Ribociclib_A-427 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Ribociclib perturbation in A-427 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Ribociclib_A-427 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A 0.156035
STARD4 StAR-related lipid transfer (START) domain containing 4 0.111761
MMP12 matrix metallopeptidase 12 0.101269
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0915702
ANXA1 annexin A1 0.0854519
NLGN1 neuroligin 1 0.0792088
TMEM41B transmembrane protein 41B 0.0756376
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0736411
VIM vimentin 0.0728653
ALDH1A1 aldehyde dehydrogenase 1 family, member A1 0.0701254
VMP1 vacuole membrane protein 1 0.069053
PDE4D phosphodiesterase 4D, cAMP-specific 0.0686466
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.0624828
EGLN1 egl-9 family hypoxia-inducible factor 1 0.0616774
ADGRG6 adhesion G protein-coupled receptor G6 0.0613579
MGAT4C MGAT4 family, member C 0.0609751
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2 0.0597104
TMEM123 transmembrane protein 123 0.058088
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0579854
DPYD dihydropyrimidine dehydrogenase 0.0572745
DST dystonin 0.0557246
BIRC3 baculoviral IAP repeat containing 3 0.0534083
CELF2 CUGBP, Elav-like family member 2 0.0522958
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.0520935
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.050632
KDM3A lysine (K)-specific demethylase 3A 0.0477761
ZNF804A zinc finger protein 804A 0.0452496
ECT2 epithelial cell transforming 2 0.0451642
NIPBL Nipped-B homolog (Drosophila) 0.0449667
CDK17 cyclin-dependent kinase 17 0.0442788
CENPF centromere protein F, 350/400kDa 0.0437794
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0437088
KIF5B kinesin family member 5B 0.0433282
CLDN1 claudin 1 0.0431683
PTMA prothymosin, alpha 0.0431137
PUM2 pumilio RNA-binding family member 2 0.0419373
NEK7 NIMA-related kinase 7 0.0414312
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) 0.0409949
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0409858
GASK1B golgi associated kinase 1B 0.0407518
PTPRZ1 protein tyrosine phosphatase, receptor-type, Z polypeptide 1 0.0405233
TXNRD1 thioredoxin reductase 1 0.0395294
RERE arginine-glutamic acid dipeptide (RE) repeats 0.039525
USP34 ubiquitin specific peptidase 34 0.0393175
PTGES3 prostaglandin E synthase 3 (cytosolic) 0.0391176
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) 0.0384992
PCDH7 protocadherin 7 0.0379799
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0375779
EDARADD EDAR-associated death domain 0.0368396
KPNB1 karyopherin (importin) beta 1 0.0368024
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0366945
DLC1 DLC1 Rho GTPase activating protein 0.0365124
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.035958
RASAL2 RAS protein activator like 2 0.0358447
MTAP methylthioadenosine phosphorylase 0.0357993
LMO7 LIM domain 7 0.0355491
IL6ST interleukin 6 signal transducer 0.0349794
NAP1L1 nucleosome assembly protein 1-like 1 0.0346596
CXADR coxsackie virus and adenovirus receptor 0.0346585
MED13L mediator complex subunit 13-like 0.0339598
IFIH1 interferon induced with helicase C domain 1 0.0337736
MKI67 marker of proliferation Ki-67 0.032865
BCHE butyrylcholinesterase 0.0326901
CLTC clathrin, heavy chain (Hc) 0.0326593
BIRC2 baculoviral IAP repeat containing 2 0.0325361
TAS2R14 taste receptor, type 2, member 14 0.0324772
MYPN myopalladin 0.0324277
SPATS2 spermatogenesis associated, serine-rich 2 0.0320661
ASPH aspartate beta-hydroxylase 0.0313021
JMJD1C jumonji domain containing 1C 0.0313009
MARCHF6 membrane associated ring-CH-type finger 6 0.0305204
ERBB4 erb-b2 receptor tyrosine kinase 4 0.0304741
TNPO1 transportin 1 0.0302854
BIRC6 baculoviral IAP repeat containing 6 0.030196
OXR1 oxidation resistance 1 0.0300405
TM4SF1 transmembrane 4 L six family member 1 0.0300182
KRR1 KRR1, small subunit (SSU) processome component, homolog (yeast) 0.029576
CUBN cubilin (intrinsic factor-cobalamin receptor) 0.0293457
CMSS1 cms1 ribosomal small subunit homolog (yeast) 0.0291449
RAD21 RAD21 homolog (S. pombe) 0.0287402
SERPINA2 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 2 (gene/pseudogene) 0.0285673
CSNK1A1 casein kinase 1, alpha 1 0.0284721
XPO1 exportin 1 0.0282842
SNCA synuclein, alpha (non A4 component of amyloid precursor) 0.0279565
PDK4 pyruvate dehydrogenase kinase, isozyme 4 0.027824
AKAP12 A kinase (PRKA) anchor protein 12 0.0277928
TPT1 tumor protein, translationally-controlled 1 0.0276181
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 0.0274432
RSL1D1 ribosomal L1 domain containing 1 0.0274015
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0271649
NF1 neurofibromin 1 0.0270036
KCMF1 potassium channel modulatory factor 1 0.0267862
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.0267483
YES1 YES proto-oncogene 1, Src family tyrosine kinase 0.026687
