Reversine Gene Set

Dataset DeepCoverMOA Drug Mechanisms of Action
Category proteomics
Type drug perturbation
Description A member of the class of purines that is 9H-purine in which the hydrogens at positions 2 and 6 are replaced by a [4-(morpholin-4-yl)phenyl]nitrilo group and a cyclohexylamino group, respectively. (Chemical Entities of Biological Interest Ontology, CHEBI_70723)
External Link https://pubchem.ncbi.nlm.nih.gov/compound/210332
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Genes

200 proteins with high or low expression in Reversine relative to other proteins from the DeepCoverMOA Drug Mechanisms of Action dataset.

high expression

Symbol Name Standardized Value
NDFIP1 Nedd4 family interacting protein 1 3.07
APOB apolipoprotein B 2.8
TMEM59 transmembrane protein 59 2.58
PAH phenylalanine hydroxylase 2.43
LAPTM4A lysosomal protein transmembrane 4 alpha 2.39
LRP10 low density lipoprotein receptor-related protein 10 2.18
ITM2C integral membrane protein 2C 2.02
NDFIP2 Nedd4 family interacting protein 2 1.99
IFNGR1 interferon gamma receptor 1 1.95
ITM2B integral membrane protein 2B 1.82
CEMIP cell migration inducing protein, hyaluronan binding 1.71
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor) 1.69
NBR1 neighbor of BRCA1 gene 1 1.66
NCOA4 nuclear receptor coactivator 4 1.63
APLP2 amyloid beta (A4) precursor-like protein 2 1.63
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 1.61
RNF149 ring finger protein 149 1.58
ALDH3B1 aldehyde dehydrogenase 3 family, member B1 1.42
APOE apolipoprotein E 1.41
CYP24A1 cytochrome P450, family 24, subfamily A, polypeptide 1 1.39
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 1.37
IL13RA1 interleukin 13 receptor, alpha 1 1.31
SLC26A11 solute carrier family 26 (anion exchanger), member 11 1.29
ACVR1B activin A receptor, type IB 1.25
F5 coagulation factor V (proaccelerin, labile factor) 1.23
SPINT2 serine peptidase inhibitor, Kunitz type, 2 1.23
APP amyloid beta (A4) precursor protein 1.23
FGB fibrinogen beta chain 1.22
AREG amphiregulin 1.21
ERBB3 erb-b2 receptor tyrosine kinase 3 1.2
ABCA3 ATP-binding cassette, sub-family A (ABC1), member 3 1.2
TSPAN3 tetraspanin 3 1.17
SERINC5 serine incorporator 5 1.16
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 1.15
CTSL cathepsin L 1.15
SZT2 seizure threshold 2 homolog (mouse) 1.1
CD63 CD63 molecule 1.1
SERINC1 serine incorporator 1 1.07
PTPRS protein tyrosine phosphatase, receptor type, S 1.06
SLC38A2 solute carrier family 38, member 2 1.06
TRIM2 tripartite motif containing 2 1.04
TTC14 tetratricopeptide repeat domain 14 1.04
SERINC3 serine incorporator 3 1.04
LMBRD1 LMBR1 domain containing 1 1.03
GINM1 glycoprotein integral membrane 1 1.03
