Ribociclib_A-172 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Ribociclib perturbation in A-172 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Ribociclib_A-172 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.228694
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.137561
FBN1 fibrillin 1 0.0955799
COL1A2 collagen, type I, alpha 2 0.0910942
ZBTB20 zinc finger and BTB domain containing 20 0.0862438
NAV1 neuron navigator 1 0.0793295
DLG1 discs, large homolog 1 (Drosophila) 0.0705542
DST dystonin 0.0703041
PRELID2 PRELI domain containing 2 0.0694586
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0685814
MX2 MX dynamin-like GTPase 2 0.0653581
LOX lysyl oxidase 0.0598023
FNDC3B fibronectin type III domain containing 3B 0.0597866
GPC6 glypican 6 0.0585862
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0579268
PLAT plasminogen activator, tissue 0.0572788
OGA O-GlcNAcase 0.0566342
COL3A1 collagen, type III, alpha 1 0.0557561
MEIS2 Meis homeobox 2 0.0531019
PARP14 poly (ADP-ribose) polymerase family, member 14 0.0499883
AHNAK AHNAK nucleoprotein 0.0493834
RHOBTB3 Rho-related BTB domain containing 3 0.0472392
LOXL2 lysyl oxidase-like 2 0.0463677
FLNB filamin B, beta 0.0459216
RUNX1 runt-related transcription factor 1 0.045448
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) 0.0453015
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) 0.0444625
CD44 CD44 molecule (Indian blood group) 0.0443715
KIFAP3 kinesin-associated protein 3 0.0442759
ANKRD10 ankyrin repeat domain 10 0.0441884
SBF2 SET binding factor 2 0.0440022
KLF7 Kruppel-like factor 7 (ubiquitous) 0.0429511
AUTS2 autism susceptibility candidate 2 0.0420935
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 0.0407621
PTK2 protein tyrosine kinase 2 0.0399825
FRMD5 FERM domain containing 5 0.0390689
MAP4 microtubule-associated protein 4 0.0388761
IRF2BP2 interferon regulatory factor 2 binding protein 2 0.0387119
PDE4D phosphodiesterase 4D, cAMP-specific 0.0386621
ELL2 elongation factor, RNA polymerase II, 2 0.0378949
VPS13C vacuolar protein sorting 13 homolog C (S. cerevisiae) 0.0375366
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 0.037535
ERRFI1 ERBB receptor feedback inhibitor 1 0.0372295
GNGT1 guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1 0.0366006
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0358606
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 0.0356609
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0350915
PSD3 pleckstrin and Sec7 domain containing 3 0.0348302
IFI16 interferon, gamma-inducible protein 16 0.0348163
EHBP1 EH domain binding protein 1 0.0345402
ZNF292 zinc finger protein 292 0.0334905
FBXL2 F-box and leucine-rich repeat protein 2 0.0329452
SP3 Sp3 transcription factor 0.032945
ATP13A3 ATPase type 13A3 0.0328633
SOD2 superoxide dismutase 2, mitochondrial 0.0325791
AKT3 v-akt murine thymoma viral oncogene homolog 3 0.0321152
WWTR1 WW domain containing transcription regulator 1 0.0312859
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.0312335
DKK1 dickkopf WNT signaling pathway inhibitor 1 0.0310698
PARD3 par-3 family cell polarity regulator 0.0305838
TENM3 teneurin transmembrane protein 3 0.0304884
BRWD1 bromodomain and WD repeat domain containing 1 0.0303652
BIRC6 baculoviral IAP repeat containing 6 0.0302758
RBMS3 RNA binding motif, single stranded interacting protein 3 0.0299872
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6 0.0299792
AKAP12 A kinase (PRKA) anchor protein 12 0.0297438
COL5A2 collagen, type V, alpha 2 0.0291759
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0289443
ZEB2 zinc finger E-box binding homeobox 2 0.0288919
TRIO trio Rho guanine nucleotide exchange factor 0.0288285
MAP3K2 mitogen-activated protein kinase kinase kinase 2 0.0285889
NF1 neurofibromin 1 0.0285881
FBXL7 F-box and leucine-rich repeat protein 7 0.0284057
NAP1L1 nucleosome assembly protein 1-like 1 0.0283729
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.0280216
BPTF bromodomain PHD finger transcription factor 0.0278307
KCTD9 potassium channel tetramerization domain containing 9 0.0275888
AFF3 AF4/FMR2 family, member 3 0.0270669
GLIS3 GLIS family zinc finger 3 0.0269758
ZMYND8 zinc finger, MYND-type containing 8 0.0267709
RICTOR RPTOR independent companion of MTOR, complex 2 0.0267351
SMC4 structural maintenance of chromosomes 4 0.0265638
RPS6KA3 ribosomal protein S6 kinase, 90kDa, polypeptide 3 0.026544
COL8A1 collagen, type VIII, alpha 1 0.0264356
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0263484
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 0.0262923
TRIM56 tripartite motif containing 56 0.0261781
USP34 ubiquitin specific peptidase 34 0.0260206
PICALM phosphatidylinositol binding clathrin assembly protein 0.0258133
YEATS2 YEATS domain containing 2 0.025448
MBNL2 muscleblind-like splicing regulator 2 0.0252074
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 0.0249646
HS3ST3A1 heparan sulfate (glucosamine) 3-O-sulfotransferase 3A1 0.0249608
GULP1 GULP, engulfment adaptor PTB domain containing 1 0.0248705
ATXN1 ataxin 1 0.0248617
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0248068