CALR calreticulin 0.0266269
NR5A2 nuclear receptor subfamily 5, group A, member 2 0.0265672
SPAG9 sperm associated antigen 9 0.0264324
HLTF helicase-like transcription factor 0.0260585
IPO7 importin 7 0.0260548
ZNF217 zinc finger protein 217 0.0259167

decreased expression

Symbol Name Standardized Value
TMSB10 thymosin beta 10 -0.147534
AREG amphiregulin -0.137295
FTL ferritin, light polypeptide -0.0943321
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0649603
RPS19 ribosomal protein S19 -0.0621332
RPS6 ribosomal protein S6 -0.0556062
CNRIP1 cannabinoid receptor interacting protein 1 -0.0547369
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0470399
RPL3 ribosomal protein L3 -0.0469651
PCBP2 poly(rC) binding protein 2 -0.0444491
RPL23 ribosomal protein L23 -0.0397805
RPL19 ribosomal protein L19 -0.0358651
RPS4X ribosomal protein S4, X-linked -0.0348897
RPLP1 ribosomal protein, large, P1 -0.0347807
POTEF POTE ankyrin domain family, member F -0.0342562
RPL11 ribosomal protein L11 -0.0340208
RPL35A ribosomal protein L35a -0.0338453
RPS27 ribosomal protein S27 -0.0320933
RPS23 ribosomal protein S23 -0.03176
LDHA lactate dehydrogenase A -0.0308629
INTS6 integrator complex subunit 6 -0.0306408
RPL36 ribosomal protein L36 -0.030555
YBX1 Y box binding protein 1 -0.0285704
ATP5F1B ATP synthase F1 subunit beta -0.0282166
PRKCE protein kinase C, epsilon -0.0276456
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0273515
RPS14 ribosomal protein S14 -0.0262729
RPLP2 ribosomal protein, large, P2 -0.0260635
APLP2 amyloid beta (A4) precursor-like protein 2 -0.0259909
RPL9 ribosomal protein L9 -0.0258515
RPL28 ribosomal protein L28 -0.025763
PTMS parathymosin -0.0250865
RPL13A ribosomal protein L13a -0.0247411
SRRM2 serine/arginine repetitive matrix 2 -0.0241056
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 -0.0239495
HLA-A major histocompatibility complex, class I, A -0.0233794
RTN4 reticulon 4 -0.0225101
RPL32 ribosomal protein L32 -0.0222505
RPL27 ribosomal protein L27 -0.0221767
FLNA filamin A, alpha -0.0221284
EEF1G eukaryotic translation elongation factor 1 gamma -0.0216432
EGR1 early growth response 1 -0.0206799
DDIT3 DNA-damage-inducible transcript 3 -0.020385
PFN1 profilin 1 -0.0203828
ZBTB20 zinc finger and BTB domain containing 20 -0.0203258
RPS26 ribosomal protein S26 -0.0201752
RPL8 ribosomal protein L8 -0.0200515
DUSP16 dual specificity phosphatase 16 -0.0199782
ZNF638 zinc finger protein 638 -0.0197025
ANKRD12 ankyrin repeat domain 12 -0.0187884
KMT2D lysine (K)-specific methyltransferase 2D -0.0186657
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 -0.0185957
KDM5A lysine (K)-specific demethylase 5A -0.0185887
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.0182296
ERC1 ELKS/RAB6-interacting/CAST family member 1 -0.0181273
LDHB lactate dehydrogenase B -0.018014
RPS20 ribosomal protein S20 -0.0178177
SETD5 SET domain containing 5 -0.0176666
GSE1 Gse1 coiled-coil protein -0.0173225
RPS5 ribosomal protein S5 -0.0170976
FOXO3 forkhead box O3 -0.0170011
GHR growth hormone receptor -0.0168661
RPS15 ribosomal protein S15 -0.0168383
HELLS helicase, lymphoid-specific -0.0168054
KDM4C lysine (K)-specific demethylase 4C -0.0166146
HNRNPA0 heterogeneous nuclear ribonucleoprotein A0 -0.0165499
TRA2B transformer 2 beta homolog (Drosophila) -0.0165106
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.0164008
RPL31 ribosomal protein L31 -0.0163068
CPNE1 copine I -0.0162699
RPS29 ribosomal protein S29 -0.0159083
NRXN3 neurexin 3 -0.0158594
CABIN1 calcineurin binding protein 1 -0.0157528
RPS21 ribosomal protein S21 -0.0157451
EXOC4 exocyst complex component 4 -0.0156356
EIF2S2 eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa -0.0153913
NDUFA4 NDUFA4, mitochondrial complex associated -0.015257
RPL27A ribosomal protein L27a -0.0152234
RPL12 ribosomal protein L12 -0.0152025
RPLP0 ribosomal protein, large, P0 -0.0151885
L3MBTL4 l(3)mbt-like 4 (Drosophila) -0.0151623
RAPGEF6 Rap guanine nucleotide exchange factor (GEF) 6 -0.0151561
UBXN4 UBX domain protein 4 -0.0150715
WWOX WW domain containing oxidoreductase -0.0150097
RPL37 ribosomal protein L37 -0.0147752
RPS11 ribosomal protein S11 -0.0147224
ATP5F1E ATP synthase F1 subunit epsilon -0.0147004
GPX4 glutathione peroxidase 4 -0.0146612
RPS27A ribosomal protein S27a -0.014631
GOLGB1 golgin B1 -0.0145165
CDK2AP2 cyclin-dependent kinase 2 associated protein 2 -0.0145084
KDM4B lysine (K)-specific demethylase 4B -0.0144554
TEX14 testis expressed 14 -0.0144348
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.0143997
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 -0.0143676
S100A9 S100 calcium binding protein A9 -0.0142552
LRMDA leucine rich melanocyte differentiation associated -0.0141549
NALF1 NALCN channel auxiliary factor 1 -0.0139823
YBX3 Y box binding protein 3 -0.0139588
ANK2 ankyrin 2, neuronal -0.0138496