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 1.02
HIST2H2AA3 histone cluster 2, H2aa3 1.01
LRP11 low density lipoprotein receptor-related protein 11 1.01
FHIT fragile histidine triad 1.01
PBXIP1 pre-B-cell leukemia homeobox interacting protein 1 1.01
TFDP2 transcription factor Dp-2 (E2F dimerization partner 2) 0.99
LTBP3 latent transforming growth factor beta binding protein 3 0.99
SCN11A sodium channel, voltage gated, type XI alpha subunit 0.98
NPDC1 neural proliferation, differentiation and control, 1 0.97
F10 coagulation factor X 0.97
GRN granulin 0.96
PSAP prosaposin 0.96
RBL2 retinoblastoma-like 2 0.96
TM7SF3 transmembrane 7 superfamily member 3 0.95
EVPL envoplakin 0.94
ADGRG6 adhesion G protein-coupled receptor G6 0.94
TMEM248 transmembrane protein 248 0.94
CLDND1 claudin domain containing 1 0.94
MEGF6 multiple EGF-like-domains 6 0.94
SLC17A5 solute carrier family 17 (acidic sugar transporter), member 5 0.94
CLDN3 claudin 3 0.93
SQSTM1 sequestosome 1 0.92
SLC49A4 solute carrier family 49 member 4 0.91
BMPR1A bone morphogenetic protein receptor, type IA 0.9
SLC43A2 solute carrier family 43 (amino acid system L transporter), member 2 0.89
SH3BGRL2 SH3 domain binding glutamate-rich protein like 2 0.89
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.89
NR4A1 nuclear receptor subfamily 4, group A, member 1 0.88
UGCG UDP-glucose ceramide glucosyltransferase 0.87
TACSTD2 tumor-associated calcium signal transducer 2 0.87
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.87
TNFSF9 tumor necrosis factor (ligand) superfamily, member 9 0.86
TMEM200A transmembrane protein 200A 0.86
IFITM3 interferon induced transmembrane protein 3 0.85
HGFAC HGF activator 0.85
FAT1 FAT atypical cadherin 1 0.85
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.84
CHST7 carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 7 0.83
NR1D1 nuclear receptor subfamily 1, group D, member 1 0.83
FZD2 frizzled class receptor 2 0.83
FN1 fibronectin 1 0.82
SEMA4G sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4G 0.82
TMC4 transmembrane channel-like 4 0.81
MMP14 matrix metallopeptidase 14 (membrane-inserted) 0.8
DDR1 discoidin domain receptor tyrosine kinase 1 0.8
PLEKHB1 pleckstrin homology domain containing, family B (evectins) member 1 0.79
PIP prolactin-induced protein 0.79
CSNK1G3 casein kinase 1, gamma 3 0.79
TJP3 tight junction protein 3 0.79
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b 0.78
PCMTD2 protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 2 0.78
RNF167 ring finger protein 167 0.78
TBX3 T-box 3 0.78
CMTM4 CKLF-like MARVEL transmembrane domain containing 4 0.78
F13A1 coagulation factor XIII, A1 polypeptide 0.78

