Retinoic acid_SW48 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Retinoic acid perturbation in SW48 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Retinoic acid_SW48 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
CD36 CD36 molecule (thrombospondin receptor) 0.127123
EGFR epidermal growth factor receptor 0.102784
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0780484
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 0.068533
ATXN1 ataxin 1 0.0630038
CCSER1 coiled-coil serine-rich protein 1 0.0567126
SMYD3 SET and MYND domain containing 3 0.040265
FAT1 FAT atypical cadherin 1 0.0395841
FHIT fragile histidine triad 0.0371778
CENPF centromere protein F, 350/400kDa 0.0367194
KITLG KIT ligand 0.0363723
RAD51B RAD51 paralog B 0.0353625
RNF43 ring finger protein 43 0.0325219
AXIN2 axin 2 0.0322841
MTUS1 microtubule associated tumor suppressor 1 0.0318695
RALGPS2 Ral GEF with PH domain and SH3 binding motif 2 0.0303017
LAMA4 laminin, alpha 4 0.0301148
NCEH1 neutral cholesterol ester hydrolase 1 0.0297506
MT2A metallothionein 2A 0.0282692
AREG amphiregulin 0.0282676
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.0281516
OXR1 oxidation resistance 1 0.0280156
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0275268
MBNL1 muscleblind-like splicing regulator 1 0.0273658
PDE4B phosphodiesterase 4B, cAMP-specific 0.0268651
NAALADL2 N-acetylated alpha-linked acidic dipeptidase-like 2 0.0266588
ARL15 ADP-ribosylation factor-like 15 0.0263183
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 0.026035
SPRED2 sprouty-related, EVH1 domain containing 2 0.0251534
MKI67 marker of proliferation Ki-67 0.0250467
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0247957
TBC1D5 TBC1 domain family, member 5 0.023842
KIAA0040 KIAA0040 0.0237796
DIAPH3 diaphanous-related formin 3 0.0237404
CTSB cathepsin B 0.0236659
SPIDR scaffolding protein involved in DNA repair 0.0236356
DPY19L1 dpy-19-like 1 (C. elegans) 0.0228157
NR4A2 nuclear receptor subfamily 4, group A, member 2 0.0227827
SLC30A10 solute carrier family 30, member 10 0.0218614
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2 0.0217632
CRACD capping protein inhibiting regulator of actin dynamics 0.0216553
EVA1C eva-1 homolog C (C. elegans) 0.0210855
OSBPL10 oxysterol binding protein-like 10 0.0205101
YAP1 Yes-associated protein 1 0.0203158
GNAT3 guanine nucleotide binding protein, alpha transducing 3 0.0202999
FOXP1 forkhead box P1 0.0195495
EDAR ectodysplasin A receptor 0.0195092
ERC1 ELKS/RAB6-interacting/CAST family member 1 0.0194332
PDE4D phosphodiesterase 4D, cAMP-specific 0.019393
CPOX coproporphyrinogen oxidase 0.019172
SAMD5 sterile alpha motif domain containing 5 0.0190276
PRELID2 PRELI domain containing 2 0.0188157
NFE2L2 nuclear factor, erythroid 2-like 2 0.018693
ZNRF3 zinc and ring finger 3 0.0181584
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.0180029
R3HDM1 R3H domain containing 1 0.0179462
KLF12 Kruppel-like factor 12 0.017827
GNG4 guanine nucleotide binding protein (G protein), gamma 4 0.0178059
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans) 0.0176275
USP34 ubiquitin specific peptidase 34 0.0175612
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0174343
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0165323
NIN ninein (GSK3B interacting protein) 0.0164226
VPS13B vacuolar protein sorting 13 homolog B (yeast) 0.0160294
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0159254
BABAM2 BRISC and BRCA1 A complex member 2 0.0158696
TGFB2 transforming growth factor, beta 2 0.0158512
SCFD1 sec1 family domain containing 1 0.015803
RB1CC1 RB1-inducible coiled-coil 1 0.0156705
ZBTB20 zinc finger and BTB domain containing 20 0.0156107
EGLN1 egl-9 family hypoxia-inducible factor 1 0.0155537
KLF6 Kruppel-like factor 6 0.015511
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 0.0153354
FBXL4 F-box and leucine-rich repeat protein 4 0.0152102
PARD3B par-3 family cell polarity regulator beta 0.0151435
TNS3 tensin 3 0.0149772
UMAD1 UBAP1-MVB12-associated (UMA) domain containing 1 0.0149451
PKP4 plakophilin 4 0.0149091
YBX3 Y box binding protein 3 0.014852
RRM2 ribonucleotide reductase M2 0.0148125
WDPCP WD repeat containing planar cell polarity effector 0.0147906
PHF3 PHD finger protein 3 0.0147676
SLCO1B3 solute carrier organic anion transporter family, member 1B3 0.0145038
DDX50 DEAD (Asp-Glu-Ala-Asp) box polypeptide 50 0.0142486
ARL5B ADP-ribosylation factor-like 5B 0.0141655
LPGAT1 lysophosphatidylglycerol acyltransferase 1 0.0140891
MPP2 membrane protein, palmitoylated 2 (MAGUK p55 subfamily member 2) 0.0140435
SYNE2 spectrin repeat containing, nuclear envelope 2 0.0140397
SHTN1 shootin 1 0.0139954
NRIP1 nuclear receptor interacting protein 1 0.0138726
ZHX2 zinc fingers and homeoboxes 2 0.013813
AVL9 AVL9 homolog (S. cerevisiase) 0.0137843
ANK3 ankyrin 3, node of Ranvier (ankyrin G) 0.0137626
ALCAM activated leukocyte cell adhesion molecule 0.0134817
RFFL ring finger and FYVE-like domain containing E3 ubiquitin protein ligase 0.0134717
