Retinoic acid_SW1417 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Retinoic acid perturbation in SW1417 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Retinoic acid_SW1417 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2 0.0789234
CEMIP cell migration inducing protein, hyaluronan binding 0.0479074
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0445291
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0439866
FNDC3B fibronectin type III domain containing 3B 0.0395804
MAML2 mastermind-like 2 (Drosophila) 0.0389186
SAMD4A sterile alpha motif domain containing 4A 0.0377884
NEBL nebulette 0.0372849
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.036298
CTBP2 C-terminal binding protein 2 0.0354885
CDK13 cyclin-dependent kinase 13 0.0352858
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0347231
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0345157
INTS6 integrator complex subunit 6 0.0339516
ZSWIM6 zinc finger, SWIM-type containing 6 0.0330927
BCL2L1 BCL2-like 1 0.0329913
GMDS GDP-mannose 4,6-dehydratase 0.0314876
NCEH1 neutral cholesterol ester hydrolase 1 0.0294046
SMAD3 SMAD family member 3 0.0284566
EHBP1 EH domain binding protein 1 0.0281284
IFRD1 interferon-related developmental regulator 1 0.027471
ARHGAP26 Rho GTPase activating protein 26 0.0272712
SNTB1 syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) 0.0270308
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.02667
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.0265832
CADPS Ca++-dependent secretion activator 0.0257515
HDAC4 histone deacetylase 4 0.0255958
PDLIM5 PDZ and LIM domain 5 0.0254404
OSBPL10 oxysterol binding protein-like 10 0.0251604
VCL vinculin 0.0250606
EXT1 exostosin glycosyltransferase 1 0.0247304
PTPRK protein tyrosine phosphatase, receptor type, K 0.0246465
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0246382
CTNNA2 catenin (cadherin-associated protein), alpha 2 0.0238793
MYO1E myosin IE 0.0234424
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit 0.0232599
LPP LIM domain containing preferred translocation partner in lipoma 0.0229656
NKD1 naked cuticle homolog 1 (Drosophila) 0.0226588
PPARD peroxisome proliferator-activated receptor delta 0.0223633
SDK1 sidekick cell adhesion molecule 1 0.022294
FBXW7 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase 0.0222412
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 0.0221973
KCNH8 potassium channel, voltage gated eag related subfamily H, member 8 0.0221382
PCSK5 proprotein convertase subtilisin/kexin type 5 0.0221315
CEMIP2 cell migration inducing hyaluronidase 2 0.0220265
APLP2 amyloid beta (A4) precursor-like protein 2 0.0219695
SHB Src homology 2 domain containing adaptor protein B 0.0216253
ZBTB20 zinc finger and BTB domain containing 20 0.0214984
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0211742
PICALM phosphatidylinositol binding clathrin assembly protein 0.0209862
PLEC plectin 0.0208889
FAM107B family with sequence similarity 107, member B 0.0208184
UBAP2 ubiquitin associated protein 2 0.0204044
RCOR1 REST corepressor 1 0.0199951
SMAD2 SMAD family member 2 0.0198504
YAP1 Yes-associated protein 1 0.0197269
ATXN1 ataxin 1 0.0192706
NABP1 nucleic acid binding protein 1 0.0188654
RIGI RNA sensor RIG-I 0.0188456
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0187379
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0185163
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.0184381
PELI2 pellino E3 ubiquitin protein ligase family member 2 0.0182056
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0180853
GLS2 glutaminase 2 (liver, mitochondrial) 0.0177214
EXOC4 exocyst complex component 4 0.0174407
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2 0.0174
RALY RALY heterogeneous nuclear ribonucleoprotein 0.0171754
SND1 staphylococcal nuclease and tudor domain containing 1 0.0171398
ANKRD11 ankyrin repeat domain 11 0.0171358
PCBP3 poly(rC) binding protein 3 0.0170608
NUP98 nucleoporin 98kDa 0.0170601
USP34 ubiquitin specific peptidase 34 0.0166679
FLNA filamin A, alpha 0.0166495
ADAM19 ADAM metallopeptidase domain 19 0.0164373
PARD3B par-3 family cell polarity regulator beta 0.0163827
CMIP c-Maf inducing protein 0.01638
MPRIP myosin phosphatase Rho interacting protein 0.0163352
TUFT1 tuftelin 1 0.0163336
MALT1 MALT1 paracaspase 0.0163194
OGDH oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide) 0.0160397
TRAPPC9 trafficking protein particle complex 9 0.0155912
AKAP13 A kinase (PRKA) anchor protein 13 0.0155529
NFIA nuclear factor I/A 0.0154068
PPP1R13B protein phosphatase 1, regulatory subunit 13B 0.0152665
PRKCA protein kinase C, alpha 0.0150784
HNF1A HNF1 homeobox A 0.0150741
OGT O-linked N-acetylglucosamine (GlcNAc) transferase 0.0150578
SETX senataxin 0.0150186
NLK nemo-like kinase 0.0148204
RAD51B RAD51 paralog B 0.0148107
ARHGAP32 Rho GTPase activating protein 32 0.0147204
TRIM2 tripartite motif containing 2 0.0146842
