Retinoic acid_hTERT-HPNE Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Retinoic acid perturbation in hTERT-HPNE cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Retinoic acid_hTERT-HPNE drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
MYO10 myosin X 0.101119
AKAP12 A kinase (PRKA) anchor protein 12 0.0950508
JARID2 jumonji, AT rich interactive domain 2 0.0935448
FN1 fibronectin 1 0.0873386
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.0837669
CD44 CD44 molecule (Indian blood group) 0.0767934
TRIO trio Rho guanine nucleotide exchange factor 0.0731682
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.071595
FMNL2 formin-like 2 0.0678173
NALF1 NALCN channel auxiliary factor 1 0.0664339
MYH9 myosin, heavy chain 9, non-muscle 0.0648262
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0606707
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0514257
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0456773
PRELID2 PRELI domain containing 2 0.045569
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0452578
ASPH aspartate beta-hydroxylase 0.0448421
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0438863
CXCL8 chemokine (C-X-C motif) ligand 8 0.041499
SMAD3 SMAD family member 3 0.0402089
FAM13A family with sequence similarity 13, member A 0.0401032
FNDC3B fibronectin type III domain containing 3B 0.0398542
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 0.039649
RUNX1 runt-related transcription factor 1 0.0387459
ELL2 elongation factor, RNA polymerase II, 2 0.0375304
PDE3A phosphodiesterase 3A, cGMP-inhibited 0.0369813
ZSWIM6 zinc finger, SWIM-type containing 6 0.0344068
OGA O-GlcNAcase 0.0343932
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0340331
GLIS3 GLIS family zinc finger 3 0.0338322
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0336288
EXT1 exostosin glycosyltransferase 1 0.0336079
COL6A1 collagen, type VI, alpha 1 0.0334839
COL6A3 collagen, type VI, alpha 3 0.0334321
VEGFA vascular endothelial growth factor A 0.0330741
RAI14 retinoic acid induced 14 0.0329975
FRMD6 FERM domain containing 6 0.0326272
PALM2AKAP2 PALM2 and AKAP2 fusion 0.0326186
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0317884
NAV1 neuron navigator 1 0.0304194
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1 0.0301936
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0300754
HDAC9 histone deacetylase 9 0.0297529
YEATS2 YEATS domain containing 2 0.0292774
SAMD4A sterile alpha motif domain containing 4A 0.0282959
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 0.0280623
MACF1 microtubule-actin crosslinking factor 1 0.0279904
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0279215
VCL vinculin 0.027881
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0276841
ZNF638 zinc finger protein 638 0.0261465
KTN1 kinectin 1 (kinesin receptor) 0.0260334
KIAA1217 KIAA1217 0.0255422
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0254846
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.0254752
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.025436
PTPRM protein tyrosine phosphatase, receptor type, M 0.0250647
MYCBP2 MYC binding protein 2, E3 ubiquitin protein ligase 0.0249093
ANKRD12 ankyrin repeat domain 12 0.0247216
MMP12 matrix metallopeptidase 12 0.0245846
PTK2 protein tyrosine kinase 2 0.0244747
EGFR epidermal growth factor receptor 0.0242988
ANO6 anoctamin 6 0.0242882
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0242587
PLEC plectin 0.0242212
TTC3 tetratricopeptide repeat domain 3 0.0241803
NOTCH2 notch 2 0.023947
TMEM165 transmembrane protein 165 0.0238321
ESYT2 extended synaptotagmin-like protein 2 0.0236907
NAV2 neuron navigator 2 0.0234284
FNIP1 folliculin interacting protein 1 0.0231093
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.0230263
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0224441
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0222415
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0219186
NBEAL1 neurobeachin-like 1 0.0218267
MYO1E myosin IE 0.0218107
NFE2L1 nuclear factor, erythroid 2-like 1 0.0217344
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.021592
FNDC3A fibronectin type III domain containing 3A 0.0214565
ERN1 endoplasmic reticulum to nucleus signaling 1 0.0211716
SEPTIN9 septin 9 0.0207452
INTS6 integrator complex subunit 6 0.0205697
AKT3 v-akt murine thymoma viral oncogene homolog 3 0.020537
CEMIP cell migration inducing protein, hyaluronan binding 0.0203216
RAD51B RAD51 paralog B 0.0200824
FER fer (fps/fes related) tyrosine kinase 0.0200708
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0200471
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0200008
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.0199405
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 0.0199096
TNS1 tensin 1 0.0197693
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0197631
TIMP2 TIMP metallopeptidase inhibitor 2 0.0197339
PAPPA pregnancy-associated plasma protein A, pappalysin 1 0.0196545
