S. cerevisiae) 0.0106189
ELOF1 elongation factor 1 homolog (S. cerevisiae) 0.010594
KAT2B K(lysine) acetyltransferase 2B 0.0105665
TTC19 tetratricopeptide repeat domain 19 0.0104618
ERRFI1 ERBB receptor feedback inhibitor 1 0.0104617
TRIO trio Rho guanine nucleotide exchange factor 0.0104514
PSD3 pleckstrin and Sec7 domain containing 3 0.0104343
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.010409
SKI SKI proto-oncogene 0.010327
SUMF1 sulfatase modifying factor 1 0.0103264
NIBAN1 niban apoptosis regulator 1 0.0103082
SNX14 sorting nexin 14 0.0102888
HSPA8 heat shock 70kDa protein 8 0.0101953
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.0101299
MGA MGA, MAX dimerization protein 0.0100748
UBE2E1 ubiquitin-conjugating enzyme E2E 1 0.0100311
SSBP2 single-stranded DNA binding protein 2 0.0100049
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.00999877
RALGAPA2 Ral GTPase activating protein, alpha subunit 2 (catalytic) 0.00993774
FAM168A family with sequence similarity 168, member A 0.00977072
KIAA0232 KIAA0232 0.00975121
IQCJ-SCHIP1 IQCJ-SCHIP1 readthrough 0.00974174
IRF1 interferon regulatory factor 1 0.00964622
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0096387
COL5A1 collagen, type V, alpha 1 0.0096269
CAMTA1 calmodulin binding transcription activator 1 0.00958575
SESN1 sestrin 1 0.00955127
USP53 ubiquitin specific peptidase 53 0.00949842
IFIT1 interferon-induced protein with tetratricopeptide repeats 1 0.00948904
UBR1 ubiquitin protein ligase E3 component n-recognin 1 0.00941302
CHD1 chromodomain helicase DNA binding protein 1 0.00935616
CTBP2 C-terminal binding protein 2 0.00934766
ADIPOR2 adiponectin receptor 2 0.00932553
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 0.00926263
DIPK2A divergent protein kinase domain 2A 0.0092298
WDR37 WD repeat domain 37 0.00918829
OASL 2'-5'-oligoadenylate synthetase-like 0.00916244
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.00914886
BBS9 Bardet-Biedl syndrome 9 0.0091081
ACSS2 acyl-CoA synthetase short-chain family member 2 0.00906553
BIRC3 baculoviral IAP repeat containing 3 0.00904498
KDM2A lysine (K)-specific demethylase 2A 0.00904262
PSPC1 paraspeckle component 1 0.00900642
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 0.00900615
FAM219A family with sequence similarity 219, member A 0.00900118

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.405592
VIM vimentin -0.183215
TMSB10 thymosin beta 10 -0.136683
TPT1 tumor protein, translationally-controlled 1 -0.0880204
PTMA prothymosin, alpha -0.0817875
LDHA lactate dehydrogenase A -0.0776553
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0548192
MT2A metallothionein 2A -0.0539278
RPL35A ribosomal protein L35a -0.0440009
RPLP1 ribosomal protein, large, P1 -0.0428958
PRRC2C proline-rich coiled-coil 2C -0.0391929
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0389057
RPS6 ribosomal protein S6 -0.0385126
POTEF POTE ankyrin domain family, member F -0.0381515
BASP1 brain abundant, membrane attached signal protein 1 -0.0373113
RPLP2 ribosomal protein, large, P2 -0.0357954
YBX3 Y box binding protein 3 -0.0354235
GOLGA4 golgin A4 -0.033702
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.0332646
TPM4 tropomyosin 4 -0.0329229
TM4SF1 transmembrane 4 L six family member 1 -0.0329044
IGF2 insulin-like growth factor 2 -0.0327454
RPL23 ribosomal protein L23 -0.0322946
RPL11 ribosomal protein L11 -0.032267
H3-3B H3.3 histone B -0.0322439
PNRC1 proline-rich nuclear receptor coactivator 1 -0.032026