DOCK1 dedicator of cytokinesis 1 0.0134543
FOCAD focadhesin 0.0134445
MAP3K5 mitogen-activated protein kinase kinase kinase 5 0.0132914
MACC1 metastasis associated in colon cancer 1 0.0131508
CENPP centromere protein P 0.013147

decreased expression

Symbol Name Standardized Value
PTMA prothymosin, alpha -0.266555
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.1553
TPT1 tumor protein, translationally-controlled 1 -0.105192
RPS27A ribosomal protein S27a -0.0935202
IER3 immediate early response 3 -0.088584
UBC ubiquitin C -0.0835423
RPL35A ribosomal protein L35a -0.0771238
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0769339
ACTG1 actin gamma 1 -0.0711921
RPL26 ribosomal protein L26 -0.0667077
RPL37A ribosomal protein L37a -0.0657644
EEF2 eukaryotic translation elongation factor 2 -0.0600546
TMSB10 thymosin beta 10 -0.058923
LAMB3 laminin, beta 3 -0.0569656
RPL23 ribosomal protein L23 -0.0532709
RPS3 ribosomal protein S3 -0.0527804
PCBP2 poly(rC) binding protein 2 -0.050985
RPS24 ribosomal protein S24 -0.0505102
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0499084
VCL vinculin -0.0497966
CANX calnexin -0.0494935
RPL31 ribosomal protein L31 -0.0484697
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0484061
RPL9 ribosomal protein L9 -0.0482978
HDAC2 histone deacetylase 2 -0.0482452
RPS8 ribosomal protein S8 -0.0478706
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0471085
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0470773
FRAS1 Fraser extracellular matrix complex subunit 1 -0.0455006
EIF1 eukaryotic translation initiation factor 1 -0.0452715
RPL34 ribosomal protein L34 -0.0452144
LDHA lactate dehydrogenase A -0.0443328
HLA-B major histocompatibility complex, class I, B -0.044318
S100A6 S100 calcium binding protein A6 -0.0440262
RAB1A RAB1A, member RAS oncogene family -0.0428848
NDRG1 N-myc downstream regulated 1 -0.0408735
SFPQ splicing factor proline/glutamine-rich -0.0406924
RPS14 ribosomal protein S14 -0.0393262
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0392391
NAP1L1 nucleosome assembly protein 1-like 1 -0.0379984
RPS25 ribosomal protein S25 -0.0363959
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.036112
IGFBP3 insulin-like growth factor binding protein 3 -0.0359256
DSCAM Down syndrome cell adhesion molecule -0.0355597
ENO1 enolase 1, (alpha) -0.0353584
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0351731
FBXO11 F-box protein 11 -0.0350753
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa -0.0343144
EEF1G eukaryotic translation elongation factor 1 gamma -0.0336341
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon -0.0334501
RPS17 ribosomal protein S17 -0.0333811
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha -0.0330752
SETD5 SET domain containing 5 -0.0326539
AKAP12 A kinase (PRKA) anchor protein 12 -0.0323678
ZNF292 zinc finger protein 292 -0.0322885
VIM vimentin -0.0320688
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0318748
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.0314143
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0304794
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0302451
RPS13 ribosomal protein S13 -0.0301403
RPS5 ribosomal protein S5 -0.0297169
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0295578
RBM39 RNA binding motif protein 39 -0.0295302
RPL7A ribosomal protein L7a -0.0293389
RPL5 ribosomal protein L5 -0.0290247
AHNAK AHNAK nucleoprotein -0.0289559
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0283748
RPS6KA5 ribosomal protein S6 kinase, 90kDa, polypeptide 5 -0.0282189
GARS1 glycyl-tRNA synthetase 1 -0.0282045
RACK1 receptor for activated C kinase 1 -0.02768
CTNND1 catenin (cadherin-associated protein), delta 1 -0.02743
ATP5F1B ATP synthase F1 subunit beta -0.0273254
PERP PERP, TP53 apoptosis effector -0.0266965
RCOR1 REST corepressor 1 -0.0266371
RPL19 ribosomal protein L19 -0.0264109
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.0261653
ANKRD17 ankyrin repeat domain 17 -0.0261395
ZCCHC7 zinc finger, CCHC domain containing 7 -0.0261288
TSC22D2 TSC22 domain family, member 2 -0.0256566
RPL28 ribosomal protein L28 -0.0255353
TOP1 topoisomerase (DNA) I -0.0255058
RHEB Ras homolog enriched in brain -0.0252243
GLG1 golgi glycoprotein 1 -0.0251568
WSB1 WD repeat and SOCS box containing 1 -0.0249027
RPL8 ribosomal protein L8 -0.0247855
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0245081
MARK3 MAP/microtubule affinity-regulating kinase 3 -0.0244892
ESYT2 extended synaptotagmin-like protein 2 -0.0243277
FTL ferritin, light polypeptide -0.0240822
KDM3A lysine (K)-specific demethylase 3A -0.0235729
ASPH aspartate beta-hydroxylase -0.0235148
CNOT1 CCR4-NOT transcription complex, subunit 1 -0.0233875
HILPDA hypoxia inducible lipid droplet-associated -0.0233721
PDIA6 protein disulfide isomerase family A, member 6 -0.0230095
CD9 CD9 molecule -0.0221379
DSTN destrin (actin depolymerizing factor) -0.0221096
YTHDC1 YTH domain containing 1 -0.0220494
RAB6A RAB6A, member RAS oncogene family -0.021732
TPM4 tropomyosin 4 -0.0216605