SOD2 superoxide dismutase 2, mitochondrial 0.0194436
LTBP1 latent transforming growth factor beta binding protein 1 0.0190689
NRIP1 nuclear receptor interacting protein 1 0.0190599
RASA2 RAS p21 protein activator 2 0.0190081
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0189986

decreased expression

Symbol Name Standardized Value
VIM vimentin -0.35628
INHBA inhibin, beta A -0.219814
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.204831
STC1 stanniocalcin 1 -0.158673
COL1A1 collagen, type I, alpha 1 -0.152243
TMSB10 thymosin beta 10 -0.109578
MMP1 matrix metallopeptidase 1 -0.0911745
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats -0.0835921
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0763416
COL1A2 collagen, type I, alpha 2 -0.0703419
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.0702376
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0667335
GREM1 gremlin 1, DAN family BMP antagonist -0.0534957
FTL ferritin, light polypeptide -0.0517647
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.0442838
CCND1 cyclin D1 -0.0399743
PTMA prothymosin, alpha -0.038149
CAV1 caveolin 1, caveolae protein, 22kDa -0.0374988
POTEF POTE ankyrin domain family, member F -0.0336943
HHIP hedgehog interacting protein -0.0299838
PDE4D phosphodiesterase 4D, cAMP-specific -0.0296052
PRSS23 protease, serine, 23 -0.0295202
EIF1 eukaryotic translation initiation factor 1 -0.0294641
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0292575
S100A6 S100 calcium binding protein A6 -0.0287478
ARHGAP21 Rho GTPase activating protein 21 -0.0273396
TPI1 triosephosphate isomerase 1 -0.0265762
COL4A2 collagen, type IV, alpha 2 -0.0255107
CAVIN1 caveolae associated protein 1 -0.0253324
LGALS1 lectin, galactoside-binding, soluble, 1 -0.0248509
LOX lysyl oxidase -0.0233942
CALD1 caldesmon 1 -0.0230594
CALU calumenin -0.0229686
ZEB1 zinc finger E-box binding homeobox 1 -0.022513
B2M beta-2-microglobulin -0.0225014
PFN1 profilin 1 -0.0221954
TMSB4X thymosin beta 4, X-linked -0.0221053
ALCAM activated leukocyte cell adhesion molecule -0.0213613
SRGN serglycin -0.0213058
FBN1 fibrillin 1 -0.0209453
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0204753
RPL35A ribosomal protein L35a -0.0198441
ATP8B1 ATPase, aminophospholipid transporter, class I, type 8B, member 1 -0.0197254
ACTG1 actin gamma 1 -0.0196803
IGFBP4 insulin-like growth factor binding protein 4 -0.0195147
TPT1 tumor protein, translationally-controlled 1 -0.0195115
GRIK5 glutamate receptor, ionotropic, kainate 5 -0.0194354
TUBB tubulin, beta class I -0.0193653
APOLD1 apolipoprotein L domain containing 1 -0.0193458
TMEM263 transmembrane protein 263 -0.0192713
NR2F2 nuclear receptor subfamily 2, group F, member 2 -0.0191564
MAP1B microtubule-associated protein 1B -0.0183406
OXR1 oxidation resistance 1 -0.0183297
RPS24 ribosomal protein S24 -0.0181427
CCNI cyclin I -0.0181185
OSMR oncostatin M receptor -0.017811
PRRX1 paired related homeobox 1 -0.0172684
CD59 CD59 molecule, complement regulatory protein -0.0172671
ANKRD28 ankyrin repeat domain 28 -0.0172414
H1-0 H1.0 linker histone -0.017228
RPS25 ribosomal protein S25 -0.0170996
TBX2 T-box 2 -0.0168244
DNER delta/notch-like EGF repeat containing -0.0167757
POMP proteasome maturation protein -0.0166719
LOC112694756 uncharaterized LOC112694756 -0.0166444
GNAS GNAS complex locus -0.0165732
LMNA lamin A/C -0.0165614
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0165524
ADAMTS4 ADAM metallopeptidase with thrombospondin type 1 motif, 4 -0.0164859
WNT5A wingless-type MMTV integration site family, member 5A -0.0164009
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0163836
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0162889
UBC ubiquitin C -0.0161729
KPNB1 karyopherin (importin) beta 1 -0.0161702
RPL32 ribosomal protein L32 -0.016145
RPL23 ribosomal protein L23 -0.016135
LAPTM4A lysosomal protein transmembrane 4 alpha -0.0160934
GLI2 GLI family zinc finger 2 -0.0159605
SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1) -0.0159225
TAGLN2 transgelin 2 -0.0157033
RNF213 ring finger protein 213 -0.0155942
POU2F2 POU class 2 homeobox 2 -0.0155905
TMEM158 transmembrane protein 158 (gene/pseudogene) -0.015563
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0154788
TFPI2 tissue factor pathway inhibitor 2 -0.0153244
COL3A1 collagen, type III, alpha 1 -0.0153045
EIF4A1 eukaryotic translation initiation factor 4A1 -0.015246
HAS2 hyaluronan synthase 2 -0.0152254
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.015219
RARS1 arginyl-tRNA synthetase 1 -0.0151384
RRBP1 ribosome binding protein 1 -0.0151363
SERINC3 serine incorporator 3 -0.0150948
KLF6 Kruppel-like factor 6 -0.0149427
H3-3B H3.3 histone B -0.0149239
RPL27A ribosomal protein L27a -0.0148626
SERF2 small EDRK-rich factor 2 -0.0148439
TNPO1 transportin 1 -0.0148356
RPS13 ribosomal protein S13 -0.0147823
GLG1 golgi glycoprotein 1 -0.0147058
CAP1 CAP, adenylate cyclase-associated protein 1 (yeast) -0.0146036