EIF1 eukaryotic translation initiation factor 1 -0.0315467
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0314712
RPS3 ribosomal protein S3 -0.0308617
OSMR oncostatin M receptor -0.0300648
RPS13 ribosomal protein S13 -0.0299431
CD44 CD44 molecule (Indian blood group) -0.0296369
EIF2S2 eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa -0.0295618
B2M beta-2-microglobulin -0.0292615
LOC112694756 uncharaterized LOC112694756 -0.0292052
RPL32 ribosomal protein L32 -0.0287552
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0286127
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.0284853
ANGPTL4 angiopoietin-like 4 -0.0284519
DIAPH3 diaphanous-related formin 3 -0.0276906
ERC2 ELKS/RAB6-interacting/CAST family member 2 -0.0275472
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0273621
UGCG UDP-glucose ceramide glucosyltransferase -0.0273037
GNAS GNAS complex locus -0.0272667
RPL19 ribosomal protein L19 -0.0272297
RACK1 receptor for activated C kinase 1 -0.0271188
NAP1L1 nucleosome assembly protein 1-like 1 -0.0267151
RPS21 ribosomal protein S21 -0.0266106
HILPDA hypoxia inducible lipid droplet-associated -0.0264506
RPL26 ribosomal protein L26 -0.026246
PKM pyruvate kinase, muscle -0.0260049
RPS14 ribosomal protein S14 -0.0251421
RPL36 ribosomal protein L36 -0.024884
SEMA4B sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B -0.0245442
ANKRD28 ankyrin repeat domain 28 -0.0244649
RAB7A RAB7A, member RAS oncogene family -0.0244155
FMN1 formin 1 -0.0244077
RPS17 ribosomal protein S17 -0.024405
RPS25 ribosomal protein S25 -0.0243934
UBB ubiquitin B -0.0242186
RPL34 ribosomal protein L34 -0.0242068
RPS8 ribosomal protein S8 -0.0240524
NDRG1 N-myc downstream regulated 1 -0.0239241
RPS23 ribosomal protein S23 -0.0239165
CENPF centromere protein F, 350/400kDa -0.0237735
S100A9 S100 calcium binding protein A9 -0.0235889
SLC38A2 solute carrier family 38, member 2 -0.0235518
RPL9 ribosomal protein L9 -0.0232565
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0232
RPL15 ribosomal protein L15 -0.0230877
ACTG1 actin gamma 1 -0.0230137
NCOR1 nuclear receptor corepressor 1 -0.0228992
DEK DEK proto-oncogene -0.0226314
RPS12 ribosomal protein S12 -0.0225288
RPL12 ribosomal protein L12 -0.0225017
RPS27A ribosomal protein S27a -0.0222577
TPI1 triosephosphate isomerase 1 -0.0222293
IGFBP3 insulin-like growth factor binding protein 3 -0.0218848
MAPKAP1 mitogen-activated protein kinase associated protein 1 -0.0217916
EEF2 eukaryotic translation elongation factor 2 -0.0217809
CELF1 CUGBP, Elav-like family member 1 -0.021266
SEPTIN7 septin 7 -0.0212639
IFITM3 interferon induced transmembrane protein 3 -0.0211375
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0211254
TUBB4B tubulin, beta 4B class IVb -0.0210327
ERBIN erbb2 interacting protein -0.0209179
PFN1 profilin 1 -0.020888
RPL37 ribosomal protein L37 -0.0206977
VMP1 vacuole membrane protein 1 -0.0206659
HNRNPK heterogeneous nuclear ribonucleoprotein K -0.0206087
RBM25 RNA binding motif protein 25 -0.0206043
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats -0.0205806
ENO2 enolase 2 (gamma, neuronal) -0.020468
CSDE1 cold shock domain containing E1, RNA-binding -0.0204609
VDAC1 voltage-dependent anion channel 1 -0.0202951
TMEM158 transmembrane protein 158 (gene/pseudogene) -0.0202663
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 -0.0202249
PRSS23 protease, serine, 23 -0.0197402
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 -0.0196887
RPL37A ribosomal protein L37a -0.0196437