Retinoic acid_SW480 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Retinoic acid perturbation in SW480 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Retinoic acid_SW480 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
NKD1 naked cuticle homolog 1 (Drosophila) 0.224799
NAV2 neuron navigator 2 0.103683
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) 0.090695
CDH13 cadherin 13 0.0858553
INTS6 integrator complex subunit 6 0.0747688
VCL vinculin 0.0692039
WWOX WW domain containing oxidoreductase 0.0655802
RAD51B RAD51 paralog B 0.0607737
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0578598
SDK1 sidekick cell adhesion molecule 1 0.057348
ADGRL2 adhesion G protein-coupled receptor L2 0.0524618
CCND1 cyclin D1 0.0521227
ASPH aspartate beta-hydroxylase 0.0436409
MSI2 musashi RNA-binding protein 2 0.0431754
EXOC4 exocyst complex component 4 0.0422682
TNS3 tensin 3 0.0417846
CDK6 cyclin-dependent kinase 6 0.0414334
GMDS GDP-mannose 4,6-dehydratase 0.0404198
SKAP1 src kinase associated phosphoprotein 1 0.0382634
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0376799
NPAS2 neuronal PAS domain protein 2 0.0364645
HDAC4 histone deacetylase 4 0.0357179
FRMD5 FERM domain containing 5 0.0355924
ACTN1 actinin, alpha 1 0.0342615
CHST11 carbohydrate (chondroitin 4) sulfotransferase 11 0.034161
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0334612
SPATA13 spermatogenesis associated 13 0.032567
MAML2 mastermind-like 2 (Drosophila) 0.0322794
FHIT fragile histidine triad 0.0319463
PCDH9 protocadherin 9 0.031734
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2 0.0315001
LPP LIM domain containing preferred translocation partner in lipoma 0.0296806
LRMDA leucine rich melanocyte differentiation associated 0.0293541
PDE4D phosphodiesterase 4D, cAMP-specific 0.0292557
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.0289845
PTPRK protein tyrosine phosphatase, receptor type, K 0.028706
PDLIM5 PDZ and LIM domain 5 0.0282327
MED13 mediator complex subunit 13 0.0269701
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.0269649
IGF1R insulin-like growth factor 1 receptor 0.0268624
MTCL1 microtubule crosslinking factor 1 0.0264187
SMYD3 SET and MYND domain containing 3 0.0263767
CUX1 cut-like homeobox 1 0.0263579
GLI3 GLI family zinc finger 3 0.0258551
SRSF1 serine/arginine-rich splicing factor 1 0.0256311
TRMT11 tRNA methyltransferase 11 homolog (S. cerevisiae) 0.0253123
CEMIP cell migration inducing protein, hyaluronan binding 0.0251803
SNTB1 syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) 0.025084
SYT1 synaptotagmin I 0.0248877
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 0.0248652
CTBP2 C-terminal binding protein 2 0.0246838
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 0.0246262
BACE2 beta-site APP-cleaving enzyme 2 0.0244283
GRIK5 glutamate receptor, ionotropic, kainate 5 0.0242371
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0237244
ANXA3 annexin A3 0.0228123
CD44 CD44 molecule (Indian blood group) 0.02228
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0221909
SYK spleen tyrosine kinase 0.0220304
DIAPH2 diaphanous-related formin 2 0.0219599
EPHB2 EPH receptor B2 0.0217803
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0217372
EGFR epidermal growth factor receptor 0.0216248
UGGT2 UDP-glucose glycoprotein glucosyltransferase 2 0.0212738
SAMD4A sterile alpha motif domain containing 4A 0.0211159
NAB1 NGFI-A binding protein 1 (EGR1 binding protein 1) 0.0210056
BICD1 bicaudal D homolog 1 (Drosophila) 0.0209779
FARP1 FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived) 0.0209351
UBAP2 ubiquitin associated protein 2 0.0207772
TNIK TRAF2 and NCK interacting kinase 0.0207681
COBL cordon-bleu WH2 repeat protein 0.0205073
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 0.0204352
EHBP1 EH domain binding protein 1 0.0201098
WDR43 WD repeat domain 43 0.0199712
ACTN4 actinin, alpha 4 0.0199056
ROCK2 Rho-associated, coiled-coil containing protein kinase 2 0.0198487
CNKSR3 CNKSR family member 3 0.0197236
GNPDA1 glucosamine-6-phosphate deaminase 1 0.0196853
RABGAP1L RAB GTPase activating protein 1-like 0.0194338
CLSTN2 calsyntenin 2 0.0192893
GALNT18 polypeptide N-acetylgalactosaminyltransferase 18 0.0192475
ANO1 anoctamin 1, calcium activated chloride channel 0.0192258
CMIP c-Maf inducing protein 0.0187778
AIG1 androgen-induced 1 0.0185799
RALY RALY heterogeneous nuclear ribonucleoprotein 0.0184981
SERINC5 serine incorporator 5 0.0184881
PHLDB2 pleckstrin homology-like domain, family B, member 2 0.0184381
NPAS3 neuronal PAS domain protein 3 0.0184024
FMNL2 formin-like 2 0.0183297
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like 0.0183141
HLCS holocarboxylase synthetase (biotin-(proprionyl-CoA-carboxylase (ATP-hydrolysing)) ligase) 0.018293
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0182123
FAT1 FAT atypical cadherin 1 0.0181022
MTAP methylthioadenosine phosphorylase 0.017992
