| Dataset | DeepCoverMOA Drug Mechanisms of Action |
| Category | proteomics |
| Type | drug perturbation |
| External Link | https://pubchem.ncbi.nlm.nih.gov/compound/44631912 |
| Similar Terms | |
| Downloads & Tools |
199 proteins with high or low expression in Ribociclib relative to other proteins from the DeepCoverMOA Drug Mechanisms of Action dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| TNFRSF6B | tumor necrosis factor receptor superfamily, member 6b, decoy | 1.44 |
| CCND1 | cyclin D1 | 1.16 |
| ALDH3B1 | aldehyde dehydrogenase 3 family, member B1 | 1.13 |
| CYBA | cytochrome b-245, alpha polypeptide | 1.04 |
| CLSTN3 | calsyntenin 3 | 1.02 |
| RBL2 | retinoblastoma-like 2 | 0.99 |
| CYP24A1 | cytochrome P450, family 24, subfamily A, polypeptide 1 | 0.92 |
| TFDP2 | transcription factor Dp-2 (E2F dimerization partner 2) | 0.91 |
| SGSH | N-sulfoglucosamine sulfohydrolase | 0.88 |
| CDK4 | cyclin-dependent kinase 4 | 0.88 |
| PDCD4 | programmed cell death 4 (neoplastic transformation inhibitor) | 0.87 |
| TNS4 | tensin 4 | 0.79 |
| LTBP3 | latent transforming growth factor beta binding protein 3 | 0.79 |
| L1CAM | L1 cell adhesion molecule | 0.78 |
| SEMA3B | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B | 0.78 |
| GATA2 | GATA binding protein 2 | 0.77 |
| TJP3 | tight junction protein 3 | 0.77 |
| MKNK2 | MAP kinase interacting serine/threonine kinase 2 | 0.77 |
| TRIM2 | tripartite motif containing 2 | 0.76 |
| BCOR | BCL6 corepressor | 0.76 |
| CDK6 | cyclin-dependent kinase 6 | 0.73 |
| SCG2 | secretogranin II | 0.72 |
| FBXL8 | F-box and leucine-rich repeat protein 8 | 0.72 |
| SEMA4G | sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4G | 0.72 |
| CUL7 | cullin 7 | 0.72 |
| CPA4 | carboxypeptidase A4 | 0.72 |
| SUSD2 | sushi domain containing 2 | 0.72 |
| TST | thiosulfate sulfurtransferase (rhodanese) | 0.71 |
| ASIC1 | acid sensing (proton gated) ion channel 1 | 0.71 |
| MSRB2 | methionine sulfoxide reductase B2 | 0.7 |
| SYNPO | synaptopodin | 0.7 |
| NR4A2 | nuclear receptor subfamily 4, group A, member 2 | 0.69 |
| EVPL | envoplakin | 0.67 |
| DHRS1 | dehydrogenase/reductase (SDR family) member 1 | 0.67 |
| NRBP2 | nuclear receptor binding protein 2 | 0.66 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | 0.66 |
| PPL | periplakin | 0.66 |
| LARGE2 | LARGE xylosyl- and glucuronyltransferase 2 | 0.65 |
| SULT1A1 | sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1 | 0.65 |
| GLRX | glutaredoxin (thioltransferase) | 0.65 |
| MSLN | mesothelin | 0.65 |
| TSPAN3 | tetraspanin 3 | 0.64 |
| BAIAP3 | BAI1-associated protein 3 | 0.63 |
| TM7SF2 | transmembrane 7 superfamily member 2 | 0.63 |
| SIDT2 | SID1 transmembrane family, member 2 | 0.63 |
| MROH6 | maestro heat-like repeat family member 6 | 0.63 |
| IGFBP6 | insulin-like growth factor binding protein 6 | 0.62 |
| TMC4 | transmembrane channel-like 4 | 0.61 |
| ARSD | arylsulfatase D | 0.59 |
| CEMIP | cell migration inducing protein, hyaluronan binding | 0.59 |
| PTGES | prostaglandin E synthase | 0.59 |
| PAQR7 | progestin and adipoQ receptor family member VII | 0.58 |
| MVP | major vault protein | 0.58 |
| CUL9 | cullin 9 | 0.58 |
| LYRM1 | LYR motif containing 1 | 0.57 |
| NEBL | nebulette | 0.57 |
| RMDN2 | regulator of microtubule dynamics 2 | 0.56 |
| RASAL1 | RAS protein activator like 1 (GAP1 like) | 0.56 |
| DISP2 | dispatched homolog 2 (Drosophila) | 0.56 |
| PCMTD2 | protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 2 | 0.56 |
| LAMB2 | laminin, beta 2 (laminin S) | 0.55 |
| NPTXR | neuronal pentraxin receptor | 0.55 |
| ABAT | 4-aminobutyrate aminotransferase | 0.55 |