JARID2 jumonji, AT rich interactive domain 2 0.0146317
DENND1A DENN/MADD domain containing 1A 0.0142674
RUNX1 runt-related transcription factor 1 0.0142288
DOCK4 dedicator of cytokinesis 4 0.014119
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0141062
KPNA4 karyopherin alpha 4 (importin alpha 3) 0.0140805
SMYD3 SET and MYND domain containing 3 0.0140433

decreased expression

Symbol Name Standardized Value
FTL ferritin, light polypeptide -0.264609
PTMA prothymosin, alpha -0.222156
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.179686
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.153692
TMSB10 thymosin beta 10 -0.115142
FTH1 ferritin, heavy polypeptide 1 -0.101801
RPS6 ribosomal protein S6 -0.0965281
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.0805311
RPL12 ribosomal protein L12 -0.0755457
B2M beta-2-microglobulin -0.0736125
RPL35A ribosomal protein L35a -0.072801
KRT18 keratin 18, type I -0.067989
LOC102724023 ES1 protein homolog, mitochondrial -0.0675767
RPLP1 ribosomal protein, large, P1 -0.0675448
EIF1 eukaryotic translation initiation factor 1 -0.0658233
GOLGA4 golgin A4 -0.0617134
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0596949
CST3 cystatin C -0.0583261
RPL23 ribosomal protein L23 -0.0569359
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0545847
EPCAM epithelial cell adhesion molecule -0.0544868
RPS13 ribosomal protein S13 -0.0539381
KRT8 keratin 8, type II -0.0532152
GSTP1 glutathione S-transferase pi 1 -0.0529289
LDHA lactate dehydrogenase A -0.0510579
LOC112694756 uncharaterized LOC112694756 -0.050825
RPS21 ribosomal protein S21 -0.0507248
RPL28 ribosomal protein L28 -0.0498175
RPLP2 ribosomal protein, large, P2 -0.0493411
RPL8 ribosomal protein L8 -0.0492297
RPL19 ribosomal protein L19 -0.0481473
UBC ubiquitin C -0.0481447
RPS19 ribosomal protein S19 -0.047782
RPS25 ribosomal protein S25 -0.0457635
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa -0.0454839
RPS5 ribosomal protein S5 -0.0446549
RPLP0 ribosomal protein, large, P0 -0.0445251
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0438925
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0436895
S100A6 S100 calcium binding protein A6 -0.0435303
RPL31 ribosomal protein L31 -0.0430757
PERP PERP, TP53 apoptosis effector -0.0429627
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 -0.0428623
TPT1 tumor protein, translationally-controlled 1 -0.0427083
RPS3 ribosomal protein S3 -0.0425672
TMEM123 transmembrane protein 123 -0.0412564
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0407048
SLC38A1 solute carrier family 38, member 1 -0.0405213
RPL37A ribosomal protein L37a -0.0402827
S100A10 S100 calcium binding protein A10 -0.0385853
RPS12 ribosomal protein S12 -0.038383
RPL32 ribosomal protein L32 -0.0381247
RPL18 ribosomal protein L18 -0.0373658
RPS8 ribosomal protein S8 -0.0373182
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0367536
ACTG1 actin gamma 1 -0.0365183
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0363775
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0363424
RPS11 ribosomal protein S11 -0.0363092
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific ) -0.0362888
RAD21 RAD21 homolog (S. pombe) -0.0359591
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.035656
PDIA3 protein disulfide isomerase family A, member 3 -0.0348329
KRT19 keratin 19, type I -0.0346111
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.034348
MKI67 marker of proliferation Ki-67 -0.0343071
EGR1 early growth response 1 -0.0343066
GNAS GNAS complex locus -0.0332193
H1-0 H1.0 linker histone -0.0330659
RPS14 ribosomal protein S14 -0.0325316
ATP5F1E ATP synthase F1 subunit epsilon -0.0323288
RACK1 receptor for activated C kinase 1 -0.0317675
PKM pyruvate kinase, muscle -0.0313169
POTEF POTE ankyrin domain family, member F -0.0312611
TMSB4X thymosin beta 4, X-linked -0.0309158
RPL11 ribosomal protein L11 -0.0308187
HLA-A major histocompatibility complex, class I, A -0.0304942
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0302876
SEPTIN7 septin 7 -0.0302855
SQSTM1 sequestosome 1 -0.0302456
RPL36 ribosomal protein L36 -0.0301189
RPS27A ribosomal protein S27a -0.0299598
EEF2 eukaryotic translation elongation factor 2 -0.0295207
RPL26 ribosomal protein L26 -0.0294852
KPNB1 karyopherin (importin) beta 1 -0.0294104
IFITM3 interferon induced transmembrane protein 3 -0.0293147
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0292449
SEMA3B sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B -0.0291413
HMGA1 high mobility group AT-hook 1 -0.0290611
RPL27A ribosomal protein L27a -0.029018
RPL15 ribosomal protein L15 -0.028688
RPL37 ribosomal protein L37 -0.0286244
RPS16 ribosomal protein S16 -0.0285731
TPM4 tropomyosin 4 -0.0284396
ANXA2 annexin A2 -0.02841
CBX3 chromobox homolog 3 -0.0282406
FOSL1 FOS-like antigen 1 -0.0280944
RPL35 ribosomal protein L35 -0.0280926
RPL34 ribosomal protein L34 -0.0276753
H3-3B H3.3 histone B -0.0275126