TMEM163 transmembrane protein 163 0.0177519
EZR ezrin 0.0177338
ARID1B AT rich interactive domain 1B (SWI1-like) 0.0176399
VOPP1 vesicular, overexpressed in cancer, prosurvival protein 1 0.0173555
LOC102724023 ES1 protein homolog, mitochondrial 0.0173096
FARS2 phenylalanyl-tRNA synthetase 2, mitochondrial 0.0171201

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.188341
RPS6 ribosomal protein S6 -0.12748
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 -0.0798396
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0731063
RPL26 ribosomal protein L26 -0.0689435
EIF1 eukaryotic translation initiation factor 1 -0.0655088
RPS2 ribosomal protein S2 -0.06059
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0582184
GOLGA4 golgin A4 -0.0570493
RPS3 ribosomal protein S3 -0.054788
RPL35A ribosomal protein L35a -0.0498453
ESYT2 extended synaptotagmin-like protein 2 -0.0477906
RPS19 ribosomal protein S19 -0.0471955
MORF4L2 mortality factor 4 like 2 -0.0470802
EEF2 eukaryotic translation elongation factor 2 -0.0467099
RPL12 ribosomal protein L12 -0.0463354
RPL7 ribosomal protein L7 -0.0460464
RBM39 RNA binding motif protein 39 -0.0458917
RPS12 ribosomal protein S12 -0.0447814
TMSB10 thymosin beta 10 -0.0447519
RPS13 ribosomal protein S13 -0.0440197
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0430404
RPLP1 ribosomal protein, large, P1 -0.0428677
ANLN anillin, actin binding protein -0.0425441
RPL19 ribosomal protein L19 -0.0423533
RPL23 ribosomal protein L23 -0.0422191
RPL11 ribosomal protein L11 -0.0415819
AKAP9 A kinase (PRKA) anchor protein 9 -0.0409501
TXNIP thioredoxin interacting protein -0.0404556
ZNF292 zinc finger protein 292 -0.0404264
TPT1 tumor protein, translationally-controlled 1 -0.0396815
RPLP2 ribosomal protein, large, P2 -0.0392311
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0385353
RPL37A ribosomal protein L37a -0.038417
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0372318
KMT2C lysine (K)-specific methyltransferase 2C -0.0370152
RPS8 ribosomal protein S8 -0.0364551
RPL5 ribosomal protein L5 -0.0361979
NKTR natural killer cell triggering receptor -0.0360197
RPL36A ribosomal protein L36a -0.035614
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 -0.0355552
THOC2 THO complex 2 -0.0352497
OGA O-GlcNAcase -0.0343836
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0342959
RPL32 ribosomal protein L32 -0.034131
PROX1 prospero homeobox 1 -0.0341001
RPS24 ribosomal protein S24 -0.0331663
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 -0.0326218
GARS1 glycyl-tRNA synthetase 1 -0.0325683
BRWD3 bromodomain and WD repeat domain containing 3 -0.0322897
PRRC2C proline-rich coiled-coil 2C -0.0319175
MKI67 marker of proliferation Ki-67 -0.0318713
MT2A metallothionein 2A -0.0316215
RPL37 ribosomal protein L37 -0.0314142
UBA6 ubiquitin-like modifier activating enzyme 6 -0.0313513
RPS25 ribosomal protein S25 -0.0312429
NDRG1 N-myc downstream regulated 1 -0.0309497
PGK1 phosphoglycerate kinase 1 -0.0308093
RPS21 ribosomal protein S21 -0.0307519
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0307107
RPS27A ribosomal protein S27a -0.0300394
DIAPH3 diaphanous-related formin 3 -0.0297319
GLG1 golgi glycoprotein 1 -0.0296674
SBF2 SET binding factor 2 -0.0295803
SETD5 SET domain containing 5 -0.0291283
TMF1 TATA element modulatory factor 1 -0.0291134
RPL18 ribosomal protein L18 -0.0291099
HMGA1 high mobility group AT-hook 1 -0.0289536
RACK1 receptor for activated C kinase 1 -0.0288043
VGLL4 vestigial-like family member 4 -0.0286783
RPL7A ribosomal protein L7a -0.0286723
USP34 ubiquitin specific peptidase 34 -0.0280738
ABHD2 abhydrolase domain containing 2 -0.0280514
RPS23 ribosomal protein S23 -0.0280298
RPL38 ribosomal protein L38 -0.0276252
KMT2E lysine (K)-specific methyltransferase 2E -0.0275108
NIPSNAP2 nipsnap homolog 2 -0.027463
CKAP2 cytoskeleton associated protein 2 -0.027229
RPLP0 ribosomal protein, large, P0 -0.0271438
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0271039
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.026951
SMC4 structural maintenance of chromosomes 4 -0.0268052
NIPBL Nipped-B homolog (Drosophila) -0.0267908
SCAF11 SR-related CTD-associated factor 11 -0.0265908
PCBP2 poly(rC) binding protein 2 -0.0265751
UBC ubiquitin C -0.026415
RPL9 ribosomal protein L9 -0.0264058
MIS18BP1 MIS18 binding protein 1 -0.0263976
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0261231
SPAG9 sperm associated antigen 9 -0.0261033
RPL31 ribosomal protein L31 -0.0260839
XPO1 exportin 1 -0.0257183
RPL36 ribosomal protein L36 -0.0254518
LUC7L3 LUC7-like 3 (S. cerevisiae) -0.0252832
PDE8A phosphodiesterase 8A -0.0251933
RIOK3 RIO kinase 3 -0.0251542
RPL28 ribosomal protein L28 -0.0251447
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) -0.025142
CCDC82 coiled-coil domain containing 82 -0.0248253
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa -0.0246501