| SLC43A2 | solute carrier family 43 (amino acid system L transporter), member 2 | 0.55 |
| PCDH1 | protocadherin 1 | 0.55 |
| PLCD1 | phospholipase C, delta 1 | 0.54 |
| OPTN | optineurin | 0.54 |
| THSD4 | thrombospondin, type I, domain containing 4 | 0.54 |
| SERPINB1 | serpin peptidase inhibitor, clade B (ovalbumin), member 1 | 0.54 |
| FAM210B | family with sequence similarity 210, member B | 0.54 |
| IFIH1 | interferon induced with helicase C domain 1 | 0.54 |
| CD63 | CD63 molecule | 0.54 |
| FBXL2 | F-box and leucine-rich repeat protein 2 | 0.54 |
| CCNE1 | cyclin E1 | 0.53 |
| SYTL1 | synaptotagmin-like 1 | 0.53 |
| PLD1 | phospholipase D1, phosphatidylcholine-specific | 0.53 |
| CMIP | c-Maf inducing protein | 0.53 |
| TPRG1L | tumor protein p63 regulated 1-like | 0.53 |
| DOCK4 | dedicator of cytokinesis 4 | 0.53 |
| TTC38 | tetratricopeptide repeat domain 38 | 0.53 |
| DENND5B | DENN/MADD domain containing 5B | 0.53 |
| FBXW8 | F-box and WD repeat domain containing 8 | 0.53 |
| TDG | thymine-DNA glycosylase | 0.52 |
| GALT | galactose-1-phosphate uridylyltransferase | 0.52 |
| PLEKHB1 | pleckstrin homology domain containing, family B (evectins) member 1 | 0.52 |
| CTH | cystathionine gamma-lyase | 0.52 |
| ZER1 | zyg-11 related, cell cycle regulator | 0.52 |
| DNASE1L1 | deoxyribonuclease I-like 1 | 0.52 |
| AHNAK2 | AHNAK nucleoprotein 2 | 0.51 |
| SLC22A18 | solute carrier family 22, member 18 | 0.51 |
| PIK3CD | phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta | 0.51 |
| CHKB | choline kinase beta | 0.51 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.51 |
| SPATA20 | spermatogenesis associated 20 | 0.51 |
| GNPAT | glyceronephosphate O-acyltransferase | 0.51 |
| TOM1L2 | target of myb1-like 2 (chicken) | 0.51 |
| DENND3 | DENN/MADD domain containing 3 | 0.5 |
| LRRC41 | leucine rich repeat containing 41 | 0.5 |
| ELMO3 | engulfment and cell motility 3 | 0.5 |
| Symbol | Name | Standardized Value |
|---|---|---|
| CHAC1 | ChaC glutathione-specific gamma-glutamylcyclotransferase 1 | -1.42 |
| ZSCAN32 | zinc finger and SCAN domain containing 32 | -1.36 |
| PRR11 | proline rich 11 | -1.35 |
| MKI67 | marker of proliferation Ki-67 | -1.17 |
| KIF20A | kinesin family member 20A | -1.17 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -1.15 |
| SLF1 | SMC5-SMC6 complex localization factor 1 | -1.15 |
| MYO3A | myosin IIIA | -1.12 |
| KIF2C | kinesin family member 2C | -1.11 |
| PTTG1 | pituitary tumor-transforming 1 | -1.11 |
| CDCA8 | cell division cycle associated 8 | -1.1 |
| PCLAF | PCNA clamp associated factor | -1.09 |
| SLC7A1 | solute carrier family 7 (cationic amino acid transporter, y+ system), member 1 | -1.09 |
| ATAD2 | ATPase family, AAA domain containing 2 | -1.08 |
| AURKB | aurora kinase B | -1.08 |
| DEPDC1B | DEP domain containing 1B | -1.06 |
| FAM111B | family with sequence similarity 111, member B | -1.04 |
| SKA1 | spindle and kinetochore associated complex subunit 1 | -1.04 |
| KNL1 | kinetochore scaffold 1 | -1.04 |
| WDR76 | WD repeat domain 76 | -1.04 |
| INCENP | inner centromere protein antigens 135/155kDa | -1.03 |
| PLK1 | polo-like kinase 1 | -1.03 |
| KIF11 | kinesin family member 11 | -1.02 |
| SUV39H1 | suppressor of variegation 3-9 homolog 1 (Drosophila) | -1.02 |
| NUF2 | NUF2, NDC80 kinetochore complex component | -1.01 |
| BIRC5 | baculoviral IAP repeat containing 5 | -1.01 |
| UBE2S | ubiquitin-conjugating enzyme E2S | -1.01 |
| CDCA3 | cell division cycle associated 3 | -1.01 |
| UHRF1 | ubiquitin-like with PHD and ring finger domains 1 | -1.0 |
| SKA2 | spindle and kinetochore associated complex subunit 2 | -1.0 |