low expression

Symbol Name Standardized Value
ZSCAN32 zinc finger and SCAN domain containing 32 -3.06
ANKRD24 ankyrin repeat domain 24 -2.56
NGFR nerve growth factor receptor -2.33
CCNF cyclin F -2.23
PARP8 poly (ADP-ribose) polymerase family, member 8 -2.18
APLP1 amyloid beta (A4) precursor-like protein 1 -2.13
JUN jun proto-oncogene -1.89
KMT2B lysine (K)-specific methyltransferase 2B -1.79
GAS2L3 growth arrest-specific 2 like 3 -1.75
CDKN3 cyclin-dependent kinase inhibitor 3 -1.71
DUOX1 dual oxidase 1 -1.7
SYCP1 synaptonemal complex protein 1 -1.67
TK1 thymidine kinase 1, soluble -1.59
ODC1 ornithine decarboxylase 1 -1.58
RRM2 ribonucleotide reductase M2 -1.56
CDC20 cell division cycle 20 -1.56
STIL SCL/TAL1 interrupting locus -1.55
RAD54L RAD54-like (S. cerevisiae) -1.52
TRAIP TRAF interacting protein -1.52
ANLN anillin, actin binding protein -1.52
BUB1 BUB1 mitotic checkpoint serine/threonine kinase -1.48
CDCA5 cell division cycle associated 5 -1.43
TROAP trophinin associated protein -1.43
TPX2 TPX2, microtubule-associated -1.41
GMNN geminin, DNA replication inhibitor -1.38
NET1 neuroepithelial cell transforming 1 -1.37
UBE2S ubiquitin-conjugating enzyme E2S -1.36
SMTN smoothelin -1.34
AEN apoptosis enhancing nuclease -1.32
SACK1D scaffolding CK1 anchoring protein D -1.32
RAD51 RAD51 recombinase -1.32
DLGAP5 discs, large (Drosophila) homolog-associated protein 5 -1.31
DHRS2 dehydrogenase/reductase (SDR family) member 2 -1.3
HMMR hyaluronan-mediated motility receptor (RHAMM) -1.3
KIF11 kinesin family member 11 -1.29
E2F7 E2F transcription factor 7 -1.27
CCNA2 cyclin A2 -1.27
WDR76 WD repeat domain 76 -1.26
CCN3 cellular communication network factor 3 -1.25
PCLAF PCNA clamp associated factor -1.24
GCH1 GTP cyclohydrolase 1 -1.23
CDC6 cell division cycle 6 -1.22
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) -1.22
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1) -1.22
CLSPN claspin -1.21
RNF115 ring finger protein 115 -1.2
PRR11 proline rich 11 -1.2
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2 -1.2
FBXO5 F-box protein 5 -1.19
FOXM1 forkhead box M1 -1.19
SGO2 shugoshin 2 -1.19
DBF4 DBF4 zinc finger -1.18
KIF2C kinesin family member 2C -1.18
MCM10 minichromosome maintenance complex component 10 -1.18
INO80D INO80 complex subunit D -1.17
PLK1 polo-like kinase 1 -1.17
SHCBP1 SHC SH2-domain binding protein 1 -1.17
CKAP2L cytoskeleton associated protein 2-like -1.16
PIMREG PICALM interacting mitotic regulator -1.16
INCENP inner centromere protein antigens 135/155kDa -1.16
DNAH14 dynein, axonemal, heavy chain 14 -1.16
AURKB aurora kinase B -1.15
CCNE2 cyclin E2 -1.14
CKAP2 cytoskeleton associated protein 2 -1.14
TOP2A topoisomerase (DNA) II alpha 170kDa -1.14
SNX29 sorting nexin 29 -1.13
TACC3 transforming, acidic coiled-coil containing protein 3 -1.12
TTK TTK protein kinase -1.12
CDC7 cell division cycle 7 -1.11
USP37 ubiquitin specific peptidase 37 -1.11
KIF22 kinesin family member 22 -1.11
ARHGAP19 Rho GTPase activating protein 19 -1.11
NUSAP1 nucleolar and spindle associated protein 1 -1.1
PIEZO2 piezo-type mechanosensitive ion channel component 2 -1.1
PRC1 protein regulator of cytokinesis 1 -1.09
DEPDC1 DEP domain containing 1 -1.09
GPSM2 G-protein signaling modulator 2 -1.08
FBXO44 F-box protein 44 -1.08
AEBP2 AE binding protein 2 -1.08
CCNB1 cyclin B1 -1.08
CDCA2 cell division cycle associated 2 -1.06
SAPCD2 suppressor APC domain containing 2 -1.06
CAPN6 calpain 6 -1.06
ESCO2 establishment of sister chromatid cohesion N-acetyltransferase 2 -1.06
EXO1 exonuclease 1 -1.05
MRFAP1 Morf4 family associated protein 1 -1.04
ATAD2 ATPase family, AAA domain containing 2 -1.04
CCND3 cyclin D3 -1.04
CCNB2 cyclin B2 -1.03
CENPF centromere protein F, 350/400kDa -1.03
CCNA1 cyclin A1 -1.03
AURKA aurora kinase A -1.03
BUB1B BUB1 mitotic checkpoint serine/threonine kinase B -1.02
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila) -1.02
SPDL1 spindle apparatus coiled-coil protein 1 -1.02
PTTG1 pituitary tumor-transforming 1 -1.02
ARHGAP11A Rho GTPase activating protein 11A -1.01
MELK maternal embryonic leucine zipper kinase -1.01
KIF18B kinesin family member 18B -1.01
GTSE1 G-2 and S-phase expressed 1 -1.01