SETD5 SET domain containing 5 0.0247963
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0246874
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha 0.0246094
MB21D2 Mab-21 domain containing 2 0.0243123

decreased expression

Symbol Name Standardized Value
VIM vimentin -0.135727
TMSB10 thymosin beta 10 -0.11481
IGFBP3 insulin-like growth factor binding protein 3 -0.112319
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.108835
PODXL podocalyxin-like -0.0932808
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.074699
CALR calreticulin -0.0738473
B2M beta-2-microglobulin -0.0683691
COL5A1 collagen, type V, alpha 1 -0.0664233
LDHA lactate dehydrogenase A -0.0629127
CSTB cystatin B (stefin B) -0.0573599
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.05674
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.0549194
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.0521941
PKM pyruvate kinase, muscle -0.0520372
TPM4 tropomyosin 4 -0.0500985
S100A6 S100 calcium binding protein A6 -0.0497404
ABI3BP ABI family, member 3 (NESH) binding protein -0.0475172
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 -0.0461044
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0438512
LOC112694756 uncharaterized LOC112694756 -0.0436454
S100A10 S100 calcium binding protein A10 -0.0430399
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0404033
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0378979
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0377871
RPS3 ribosomal protein S3 -0.035908
ENO1 enolase 1, (alpha) -0.0356035
LMNA lamin A/C -0.0347335
FLNA filamin A, alpha -0.0342717
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2 -0.0336396
DGKG diacylglycerol kinase, gamma 90kDa -0.0335717
ANXA2 annexin A2 -0.033229
HSPA9 heat shock 70kDa protein 9 (mortalin) -0.0327355
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 -0.0325643
POTEF POTE ankyrin domain family, member F -0.032392
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) -0.0317012
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0316528
EEF2 eukaryotic translation elongation factor 2 -0.0313904
CENPF centromere protein F, 350/400kDa -0.0305485
COPA coatomer protein complex, subunit alpha -0.0296184
FLT1 fms-related tyrosine kinase 1 -0.0291438
TMSB4X thymosin beta 4, X-linked -0.0286229
LAMC1 laminin, gamma 1 (formerly LAMB2) -0.0284981
AHNAK2 AHNAK nucleoprotein 2 -0.0283238
CDH13 cadherin 13 -0.0276058
UBC ubiquitin C -0.0274862
RSAD2 radical S-adenosyl methionine domain containing 2 -0.0274713
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 -0.0272819
IGFN1 immunoglobulin-like and fibronectin type III domain containing 1 -0.0268505
RND3 Rho family GTPase 3 -0.0266952
CTSB cathepsin B -0.0265865
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0265617
RACK1 receptor for activated C kinase 1 -0.0265209
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma -0.0260853
SIPA1L3 signal-induced proliferation-associated 1 like 3 -0.0258877
ANXA1 annexin A1 -0.0258742
FSTL1 follistatin-like 1 -0.0257347
PPP1R15A protein phosphatase 1, regulatory subunit 15A -0.0255381
RPS2 ribosomal protein S2 -0.0253093
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide) -0.0248547
IFITM3 interferon induced transmembrane protein 3 -0.0245545
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0244545
SLC38A1 solute carrier family 38, member 1 -0.023664
SORBS2 sorbin and SH3 domain containing 2 -0.0229256
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -0.0224079
TAGLN2 transgelin 2 -0.0223081
S100A11 S100 calcium binding protein A11 -0.022268
BHLHE40 basic helix-loop-helix family, member e40 -0.0222573
EGFR epidermal growth factor receptor -0.0222422
IFIT1 interferon-induced protein with tetratricopeptide repeats 1 -0.0220822
EGR1 early growth response 1 -0.0217583
APP amyloid beta (A4) precursor protein -0.0215143
TPM3 tropomyosin 3 -0.0213416
EIF3A eukaryotic translation initiation factor 3, subunit A -0.0213091
PALM2AKAP2 PALM2 and AKAP2 fusion -0.0212528
RPS12 ribosomal protein S12 -0.0210939
FTH1 ferritin, heavy polypeptide 1 -0.0209482
BRD2 bromodomain containing 2 -0.0207242
RPL28 ribosomal protein L28 -0.0206812
TUFT1 tuftelin 1 -0.0204357
RPL35 ribosomal protein L35 -0.0200501
GADD45B growth arrest and DNA-damage-inducible, beta -0.0198886
IL7R interleukin 7 receptor -0.0198311
PFN1 profilin 1 -0.0196056
JUN jun proto-oncogene -0.0195936
ANXA5 annexin A5 -0.0195317
CYTH3 cytohesin 3 -0.0193391
BSG basigin (Ok blood group) -0.0192293
MSN moesin -0.0192109
ANKRD33B ankyrin repeat domain 33B -0.0188882
RPL23 ribosomal protein L23 -0.0188434
RIGI RNA sensor RIG-I -0.0187778
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.0186709
IFRD1 interferon-related developmental regulator 1 -0.0185032
MYH9 myosin, heavy chain 9, non-muscle -0.0183151
PLEC plectin -0.0181992
NFE2L1 nuclear factor, erythroid 2-like 1 -0.0181959
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 -0.0181057
GADD45A growth arrest and DNA-damage-inducible, alpha -0.0180494
EIF4H eukaryotic translation initiation factor 4H -0.0177897