| RACGAP1 | Rac GTPase activating protein 1 | -0.97 |
| RAD51AP1 | RAD51 associated protein 1 | -0.95 |
| TYMS | thymidylate synthetase | -0.94 |
| CDCA2 | cell division cycle associated 2 | -0.94 |
| PHF19 | PHD finger protein 19 | -0.94 |
| CCNB2 | cyclin B2 | -0.94 |
| PBK | PDZ binding kinase | -0.94 |
| SHCBP1 | SHC SH2-domain binding protein 1 | -0.93 |
| H1-2 | H1.2 linker histone, cluster member | -0.93 |
| HELLS | helicase, lymphoid-specific | -0.93 |
| CDKN3 | cyclin-dependent kinase inhibitor 3 | -0.93 |
| NDC80 | NDC80 kinetochore complex component | -0.92 |
| KIF23 | kinesin family member 23 | -0.92 |
| ASPM | asp (abnormal spindle) homolog, microcephaly associated (Drosophila) | -0.92 |
| NUSAP1 | nucleolar and spindle associated protein 1 | -0.92 |
| HIST1H1T | histone cluster 1, H1t | -0.91 |
| ITGB3BP | integrin beta 3 binding protein (beta3-endonexin) | -0.91 |
| HJURP | Holliday junction recognition protein | -0.89 |
| DLGAP5 | discs, large (Drosophila) homolog-associated protein 5 | -0.89 |
| RRM2 | ribonucleotide reductase M2 | -0.88 |
| ESPL1 | extra spindle pole bodies homolog 1 (S. cerevisiae) | -0.88 |
| ARHGAP19 | Rho GTPase activating protein 19 | -0.88 |
| CENPF | centromere protein F, 350/400kDa | -0.88 |
| CENPU | centromere protein U | -0.87 |
| CENPP | centromere protein P | -0.87 |
| GAS2L3 | growth arrest-specific 2 like 3 | -0.87 |
| CCNB1 | cyclin B1 | -0.86 |
| CKAP2L | cytoskeleton associated protein 2-like | -0.85 |
| RGS3 | regulator of G-protein signaling 3 | -0.85 |
| SMTN | smoothelin | -0.84 |
| HMMR | hyaluronan-mediated motility receptor (RHAMM) | -0.84 |
| KIF18B | kinesin family member 18B | -0.84 |
| DNPH1 | 2'-deoxynucleoside 5'-phosphate N-hydrolase 1 | -0.83 |
| ARHGAP11A | Rho GTPase activating protein 11A | -0.83 |
| SGO1 | shugoshin 1 | -0.83 |
| AZIN1 | antizyme inhibitor 1 | -0.82 |
| MIS18BP1 | MIS18 binding protein 1 | -0.82 |
| H1-3 | H1.3 linker histone, cluster member | -0.82 |
| CCNA2 | cyclin A2 | -0.82 |
| DONSON | downstream neighbor of SON | -0.81 |
| KNSTRN | kinetochore-localized astrin/SPAG5 binding protein | -0.81 |
| CENPQ | centromere protein Q | -0.8 |
| CDC45 | cell division cycle 45 | -0.8 |
| PRC1 | protein regulator of cytokinesis 1 | -0.8 |
| USP37 | ubiquitin specific peptidase 37 | -0.8 |
| TROAP | trophinin associated protein | -0.8 |
| UBE2T | ubiquitin-conjugating enzyme E2T | -0.8 |
| CHEK1 | checkpoint kinase 1 | -0.79 |
| ZWINT | ZW10 interacting kinetochore protein | -0.79 |
| KIF22 | kinesin family member 22 | -0.79 |
| MCM10 | minichromosome maintenance complex component 10 | -0.79 |
| H3C1 | H3 clustered histone 1 | -0.79 |
| CLSPN | claspin | -0.79 |
| PSRC1 | proline/serine-rich coiled-coil 1 | -0.78 |
| GMNN | geminin, DNA replication inhibitor | -0.78 |
| AEN | apoptosis enhancing nuclease | -0.77 |
| IFRD1 | interferon-related developmental regulator 1 | -0.77 |
| SKA3 | spindle and kinetochore associated complex subunit 3 | -0.77 |
| FOSL1 | FOS-like antigen 1 | -0.76 |
| MAFF | v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F | -0.76 |
| CIT | citron rho-interacting serine/threonine kinase | -0.76 |
| BRCA1 | breast cancer 1, early onset | -0.76 |
| GTSE1 | G-2 and S-phase expressed 1 | -0.76 |
| GIN1 | gypsy retrotransposon integrase 1 | -0.75 |
| SPAG5 | sperm associated antigen 5 | -0.75 |
| KIF20B | kinesin family member 20B | -0.75 |
| H1-4 | H1.4 linker histone, cluster member | -0.74 |
| HIST2H2BC | histone cluster 2, H2bc (pseudogene) | -0.74 |
| ANLN | anillin, actin binding protein | -0.74 |
| DCLRE1A | DNA cross-link repair 1A | -0.74 |
